Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis
Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbi...
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| Autor*in: |
Manabe, Yusuke [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2023 |
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| Übergeordnetes Werk: |
Enthalten in: Arthritis Research & Therapy - London : BioMed Central, 1999, 25(2023), 1 vom: 24. März |
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| Übergeordnetes Werk: |
volume:25 ; year:2023 ; number:1 ; day:24 ; month:03 |
| Links: |
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| DOI / URN: |
10.1186/s13075-023-03031-9 |
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| Katalog-ID: |
SPR049825887 |
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| 100 | 1 | |a Manabe, Yusuke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis |
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| 520 | |a Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. | ||
| 650 | 4 | |a Takayasu arteritis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Microbiota |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oral bacteria |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Proton pump inhibitor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Aortic aneurysm |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Campylobacter |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ishibashi, Tomohiko |4 aut | |
| 700 | 1 | |a Asano, Ryotaro |4 aut | |
| 700 | 1 | |a Tonomura, Shuichi |4 aut | |
| 700 | 1 | |a Maeda, Yuichi |4 aut | |
| 700 | 1 | |a Motooka, Daisuke |4 aut | |
| 700 | 1 | |a Ueda, Jin |4 aut | |
| 700 | 1 | |a Yanagawa, Masahiro |4 aut | |
| 700 | 1 | |a Edamoto-Taira, Yuko |4 aut | |
| 700 | 1 | |a Chikaishi-Kirino, Tomomi |4 aut | |
| 700 | 1 | |a Masaki, Takeshi |4 aut | |
| 700 | 1 | |a Inagaki, Tadakatsu |4 aut | |
| 700 | 1 | |a Nakamura, Shota |4 aut | |
| 700 | 1 | |a Katada, Yoshinori |4 aut | |
| 700 | 1 | |a Okazawa, Makoto |4 aut | |
| 700 | 1 | |a Narazaki, Masashi |4 aut | |
| 700 | 1 | |a Ogo, Takeshi |4 aut | |
| 700 | 1 | |a Kumanogoh, Atsushi |4 aut | |
| 700 | 1 | |a Nakaoka, Yoshikazu |0 (orcid)0000-0002-8404-2587 |4 aut | |
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10.1186/s13075-023-03031-9 doi (DE-627)SPR049825887 (SPR)s13075-023-03031-9-e DE-627 ger DE-627 rakwb eng Manabe, Yusuke verfasserin aut Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. Takayasu arteritis (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Oral bacteria (dpeaa)DE-He213 Proton pump inhibitor (dpeaa)DE-He213 Aortic aneurysm (dpeaa)DE-He213 Campylobacter (dpeaa)DE-He213 Ishibashi, Tomohiko aut Asano, Ryotaro aut Tonomura, Shuichi aut Maeda, Yuichi aut Motooka, Daisuke aut Ueda, Jin aut Yanagawa, Masahiro aut Edamoto-Taira, Yuko aut Chikaishi-Kirino, Tomomi aut Masaki, Takeshi aut Inagaki, Tadakatsu aut Nakamura, Shota aut Katada, Yoshinori aut Okazawa, Makoto aut Narazaki, Masashi aut Ogo, Takeshi aut Kumanogoh, Atsushi aut Nakaoka, Yoshikazu (orcid)0000-0002-8404-2587 aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 25(2023), 1 vom: 24. März (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:25 year:2023 number:1 day:24 month:03 https://dx.doi.org/10.1186/s13075-023-03031-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1 24 03 |
| spelling |
10.1186/s13075-023-03031-9 doi (DE-627)SPR049825887 (SPR)s13075-023-03031-9-e DE-627 ger DE-627 rakwb eng Manabe, Yusuke verfasserin aut Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. Takayasu arteritis (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Oral bacteria (dpeaa)DE-He213 Proton pump inhibitor (dpeaa)DE-He213 Aortic aneurysm (dpeaa)DE-He213 Campylobacter (dpeaa)DE-He213 Ishibashi, Tomohiko aut Asano, Ryotaro aut Tonomura, Shuichi aut Maeda, Yuichi aut Motooka, Daisuke aut Ueda, Jin aut Yanagawa, Masahiro aut Edamoto-Taira, Yuko aut Chikaishi-Kirino, Tomomi aut Masaki, Takeshi aut Inagaki, Tadakatsu aut Nakamura, Shota aut Katada, Yoshinori aut Okazawa, Makoto aut Narazaki, Masashi aut Ogo, Takeshi aut Kumanogoh, Atsushi aut Nakaoka, Yoshikazu (orcid)0000-0002-8404-2587 aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 25(2023), 1 vom: 24. März (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:25 year:2023 number:1 day:24 month:03 https://dx.doi.org/10.1186/s13075-023-03031-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1 24 03 |
| allfields_unstemmed |
10.1186/s13075-023-03031-9 doi (DE-627)SPR049825887 (SPR)s13075-023-03031-9-e DE-627 ger DE-627 rakwb eng Manabe, Yusuke verfasserin aut Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. Takayasu arteritis (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Oral bacteria (dpeaa)DE-He213 Proton pump inhibitor (dpeaa)DE-He213 Aortic aneurysm (dpeaa)DE-He213 Campylobacter (dpeaa)DE-He213 Ishibashi, Tomohiko aut Asano, Ryotaro aut Tonomura, Shuichi aut Maeda, Yuichi aut Motooka, Daisuke aut Ueda, Jin aut Yanagawa, Masahiro aut Edamoto-Taira, Yuko aut Chikaishi-Kirino, Tomomi aut Masaki, Takeshi aut Inagaki, Tadakatsu aut Nakamura, Shota aut Katada, Yoshinori aut Okazawa, Makoto aut Narazaki, Masashi aut Ogo, Takeshi aut Kumanogoh, Atsushi aut Nakaoka, Yoshikazu (orcid)0000-0002-8404-2587 aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 25(2023), 1 vom: 24. März (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:25 year:2023 number:1 day:24 month:03 https://dx.doi.org/10.1186/s13075-023-03031-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1 24 03 |
