Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt

Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstr...
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Autor*in:	de Miranda, Joachim R. [verfasserIn] Brettell, Laura E. Chejanovsky, Nor Childers, Anna K. Dalmon, Anne Deboutte, Ward de Graaf, Dirk C. Doublet, Vincent Gebremedhn, Haftom Genersch, Elke Gisder, Sebastian Granberg, Fredrik Haddad, Nizar J. Kaden, Rene Manley, Robyn Matthijnssens, Jelle Meeus, Ivan Migdadi, Hussein Milbrath, Meghan O. Mondet, Fanny Remnant, Emily J. Roberts, John M. K. Ryabov, Eugene V. Sela, Noa Smagghe, Guy Somanathan, Hema Wilfert, Lena Wright, Owen N. Martin, Stephen J. Ball, Brenda V.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Egypt bee virus Deformed wing virus Master strain Honeybee Western blot RNA sequencing Bioinformatic screening

Anmerkung:	© The Author(s) 2022. corrected publication 2022

Übergeordnetes Werk:	Enthalten in: Virology journal - London : BioMed Central, 2004, 19(2022), 1 vom: 15. Jan.
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:1 ; day:15 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12985-022-01740-2

Katalog-ID:	SPR050418009

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100	1		\|a de Miranda, Joachim R. \|e verfasserin \|0 (orcid)0000-0002-0335-0386 \|4 aut
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520			\|a Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.
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700	1		\|a Brettell, Laura E. \|4 aut
700	1		\|a Chejanovsky, Nor \|4 aut
700	1		\|a Childers, Anna K. \|4 aut
700	1		\|a Dalmon, Anne \|4 aut
700	1		\|a Deboutte, Ward \|4 aut
700	1		\|a de Graaf, Dirk C. \|4 aut
700	1		\|a Doublet, Vincent \|4 aut
700	1		\|a Gebremedhn, Haftom \|4 aut
700	1		\|a Genersch, Elke \|4 aut
700	1		\|a Gisder, Sebastian \|4 aut
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700	1		\|a Matthijnssens, Jelle \|4 aut
700	1		\|a Meeus, Ivan \|4 aut
700	1		\|a Migdadi, Hussein \|4 aut
700	1		\|a Milbrath, Meghan O. \|4 aut
700	1		\|a Mondet, Fanny \|4 aut
700	1		\|a Remnant, Emily J. \|4 aut
700	1		\|a Roberts, John M. K. \|4 aut
700	1		\|a Ryabov, Eugene V. \|4 aut
700	1		\|a Sela, Noa \|4 aut
700	1		\|a Smagghe, Guy \|4 aut
700	1		\|a Somanathan, Hema \|4 aut
700	1		\|a Wilfert, Lena \|4 aut
700	1		\|a Wright, Owen N. \|4 aut
700	1		\|a Martin, Stephen J. \|4 aut
700	1		\|a Ball, Brenda V. \|4 aut
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allfields	10.1186/s12985-022-01740-2 doi (DE-627)SPR050418009 (SPR)s12985-022-01740-2-e DE-627 ger DE-627 rakwb eng de Miranda, Joachim R. verfasserin (orcid)0000-0002-0335-0386 aut Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022. corrected publication 2022 Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. Egypt bee virus (dpeaa)DE-He213 Deformed wing virus (dpeaa)DE-He213 Master strain (dpeaa)DE-He213 Honeybee (dpeaa)DE-He213 Western blot (dpeaa)DE-He213 RNA sequencing (dpeaa)DE-He213 Bioinformatic screening (dpeaa)DE-He213 Brettell, Laura E. aut Chejanovsky, Nor aut Childers, Anna K. aut Dalmon, Anne aut Deboutte, Ward aut de Graaf, Dirk C. aut Doublet, Vincent aut Gebremedhn, Haftom aut Genersch, Elke aut Gisder, Sebastian aut Granberg, Fredrik aut Haddad, Nizar J. aut Kaden, Rene aut Manley, Robyn aut Matthijnssens, Jelle aut Meeus, Ivan aut Migdadi, Hussein aut Milbrath, Meghan O. aut Mondet, Fanny aut Remnant, Emily J. aut Roberts, John M. K. aut Ryabov, Eugene V. aut Sela, Noa aut Smagghe, Guy aut Somanathan, Hema aut Wilfert, Lena aut Wright, Owen N. aut Martin, Stephen J. aut Ball, Brenda V. aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 15. Jan. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:15 month:01 https://dx.doi.org/10.1186/s12985-022-01740-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 15 01
