Crown ether-thiourea conjugates as ion transporters

Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion...
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Autor*in:	Zhao, Zhixing [verfasserIn] Tang, Bailing Yan, Xiaosheng Wu, Xin Li, Zhao Gale, Philip A. Jiang, Yun-Bao

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	ion transport thiourea crown ether symport

Anmerkung:	© Higher Education Press 2021

Übergeordnetes Werk:	Enthalten in: Frontiers of chemical engineering in China - Beijing : Higher Education Press, 2007, 16(2021), 1 vom: 15. Mai, Seite 81-91
Übergeordnetes Werk:	volume:16 ; year:2021 ; number:1 ; day:15 ; month:05 ; pages:81-91

Links:	Volltext

DOI / URN:	10.1007/s11705-021-2049-7

Katalog-ID:	SPR050400746

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520			\|a Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications.
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allfields	10.1007/s11705-021-2049-7 doi (DE-627)SPR050400746 (SPR)s11705-021-2049-7-e DE-627 ger DE-627 rakwb eng Zhao, Zhixing verfasserin aut Crown ether-thiourea conjugates as ion transporters 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press 2021 Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. ion transport (dpeaa)DE-He213 thiourea (dpeaa)DE-He213 crown ether (dpeaa)DE-He213 symport (dpeaa)DE-He213 Tang, Bailing aut Yan, Xiaosheng aut Wu, Xin aut Li, Zhao aut Gale, Philip A. aut Jiang, Yun-Bao aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 16(2021), 1 vom: 15. Mai, Seite 81-91 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:16 year:2021 number:1 day:15 month:05 pages:81-91 https://dx.doi.org/10.1007/s11705-021-2049-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 16 2021 1 15 05 81-91
spelling	10.1007/s11705-021-2049-7 doi (DE-627)SPR050400746 (SPR)s11705-021-2049-7-e DE-627 ger DE-627 rakwb eng Zhao, Zhixing verfasserin aut Crown ether-thiourea conjugates as ion transporters 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press 2021 Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. ion transport (dpeaa)DE-He213 thiourea (dpeaa)DE-He213 crown ether (dpeaa)DE-He213 symport (dpeaa)DE-He213 Tang, Bailing aut Yan, Xiaosheng aut Wu, Xin aut Li, Zhao aut Gale, Philip A. aut Jiang, Yun-Bao aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 16(2021), 1 vom: 15. Mai, Seite 81-91 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:16 year:2021 number:1 day:15 month:05 pages:81-91 https://dx.doi.org/10.1007/s11705-021-2049-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 16 2021 1 15 05 81-91
allfields_unstemmed	10.1007/s11705-021-2049-7 doi (DE-627)SPR050400746 (SPR)s11705-021-2049-7-e DE-627 ger DE-627 rakwb eng Zhao, Zhixing verfasserin aut Crown ether-thiourea conjugates as ion transporters 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press 2021 Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. ion transport (dpeaa)DE-He213 thiourea (dpeaa)DE-He213 crown ether (dpeaa)DE-He213 symport (dpeaa)DE-He213 Tang, Bailing aut Yan, Xiaosheng aut Wu, Xin aut Li, Zhao aut Gale, Philip A. aut Jiang, Yun-Bao aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 16(2021), 1 vom: 15. Mai, Seite 81-91 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:16 year:2021 number:1 day:15 month:05 pages:81-91 https://dx.doi.org/10.1007/s11705-021-2049-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 16 2021 1 15 05 81-91
allfieldsGer	10.1007/s11705-021-2049-7 doi (DE-627)SPR050400746 (SPR)s11705-021-2049-7-e DE-627 ger DE-627 rakwb eng Zhao, Zhixing verfasserin aut Crown ether-thiourea conjugates as ion transporters 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press 2021 Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. ion transport (dpeaa)DE-He213 thiourea (dpeaa)DE-He213 crown ether (dpeaa)DE-He213 symport (dpeaa)DE-He213 Tang, Bailing aut Yan, Xiaosheng aut Wu, Xin aut Li, Zhao aut Gale, Philip A. aut Jiang, Yun-Bao aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 16(2021), 1 vom: 15. Mai, Seite 81-91 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:16 year:2021 number:1 day:15 month:05 pages:81-91 https://dx.doi.org/10.1007/s11705-021-2049-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 16 2021 1 15 05 81-91
