Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium
Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yılmaz, Eren [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© Institute of Chemistry, Slovak Academy of Sciences 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Chemical papers - Wien : Springer Vienna, 1947, 76(2022), 4 vom: 05. Jan., Seite 2459-2467 |
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| Übergeordnetes Werk: |
volume:76 ; year:2022 ; number:4 ; day:05 ; month:01 ; pages:2459-2467 |
| Links: |
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| DOI / URN: |
10.1007/s11696-021-02045-4 |
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| Katalog-ID: |
SPR050562940 |
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| 520 | |a Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. | ||
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| 650 | 4 | |a Nano-network structure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antibacterial |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Drug loading |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Türk, Serbülent |4 aut | |
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10.1007/s11696-021-02045-4 doi (DE-627)SPR050562940 (SPR)s11696-021-02045-4-e DE-627 ger DE-627 rakwb eng Yılmaz, Eren verfasserin (orcid)0000-0001-7264-2588 aut Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Chemistry, Slovak Academy of Sciences 2022 Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. Alkaline treatment (dpeaa)DE-He213 Nano-network structure (dpeaa)DE-He213 Antibacterial (dpeaa)DE-He213 Drug loading (dpeaa)DE-He213 Türk, Serbülent aut Enthalten in Chemical papers Wien : Springer Vienna, 1947 76(2022), 4 vom: 05. Jan., Seite 2459-2467 (DE-627)518347737 (DE-600)2252770-9 1336-9075 nnns volume:76 year:2022 number:4 day:05 month:01 pages:2459-2467 https://dx.doi.org/10.1007/s11696-021-02045-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 76 2022 4 05 01 2459-2467 |
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10.1007/s11696-021-02045-4 doi (DE-627)SPR050562940 (SPR)s11696-021-02045-4-e DE-627 ger DE-627 rakwb eng Yılmaz, Eren verfasserin (orcid)0000-0001-7264-2588 aut Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Chemistry, Slovak Academy of Sciences 2022 Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. Alkaline treatment (dpeaa)DE-He213 Nano-network structure (dpeaa)DE-He213 Antibacterial (dpeaa)DE-He213 Drug loading (dpeaa)DE-He213 Türk, Serbülent aut Enthalten in Chemical papers Wien : Springer Vienna, 1947 76(2022), 4 vom: 05. Jan., Seite 2459-2467 (DE-627)518347737 (DE-600)2252770-9 1336-9075 nnns volume:76 year:2022 number:4 day:05 month:01 pages:2459-2467 https://dx.doi.org/10.1007/s11696-021-02045-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 76 2022 4 05 01 2459-2467 |
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10.1007/s11696-021-02045-4 doi (DE-627)SPR050562940 (SPR)s11696-021-02045-4-e DE-627 ger DE-627 rakwb eng Yılmaz, Eren verfasserin (orcid)0000-0001-7264-2588 aut Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Chemistry, Slovak Academy of Sciences 2022 Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. Alkaline treatment (dpeaa)DE-He213 Nano-network structure (dpeaa)DE-He213 Antibacterial (dpeaa)DE-He213 Drug loading (dpeaa)DE-He213 Türk, Serbülent aut Enthalten in Chemical papers Wien : Springer Vienna, 1947 76(2022), 4 vom: 05. Jan., Seite 2459-2467 (DE-627)518347737 (DE-600)2252770-9 1336-9075 nnns volume:76 year:2022 number:4 day:05 month:01 pages:2459-2467 https://dx.doi.org/10.1007/s11696-021-02045-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 76 2022 4 05 01 2459-2467 |
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10.1007/s11696-021-02045-4 doi (DE-627)SPR050562940 (SPR)s11696-021-02045-4-e DE-627 ger DE-627 rakwb eng Yılmaz, Eren verfasserin (orcid)0000-0001-7264-2588 aut Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Chemistry, Slovak Academy of Sciences 2022 Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. Alkaline treatment (dpeaa)DE-He213 Nano-network structure (dpeaa)DE-He213 Antibacterial (dpeaa)DE-He213 Drug loading (dpeaa)DE-He213 Türk, Serbülent aut Enthalten in Chemical papers Wien : Springer Vienna, 1947 76(2022), 4 vom: 05. Jan., Seite 2459-2467 (DE-627)518347737 (DE-600)2252770-9 1336-9075 nnns volume:76 year:2022 number:4 day:05 month:01 pages:2459-2467 https://dx.doi.org/10.1007/s11696-021-02045-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 76 2022 4 05 01 2459-2467 |
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10.1007/s11696-021-02045-4 doi (DE-627)SPR050562940 (SPR)s11696-021-02045-4-e DE-627 ger DE-627 rakwb eng Yılmaz, Eren verfasserin (orcid)0000-0001-7264-2588 aut Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Chemistry, Slovak Academy of Sciences 2022 Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. Alkaline treatment (dpeaa)DE-He213 Nano-network structure (dpeaa)DE-He213 Antibacterial (dpeaa)DE-He213 Drug loading (dpeaa)DE-He213 Türk, Serbülent aut Enthalten in Chemical papers Wien : Springer Vienna, 1947 76(2022), 4 vom: 05. Jan., Seite 2459-2467 (DE-627)518347737 (DE-600)2252770-9 1336-9075 nnns volume:76 year:2022 number:4 day:05 month:01 pages:2459-2467 https://dx.doi.org/10.1007/s11696-021-02045-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 76 2022 4 05 01 2459-2467 |
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Yılmaz, Eren |
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Yılmaz, Eren misc Alkaline treatment misc Nano-network structure misc Antibacterial misc Drug loading Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium |
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Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium Alkaline treatment (dpeaa)DE-He213 Nano-network structure (dpeaa)DE-He213 Antibacterial (dpeaa)DE-He213 Drug loading (dpeaa)DE-He213 |
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loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium |
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Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium |
| abstract |
Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. © Institute of Chemistry, Slovak Academy of Sciences 2022 |
| abstractGer |
Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. © Institute of Chemistry, Slovak Academy of Sciences 2022 |
| abstract_unstemmed |
Abstract Bone-implant bonding can be achieved by stimulating the apatite formation with the alkaline chemical process applied to the surface of Ti and its alloys. Although the bioactivity can improve the osseointegration feature of the implant, the shortening of the implant life due to the risk of infection during implantation is a problem frequently encountered in biomedical applications and causes the removal of the implant. Therefore, in this study, NaOH pretreatment was performed on Ti plates to create a nano-networked surface that can stimulate apatite formation. It aimed to reduce the risk of infection by loading antibiotics on these surfaces. After alkali treatment, a nano-network structure with 80–150 nm pore sizes with alpha titanium and sodium hydrogen titanate phases was formed. It has been observed that this surface provides apatite formation when kept in simulated body fluid for 3 days. The appearance of an inhibition zone after drug loading proved its antibacterial property. At the same time, the cell viability of the drug-loaded alkaline treated surface was 85%. It was concluded that antibiotic-loaded nano-networked NaOH surfaces could be recommended for dental and orthopedic implants in terms of both cellular behavior and infection risk. © Institute of Chemistry, Slovak Academy of Sciences 2022 |
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Loading antibiotics on the surface of nano-networked sodium hydroxide treated titanium |
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10.1007/s11696-021-02045-4 |
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2024-07-03T16:20:22.182Z |
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