spelling	10.1186/s12985-022-01740-2 doi (DE-627)SPR050418009 (SPR)s12985-022-01740-2-e DE-627 ger DE-627 rakwb eng de Miranda, Joachim R. verfasserin (orcid)0000-0002-0335-0386 aut Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022. corrected publication 2022 Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. Egypt bee virus (dpeaa)DE-He213 Deformed wing virus (dpeaa)DE-He213 Master strain (dpeaa)DE-He213 Honeybee (dpeaa)DE-He213 Western blot (dpeaa)DE-He213 RNA sequencing (dpeaa)DE-He213 Bioinformatic screening (dpeaa)DE-He213 Brettell, Laura E. aut Chejanovsky, Nor aut Childers, Anna K. aut Dalmon, Anne aut Deboutte, Ward aut de Graaf, Dirk C. aut Doublet, Vincent aut Gebremedhn, Haftom aut Genersch, Elke aut Gisder, Sebastian aut Granberg, Fredrik aut Haddad, Nizar J. aut Kaden, Rene aut Manley, Robyn aut Matthijnssens, Jelle aut Meeus, Ivan aut Migdadi, Hussein aut Milbrath, Meghan O. aut Mondet, Fanny aut Remnant, Emily J. aut Roberts, John M. K. aut Ryabov, Eugene V. aut Sela, Noa aut Smagghe, Guy aut Somanathan, Hema aut Wilfert, Lena aut Wright, Owen N. aut Martin, Stephen J. aut Ball, Brenda V. aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 15. Jan. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:15 month:01 https://dx.doi.org/10.1186/s12985-022-01740-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 15 01
allfields_unstemmed	10.1186/s12985-022-01740-2 doi (DE-627)SPR050418009 (SPR)s12985-022-01740-2-e DE-627 ger DE-627 rakwb eng de Miranda, Joachim R. verfasserin (orcid)0000-0002-0335-0386 aut Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022. corrected publication 2022 Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. Egypt bee virus (dpeaa)DE-He213 Deformed wing virus (dpeaa)DE-He213 Master strain (dpeaa)DE-He213 Honeybee (dpeaa)DE-He213 Western blot (dpeaa)DE-He213 RNA sequencing (dpeaa)DE-He213 Bioinformatic screening (dpeaa)DE-He213 Brettell, Laura E. aut Chejanovsky, Nor aut Childers, Anna K. aut Dalmon, Anne aut Deboutte, Ward aut de Graaf, Dirk C. aut Doublet, Vincent aut Gebremedhn, Haftom aut Genersch, Elke aut Gisder, Sebastian aut Granberg, Fredrik aut Haddad, Nizar J. aut Kaden, Rene aut Manley, Robyn aut Matthijnssens, Jelle aut Meeus, Ivan aut Migdadi, Hussein aut Milbrath, Meghan O. aut Mondet, Fanny aut Remnant, Emily J. aut Roberts, John M. K. aut Ryabov, Eugene V. aut Sela, Noa aut Smagghe, Guy aut Somanathan, Hema aut Wilfert, Lena aut Wright, Owen N. aut Martin, Stephen J. aut Ball, Brenda V. aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 15. Jan. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:15 month:01 https://dx.doi.org/10.1186/s12985-022-01740-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 15 01
allfieldsGer	10.1186/s12985-022-01740-2 doi (DE-627)SPR050418009 (SPR)s12985-022-01740-2-e DE-627 ger DE-627 rakwb eng de Miranda, Joachim R. verfasserin (orcid)0000-0002-0335-0386 aut Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022. corrected publication 2022 Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. Egypt bee virus (dpeaa)DE-He213 Deformed wing virus (dpeaa)DE-He213 Master strain (dpeaa)DE-He213 Honeybee (dpeaa)DE-He213 Western blot (dpeaa)DE-He213 RNA sequencing (dpeaa)DE-He213 Bioinformatic screening (dpeaa)DE-He213 Brettell, Laura E. aut Chejanovsky, Nor aut Childers, Anna K. aut Dalmon, Anne aut Deboutte, Ward aut de Graaf, Dirk C. aut Doublet, Vincent aut Gebremedhn, Haftom aut Genersch, Elke aut Gisder, Sebastian aut Granberg, Fredrik aut Haddad, Nizar J. aut Kaden, Rene aut Manley, Robyn aut Matthijnssens, Jelle aut Meeus, Ivan aut Migdadi, Hussein aut Milbrath, Meghan O. aut Mondet, Fanny aut Remnant, Emily J. aut Roberts, John M. K. aut Ryabov, Eugene V. aut Sela, Noa aut Smagghe, Guy aut Somanathan, Hema aut Wilfert, Lena aut Wright, Owen N. aut Martin, Stephen J. aut Ball, Brenda V. aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 15. Jan. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:15 month:01 https://dx.doi.org/10.1186/s12985-022-01740-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 15 01
allfieldsSound	10.1186/s12985-022-01740-2 doi (DE-627)SPR050418009 (SPR)s12985-022-01740-2-e DE-627 ger DE-627 rakwb eng de Miranda, Joachim R. verfasserin (orcid)0000-0002-0335-0386 aut Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022. corrected publication 2022 Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. Egypt bee virus (dpeaa)DE-He213 Deformed wing virus (dpeaa)DE-He213 Master strain (dpeaa)DE-He213 Honeybee (dpeaa)DE-He213 Western blot (dpeaa)DE-He213 RNA sequencing (dpeaa)DE-He213 Bioinformatic screening (dpeaa)DE-He213 Brettell, Laura E. aut Chejanovsky, Nor aut Childers, Anna K. aut Dalmon, Anne aut Deboutte, Ward aut de Graaf, Dirk C. aut Doublet, Vincent aut Gebremedhn, Haftom aut Genersch, Elke aut Gisder, Sebastian aut Granberg, Fredrik aut Haddad, Nizar J. aut Kaden, Rene aut Manley, Robyn aut Matthijnssens, Jelle aut Meeus, Ivan aut Migdadi, Hussein aut Milbrath, Meghan O. aut Mondet, Fanny aut Remnant, Emily J. aut Roberts, John M. K. aut Ryabov, Eugene V. aut Sela, Noa aut Smagghe, Guy aut Somanathan, Hema aut Wilfert, Lena aut Wright, Owen N. aut Martin, Stephen J. aut Ball, Brenda V. aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 15. Jan. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:15 month:01 https://dx.doi.org/10.1186/s12985-022-01740-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 15 01
