Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults
Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting...
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| Autor*in: |
Weidner, Kathrin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2022 |
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| Übergeordnetes Werk: |
Enthalten in: BMC cardiovascular disorders - London : BioMed Central, 2001, 22(2022), 1 vom: 31. März |
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| Übergeordnetes Werk: |
volume:22 ; year:2022 ; number:1 ; day:31 ; month:03 |
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| DOI / URN: |
10.1186/s12872-022-02552-6 |
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| Katalog-ID: |
SPR050605682 |
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| 520 | |a Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. | ||
| 650 | 4 | |a Young adults |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Age |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ventricular tachyarrhythmia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardiovascular risk factors |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Coronary artery disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Long-term mortality |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardiac-related disease |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Behnes, Michael |4 aut | |
| 700 | 1 | |a Schupp, Tobias |4 aut | |
| 700 | 1 | |a Hoppner, Jorge |4 aut | |
| 700 | 1 | |a El-Battrawy, Ibrahim |4 aut | |
| 700 | 1 | |a Ansari, Uzair |4 aut | |
| 700 | 1 | |a Saleh, Ahmad |4 aut | |
| 700 | 1 | |a Taton, Gabriel |4 aut | |
| 700 | 1 | |a Reiser, Linda |4 aut | |
| 700 | 1 | |a Bollow, Armin |4 aut | |
| 700 | 1 | |a Reichelt, Thomas |4 aut | |
| 700 | 1 | |a Ellguth, Dominik |4 aut | |
| 700 | 1 | |a Engelke, Niko |4 aut | |
| 700 | 1 | |a Bertsch, Thomas |4 aut | |
| 700 | 1 | |a Große Meininghaus, Dirk |4 aut | |
| 700 | 1 | |a Hoffmann, Ursula |4 aut | |
| 700 | 1 | |a Akin, Ibrahim |4 aut | |
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10.1186/s12872-022-02552-6 doi (DE-627)SPR050605682 (SPR)s12872-022-02552-6-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. Young adults (dpeaa)DE-He213 Age (dpeaa)DE-He213 Ventricular tachyarrhythmia (dpeaa)DE-He213 Cardiovascular risk factors (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Long-term mortality (dpeaa)DE-He213 Cardiac-related disease (dpeaa)DE-He213 Behnes, Michael aut Schupp, Tobias aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Ansari, Uzair aut Saleh, Ahmad aut Taton, Gabriel aut Reiser, Linda aut Bollow, Armin aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Bertsch, Thomas aut Große Meininghaus, Dirk aut Hoffmann, Ursula aut Akin, Ibrahim aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 22(2022), 1 vom: 31. März (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:22 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12872-022-02552-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 31 03 |
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10.1186/s12872-022-02552-6 doi (DE-627)SPR050605682 (SPR)s12872-022-02552-6-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. Young adults (dpeaa)DE-He213 Age (dpeaa)DE-He213 Ventricular tachyarrhythmia (dpeaa)DE-He213 Cardiovascular risk factors (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Long-term mortality (dpeaa)DE-He213 Cardiac-related disease (dpeaa)DE-He213 Behnes, Michael aut Schupp, Tobias aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Ansari, Uzair aut Saleh, Ahmad aut Taton, Gabriel aut Reiser, Linda aut Bollow, Armin aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Bertsch, Thomas aut Große Meininghaus, Dirk aut Hoffmann, Ursula aut Akin, Ibrahim aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 22(2022), 1 vom: 31. März (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:22 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12872-022-02552-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 31 03 |
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10.1186/s12872-022-02552-6 doi (DE-627)SPR050605682 (SPR)s12872-022-02552-6-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. Young adults (dpeaa)DE-He213 Age (dpeaa)DE-He213 Ventricular tachyarrhythmia (dpeaa)DE-He213 Cardiovascular risk factors (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Long-term mortality (dpeaa)DE-He213 Cardiac-related disease (dpeaa)DE-He213 Behnes, Michael aut Schupp, Tobias aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Ansari, Uzair aut Saleh, Ahmad aut Taton, Gabriel aut Reiser, Linda aut Bollow, Armin aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Bertsch, Thomas aut Große Meininghaus, Dirk aut Hoffmann, Ursula aut Akin, Ibrahim aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 22(2022), 1 vom: 31. März (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:22 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12872-022-02552-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 31 03 |
