High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography

Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In...
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Gespeichert in:

Autor*in:	Liu, Zhuang [verfasserIn] Zhao, Menglong Wang, Han Fu, Zi Gao, Hongbo Peng, Weijun Ni, Dalong Tang, Wei Gu, Yajia

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	MR angiography Contrast agent Vascular imaging Magnetic nanoparticles Gd-chelate

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Journal of nanobiotechnology - London : Biomed Central, 2003, 20(2022), 1 vom: 31. März
Übergeordnetes Werk:	volume:20 ; year:2022 ; number:1 ; day:31 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s12951-022-01363-3

Katalog-ID:	SPR050606662

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520			\|a Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract
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allfields	10.1186/s12951-022-01363-3 doi (DE-627)SPR050606662 (SPR)s12951-022-01363-3-e DE-627 ger DE-627 rakwb eng Liu, Zhuang verfasserin aut High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract MR angiography (dpeaa)DE-He213 Contrast agent (dpeaa)DE-He213 Vascular imaging (dpeaa)DE-He213 Magnetic nanoparticles (dpeaa)DE-He213 Gd-chelate (dpeaa)DE-He213 Zhao, Menglong aut Wang, Han aut Fu, Zi aut Gao, Hongbo aut Peng, Weijun aut Ni, Dalong aut Tang, Wei aut Gu, Yajia aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 20(2022), 1 vom: 31. März (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:20 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12951-022-01363-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 31 03
spelling	10.1186/s12951-022-01363-3 doi (DE-627)SPR050606662 (SPR)s12951-022-01363-3-e DE-627 ger DE-627 rakwb eng Liu, Zhuang verfasserin aut High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract MR angiography (dpeaa)DE-He213 Contrast agent (dpeaa)DE-He213 Vascular imaging (dpeaa)DE-He213 Magnetic nanoparticles (dpeaa)DE-He213 Gd-chelate (dpeaa)DE-He213 Zhao, Menglong aut Wang, Han aut Fu, Zi aut Gao, Hongbo aut Peng, Weijun aut Ni, Dalong aut Tang, Wei aut Gu, Yajia aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 20(2022), 1 vom: 31. März (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:20 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12951-022-01363-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 31 03
allfields_unstemmed	10.1186/s12951-022-01363-3 doi (DE-627)SPR050606662 (SPR)s12951-022-01363-3-e DE-627 ger DE-627 rakwb eng Liu, Zhuang verfasserin aut High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract MR angiography (dpeaa)DE-He213 Contrast agent (dpeaa)DE-He213 Vascular imaging (dpeaa)DE-He213 Magnetic nanoparticles (dpeaa)DE-He213 Gd-chelate (dpeaa)DE-He213 Zhao, Menglong aut Wang, Han aut Fu, Zi aut Gao, Hongbo aut Peng, Weijun aut Ni, Dalong aut Tang, Wei aut Gu, Yajia aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 20(2022), 1 vom: 31. März (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:20 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12951-022-01363-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 31 03
allfieldsGer	10.1186/s12951-022-01363-3 doi (DE-627)SPR050606662 (SPR)s12951-022-01363-3-e DE-627 ger DE-627 rakwb eng Liu, Zhuang verfasserin aut High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract MR angiography (dpeaa)DE-He213 Contrast agent (dpeaa)DE-He213 Vascular imaging (dpeaa)DE-He213 Magnetic nanoparticles (dpeaa)DE-He213 Gd-chelate (dpeaa)DE-He213 Zhao, Menglong aut Wang, Han aut Fu, Zi aut Gao, Hongbo aut Peng, Weijun aut Ni, Dalong aut Tang, Wei aut Gu, Yajia aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 20(2022), 1 vom: 31. März (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:20 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12951-022-01363-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 31 03
allfieldsSound	10.1186/s12951-022-01363-3 doi (DE-627)SPR050606662 (SPR)s12951-022-01363-3-e DE-627 ger DE-627 rakwb eng Liu, Zhuang verfasserin aut High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract MR angiography (dpeaa)DE-He213 Contrast agent (dpeaa)DE-He213 Vascular imaging (dpeaa)DE-He213 Magnetic nanoparticles (dpeaa)DE-He213 Gd-chelate (dpeaa)DE-He213 Zhao, Menglong aut Wang, Han aut Fu, Zi aut Gao, Hongbo aut Peng, Weijun aut Ni, Dalong aut Tang, Wei aut Gu, Yajia aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 20(2022), 1 vom: 31. März (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:20 year:2022 number:1 day:31 month:03 https://dx.doi.org/10.1186/s12951-022-01363-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 31 03
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source	Enthalten in Journal of nanobiotechnology 20(2022), 1 vom: 31. März volume:20 year:2022 number:1 day:31 month:03
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topic_facet	MR angiography Contrast agent Vascular imaging Magnetic nanoparticles Gd-chelate
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authorswithroles_txt_mv	Liu, Zhuang @@aut@@ Zhao, Menglong @@aut@@ Wang, Han @@aut@@ Fu, Zi @@aut@@ Gao, Hongbo @@aut@@ Peng, Weijun @@aut@@ Ni, Dalong @@aut@@ Tang, Wei @@aut@@ Gu, Yajia @@aut@@
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author	Liu, Zhuang
spellingShingle	Liu, Zhuang misc MR angiography misc Contrast agent misc Vascular imaging misc Magnetic nanoparticles misc Gd-chelate High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography
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topic_title	High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography MR angiography (dpeaa)DE-He213 Contrast agent (dpeaa)DE-He213 Vascular imaging (dpeaa)DE-He213 Magnetic nanoparticles (dpeaa)DE-He213 Gd-chelate (dpeaa)DE-He213
topic	misc MR angiography misc Contrast agent misc Vascular imaging misc Magnetic nanoparticles misc Gd-chelate
topic_unstemmed	misc MR angiography misc Contrast agent misc Vascular imaging misc Magnetic nanoparticles misc Gd-chelate
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title	High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography
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title_full	High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography
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author_browse	Liu, Zhuang Zhao, Menglong Wang, Han Fu, Zi Gao, Hongbo Peng, Weijun Ni, Dalong Tang, Wei Gu, Yajia
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title_sort	high relaxivity $ gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography
title_auth	High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography
abstract	Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract © The Author(s) 2022
abstractGer	Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract © The Author(s) 2022
abstract_unstemmed	Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract © The Author(s) 2022
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title_short	High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography
url	https://dx.doi.org/10.1186/s12951-022-01363-3
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author2	Zhao, Menglong Wang, Han Fu, Zi Gao, Hongbo Peng, Weijun Ni, Dalong Tang, Wei Gu, Yajia
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up_date	2024-07-03T16:37:26.200Z
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Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T1-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for $ Gd^{3+} $ coordination to improve the relaxivity and avoid leakage of the $ Gd^{3+} $ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 $ mM^{− 1} $ $ s^{− 1} $ at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. 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High relaxivity $ Gd^{3+} $-based organic nanoparticles for efficient magnetic resonance angiography

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