5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase

Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Liu, Junfeng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	RNA 5-methylcytosine Methylation rate Methylation level

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 15(2022), 1 vom: 23. Feb.
Übergeordnetes Werk:	volume:15 ; year:2022 ; number:1 ; day:23 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s13104-022-05968-7

Katalog-ID:	SPR050512730

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245	1	0	\|a 5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase
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520			\|a Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals.
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author_variant	j l jl
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allfields	10.1186/s13104-022-05968-7 doi (DE-627)SPR050512730 (SPR)s13104-022-05968-7-e DE-627 ger DE-627 rakwb eng Liu, Junfeng verfasserin (orcid)0000-0002-2651-4654 aut 5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. RNA 5-methylcytosine (dpeaa)DE-He213 Methylation rate (dpeaa)DE-He213 Methylation level (dpeaa)DE-He213 Enthalten in BMC Research Notes London, 2008 15(2022), 1 vom: 23. Feb. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:15 year:2022 number:1 day:23 month:02 https://dx.doi.org/10.1186/s13104-022-05968-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1 23 02
spelling	10.1186/s13104-022-05968-7 doi (DE-627)SPR050512730 (SPR)s13104-022-05968-7-e DE-627 ger DE-627 rakwb eng Liu, Junfeng verfasserin (orcid)0000-0002-2651-4654 aut 5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. RNA 5-methylcytosine (dpeaa)DE-He213 Methylation rate (dpeaa)DE-He213 Methylation level (dpeaa)DE-He213 Enthalten in BMC Research Notes London, 2008 15(2022), 1 vom: 23. Feb. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:15 year:2022 number:1 day:23 month:02 https://dx.doi.org/10.1186/s13104-022-05968-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1 23 02
allfields_unstemmed	10.1186/s13104-022-05968-7 doi (DE-627)SPR050512730 (SPR)s13104-022-05968-7-e DE-627 ger DE-627 rakwb eng Liu, Junfeng verfasserin (orcid)0000-0002-2651-4654 aut 5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. RNA 5-methylcytosine (dpeaa)DE-He213 Methylation rate (dpeaa)DE-He213 Methylation level (dpeaa)DE-He213 Enthalten in BMC Research Notes London, 2008 15(2022), 1 vom: 23. Feb. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:15 year:2022 number:1 day:23 month:02 https://dx.doi.org/10.1186/s13104-022-05968-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1 23 02
allfieldsGer	10.1186/s13104-022-05968-7 doi (DE-627)SPR050512730 (SPR)s13104-022-05968-7-e DE-627 ger DE-627 rakwb eng Liu, Junfeng verfasserin (orcid)0000-0002-2651-4654 aut 5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. RNA 5-methylcytosine (dpeaa)DE-He213 Methylation rate (dpeaa)DE-He213 Methylation level (dpeaa)DE-He213 Enthalten in BMC Research Notes London, 2008 15(2022), 1 vom: 23. Feb. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:15 year:2022 number:1 day:23 month:02 https://dx.doi.org/10.1186/s13104-022-05968-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1 23 02
allfieldsSound	10.1186/s13104-022-05968-7 doi (DE-627)SPR050512730 (SPR)s13104-022-05968-7-e DE-627 ger DE-627 rakwb eng Liu, Junfeng verfasserin (orcid)0000-0002-2651-4654 aut 5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. RNA 5-methylcytosine (dpeaa)DE-He213 Methylation rate (dpeaa)DE-He213 Methylation level (dpeaa)DE-He213 Enthalten in BMC Research Notes London, 2008 15(2022), 1 vom: 23. Feb. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:15 year:2022 number:1 day:23 month:02 https://dx.doi.org/10.1186/s13104-022-05968-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 1 23 02
language	English
source	Enthalten in BMC Research Notes 15(2022), 1 vom: 23. Feb. volume:15 year:2022 number:1 day:23 month:02
sourceStr	Enthalten in BMC Research Notes 15(2022), 1 vom: 23. Feb. volume:15 year:2022 number:1 day:23 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	RNA 5-methylcytosine Methylation rate Methylation level
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container_title	BMC Research Notes
authorswithroles_txt_mv	Liu, Junfeng @@aut@@
publishDateDaySort_date	2022-02-23T00:00:00Z
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Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. 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author	Liu, Junfeng
spellingShingle	Liu, Junfeng misc RNA 5-methylcytosine misc Methylation rate misc Methylation level 5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase
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topic_title	5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase RNA 5-methylcytosine (dpeaa)DE-He213 Methylation rate (dpeaa)DE-He213 Methylation level (dpeaa)DE-He213
topic	misc RNA 5-methylcytosine misc Methylation rate misc Methylation level
topic_unstemmed	misc RNA 5-methylcytosine misc Methylation rate misc Methylation level
topic_browse	misc RNA 5-methylcytosine misc Methylation rate misc Methylation level
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title	5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase
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title_full	5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase
author_sort	Liu, Junfeng
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title_sort	5-methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $c formation catalyzed by rna methyltransferase
title_auth	5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase
abstract	Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. © The Author(s) 2022
abstractGer	Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. © The Author(s) 2022
abstract_unstemmed	Objective 5-Methylcytosine ($ m^{5} $C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA $ m^{5} $C has been extensively studied over the past years, the distribution and biological function of RNA $ m^{5} $C still remain to be elucidated. Here, I explored the profiles of RNA $ m^{5} $C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA $ m^{5} $C data. Results I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula suggests that the methylation levels at most $ m^{5} $C sites are the same in four mouse tissues. Therefore, I proposed a hypothesis that the $ m^{5} $C formation catalyzed by RNA methyltransferase is random and with the same probability at most $ m^{5} $C sites, which is the methylation rate of cytosine. My hypothesis can be used to explain the observed profiles of RNA $ m^{5} $C in four mouse tissues and will be benefit to future studies of the distribution and biological function of RNA $ m^{5} $C in mammals. © The Author(s) 2022
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title_short	5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase
url	https://dx.doi.org/10.1186/s13104-022-05968-7
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5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of $ m^{5} $C formation catalyzed by RNA methyltransferase

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