Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer
Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor imm...
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| Autor*in: |
Zhang, Ke [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2022 |
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| Übergeordnetes Werk: |
Enthalten in: BMC genetics - London : BioMed Central, 2000, 23(2022), 1 vom: 10. Jan. |
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| Übergeordnetes Werk: |
volume:23 ; year:2022 ; number:1 ; day:10 ; month:01 |
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10.1186/s12863-021-01019-5 |
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SPR050402927 |
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| 520 | |a Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. | ||
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10.1186/s12863-021-01019-5 doi (DE-627)SPR050402927 (SPR)s12863-021-01019-5-e DE-627 ger DE-627 rakwb eng Zhang, Ke verfasserin aut Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. Pancreatic cancer (dpeaa)DE-He213 Bioinformatics analysis (dpeaa)DE-He213 Interference factor (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immune infiltration (dpeaa)DE-He213 Xu, Pan-Ling aut Li, Yu-Jie aut Dong, Shu aut Gao, Hui-Feng aut Chen, Lian-Yu aut Chen, Hao aut Chen, Zhen aut Enthalten in BMC genetics London : BioMed Central, 2000 23(2022), 1 vom: 10. Jan. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:23 year:2022 number:1 day:10 month:01 https://dx.doi.org/10.1186/s12863-021-01019-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_22 GBV_ILN_2003 GBV_ILN_2021 GBV_ILN_4305 AR 23 2022 1 10 01 |
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10.1186/s12863-021-01019-5 doi (DE-627)SPR050402927 (SPR)s12863-021-01019-5-e DE-627 ger DE-627 rakwb eng Zhang, Ke verfasserin aut Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. Pancreatic cancer (dpeaa)DE-He213 Bioinformatics analysis (dpeaa)DE-He213 Interference factor (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immune infiltration (dpeaa)DE-He213 Xu, Pan-Ling aut Li, Yu-Jie aut Dong, Shu aut Gao, Hui-Feng aut Chen, Lian-Yu aut Chen, Hao aut Chen, Zhen aut Enthalten in BMC genetics London : BioMed Central, 2000 23(2022), 1 vom: 10. Jan. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:23 year:2022 number:1 day:10 month:01 https://dx.doi.org/10.1186/s12863-021-01019-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_22 GBV_ILN_2003 GBV_ILN_2021 GBV_ILN_4305 AR 23 2022 1 10 01 |
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10.1186/s12863-021-01019-5 doi (DE-627)SPR050402927 (SPR)s12863-021-01019-5-e DE-627 ger DE-627 rakwb eng Zhang, Ke verfasserin aut Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. Pancreatic cancer (dpeaa)DE-He213 Bioinformatics analysis (dpeaa)DE-He213 Interference factor (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immune infiltration (dpeaa)DE-He213 Xu, Pan-Ling aut Li, Yu-Jie aut Dong, Shu aut Gao, Hui-Feng aut Chen, Lian-Yu aut Chen, Hao aut Chen, Zhen aut Enthalten in BMC genetics London : BioMed Central, 2000 23(2022), 1 vom: 10. Jan. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:23 year:2022 number:1 day:10 month:01 https://dx.doi.org/10.1186/s12863-021-01019-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_22 GBV_ILN_2003 GBV_ILN_2021 GBV_ILN_4305 AR 23 2022 1 10 01 |
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10.1186/s12863-021-01019-5 doi (DE-627)SPR050402927 (SPR)s12863-021-01019-5-e DE-627 ger DE-627 rakwb eng Zhang, Ke verfasserin aut Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. Pancreatic cancer (dpeaa)DE-He213 Bioinformatics analysis (dpeaa)DE-He213 Interference factor (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immune infiltration (dpeaa)DE-He213 Xu, Pan-Ling aut Li, Yu-Jie aut Dong, Shu aut Gao, Hui-Feng aut Chen, Lian-Yu aut Chen, Hao aut Chen, Zhen aut Enthalten in BMC genetics London : BioMed Central, 2000 23(2022), 1 vom: 10. Jan. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:23 year:2022 number:1 day:10 month:01 https://dx.doi.org/10.1186/s12863-021-01019-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_22 GBV_ILN_2003 GBV_ILN_2021 GBV_ILN_4305 AR 23 2022 1 10 01 |
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10.1186/s12863-021-01019-5 doi (DE-627)SPR050402927 (SPR)s12863-021-01019-5-e DE-627 ger DE-627 rakwb eng Zhang, Ke verfasserin aut Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. Pancreatic cancer (dpeaa)DE-He213 Bioinformatics analysis (dpeaa)DE-He213 Interference factor (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immune infiltration (dpeaa)DE-He213 Xu, Pan-Ling aut Li, Yu-Jie aut Dong, Shu aut Gao, Hui-Feng aut Chen, Lian-Yu aut Chen, Hao aut Chen, Zhen aut Enthalten in BMC genetics London : BioMed Central, 2000 23(2022), 1 vom: 10. Jan. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:23 year:2022 number:1 day:10 month:01 https://dx.doi.org/10.1186/s12863-021-01019-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_22 GBV_ILN_2003 GBV_ILN_2021 GBV_ILN_4305 AR 23 2022 1 10 01 |
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Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer Pancreatic cancer (dpeaa)DE-He213 Bioinformatics analysis (dpeaa)DE-He213 Interference factor (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immune infiltration (dpeaa)DE-He213 |
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Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer |
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Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer |
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Zhang, Ke |
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Zhang, Ke Xu, Pan-Ling Li, Yu-Jie Dong, Shu Gao, Hui-Feng Chen, Lian-Yu Chen, Hao Chen, Zhen |
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comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer |
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Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer |
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Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. © The Author(s) 2022 |
| abstractGer |
Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. © The Author(s) 2022 |
| abstract_unstemmed |
Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC. Results We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients’ pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expression, amplification and, deep deletion were the three most common types of genetic alterations of IRFs in PC. Low expression of IRF2, 4, 5, and 8 was resistant to most of the drugs or small molecules from Genomics of Drug Sensitivity in Cancer. Moreover, IRFs were positively correlated with the abundance of tumor infiltrating immune cells in PC, including B cells, CD8+ T cells, CD4+ T cells, macrophages, Neutrophil, and Dendritic cells. Functional analysis indicated that IRFs were involved in T cell receptor signaling pathway, immune response, and Toll-like receptor signaling pathway. Conclusions Our results indicated that certain IRFs could serve as potential therapeutic targets and prognostic biomarkers for PC patients. Further basic and clinical studies are needed to validate our findings and generalize the clinical application of IRFs in PC. © The Author(s) 2022 |
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