allfieldsSound	10.1007/s11705-021-2049-7 doi (DE-627)SPR050400746 (SPR)s11705-021-2049-7-e DE-627 ger DE-627 rakwb eng Zhao, Zhixing verfasserin aut Crown ether-thiourea conjugates as ion transporters 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press 2021 Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. ion transport (dpeaa)DE-He213 thiourea (dpeaa)DE-He213 crown ether (dpeaa)DE-He213 symport (dpeaa)DE-He213 Tang, Bailing aut Yan, Xiaosheng aut Wu, Xin aut Li, Zhao aut Gale, Philip A. aut Jiang, Yun-Bao aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 16(2021), 1 vom: 15. Mai, Seite 81-91 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:16 year:2021 number:1 day:15 month:05 pages:81-91 https://dx.doi.org/10.1007/s11705-021-2049-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 16 2021 1 15 05 81-91
language	English
source	Enthalten in Frontiers of chemical engineering in China 16(2021), 1 vom: 15. Mai, Seite 81-91 volume:16 year:2021 number:1 day:15 month:05 pages:81-91
sourceStr	Enthalten in Frontiers of chemical engineering in China 16(2021), 1 vom: 15. Mai, Seite 81-91 volume:16 year:2021 number:1 day:15 month:05 pages:81-91
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ion transport thiourea crown ether symport
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container_title	Frontiers of chemical engineering in China
authorswithroles_txt_mv	Zhao, Zhixing @@aut@@ Tang, Bailing @@aut@@ Yan, Xiaosheng @@aut@@ Wu, Xin @@aut@@ Li, Zhao @@aut@@ Gale, Philip A. @@aut@@ Jiang, Yun-Bao @@aut@@
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author	Zhao, Zhixing
spellingShingle	Zhao, Zhixing misc ion transport misc thiourea misc crown ether misc symport Crown ether-thiourea conjugates as ion transporters
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topic_title	Crown ether-thiourea conjugates as ion transporters ion transport (dpeaa)DE-He213 thiourea (dpeaa)DE-He213 crown ether (dpeaa)DE-He213 symport (dpeaa)DE-He213
topic	misc ion transport misc thiourea misc crown ether misc symport
topic_unstemmed	misc ion transport misc thiourea misc crown ether misc symport
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title	Crown ether-thiourea conjugates as ion transporters
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title_full	Crown ether-thiourea conjugates as ion transporters
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author_browse	Zhao, Zhixing Tang, Bailing Yan, Xiaosheng Wu, Xin Li, Zhao Gale, Philip A. Jiang, Yun-Bao
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format_se	Elektronische Aufsätze
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doi_str_mv	10.1007/s11705-021-2049-7
title_sort	crown ether-thiourea conjugates as ion transporters
title_auth	Crown ether-thiourea conjugates as ion transporters
abstract	Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. © Higher Education Press 2021
abstractGer	Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. © Higher Education Press 2021
abstract_unstemmed	Abstract $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both $ Na^{+} $ and $ Cl^{−} $ across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of $ K^{+} $ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for $ K^{+} $ ions, which led to predominant partitioning of the transporters as the $ K^{+} $ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with $ Na^{+} $, $ Cl^{−} $ and $ K^{+} $ transport capabilities may have potential biological and medicinal applications. © Higher Education Press 2021
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title_short	Crown ether-thiourea conjugates as ion transporters
url	https://dx.doi.org/10.1007/s11705-021-2049-7
remote_bool	true
author2	Tang, Bailing Yan, Xiaosheng Wu, Xin Li, Zhao Gale, Philip A. Jiang, Yun-Bao
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up_date	2024-07-03T15:18:05.607Z
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