language	English
source	Enthalten in Virology journal 19(2022), 1 vom: 15. Jan. volume:19 year:2022 number:1 day:15 month:01
sourceStr	Enthalten in Virology journal 19(2022), 1 vom: 15. Jan. volume:19 year:2022 number:1 day:15 month:01
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Egypt bee virus Deformed wing virus Master strain Honeybee Western blot RNA sequencing Bioinformatic screening
isfreeaccess_bool	true
container_title	Virology journal
authorswithroles_txt_mv	de Miranda, Joachim R. @@aut@@ Brettell, Laura E. @@aut@@ Chejanovsky, Nor @@aut@@ Childers, Anna K. @@aut@@ Dalmon, Anne @@aut@@ Deboutte, Ward @@aut@@ de Graaf, Dirk C. @@aut@@ Doublet, Vincent @@aut@@ Gebremedhn, Haftom @@aut@@ Genersch, Elke @@aut@@ Gisder, Sebastian @@aut@@ Granberg, Fredrik @@aut@@ Haddad, Nizar J. @@aut@@ Kaden, Rene @@aut@@ Manley, Robyn @@aut@@ Matthijnssens, Jelle @@aut@@ Meeus, Ivan @@aut@@ Migdadi, Hussein @@aut@@ Milbrath, Meghan O. @@aut@@ Mondet, Fanny @@aut@@ Remnant, Emily J. @@aut@@ Roberts, John M. K. @@aut@@ Ryabov, Eugene V. @@aut@@ Sela, Noa @@aut@@ Smagghe, Guy @@aut@@ Somanathan, Hema @@aut@@ Wilfert, Lena @@aut@@ Wright, Owen N. @@aut@@ Martin, Stephen J. @@aut@@ Ball, Brenda V. @@aut@@
publishDateDaySort_date	2022-01-15T00:00:00Z
hierarchy_top_id	394165004
id	SPR050418009
language_de	englisch
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author	de Miranda, Joachim R.
spellingShingle	de Miranda, Joachim R. misc Egypt bee virus misc Deformed wing virus misc Master strain misc Honeybee misc Western blot misc RNA sequencing misc Bioinformatic screening Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt
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topic_title	Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt Egypt bee virus (dpeaa)DE-He213 Deformed wing virus (dpeaa)DE-He213 Master strain (dpeaa)DE-He213 Honeybee (dpeaa)DE-He213 Western blot (dpeaa)DE-He213 RNA sequencing (dpeaa)DE-He213 Bioinformatic screening (dpeaa)DE-He213
topic	misc Egypt bee virus misc Deformed wing virus misc Master strain misc Honeybee misc Western blot misc RNA sequencing misc Bioinformatic screening
topic_unstemmed	misc Egypt bee virus misc Deformed wing virus misc Master strain misc Honeybee misc Western blot misc RNA sequencing misc Bioinformatic screening
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title	Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt
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title_full	Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt
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author_browse	de Miranda, Joachim R. Brettell, Laura E. Chejanovsky, Nor Childers, Anna K. Dalmon, Anne Deboutte, Ward de Graaf, Dirk C. Doublet, Vincent Gebremedhn, Haftom Genersch, Elke Gisder, Sebastian Granberg, Fredrik Haddad, Nizar J. Kaden, Rene Manley, Robyn Matthijnssens, Jelle Meeus, Ivan Migdadi, Hussein Milbrath, Meghan O. Mondet, Fanny Remnant, Emily J. Roberts, John M. K. Ryabov, Eugene V. Sela, Noa Smagghe, Guy Somanathan, Hema Wilfert, Lena Wright, Owen N. Martin, Stephen J. Ball, Brenda V.
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title_sort	cold case: the disappearance of egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s egypt
title_auth	Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt
abstract	Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. © The Author(s) 2022. corrected publication 2022
abstractGer	Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. © The Author(s) 2022. corrected publication 2022
abstract_unstemmed	Abstract In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes. © The Author(s) 2022. corrected publication 2022
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title_short	Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt
url	https://dx.doi.org/10.1186/s12985-022-01740-2
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Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt

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