Increased social interaction in Shank2-deficient mice following acute social isolation

Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isola...
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Autor*in:	Choi, Ja Eun [verfasserIn] Kaang, Bong-Kiun

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Social isolation Social interaction Sexual dimorphism

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Molecular brain - London : BioMed Central, 2008, 16(2023), 1 vom: 15. Apr.
Übergeordnetes Werk:	volume:16 ; year:2023 ; number:1 ; day:15 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s13041-023-01025-x

Katalog-ID:	SPR050053264

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allfields	10.1186/s13041-023-01025-x doi (DE-627)SPR050053264 (SPR)s13041-023-01025-x-e DE-627 ger DE-627 rakwb eng Choi, Ja Eun verfasserin aut Increased social interaction in Shank2-deficient mice following acute social isolation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. Social isolation (dpeaa)DE-He213 Social interaction (dpeaa)DE-He213 Sexual dimorphism (dpeaa)DE-He213 Kaang, Bong-Kiun (orcid)0000-0001-7593-9707 aut Enthalten in Molecular brain London : BioMed Central, 2008 16(2023), 1 vom: 15. Apr. (DE-627)571612873 (DE-600)2436057-0 1756-6606 nnns volume:16 year:2023 number:1 day:15 month:04 https://dx.doi.org/10.1186/s13041-023-01025-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 1 15 04
spelling	10.1186/s13041-023-01025-x doi (DE-627)SPR050053264 (SPR)s13041-023-01025-x-e DE-627 ger DE-627 rakwb eng Choi, Ja Eun verfasserin aut Increased social interaction in Shank2-deficient mice following acute social isolation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. Social isolation (dpeaa)DE-He213 Social interaction (dpeaa)DE-He213 Sexual dimorphism (dpeaa)DE-He213 Kaang, Bong-Kiun (orcid)0000-0001-7593-9707 aut Enthalten in Molecular brain London : BioMed Central, 2008 16(2023), 1 vom: 15. Apr. (DE-627)571612873 (DE-600)2436057-0 1756-6606 nnns volume:16 year:2023 number:1 day:15 month:04 https://dx.doi.org/10.1186/s13041-023-01025-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 1 15 04
allfields_unstemmed	10.1186/s13041-023-01025-x doi (DE-627)SPR050053264 (SPR)s13041-023-01025-x-e DE-627 ger DE-627 rakwb eng Choi, Ja Eun verfasserin aut Increased social interaction in Shank2-deficient mice following acute social isolation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. Social isolation (dpeaa)DE-He213 Social interaction (dpeaa)DE-He213 Sexual dimorphism (dpeaa)DE-He213 Kaang, Bong-Kiun (orcid)0000-0001-7593-9707 aut Enthalten in Molecular brain London : BioMed Central, 2008 16(2023), 1 vom: 15. Apr. (DE-627)571612873 (DE-600)2436057-0 1756-6606 nnns volume:16 year:2023 number:1 day:15 month:04 https://dx.doi.org/10.1186/s13041-023-01025-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 1 15 04
allfieldsGer	10.1186/s13041-023-01025-x doi (DE-627)SPR050053264 (SPR)s13041-023-01025-x-e DE-627 ger DE-627 rakwb eng Choi, Ja Eun verfasserin aut Increased social interaction in Shank2-deficient mice following acute social isolation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. Social isolation (dpeaa)DE-He213 Social interaction (dpeaa)DE-He213 Sexual dimorphism (dpeaa)DE-He213 Kaang, Bong-Kiun (orcid)0000-0001-7593-9707 aut Enthalten in Molecular brain London : BioMed Central, 2008 16(2023), 1 vom: 15. Apr. (DE-627)571612873 (DE-600)2436057-0 1756-6606 nnns volume:16 year:2023 number:1 day:15 month:04 https://dx.doi.org/10.1186/s13041-023-01025-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 1 15 04
allfieldsSound	10.1186/s13041-023-01025-x doi (DE-627)SPR050053264 (SPR)s13041-023-01025-x-e DE-627 ger DE-627 rakwb eng Choi, Ja Eun verfasserin aut Increased social interaction in Shank2-deficient mice following acute social isolation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. Social isolation (dpeaa)DE-He213 Social interaction (dpeaa)DE-He213 Sexual dimorphism (dpeaa)DE-He213 Kaang, Bong-Kiun (orcid)0000-0001-7593-9707 aut Enthalten in Molecular brain London : BioMed Central, 2008 16(2023), 1 vom: 15. Apr. (DE-627)571612873 (DE-600)2436057-0 1756-6606 nnns volume:16 year:2023 number:1 day:15 month:04 https://dx.doi.org/10.1186/s13041-023-01025-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 1 15 04
language	English
source	Enthalten in Molecular brain 16(2023), 1 vom: 15. Apr. volume:16 year:2023 number:1 day:15 month:04
sourceStr	Enthalten in Molecular brain 16(2023), 1 vom: 15. Apr. volume:16 year:2023 number:1 day:15 month:04
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institution	findex.gbv.de
topic_facet	Social isolation Social interaction Sexual dimorphism
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container_title	Molecular brain
authorswithroles_txt_mv	Choi, Ja Eun @@aut@@ Kaang, Bong-Kiun @@aut@@
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author	Choi, Ja Eun
spellingShingle	Choi, Ja Eun misc Social isolation misc Social interaction misc Sexual dimorphism Increased social interaction in Shank2-deficient mice following acute social isolation
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topic_title	Increased social interaction in Shank2-deficient mice following acute social isolation Social isolation (dpeaa)DE-He213 Social interaction (dpeaa)DE-He213 Sexual dimorphism (dpeaa)DE-He213
topic	misc Social isolation misc Social interaction misc Sexual dimorphism
topic_unstemmed	misc Social isolation misc Social interaction misc Sexual dimorphism
topic_browse	misc Social isolation misc Social interaction misc Sexual dimorphism
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title	Increased social interaction in Shank2-deficient mice following acute social isolation
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title_full	Increased social interaction in Shank2-deficient mice following acute social isolation
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author_browse	Choi, Ja Eun Kaang, Bong-Kiun
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title_sort	increased social interaction in shank2-deficient mice following acute social isolation
title_auth	Increased social interaction in Shank2-deficient mice following acute social isolation
abstract	Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. © The Author(s) 2023
abstractGer	Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. © The Author(s) 2023
abstract_unstemmed	Abstract Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with ASD and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner, as only the male mice show increase in sociability following isolation. However, it remains to be explored whether the effects of loneliness in ASD differ between genders. Here, we used Shank2-deficient (Shank2−/−) mice, one of the animal models of ASD, to examine the sociability changes after acute social isolation. While only the male wild-type (WT) mice display increased sociability following 24-h isolation, both sexes of Shank2−/− mice show an increase in social interaction following isolation. These observations provide evidence that animal models of ASD have the sensitivity to acute social isolation and further show the motivation to socially interact. © The Author(s) 2023
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title_short	Increased social interaction in Shank2-deficient mice following acute social isolation
url	https://dx.doi.org/10.1186/s13041-023-01025-x
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