| allfieldsGer |
10.1186/s13075-023-03031-9 doi (DE-627)SPR049825887 (SPR)s13075-023-03031-9-e DE-627 ger DE-627 rakwb eng Manabe, Yusuke verfasserin aut Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. Takayasu arteritis (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Oral bacteria (dpeaa)DE-He213 Proton pump inhibitor (dpeaa)DE-He213 Aortic aneurysm (dpeaa)DE-He213 Campylobacter (dpeaa)DE-He213 Ishibashi, Tomohiko aut Asano, Ryotaro aut Tonomura, Shuichi aut Maeda, Yuichi aut Motooka, Daisuke aut Ueda, Jin aut Yanagawa, Masahiro aut Edamoto-Taira, Yuko aut Chikaishi-Kirino, Tomomi aut Masaki, Takeshi aut Inagaki, Tadakatsu aut Nakamura, Shota aut Katada, Yoshinori aut Okazawa, Makoto aut Narazaki, Masashi aut Ogo, Takeshi aut Kumanogoh, Atsushi aut Nakaoka, Yoshikazu (orcid)0000-0002-8404-2587 aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 25(2023), 1 vom: 24. März (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:25 year:2023 number:1 day:24 month:03 https://dx.doi.org/10.1186/s13075-023-03031-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1 24 03 |
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10.1186/s13075-023-03031-9 doi (DE-627)SPR049825887 (SPR)s13075-023-03031-9-e DE-627 ger DE-627 rakwb eng Manabe, Yusuke verfasserin aut Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. Takayasu arteritis (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Oral bacteria (dpeaa)DE-He213 Proton pump inhibitor (dpeaa)DE-He213 Aortic aneurysm (dpeaa)DE-He213 Campylobacter (dpeaa)DE-He213 Ishibashi, Tomohiko aut Asano, Ryotaro aut Tonomura, Shuichi aut Maeda, Yuichi aut Motooka, Daisuke aut Ueda, Jin aut Yanagawa, Masahiro aut Edamoto-Taira, Yuko aut Chikaishi-Kirino, Tomomi aut Masaki, Takeshi aut Inagaki, Tadakatsu aut Nakamura, Shota aut Katada, Yoshinori aut Okazawa, Makoto aut Narazaki, Masashi aut Ogo, Takeshi aut Kumanogoh, Atsushi aut Nakaoka, Yoshikazu (orcid)0000-0002-8404-2587 aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 25(2023), 1 vom: 24. März (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:25 year:2023 number:1 day:24 month:03 https://dx.doi.org/10.1186/s13075-023-03031-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1 24 03 |
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gut dysbiosis is associated with aortic aneurysm formation and progression in takayasu arteritis |
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Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis |
| abstract |
Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. © The Author(s) 2023 |
| abstractGer |
Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. © The Author(s) 2023 |
| abstract_unstemmed |
Background Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK. Methods We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters. Results The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria, such as Streptococcus and Campylobacter, regardless of the disease activity, than HCs. This increase was significantly associated with the administration of a proton pump inhibitor used for preventing gastric ulcers in patients treated with aspirin and glucocorticoids. Among patients taking a proton pump inhibitor, Campylobacter was more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation than in those who did not. Among the genus of Campylobacter, Campylobacter gracilis in the gut microbiome was significantly associated with clinical events related to aortic aneurysm formation/worsening in patients with TAK. In a prospective analysis, patients with a gut microbiome positive for Campylobacter were significantly more likely to require interventions for aortic dilatation than those who were negative for Campylobacter. Furthermore, patients with TAK who were positive for C. gracilis by polymerase chain reaction showed a tendency to have severe aortic aneurysms. Conclusions A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK. © The Author(s) 2023 |
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Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis |
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Ishibashi, Tomohiko Asano, Ryotaro Tonomura, Shuichi Maeda, Yuichi Motooka, Daisuke Ueda, Jin Yanagawa, Masahiro Edamoto-Taira, Yuko Chikaishi-Kirino, Tomomi Masaki, Takeshi Inagaki, Tadakatsu Nakamura, Shota Katada, Yoshinori Okazawa, Makoto Narazaki, Masashi Ogo, Takeshi Kumanogoh, Atsushi Nakaoka, Yoshikazu |
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Ishibashi, Tomohiko Asano, Ryotaro Tonomura, Shuichi Maeda, Yuichi Motooka, Daisuke Ueda, Jin Yanagawa, Masahiro Edamoto-Taira, Yuko Chikaishi-Kirino, Tomomi Masaki, Takeshi Inagaki, Tadakatsu Nakamura, Shota Katada, Yoshinori Okazawa, Makoto Narazaki, Masashi Ogo, Takeshi Kumanogoh, Atsushi Nakaoka, Yoshikazu |
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