Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk

Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV out...
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Autor*in:	Böhm, Michael [verfasserIn] Schumacher, Helmut Werner, Christian Teo, Koon K. Lonn, Eva M. Mahfoud, Felix Speer, Thimoteus Mancia, Giuseppe Redon, Josep Schmieder, Roland E. Sliwa, Karen Marx, Nikolaus Weber, Michael A. Laufs, Ulrich Williams, Bryan Yusuf, Salim Mann, Johannes F. E.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Physical activity Cardiovascular outcomes Renal outcomes Secondary prevention

Anmerkung:	© The Author(s) 2021. corrected publication 2022

Übergeordnetes Werk:	Enthalten in: Cardiovascular diabetology - London : BioMed Central, 2002, 21(2022), 1 vom: 20. Jan.
Übergeordnetes Werk:	volume:21 ; year:2022 ; number:1 ; day:20 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12933-021-01429-w

Katalog-ID:	SPR050429531

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520			\|a Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101.
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650		4	\|a Secondary prevention \|7 (dpeaa)DE-He213
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700	1		\|a Werner, Christian \|4 aut
700	1		\|a Teo, Koon K. \|4 aut
700	1		\|a Lonn, Eva M. \|4 aut
700	1		\|a Mahfoud, Felix \|4 aut
700	1		\|a Speer, Thimoteus \|4 aut
700	1		\|a Mancia, Giuseppe \|4 aut
700	1		\|a Redon, Josep \|4 aut
700	1		\|a Schmieder, Roland E. \|4 aut
700	1		\|a Sliwa, Karen \|4 aut
700	1		\|a Marx, Nikolaus \|4 aut
700	1		\|a Weber, Michael A. \|4 aut
700	1		\|a Laufs, Ulrich \|4 aut
700	1		\|a Williams, Bryan \|4 aut
700	1		\|a Yusuf, Salim \|4 aut
700	1		\|a Mann, Johannes F. E. \|4 aut
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allfields	10.1186/s12933-021-01429-w doi (DE-627)SPR050429531 (SPR)s12933-021-01429-w-e DE-627 ger DE-627 rakwb eng Böhm, Michael verfasserin (orcid)0000-0002-2976-2514 aut Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. Physical activity (dpeaa)DE-He213 Cardiovascular outcomes (dpeaa)DE-He213 Renal outcomes (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Schumacher, Helmut aut Werner, Christian aut Teo, Koon K. aut Lonn, Eva M. aut Mahfoud, Felix aut Speer, Thimoteus aut Mancia, Giuseppe aut Redon, Josep aut Schmieder, Roland E. aut Sliwa, Karen aut Marx, Nikolaus aut Weber, Michael A. aut Laufs, Ulrich aut Williams, Bryan aut Yusuf, Salim aut Mann, Johannes F. E. aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 21(2022), 1 vom: 20. Jan. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:21 year:2022 number:1 day:20 month:01 https://dx.doi.org/10.1186/s12933-021-01429-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 1 20 01
spelling	10.1186/s12933-021-01429-w doi (DE-627)SPR050429531 (SPR)s12933-021-01429-w-e DE-627 ger DE-627 rakwb eng Böhm, Michael verfasserin (orcid)0000-0002-2976-2514 aut Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. Physical activity (dpeaa)DE-He213 Cardiovascular outcomes (dpeaa)DE-He213 Renal outcomes (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Schumacher, Helmut aut Werner, Christian aut Teo, Koon K. aut Lonn, Eva M. aut Mahfoud, Felix aut Speer, Thimoteus aut Mancia, Giuseppe aut Redon, Josep aut Schmieder, Roland E. aut Sliwa, Karen aut Marx, Nikolaus aut Weber, Michael A. aut Laufs, Ulrich aut Williams, Bryan aut Yusuf, Salim aut Mann, Johannes F. E. aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 21(2022), 1 vom: 20. Jan. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:21 year:2022 number:1 day:20 month:01 https://dx.doi.org/10.1186/s12933-021-01429-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 1 20 01
allfields_unstemmed	10.1186/s12933-021-01429-w doi (DE-627)SPR050429531 (SPR)s12933-021-01429-w-e DE-627 ger DE-627 rakwb eng Böhm, Michael verfasserin (orcid)0000-0002-2976-2514 aut Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. Physical activity (dpeaa)DE-He213 Cardiovascular outcomes (dpeaa)DE-He213 Renal outcomes (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Schumacher, Helmut aut Werner, Christian aut Teo, Koon K. aut Lonn, Eva M. aut Mahfoud, Felix aut Speer, Thimoteus aut Mancia, Giuseppe aut Redon, Josep aut Schmieder, Roland E. aut Sliwa, Karen aut Marx, Nikolaus aut Weber, Michael A. aut Laufs, Ulrich aut Williams, Bryan aut Yusuf, Salim aut Mann, Johannes F. E. aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 21(2022), 1 vom: 20. Jan. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:21 year:2022 number:1 day:20 month:01 https://dx.doi.org/10.1186/s12933-021-01429-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 1 20 01
allfieldsGer	10.1186/s12933-021-01429-w doi (DE-627)SPR050429531 (SPR)s12933-021-01429-w-e DE-627 ger DE-627 rakwb eng Böhm, Michael verfasserin (orcid)0000-0002-2976-2514 aut Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. Physical activity (dpeaa)DE-He213 Cardiovascular outcomes (dpeaa)DE-He213 Renal outcomes (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Schumacher, Helmut aut Werner, Christian aut Teo, Koon K. aut Lonn, Eva M. aut Mahfoud, Felix aut Speer, Thimoteus aut Mancia, Giuseppe aut Redon, Josep aut Schmieder, Roland E. aut Sliwa, Karen aut Marx, Nikolaus aut Weber, Michael A. aut Laufs, Ulrich aut Williams, Bryan aut Yusuf, Salim aut Mann, Johannes F. E. aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 21(2022), 1 vom: 20. Jan. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:21 year:2022 number:1 day:20 month:01 https://dx.doi.org/10.1186/s12933-021-01429-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 1 20 01
