Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer

Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was ana...
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Autor*in:	Zhang, Xudong [verfasserIn] Cui, Hao Hu, Nana Han, Peng Fan, Wei Wang, Panting Zuo, Xiaoxuan Zhao, Dantong Huang, He Li, Shuo Kong, Hanqing Peng, Fuhui Tian, Jiawei Zhang, Lei

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Breast cancer Androgen receptor Ultrasound Nomogram Prognosis

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Insights into imaging - Berlin : Springer, 2010, 14(2023), 1 vom: 16. März
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:1 ; day:16 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s13244-023-01387-9

Katalog-ID:	SPR049715593

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520			\|a Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer.
520			\|a Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer.
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allfields	10.1186/s13244-023-01387-9 doi (DE-627)SPR049715593 (SPR)s13244-023-01387-9-e DE-627 ger DE-627 rakwb eng Zhang, Xudong verfasserin aut Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. Breast cancer (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Ultrasound (dpeaa)DE-He213 Nomogram (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cui, Hao aut Hu, Nana aut Han, Peng aut Fan, Wei aut Wang, Panting aut Zuo, Xiaoxuan aut Zhao, Dantong aut Huang, He aut Li, Shuo aut Kong, Hanqing aut Peng, Fuhui aut Tian, Jiawei aut Zhang, Lei (orcid)0000-0003-4143-668X aut Enthalten in Insights into imaging Berlin : Springer, 2010 14(2023), 1 vom: 16. März (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:14 year:2023 number:1 day:16 month:03 https://dx.doi.org/10.1186/s13244-023-01387-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 16 03
spelling	10.1186/s13244-023-01387-9 doi (DE-627)SPR049715593 (SPR)s13244-023-01387-9-e DE-627 ger DE-627 rakwb eng Zhang, Xudong verfasserin aut Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. Breast cancer (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Ultrasound (dpeaa)DE-He213 Nomogram (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cui, Hao aut Hu, Nana aut Han, Peng aut Fan, Wei aut Wang, Panting aut Zuo, Xiaoxuan aut Zhao, Dantong aut Huang, He aut Li, Shuo aut Kong, Hanqing aut Peng, Fuhui aut Tian, Jiawei aut Zhang, Lei (orcid)0000-0003-4143-668X aut Enthalten in Insights into imaging Berlin : Springer, 2010 14(2023), 1 vom: 16. März (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:14 year:2023 number:1 day:16 month:03 https://dx.doi.org/10.1186/s13244-023-01387-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 16 03
allfields_unstemmed	10.1186/s13244-023-01387-9 doi (DE-627)SPR049715593 (SPR)s13244-023-01387-9-e DE-627 ger DE-627 rakwb eng Zhang, Xudong verfasserin aut Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. Breast cancer (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Ultrasound (dpeaa)DE-He213 Nomogram (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cui, Hao aut Hu, Nana aut Han, Peng aut Fan, Wei aut Wang, Panting aut Zuo, Xiaoxuan aut Zhao, Dantong aut Huang, He aut Li, Shuo aut Kong, Hanqing aut Peng, Fuhui aut Tian, Jiawei aut Zhang, Lei (orcid)0000-0003-4143-668X aut Enthalten in Insights into imaging Berlin : Springer, 2010 14(2023), 1 vom: 16. März (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:14 year:2023 number:1 day:16 month:03 https://dx.doi.org/10.1186/s13244-023-01387-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 16 03
allfieldsGer	10.1186/s13244-023-01387-9 doi (DE-627)SPR049715593 (SPR)s13244-023-01387-9-e DE-627 ger DE-627 rakwb eng Zhang, Xudong verfasserin aut Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. Breast cancer (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Ultrasound (dpeaa)DE-He213 Nomogram (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cui, Hao aut Hu, Nana aut Han, Peng aut Fan, Wei aut Wang, Panting aut Zuo, Xiaoxuan aut Zhao, Dantong aut Huang, He aut Li, Shuo aut Kong, Hanqing aut Peng, Fuhui aut Tian, Jiawei aut Zhang, Lei (orcid)0000-0003-4143-668X aut Enthalten in Insights into imaging Berlin : Springer, 2010 14(2023), 1 vom: 16. März (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:14 year:2023 number:1 day:16 month:03 https://dx.doi.org/10.1186/s13244-023-01387-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 16 03
allfieldsSound	10.1186/s13244-023-01387-9 doi (DE-627)SPR049715593 (SPR)s13244-023-01387-9-e DE-627 ger DE-627 rakwb eng Zhang, Xudong verfasserin aut Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. Breast cancer (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Ultrasound (dpeaa)DE-He213 Nomogram (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cui, Hao aut Hu, Nana aut Han, Peng aut Fan, Wei aut Wang, Panting aut Zuo, Xiaoxuan aut Zhao, Dantong aut Huang, He aut Li, Shuo aut Kong, Hanqing aut Peng, Fuhui aut Tian, Jiawei aut Zhang, Lei (orcid)0000-0003-4143-668X aut Enthalten in Insights into imaging Berlin : Springer, 2010 14(2023), 1 vom: 16. März (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:14 year:2023 number:1 day:16 month:03 https://dx.doi.org/10.1186/s13244-023-01387-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 16 03
language	English
source	Enthalten in Insights into imaging 14(2023), 1 vom: 16. März volume:14 year:2023 number:1 day:16 month:03
