Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model

Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Albertsson-Wikland, Kerstin [verfasserIn] Niklasson, Aimon Gelander, Lars Holmgren, Anton Nierop, Andreas F. M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Pubertal growth Personalized growth Biological age SDS Standard reference population

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: BMC pediatrics - London : BioMed Central, 2001, 22(2022), 1 vom: 30. Apr.
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:30 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s12887-022-03304-3

Katalog-ID:	SPR050679287

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520			\|a Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth.
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allfields	10.1186/s12887-022-03304-3 doi (DE-627)SPR050679287 (SPR)s12887-022-03304-3-e DE-627 ger DE-627 rakwb eng Albertsson-Wikland, Kerstin verfasserin (orcid)0000-0003-3167-0667 aut Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. Pubertal growth (dpeaa)DE-He213 Personalized growth (dpeaa)DE-He213 Biological age (dpeaa)DE-He213 SDS (dpeaa)DE-He213 Standard reference population (dpeaa)DE-He213 Niklasson, Aimon (orcid)0000-0001-5839-4207 aut Gelander, Lars (orcid)0000-0003-1728-4014 aut Holmgren, Anton (orcid)0000-0003-0940-8726 aut Nierop, Andreas F. M. (orcid)0000-0002-6709-4836 aut Enthalten in BMC pediatrics London : BioMed Central, 2001 22(2022), 1 vom: 30. Apr. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:22 year:2022 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12887-022-03304-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 30 04
spelling	10.1186/s12887-022-03304-3 doi (DE-627)SPR050679287 (SPR)s12887-022-03304-3-e DE-627 ger DE-627 rakwb eng Albertsson-Wikland, Kerstin verfasserin (orcid)0000-0003-3167-0667 aut Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. Pubertal growth (dpeaa)DE-He213 Personalized growth (dpeaa)DE-He213 Biological age (dpeaa)DE-He213 SDS (dpeaa)DE-He213 Standard reference population (dpeaa)DE-He213 Niklasson, Aimon (orcid)0000-0001-5839-4207 aut Gelander, Lars (orcid)0000-0003-1728-4014 aut Holmgren, Anton (orcid)0000-0003-0940-8726 aut Nierop, Andreas F. M. (orcid)0000-0002-6709-4836 aut Enthalten in BMC pediatrics London : BioMed Central, 2001 22(2022), 1 vom: 30. Apr. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:22 year:2022 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12887-022-03304-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 30 04
allfields_unstemmed	10.1186/s12887-022-03304-3 doi (DE-627)SPR050679287 (SPR)s12887-022-03304-3-e DE-627 ger DE-627 rakwb eng Albertsson-Wikland, Kerstin verfasserin (orcid)0000-0003-3167-0667 aut Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. Pubertal growth (dpeaa)DE-He213 Personalized growth (dpeaa)DE-He213 Biological age (dpeaa)DE-He213 SDS (dpeaa)DE-He213 Standard reference population (dpeaa)DE-He213 Niklasson, Aimon (orcid)0000-0001-5839-4207 aut Gelander, Lars (orcid)0000-0003-1728-4014 aut Holmgren, Anton (orcid)0000-0003-0940-8726 aut Nierop, Andreas F. M. (orcid)0000-0002-6709-4836 aut Enthalten in BMC pediatrics London : BioMed Central, 2001 22(2022), 1 vom: 30. Apr. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:22 year:2022 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12887-022-03304-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 30 04
allfieldsGer	10.1186/s12887-022-03304-3 doi (DE-627)SPR050679287 (SPR)s12887-022-03304-3-e DE-627 ger DE-627 rakwb eng Albertsson-Wikland, Kerstin verfasserin (orcid)0000-0003-3167-0667 aut Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. Pubertal growth (dpeaa)DE-He213 Personalized growth (dpeaa)DE-He213 Biological age (dpeaa)DE-He213 SDS (dpeaa)DE-He213 Standard reference population (dpeaa)DE-He213 Niklasson, Aimon (orcid)0000-0001-5839-4207 aut Gelander, Lars (orcid)0000-0003-1728-4014 aut Holmgren, Anton (orcid)0000-0003-0940-8726 aut Nierop, Andreas F. M. (orcid)0000-0002-6709-4836 aut Enthalten in BMC pediatrics London : BioMed Central, 2001 22(2022), 1 vom: 30. Apr. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:22 year:2022 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12887-022-03304-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 30 04
allfieldsSound	10.1186/s12887-022-03304-3 doi (DE-627)SPR050679287 (SPR)s12887-022-03304-3-e DE-627 ger DE-627 rakwb eng Albertsson-Wikland, Kerstin verfasserin (orcid)0000-0003-3167-0667 aut Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. Pubertal growth (dpeaa)DE-He213 Personalized growth (dpeaa)DE-He213 Biological age (dpeaa)DE-He213 SDS (dpeaa)DE-He213 Standard reference population (dpeaa)DE-He213 Niklasson, Aimon (orcid)0000-0001-5839-4207 aut Gelander, Lars (orcid)0000-0003-1728-4014 aut Holmgren, Anton (orcid)0000-0003-0940-8726 aut Nierop, Andreas F. M. (orcid)0000-0002-6709-4836 aut Enthalten in BMC pediatrics London : BioMed Central, 2001 22(2022), 1 vom: 30. Apr. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:22 year:2022 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12887-022-03304-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 30 04
language	English
source	Enthalten in BMC pediatrics 22(2022), 1 vom: 30. Apr. volume:22 year:2022 number:1 day:30 month:04
sourceStr	Enthalten in BMC pediatrics 22(2022), 1 vom: 30. Apr. volume:22 year:2022 number:1 day:30 month:04
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pubertal growth Personalized growth Biological age SDS Standard reference population
