Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools
Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blan...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
dos Santos Dantas, Thainá [verfasserIn] dos Santos, Ewelyn Cintya Felipe Machado, Janaína Carla Barbosa da Costa Souza, Eloiza Marcelle |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Revista Brasileira de farmacognosia - Critiba : Soc. Brasileira de Farmacognosia, 1986, 33(2023), 3 vom: 02. Mai, Seite 629-640 |
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| Übergeordnetes Werk: |
volume:33 ; year:2023 ; number:3 ; day:02 ; month:05 ; pages:629-640 |
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| DOI / URN: |
10.1007/s43450-023-00398-3 |
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| Katalog-ID: |
SPR050301616 |
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| 245 | 1 | 0 | |a Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools |
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| 520 | |a Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract | ||
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| 650 | 4 | |a Spray-dried extract |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a dos Santos, Ewelyn Cintya Felipe |0 (orcid)0000-0001-5199-3864 |4 aut | |
| 700 | 1 | |a Machado, Janaína Carla Barbosa |0 (orcid)0000-0002-0790-1325 |4 aut | |
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| 700 | 1 | |a Soares, Luiz Alberto Lira |0 (orcid)0000-0002-3142-6173 |4 aut | |
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10.1007/s43450-023-00398-3 doi (DE-627)SPR050301616 (SPR)s43450-023-00398-3-e DE-627 ger DE-627 rakwb eng dos Santos Dantas, Thainá verfasserin (orcid)0000-0002-5237-5723 aut Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract Herbal drug (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Mixture design (dpeaa)DE-He213 Spray-dried extract (dpeaa)DE-He213 dos Santos, Ewelyn Cintya Felipe (orcid)0000-0001-5199-3864 aut Machado, Janaína Carla Barbosa (orcid)0000-0002-0790-1325 aut da Costa Souza, Eloiza Marcelle (orcid)0000-0001-8210-8813 aut de Melo, Demis Ferreira (orcid)0000-0001-8486-5578 aut de Souza, Myla Lôbo (orcid)0000-0002-2021-5418 aut Neto, Pedro José Rolim (orcid)0000-0003-0723-2587 aut de Oliveira, Alisson Macário (orcid)0000-0003-4152-150X aut Ferreira, Magda Rhayanny Assunção (orcid)0000-0001-8668-6223 aut Soares, Luiz Alberto Lira (orcid)0000-0002-3142-6173 aut Enthalten in Revista Brasileira de farmacognosia Critiba : Soc. Brasileira de Farmacognosia, 1986 33(2023), 3 vom: 02. Mai, Seite 629-640 (DE-627)730275531 (DE-600)2690840-2 1981-528X nnns volume:33 year:2023 number:3 day:02 month:05 pages:629-640 https://dx.doi.org/10.1007/s43450-023-00398-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 3 02 05 629-640 |
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10.1007/s43450-023-00398-3 doi (DE-627)SPR050301616 (SPR)s43450-023-00398-3-e DE-627 ger DE-627 rakwb eng dos Santos Dantas, Thainá verfasserin (orcid)0000-0002-5237-5723 aut Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract Herbal drug (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Mixture design (dpeaa)DE-He213 Spray-dried extract (dpeaa)DE-He213 dos Santos, Ewelyn Cintya Felipe (orcid)0000-0001-5199-3864 aut Machado, Janaína Carla Barbosa (orcid)0000-0002-0790-1325 aut da Costa Souza, Eloiza Marcelle (orcid)0000-0001-8210-8813 aut de Melo, Demis Ferreira (orcid)0000-0001-8486-5578 aut de Souza, Myla Lôbo (orcid)0000-0002-2021-5418 aut Neto, Pedro José Rolim (orcid)0000-0003-0723-2587 aut de Oliveira, Alisson Macário (orcid)0000-0003-4152-150X aut Ferreira, Magda Rhayanny Assunção (orcid)0000-0001-8668-6223 aut Soares, Luiz Alberto Lira (orcid)0000-0002-3142-6173 aut Enthalten in Revista Brasileira de farmacognosia Critiba : Soc. Brasileira de Farmacognosia, 1986 33(2023), 3 vom: 02. Mai, Seite 629-640 (DE-627)730275531 (DE-600)2690840-2 1981-528X nnns volume:33 year:2023 number:3 day:02 month:05 pages:629-640 https://dx.doi.org/10.1007/s43450-023-00398-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 3 02 05 629-640 |