allfieldsSound	10.1186/s12933-021-01429-w doi (DE-627)SPR050429531 (SPR)s12933-021-01429-w-e DE-627 ger DE-627 rakwb eng Böhm, Michael verfasserin (orcid)0000-0002-2976-2514 aut Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. Physical activity (dpeaa)DE-He213 Cardiovascular outcomes (dpeaa)DE-He213 Renal outcomes (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Schumacher, Helmut aut Werner, Christian aut Teo, Koon K. aut Lonn, Eva M. aut Mahfoud, Felix aut Speer, Thimoteus aut Mancia, Giuseppe aut Redon, Josep aut Schmieder, Roland E. aut Sliwa, Karen aut Marx, Nikolaus aut Weber, Michael A. aut Laufs, Ulrich aut Williams, Bryan aut Yusuf, Salim aut Mann, Johannes F. E. aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 21(2022), 1 vom: 20. Jan. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:21 year:2022 number:1 day:20 month:01 https://dx.doi.org/10.1186/s12933-021-01429-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 1 20 01
language	English
source	Enthalten in Cardiovascular diabetology 21(2022), 1 vom: 20. Jan. volume:21 year:2022 number:1 day:20 month:01
sourceStr	Enthalten in Cardiovascular diabetology 21(2022), 1 vom: 20. Jan. volume:21 year:2022 number:1 day:20 month:01
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Physical activity Cardiovascular outcomes Renal outcomes Secondary prevention
isfreeaccess_bool	true
container_title	Cardiovascular diabetology
authorswithroles_txt_mv	Böhm, Michael @@aut@@ Schumacher, Helmut @@aut@@ Werner, Christian @@aut@@ Teo, Koon K. @@aut@@ Lonn, Eva M. @@aut@@ Mahfoud, Felix @@aut@@ Speer, Thimoteus @@aut@@ Mancia, Giuseppe @@aut@@ Redon, Josep @@aut@@ Schmieder, Roland E. @@aut@@ Sliwa, Karen @@aut@@ Marx, Nikolaus @@aut@@ Weber, Michael A. @@aut@@ Laufs, Ulrich @@aut@@ Williams, Bryan @@aut@@ Yusuf, Salim @@aut@@ Mann, Johannes F. E. @@aut@@
publishDateDaySort_date	2022-01-20T00:00:00Z
hierarchy_top_id	356593665
id	SPR050429531
language_de	englisch
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The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. 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author	Böhm, Michael
spellingShingle	Böhm, Michael misc Physical activity misc Cardiovascular outcomes misc Renal outcomes misc Secondary prevention Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk
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topic_title	Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk Physical activity (dpeaa)DE-He213 Cardiovascular outcomes (dpeaa)DE-He213 Renal outcomes (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213
topic	misc Physical activity misc Cardiovascular outcomes misc Renal outcomes misc Secondary prevention
topic_unstemmed	misc Physical activity misc Cardiovascular outcomes misc Renal outcomes misc Secondary prevention
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title	Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk
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title_full	Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk
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author_browse	Böhm, Michael Schumacher, Helmut Werner, Christian Teo, Koon K. Lonn, Eva M. Mahfoud, Felix Speer, Thimoteus Mancia, Giuseppe Redon, Josep Schmieder, Roland E. Sliwa, Karen Marx, Nikolaus Weber, Michael A. Laufs, Ulrich Williams, Bryan Yusuf, Salim Mann, Johannes F. E.
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title_sort	association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk
title_auth	Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk
abstract	Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. © The Author(s) 2021. corrected publication 2022
abstractGer	Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. © The Author(s) 2021. corrected publication 2022
abstract_unstemmed	Background Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and $ χ^{2} $-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05). Conclusions Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101. © The Author(s) 2021. corrected publication 2022
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title_short	Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk
url	https://dx.doi.org/10.1186/s12933-021-01429-w
remote_bool	true
author2	Schumacher, Helmut Werner, Christian Teo, Koon K. Lonn, Eva M. Mahfoud, Felix Speer, Thimoteus Mancia, Giuseppe Redon, Josep Schmieder, Roland E. Sliwa, Karen Marx, Nikolaus Weber, Michael A. Laufs, Ulrich Williams, Bryan Yusuf, Salim Mann, Johannes F. E.
author2Str	Schumacher, Helmut Werner, Christian Teo, Koon K. Lonn, Eva M. Mahfoud, Felix Speer, Thimoteus Mancia, Giuseppe Redon, Josep Schmieder, Roland E. Sliwa, Karen Marx, Nikolaus Weber, Michael A. Laufs, Ulrich Williams, Bryan Yusuf, Salim Mann, Johannes F. E.
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Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk

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