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container_title	BMC pediatrics
authorswithroles_txt_mv	Albertsson-Wikland, Kerstin @@aut@@ Niklasson, Aimon @@aut@@ Gelander, Lars @@aut@@ Holmgren, Anton @@aut@@ Nierop, Andreas F. M. @@aut@@
publishDateDaySort_date	2022-04-30T00:00:00Z
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Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. 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author	Albertsson-Wikland, Kerstin
spellingShingle	Albertsson-Wikland, Kerstin misc Pubertal growth misc Personalized growth misc Biological age misc SDS misc Standard reference population Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model
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topic_title	Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model Pubertal growth (dpeaa)DE-He213 Personalized growth (dpeaa)DE-He213 Biological age (dpeaa)DE-He213 SDS (dpeaa)DE-He213 Standard reference population (dpeaa)DE-He213
topic	misc Pubertal growth misc Personalized growth misc Biological age misc SDS misc Standard reference population
topic_unstemmed	misc Pubertal growth misc Personalized growth misc Biological age misc SDS misc Standard reference population
topic_browse	misc Pubertal growth misc Personalized growth misc Biological age misc SDS misc Standard reference population
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title	Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model
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title_full	Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model
author_sort	Albertsson-Wikland, Kerstin
journal	BMC pediatrics
journalStr	BMC pediatrics
lang_code	eng
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publishDateSort	2022
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author_browse	Albertsson-Wikland, Kerstin Niklasson, Aimon Gelander, Lars Holmgren, Anton Nierop, Andreas F. M.
container_volume	22
format_se	Elektronische Aufsätze
author-letter	Albertsson-Wikland, Kerstin
doi_str_mv	10.1186/s12887-022-03304-3
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normlink_prefix_str_mv	(orcid)0000-0003-3167-0667 (orcid)0000-0001-5839-4207 (orcid)0000-0003-1728-4014 (orcid)0000-0003-0940-8726 (orcid)0000-0002-6709-4836
title_sort	novel type of references for bmi aligned for onset of puberty – using the qeps growth model
title_auth	Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model
abstract	Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. © The Author(s) 2022
abstractGer	Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. © The Author(s) 2022
abstract_unstemmed	Objectives Despite inter-individual variations in pubertal timing, growth references are conventionally constructed relative to chronological age (C-age). Thus, they are based on reference populations containing a mix of prepubertal and pubertal individuals, making them of limited use for detecting abnormal growth during adolescence. Recently we developed new types of height and weight references, with growth aligned to age at onset of the pubertal growth spurt (P-age). Here, we aim to develop a corresponding reference for pubertal BMI. Methods The QEPS-height and weight models were used to define a corresponding QEPS-BMI model. QEPS-BMI was modified by the same individual, constitutional weight–height-factor (WHF) as computed for QEPS-weight. QEPS-BMI functions were computed with QEPS weight and height functions fitted on longitudinal measurements from 1418 individuals (698 girls) from $ GrowUp_{1990} $Gothenburg cohort. These individual BMI functions were used to develop BMI references aligned for height at AgeP5; when 5% of specific puberty-related (P-function) height had been attained. Pubertal timing, stature at pubertal onset, and childhood BMI, were investigated in subgroups of children from the cohort $ GrowUp_{1974} $Gothenburg using the new references. Results References (median, standard deviation score (SDS)) were generated for total BMI (QEPS-functions), for ongoing prepubertal growth (QE-function) vs C-age, and for total BMI and separated into BMI specific to puberty (P-function) and BMI gain from ongoing basic growth (QES-functions), allowing individual growth to be aligned based on P-age. Growth in basic BMI was greater than average for children categorized as tall and/or with high-BMI at puberty-start. In children categorized as short at puberty-start, P-function-related-BMI was greater than average. Conclusions Use of these new pubertal BMI references will make it possible for the first time to consider individual variations owing to pubertal timing when evaluating BMI. This will improve the detection of abnormal changes in body composition when used in combination with pubertal height and weight references also abnormal growth. Other benefits in the clinic will include improved growth monitoring during treatment for children who are overweight/obese or underweight. Furthermore, in research settings these new references represent a novel tool for exploring human growth. © The Author(s) 2022
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title_short	Novel type of references for BMI aligned for onset of puberty – using the QEPS growth model
url	https://dx.doi.org/10.1186/s12887-022-03304-3
remote_bool	true
author2	Niklasson, Aimon Gelander, Lars Holmgren, Anton Nierop, Andreas F. M.
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doi_str	10.1186/s12887-022-03304-3
up_date	2024-07-03T17:04:57.150Z
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