No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients

Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevale...
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Autor*in:	Philippot, Quentin [verfasserIn] Bastard, Paul Puel, Anne Casanova, Jean-Laurent Cobat, Aurélie Laouénan, Cédric Tardivon, Coralie Crestani, Bruno Borie, Raphael

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	COVID-19 Idiopathic pulmonary fibrosis Autoimmunity

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Respiratory research - London : BioMed Central, 2001, 24(2023), 1 vom: 20. März
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:1 ; day:20 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s12931-023-02396-4

Katalog-ID:	SPR049761048

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allfields	10.1186/s12931-023-02396-4 doi (DE-627)SPR049761048 (SPR)s12931-023-02396-4-e DE-627 ger DE-627 rakwb eng Philippot, Quentin verfasserin aut No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. COVID-19 (dpeaa)DE-He213 Idiopathic pulmonary fibrosis (dpeaa)DE-He213 Autoimmunity (dpeaa)DE-He213 Bastard, Paul aut Puel, Anne aut Casanova, Jean-Laurent aut Cobat, Aurélie aut Laouénan, Cédric aut Tardivon, Coralie aut Crestani, Bruno aut Borie, Raphael aut Enthalten in Respiratory research London : BioMed Central, 2001 24(2023), 1 vom: 20. März (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:24 year:2023 number:1 day:20 month:03 https://dx.doi.org/10.1186/s12931-023-02396-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 20 03
spelling	10.1186/s12931-023-02396-4 doi (DE-627)SPR049761048 (SPR)s12931-023-02396-4-e DE-627 ger DE-627 rakwb eng Philippot, Quentin verfasserin aut No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. COVID-19 (dpeaa)DE-He213 Idiopathic pulmonary fibrosis (dpeaa)DE-He213 Autoimmunity (dpeaa)DE-He213 Bastard, Paul aut Puel, Anne aut Casanova, Jean-Laurent aut Cobat, Aurélie aut Laouénan, Cédric aut Tardivon, Coralie aut Crestani, Bruno aut Borie, Raphael aut Enthalten in Respiratory research London : BioMed Central, 2001 24(2023), 1 vom: 20. März (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:24 year:2023 number:1 day:20 month:03 https://dx.doi.org/10.1186/s12931-023-02396-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 20 03
allfields_unstemmed	10.1186/s12931-023-02396-4 doi (DE-627)SPR049761048 (SPR)s12931-023-02396-4-e DE-627 ger DE-627 rakwb eng Philippot, Quentin verfasserin aut No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. COVID-19 (dpeaa)DE-He213 Idiopathic pulmonary fibrosis (dpeaa)DE-He213 Autoimmunity (dpeaa)DE-He213 Bastard, Paul aut Puel, Anne aut Casanova, Jean-Laurent aut Cobat, Aurélie aut Laouénan, Cédric aut Tardivon, Coralie aut Crestani, Bruno aut Borie, Raphael aut Enthalten in Respiratory research London : BioMed Central, 2001 24(2023), 1 vom: 20. März (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:24 year:2023 number:1 day:20 month:03 https://dx.doi.org/10.1186/s12931-023-02396-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 20 03
allfieldsGer	10.1186/s12931-023-02396-4 doi (DE-627)SPR049761048 (SPR)s12931-023-02396-4-e DE-627 ger DE-627 rakwb eng Philippot, Quentin verfasserin aut No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. COVID-19 (dpeaa)DE-He213 Idiopathic pulmonary fibrosis (dpeaa)DE-He213 Autoimmunity (dpeaa)DE-He213 Bastard, Paul aut Puel, Anne aut Casanova, Jean-Laurent aut Cobat, Aurélie aut Laouénan, Cédric aut Tardivon, Coralie aut Crestani, Bruno aut Borie, Raphael aut Enthalten in Respiratory research London : BioMed Central, 2001 24(2023), 1 vom: 20. März (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:24 year:2023 number:1 day:20 month:03 https://dx.doi.org/10.1186/s12931-023-02396-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 20 03
allfieldsSound	10.1186/s12931-023-02396-4 doi (DE-627)SPR049761048 (SPR)s12931-023-02396-4-e DE-627 ger DE-627 rakwb eng Philippot, Quentin verfasserin aut No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. COVID-19 (dpeaa)DE-He213 Idiopathic pulmonary fibrosis (dpeaa)DE-He213 Autoimmunity (dpeaa)DE-He213 Bastard, Paul aut Puel, Anne aut Casanova, Jean-Laurent aut Cobat, Aurélie aut Laouénan, Cédric aut Tardivon, Coralie aut Crestani, Bruno aut Borie, Raphael aut Enthalten in Respiratory research London : BioMed Central, 2001 24(2023), 1 vom: 20. März (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:24 year:2023 number:1 day:20 month:03 https://dx.doi.org/10.1186/s12931-023-02396-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 20 03
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source	Enthalten in Respiratory research 24(2023), 1 vom: 20. März volume:24 year:2023 number:1 day:20 month:03
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authorswithroles_txt_mv	Philippot, Quentin @@aut@@ Bastard, Paul @@aut@@ Puel, Anne @@aut@@ Casanova, Jean-Laurent @@aut@@ Cobat, Aurélie @@aut@@ Laouénan, Cédric @@aut@@ Tardivon, Coralie @@aut@@ Crestani, Bruno @@aut@@ Borie, Raphael @@aut@@
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author	Philippot, Quentin
spellingShingle	Philippot, Quentin misc COVID-19 misc Idiopathic pulmonary fibrosis misc Autoimmunity No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients
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topic_title	No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients COVID-19 (dpeaa)DE-He213 Idiopathic pulmonary fibrosis (dpeaa)DE-He213 Autoimmunity (dpeaa)DE-He213
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title	No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients
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title_full	No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients
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author_browse	Philippot, Quentin Bastard, Paul Puel, Anne Casanova, Jean-Laurent Cobat, Aurélie Laouénan, Cédric Tardivon, Coralie Crestani, Bruno Borie, Raphael
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title_sort	no increased prevalence of autoantibodies neutralizing type i ifns in idiopathic pulmonary fibrosis patients
title_auth	No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients
abstract	Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. © The Author(s) 2023
abstractGer	Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. © The Author(s) 2023
abstract_unstemmed	Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF. © The Author(s) 2023
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title_short	No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients
url	https://dx.doi.org/10.1186/s12931-023-02396-4
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author2	Bastard, Paul Puel, Anne Casanova, Jean-Laurent Cobat, Aurélie Laouénan, Cédric Tardivon, Coralie Crestani, Bruno Borie, Raphael
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up_date	2024-07-04T02:10:55.755Z
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No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients

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