Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form
The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the disso...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sergeeva, M. S. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Pharmaceutical chemistry journal - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967, 57(2023), 1 vom: Apr., Seite 123-128 |
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| Übergeordnetes Werk: |
volume:57 ; year:2023 ; number:1 ; month:04 ; pages:123-128 |
| Links: |
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| DOI / URN: |
10.1007/s11094-023-02859-4 |
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| Katalog-ID: |
SPR050293494 |
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| 520 | |a The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. | ||
| 650 | 4 | |a afobazole |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a dissolution test |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a mathematical models |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a prolonged release |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a matrix tablets |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Grushevskaya, L. N. |4 aut | |
| 700 | 1 | |a Gaevaya, L. M. |4 aut | |
| 700 | 1 | |a Dudenkova, M. E. |4 aut | |
| 700 | 1 | |a Denisenko, E. D. |4 aut | |
| 700 | 1 | |a Minaev, S. V. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pharmaceutical chemistry journal |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 |g 57(2023), 1 vom: Apr., Seite 123-128 |w (DE-627)325700621 |w (DE-600)2039418-4 |x 1573-9031 |7 nnns |
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10.1007/s11094-023-02859-4 doi (DE-627)SPR050293494 (SPR)s11094-023-02859-4-e DE-627 ger DE-627 rakwb eng Sergeeva, M. S. verfasserin aut Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. afobazole (dpeaa)DE-He213 dissolution test (dpeaa)DE-He213 mathematical models (dpeaa)DE-He213 prolonged release (dpeaa)DE-He213 matrix tablets (dpeaa)DE-He213 Grushevskaya, L. N. aut Gaevaya, L. M. aut Dudenkova, M. E. aut Denisenko, E. D. aut Minaev, S. V. aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 57(2023), 1 vom: Apr., Seite 123-128 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:57 year:2023 number:1 month:04 pages:123-128 https://dx.doi.org/10.1007/s11094-023-02859-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 57 2023 1 04 123-128 |
| spelling |
10.1007/s11094-023-02859-4 doi (DE-627)SPR050293494 (SPR)s11094-023-02859-4-e DE-627 ger DE-627 rakwb eng Sergeeva, M. S. verfasserin aut Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. afobazole (dpeaa)DE-He213 dissolution test (dpeaa)DE-He213 mathematical models (dpeaa)DE-He213 prolonged release (dpeaa)DE-He213 matrix tablets (dpeaa)DE-He213 Grushevskaya, L. N. aut Gaevaya, L. M. aut Dudenkova, M. E. aut Denisenko, E. D. aut Minaev, S. V. aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 57(2023), 1 vom: Apr., Seite 123-128 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:57 year:2023 number:1 month:04 pages:123-128 https://dx.doi.org/10.1007/s11094-023-02859-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 57 2023 1 04 123-128 |
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10.1007/s11094-023-02859-4 doi (DE-627)SPR050293494 (SPR)s11094-023-02859-4-e DE-627 ger DE-627 rakwb eng Sergeeva, M. S. verfasserin aut Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. afobazole (dpeaa)DE-He213 dissolution test (dpeaa)DE-He213 mathematical models (dpeaa)DE-He213 prolonged release (dpeaa)DE-He213 matrix tablets (dpeaa)DE-He213 Grushevskaya, L. N. aut Gaevaya, L. M. aut Dudenkova, M. E. aut Denisenko, E. D. aut Minaev, S. V. aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 57(2023), 1 vom: Apr., Seite 123-128 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:57 year:2023 number:1 month:04 pages:123-128 https://dx.doi.org/10.1007/s11094-023-02859-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 57 2023 1 04 123-128 |
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10.1007/s11094-023-02859-4 doi (DE-627)SPR050293494 (SPR)s11094-023-02859-4-e DE-627 ger DE-627 rakwb eng Sergeeva, M. S. verfasserin aut Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. afobazole (dpeaa)DE-He213 dissolution test (dpeaa)DE-He213 mathematical models (dpeaa)DE-He213 prolonged release (dpeaa)DE-He213 matrix tablets (dpeaa)DE-He213 Grushevskaya, L. N. aut Gaevaya, L. M. aut Dudenkova, M. E. aut Denisenko, E. D. aut Minaev, S. V. aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 57(2023), 1 vom: Apr., Seite 123-128 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:57 year:2023 number:1 month:04 pages:123-128 https://dx.doi.org/10.1007/s11094-023-02859-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 57 2023 1 04 123-128 |
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10.1007/s11094-023-02859-4 doi (DE-627)SPR050293494 (SPR)s11094-023-02859-4-e DE-627 ger DE-627 rakwb eng Sergeeva, M. S. verfasserin aut Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. afobazole (dpeaa)DE-He213 dissolution test (dpeaa)DE-He213 mathematical models (dpeaa)DE-He213 prolonged release (dpeaa)DE-He213 matrix tablets (dpeaa)DE-He213 Grushevskaya, L. N. aut Gaevaya, L. M. aut Dudenkova, M. E. aut Denisenko, E. D. aut Minaev, S. V. aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 57(2023), 1 vom: Apr., Seite 123-128 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:57 year:2023 number:1 month:04 pages:123-128 https://dx.doi.org/10.1007/s11094-023-02859-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 57 2023 1 04 123-128 |
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Sergeeva, M. S. @@aut@@ Grushevskaya, L. N. @@aut@@ Gaevaya, L. M. @@aut@@ Dudenkova, M. E. @@aut@@ Denisenko, E. D. @@aut@@ Minaev, S. V. @@aut@@ |
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Sergeeva, M. S. |
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Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form afobazole (dpeaa)DE-He213 dissolution test (dpeaa)DE-He213 mathematical models (dpeaa)DE-He213 prolonged release (dpeaa)DE-He213 matrix tablets (dpeaa)DE-He213 |
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release kinetics study and development of conditions for dissolution test of afobazole new prolonged-release solid dosage form |
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Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form |
| abstract |
The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model. © Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form |
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https://dx.doi.org/10.1007/s11094-023-02859-4 |
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Grushevskaya, L. N. Gaevaya, L. M. Dudenkova, M. E. Denisenko, E. D. Minaev, S. V. |
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Grushevskaya, L. N. Gaevaya, L. M. Dudenkova, M. E. Denisenko, E. D. Minaev, S. V. |
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2024-07-03T14:37:16.662Z |
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| score |
7.399541 |