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10.1007/s43450-023-00398-3 doi (DE-627)SPR050301616 (SPR)s43450-023-00398-3-e DE-627 ger DE-627 rakwb eng dos Santos Dantas, Thainá verfasserin (orcid)0000-0002-5237-5723 aut Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract Herbal drug (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Mixture design (dpeaa)DE-He213 Spray-dried extract (dpeaa)DE-He213 dos Santos, Ewelyn Cintya Felipe (orcid)0000-0001-5199-3864 aut Machado, Janaína Carla Barbosa (orcid)0000-0002-0790-1325 aut da Costa Souza, Eloiza Marcelle (orcid)0000-0001-8210-8813 aut de Melo, Demis Ferreira (orcid)0000-0001-8486-5578 aut de Souza, Myla Lôbo (orcid)0000-0002-2021-5418 aut Neto, Pedro José Rolim (orcid)0000-0003-0723-2587 aut de Oliveira, Alisson Macário (orcid)0000-0003-4152-150X aut Ferreira, Magda Rhayanny Assunção (orcid)0000-0001-8668-6223 aut Soares, Luiz Alberto Lira (orcid)0000-0002-3142-6173 aut Enthalten in Revista Brasileira de farmacognosia Critiba : Soc. Brasileira de Farmacognosia, 1986 33(2023), 3 vom: 02. Mai, Seite 629-640 (DE-627)730275531 (DE-600)2690840-2 1981-528X nnns volume:33 year:2023 number:3 day:02 month:05 pages:629-640 https://dx.doi.org/10.1007/s43450-023-00398-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 3 02 05 629-640 |
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10.1007/s43450-023-00398-3 doi (DE-627)SPR050301616 (SPR)s43450-023-00398-3-e DE-627 ger DE-627 rakwb eng dos Santos Dantas, Thainá verfasserin (orcid)0000-0002-5237-5723 aut Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract Herbal drug (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Mixture design (dpeaa)DE-He213 Spray-dried extract (dpeaa)DE-He213 dos Santos, Ewelyn Cintya Felipe (orcid)0000-0001-5199-3864 aut Machado, Janaína Carla Barbosa (orcid)0000-0002-0790-1325 aut da Costa Souza, Eloiza Marcelle (orcid)0000-0001-8210-8813 aut de Melo, Demis Ferreira (orcid)0000-0001-8486-5578 aut de Souza, Myla Lôbo (orcid)0000-0002-2021-5418 aut Neto, Pedro José Rolim (orcid)0000-0003-0723-2587 aut de Oliveira, Alisson Macário (orcid)0000-0003-4152-150X aut Ferreira, Magda Rhayanny Assunção (orcid)0000-0001-8668-6223 aut Soares, Luiz Alberto Lira (orcid)0000-0002-3142-6173 aut Enthalten in Revista Brasileira de farmacognosia Critiba : Soc. Brasileira de Farmacognosia, 1986 33(2023), 3 vom: 02. Mai, Seite 629-640 (DE-627)730275531 (DE-600)2690840-2 1981-528X nnns volume:33 year:2023 number:3 day:02 month:05 pages:629-640 https://dx.doi.org/10.1007/s43450-023-00398-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 3 02 05 629-640 |
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10.1007/s43450-023-00398-3 doi (DE-627)SPR050301616 (SPR)s43450-023-00398-3-e DE-627 ger DE-627 rakwb eng dos Santos Dantas, Thainá verfasserin (orcid)0000-0002-5237-5723 aut Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract Herbal drug (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Mixture design (dpeaa)DE-He213 Spray-dried extract (dpeaa)DE-He213 dos Santos, Ewelyn Cintya Felipe (orcid)0000-0001-5199-3864 aut Machado, Janaína Carla Barbosa (orcid)0000-0002-0790-1325 aut da Costa Souza, Eloiza Marcelle (orcid)0000-0001-8210-8813 aut de Melo, Demis Ferreira (orcid)0000-0001-8486-5578 aut de Souza, Myla Lôbo (orcid)0000-0002-2021-5418 aut Neto, Pedro José Rolim (orcid)0000-0003-0723-2587 aut de Oliveira, Alisson Macário (orcid)0000-0003-4152-150X aut Ferreira, Magda Rhayanny Assunção (orcid)0000-0001-8668-6223 aut Soares, Luiz Alberto Lira (orcid)0000-0002-3142-6173 aut Enthalten in Revista Brasileira de farmacognosia Critiba : Soc. Brasileira de Farmacognosia, 1986 33(2023), 3 vom: 02. Mai, Seite 629-640 (DE-627)730275531 (DE-600)2690840-2 1981-528X nnns volume:33 year:2023 number:3 day:02 month:05 pages:629-640 https://dx.doi.org/10.1007/s43450-023-00398-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 3 02 05 629-640 |
