Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol
Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recove...
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Gespeichert in:
| Autor*in: |
Zanardo, Moreno [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2023 |
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| Übergeordnetes Werk: |
Enthalten in: European radiology experimental - [Cham] : Springer International Publishing, 2017, 7(2023), 1 vom: 04. Mai |
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| Übergeordnetes Werk: |
volume:7 ; year:2023 ; number:1 ; day:04 ; month:05 |
| Links: |
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| DOI / URN: |
10.1186/s41747-023-00337-w |
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SPR050300512 |
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| 520 | |a Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. | ||
| 650 | 4 | |a Contrast media |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gadolinium |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Iodine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Outpatients |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Urinalysis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Cozzi, Andrea |4 aut | |
| 700 | 1 | |a Cardani, Rosanna |4 aut | |
| 700 | 1 | |a Renna, Laura Valentina |4 aut | |
| 700 | 1 | |a Pomati, Francesco |4 aut | |
| 700 | 1 | |a Asmundo, Luigi |4 aut | |
| 700 | 1 | |a Di Leo, Giovanni |4 aut | |
| 700 | 1 | |a Sardanelli, Francesco |4 aut | |
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10.1186/s41747-023-00337-w doi (DE-627)SPR050300512 (SPR)s41747-023-00337-w-e DE-627 ger DE-627 rakwb eng Zanardo, Moreno verfasserin (orcid)0000-0001-9640-8534 aut Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. Contrast media (dpeaa)DE-He213 Gadolinium (dpeaa)DE-He213 Iodine (dpeaa)DE-He213 Outpatients (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Cozzi, Andrea aut Cardani, Rosanna aut Renna, Laura Valentina aut Pomati, Francesco aut Asmundo, Luigi aut Di Leo, Giovanni aut Sardanelli, Francesco aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 7(2023), 1 vom: 04. Mai (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:7 year:2023 number:1 day:04 month:05 https://dx.doi.org/10.1186/s41747-023-00337-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2023 1 04 05 |
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10.1186/s41747-023-00337-w doi (DE-627)SPR050300512 (SPR)s41747-023-00337-w-e DE-627 ger DE-627 rakwb eng Zanardo, Moreno verfasserin (orcid)0000-0001-9640-8534 aut Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. Contrast media (dpeaa)DE-He213 Gadolinium (dpeaa)DE-He213 Iodine (dpeaa)DE-He213 Outpatients (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Cozzi, Andrea aut Cardani, Rosanna aut Renna, Laura Valentina aut Pomati, Francesco aut Asmundo, Luigi aut Di Leo, Giovanni aut Sardanelli, Francesco aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 7(2023), 1 vom: 04. Mai (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:7 year:2023 number:1 day:04 month:05 https://dx.doi.org/10.1186/s41747-023-00337-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2023 1 04 05 |
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10.1186/s41747-023-00337-w doi (DE-627)SPR050300512 (SPR)s41747-023-00337-w-e DE-627 ger DE-627 rakwb eng Zanardo, Moreno verfasserin (orcid)0000-0001-9640-8534 aut Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. Contrast media (dpeaa)DE-He213 Gadolinium (dpeaa)DE-He213 Iodine (dpeaa)DE-He213 Outpatients (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Cozzi, Andrea aut Cardani, Rosanna aut Renna, Laura Valentina aut Pomati, Francesco aut Asmundo, Luigi aut Di Leo, Giovanni aut Sardanelli, Francesco aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 7(2023), 1 vom: 04. Mai (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:7 year:2023 number:1 day:04 month:05 https://dx.doi.org/10.1186/s41747-023-00337-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2023 1 04 05 |
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10.1186/s41747-023-00337-w doi (DE-627)SPR050300512 (SPR)s41747-023-00337-w-e DE-627 ger DE-627 rakwb eng Zanardo, Moreno verfasserin (orcid)0000-0001-9640-8534 aut Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. Contrast media (dpeaa)DE-He213 Gadolinium (dpeaa)DE-He213 Iodine (dpeaa)DE-He213 Outpatients (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Cozzi, Andrea aut Cardani, Rosanna aut Renna, Laura Valentina aut Pomati, Francesco aut Asmundo, Luigi aut Di Leo, Giovanni aut Sardanelli, Francesco aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 7(2023), 1 vom: 04. Mai (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:7 year:2023 number:1 day:04 month:05 https://dx.doi.org/10.1186/s41747-023-00337-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2023 1 04 05 |
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10.1186/s41747-023-00337-w doi (DE-627)SPR050300512 (SPR)s41747-023-00337-w-e DE-627 ger DE-627 rakwb eng Zanardo, Moreno verfasserin (orcid)0000-0001-9640-8534 aut Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. Contrast media (dpeaa)DE-He213 Gadolinium (dpeaa)DE-He213 Iodine (dpeaa)DE-He213 Outpatients (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Cozzi, Andrea aut Cardani, Rosanna aut Renna, Laura Valentina aut Pomati, Francesco aut Asmundo, Luigi aut Di Leo, Giovanni aut Sardanelli, Francesco aut Enthalten in European radiology experimental [Cham] : Springer International Publishing, 2017 7(2023), 1 vom: 04. Mai (DE-627)898118557 (DE-600)2905812-0 2509-9280 nnns volume:7 year:2023 number:1 day:04 month:05 https://dx.doi.org/10.1186/s41747-023-00337-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2023 1 04 05 |
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reducing contrast agent residuals in hospital wastewater: the greenwater study protocol |
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Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol |
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Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. © The Author(s) 2023 |
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Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. © The Author(s) 2023 |
| abstract_unstemmed |
Abstract The potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”. © The Author(s) 2023 |
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However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings. Key points • Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention. • Current wastewater treatment is unable to retrieve and recycle contrast agents. • Prolonging hospital stay may allow contrast agents retrieval from patients’ urine. • The GREENWATER study will assess the effectively retrievable contrast agents’ quantities. • The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Contrast media</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gadolinium</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Iodine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Outpatients</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Urinalysis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cozzi, Andrea</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cardani, Rosanna</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Renna, Laura Valentina</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pomati, Francesco</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Asmundo, Luigi</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Di Leo, Giovanni</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sardanelli, Francesco</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">European radiology experimental</subfield><subfield code="d">[Cham] : Springer International Publishing, 2017</subfield><subfield code="g">7(2023), 1 vom: 04. 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