sourceStr	Enthalten in Insights into imaging 14(2023), 1 vom: 16. März volume:14 year:2023 number:1 day:16 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Breast cancer Androgen receptor Ultrasound Nomogram Prognosis
isfreeaccess_bool	true
container_title	Insights into imaging
authorswithroles_txt_mv	Zhang, Xudong @@aut@@ Cui, Hao @@aut@@ Hu, Nana @@aut@@ Han, Peng @@aut@@ Fan, Wei @@aut@@ Wang, Panting @@aut@@ Zuo, Xiaoxuan @@aut@@ Zhao, Dantong @@aut@@ Huang, He @@aut@@ Li, Shuo @@aut@@ Kong, Hanqing @@aut@@ Peng, Fuhui @@aut@@ Tian, Jiawei @@aut@@ Zhang, Lei @@aut@@
publishDateDaySort_date	2023-03-16T00:00:00Z
hierarchy_top_id	621547425
id	SPR049715593
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR049715593</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230323113000.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230323s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13244-023-01387-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR049715593</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13244-023-01387-9-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Zhang, Xudong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2023</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. 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author	Zhang, Xudong
spellingShingle	Zhang, Xudong misc Breast cancer misc Androgen receptor misc Ultrasound misc Nomogram misc Prognosis Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer
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topic_title	Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer Breast cancer (dpeaa)DE-He213 Androgen receptor (dpeaa)DE-He213 Ultrasound (dpeaa)DE-He213 Nomogram (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213
topic	misc Breast cancer misc Androgen receptor misc Ultrasound misc Nomogram misc Prognosis
topic_unstemmed	misc Breast cancer misc Androgen receptor misc Ultrasound misc Nomogram misc Prognosis
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title	Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer
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title_full	Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer
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author_browse	Zhang, Xudong Cui, Hao Hu, Nana Han, Peng Fan, Wei Wang, Panting Zuo, Xiaoxuan Zhao, Dantong Huang, He Li, Shuo Kong, Hanqing Peng, Fuhui Tian, Jiawei Zhang, Lei
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title_sort	correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer
title_auth	Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer
abstract	Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. © The Author(s) 2023
abstractGer	Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. © The Author(s) 2023
abstract_unstemmed	Background This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer. Methods A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry. The images of B-mode, color Doppler and strain elastography from 104 patients were collected continuously, and the corresponding ultrasound characteristics were obtained. The differences in ultrasound and clinicopathological features in different AR status were analyzed. Progression-free survival (PFS) of patients was obtained through up to 90 months of follow-up; then, the effect of AR on PFS was analyzed. Subsequently, a nomogram was constructed to predict the AR status. The predictive accuracy was calculated using C-index. Results The positive expression of AR (AR +) was associated with lower histological grade (p = 0.034) and lower Ki-67 level (p = 0.029). Triple-negative breast cancer (TNBC) had the lowest probability of AR + (p < 0.001). The AR + group mostly showed unsmooth margin (p < 0.001), posterior acoustic shadowing (p = 0.002) and higher elasticity score (p = 0.022) on ultrasound. The echo pattern of most tumors with AR + was heterogeneous (p = 0.024) in Luminal A subtype. AR + could be a sign of a better prognosis in overall breast cancer (p < 0.001), as well as in human epidermal growth factor receptor 2 (HER2) overexpression and Luminal B subtypes (p = 0.001 and 0.025). The nomogram showed relatively reliable performance with a C-index of 0.799. Conclusion Our research demonstrated that AR expression was closely related to ultrasound, clinicopathological features and prognosis of breast cancer. Key points In terms of clinicopathology, the probability of AR expression in different subtypes of breast cancer was various, and the positive expression of AR was associated with lower histological grade and lower Ki-67 level.In terms of ultrasound, the positive expression of AR was associated with unsmooth margin, posterior acoustic shadowing and stiffer on strain elastography, and AR + and AR– tumors performed differently when analyzed separately according to different molecular subtypes.The positive expression of AR could be a sign of a better prognosis in breast cancer. © The Author(s) 2023
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title_short	Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer
url	https://dx.doi.org/10.1186/s13244-023-01387-9
remote_bool	true
author2	Cui, Hao Hu, Nana Han, Peng Fan, Wei Wang, Panting Zuo, Xiaoxuan Zhao, Dantong Huang, He Li, Shuo Kong, Hanqing Peng, Fuhui Tian, Jiawei Zhang, Lei
author2Str	Cui, Hao Hu, Nana Han, Peng Fan, Wei Wang, Panting Zuo, Xiaoxuan Zhao, Dantong Huang, He Li, Shuo Kong, Hanqing Peng, Fuhui Tian, Jiawei Zhang, Lei
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Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer

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