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dos Santos Dantas, Thainá @@aut@@ dos Santos, Ewelyn Cintya Felipe @@aut@@ Machado, Janaína Carla Barbosa @@aut@@ da Costa Souza, Eloiza Marcelle @@aut@@ de Melo, Demis Ferreira @@aut@@ de Souza, Myla Lôbo @@aut@@ Neto, Pedro José Rolim @@aut@@ de Oliveira, Alisson Macário @@aut@@ Ferreira, Magda Rhayanny Assunção @@aut@@ Soares, Luiz Alberto Lira @@aut@@ |
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dos Santos Dantas, Thainá |
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dos Santos Dantas, Thainá misc Herbal drug misc Flavonoids misc Mixture design misc Spray-dried extract Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools |
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Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools Herbal drug (dpeaa)DE-He213 Flavonoids (dpeaa)DE-He213 Mixture design (dpeaa)DE-He213 Spray-dried extract (dpeaa)DE-He213 |
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Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools |
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Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools |
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dos Santos Dantas, Thainá dos Santos, Ewelyn Cintya Felipe Machado, Janaína Carla Barbosa da Costa Souza, Eloiza Marcelle de Melo, Demis Ferreira de Souza, Myla Lôbo Neto, Pedro José Rolim de Oliveira, Alisson Macário Ferreira, Magda Rhayanny Assunção Soares, Luiz Alberto Lira |
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statistical optimization of spray-dried extract from leaves of croton blanchetianus: simplex centroid and factorial design as basic tools |
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Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools |
| abstract |
Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. Graphical Abstract © The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools |
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dos Santos, Ewelyn Cintya Felipe Machado, Janaína Carla Barbosa da Costa Souza, Eloiza Marcelle de Melo, Demis Ferreira de Souza, Myla Lôbo Neto, Pedro José Rolim de Oliveira, Alisson Macário Ferreira, Magda Rhayanny Assunção Soares, Luiz Alberto Lira |
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dos Santos, Ewelyn Cintya Felipe Machado, Janaína Carla Barbosa da Costa Souza, Eloiza Marcelle de Melo, Demis Ferreira de Souza, Myla Lôbo Neto, Pedro José Rolim de Oliveira, Alisson Macário Ferreira, Magda Rhayanny Assunção Soares, Luiz Alberto Lira |
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10.1007/s43450-023-00398-3 |
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2024-07-03T14:40:39.867Z |
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With the absence of studies directed to obtain optimized extracts, the objective of this work was to obtain and characterize a spray-dried extract of C. blanchetianus leaves using different statistical tools. The extracts were optimized by a simplex centroid by analysis of residue, total polyphenol, total flavonoid, and rutin content, besides the fingerprints by high-performance thin layer and high-performance liquid chromatography. The spray-dried extract was obtained with maltodextrin/colloidal silicon dioxide. A factorial design evaluated the drying conditions with factors temperature (°C) and flow rate (l/h), and the responses were moisture content, yield, total flavonoid, total polyphenol, rutin content, and rheological properties. Higher total flavonoid and better response of dry residue and total polyphenol were observed with the water:acetone mixture. Regarding the drying process, the maltodextrin did not show interference, obtaining extract with higher polyphenol content, better thermal stability, and flow properties. It was possible to obtain a dry extract with better characteristics using 0.5 l/h and 150 °C, without affecting the chemical profile. These results establish that C. blanchetianus can be an alternative source of flavonoids which infers its potential in pharmaceutical products. 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