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10.1186/s12872-022-02552-6 doi (DE-627)SPR050605682 (SPR)s12872-022-02552-6-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. Young adults (dpeaa)DE-He213 Age (dpeaa)DE-He213 Ventricular tachyarrhythmia (dpeaa)DE-He213 Cardiovascular risk factors (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Long-term mortality (dpeaa)DE-He213 Cardiac-related disease (dpeaa)DE-He213 Behnes, Michael aut Schupp, Tobias aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Ansari, Uzair aut Saleh, Ahmad aut Taton, Gabriel aut Reiser, Linda aut Bollow, Armin aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Bertsch, Thomas aut Große Meininghaus, Dirk aut Hoffmann, Ursula aut Akin, Ibrahim aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 22(2022), 1 vom: 31. März (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:22 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12872-022-02552-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 31 03 |
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10.1186/s12872-022-02552-6 doi (DE-627)SPR050605682 (SPR)s12872-022-02552-6-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. Young adults (dpeaa)DE-He213 Age (dpeaa)DE-He213 Ventricular tachyarrhythmia (dpeaa)DE-He213 Cardiovascular risk factors (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Long-term mortality (dpeaa)DE-He213 Cardiac-related disease (dpeaa)DE-He213 Behnes, Michael aut Schupp, Tobias aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Ansari, Uzair aut Saleh, Ahmad aut Taton, Gabriel aut Reiser, Linda aut Bollow, Armin aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Bertsch, Thomas aut Große Meininghaus, Dirk aut Hoffmann, Ursula aut Akin, Ibrahim aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 22(2022), 1 vom: 31. März (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:22 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12872-022-02552-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 31 03 |
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Weidner, Kathrin @@aut@@ Behnes, Michael @@aut@@ Schupp, Tobias @@aut@@ Hoppner, Jorge @@aut@@ El-Battrawy, Ibrahim @@aut@@ Ansari, Uzair @@aut@@ Saleh, Ahmad @@aut@@ Taton, Gabriel @@aut@@ Reiser, Linda @@aut@@ Bollow, Armin @@aut@@ Reichelt, Thomas @@aut@@ Ellguth, Dominik @@aut@@ Engelke, Niko @@aut@@ Bertsch, Thomas @@aut@@ Große Meininghaus, Dirk @@aut@@ Hoffmann, Ursula @@aut@@ Akin, Ibrahim @@aut@@ |
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Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults |
| abstract |
Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. © The Author(s) 2022 |
| abstractGer |
Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. © The Author(s) 2022 |
| abstract_unstemmed |
Background This study evaluates cardiac diseases and prognosis in young adults and adults presenting with ventricular tachyarrhythmias (VTA). Methods The present longitudinal, observational, registry-based, monocentric cohort study includes all consecutive patients 45 years old or younger presenting with VTA at admission from 2002 to 2016. Rates of coronary angiography, coronary artery disease (CAD) and need for percutaneous coronary intervention (PCI), cardiac diseases associated with VTA, and differences in long-term prognostic endpoints for young adults (20–34 years old) were analyzed and compared to those of adults (35–45 years old), for whom multivariable risk prediction models were developed. Kaplan–Meier analyses were performed according to age and type of VTA. Results A total of 259 consecutive patients were included in the study (36% young adults and 64% adults). At admission, 38% of young adults had VTA due to CAD that required PCI. Furthermore, VTA in young adults was commonly idiopathic (27%), or had underlying channelopathies (18%), primary cardiomyopathies (13%) or acute myocardial infarction (AMI, 11%). In adults, VTA was mostly associated with AMI (28%), though the rate of idiopathy was still high (20%). A total 41% of all patients received cardiopulmonary resuscitation (CPR), for whom AMI (STEMI 17%, NSTEMI 24%) was most frequently observed. Irrespective of the type of VTA, all-cause mortality was similar for young adults and adults. In young adults, left ventricular ejection fraction (LVEF) < 35% (HR = 33.590) was associated with increased long-term all-cause mortality. Conclusion Despite high rates of idiopathic ventricular tachyarrhythmias, CAD and AMI are common causes of VTA and CPR in adults 45 years old and younger. Young adults and adults had comparable survival at index hospitalization and after 2.5 years irrespective of the type of VTA. Clinical trial registration clinicaltrials.gov identifier: NCT02982473. © The Author(s) 2022 |
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Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults |
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https://dx.doi.org/10.1186/s12872-022-02552-6 |
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Behnes, Michael Schupp, Tobias Hoppner, Jorge El-Battrawy, Ibrahim Ansari, Uzair Saleh, Ahmad Taton, Gabriel Reiser, Linda Bollow, Armin Reichelt, Thomas Ellguth, Dominik Engelke, Niko Bertsch, Thomas Große Meininghaus, Dirk Hoffmann, Ursula Akin, Ibrahim |
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Behnes, Michael Schupp, Tobias Hoppner, Jorge El-Battrawy, Ibrahim Ansari, Uzair Saleh, Ahmad Taton, Gabriel Reiser, Linda Bollow, Armin Reichelt, Thomas Ellguth, Dominik Engelke, Niko Bertsch, Thomas Große Meininghaus, Dirk Hoffmann, Ursula Akin, Ibrahim |
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