Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients
Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs...
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| Autor*in: |
Song, Shiyao [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Chemical Research in Chinese Universities - Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012, 38(2022), 3 vom: 26. Apr., Seite 809-815 |
|---|---|
| Übergeordnetes Werk: |
volume:38 ; year:2022 ; number:3 ; day:26 ; month:04 ; pages:809-815 |
| Links: |
|---|
| DOI / URN: |
10.1007/s40242-022-2035-8 |
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SPR050742981 |
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| 520 | |a Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. | ||
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10.1007/s40242-022-2035-8 doi (DE-627)SPR050742981 (SPR)s40242-022-2035-8-e DE-627 ger DE-627 rakwb eng Song, Shiyao verfasserin aut Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. Migraine (dpeaa)DE-He213 Bile acid (dpeaa)DE-He213 Metabolomics (dpeaa)DE-He213 Liquid chromatography-tandem mass spectrometry(LC-MS/MS) (dpeaa)DE-He213 Gender-stratified analysis (dpeaa)DE-He213 Tang, Wenjing aut Yu, Shengyuan aut Liu, Huwei aut Bai, Yu aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 3 vom: 26. Apr., Seite 809-815 (DE-627)SPR03290777X nnns volume:38 year:2022 number:3 day:26 month:04 pages:809-815 https://dx.doi.org/10.1007/s40242-022-2035-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 3 26 04 809-815 |
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10.1007/s40242-022-2035-8 doi (DE-627)SPR050742981 (SPR)s40242-022-2035-8-e DE-627 ger DE-627 rakwb eng Song, Shiyao verfasserin aut Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. Migraine (dpeaa)DE-He213 Bile acid (dpeaa)DE-He213 Metabolomics (dpeaa)DE-He213 Liquid chromatography-tandem mass spectrometry(LC-MS/MS) (dpeaa)DE-He213 Gender-stratified analysis (dpeaa)DE-He213 Tang, Wenjing aut Yu, Shengyuan aut Liu, Huwei aut Bai, Yu aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 3 vom: 26. Apr., Seite 809-815 (DE-627)SPR03290777X nnns volume:38 year:2022 number:3 day:26 month:04 pages:809-815 https://dx.doi.org/10.1007/s40242-022-2035-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 3 26 04 809-815 |
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10.1007/s40242-022-2035-8 doi (DE-627)SPR050742981 (SPR)s40242-022-2035-8-e DE-627 ger DE-627 rakwb eng Song, Shiyao verfasserin aut Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. Migraine (dpeaa)DE-He213 Bile acid (dpeaa)DE-He213 Metabolomics (dpeaa)DE-He213 Liquid chromatography-tandem mass spectrometry(LC-MS/MS) (dpeaa)DE-He213 Gender-stratified analysis (dpeaa)DE-He213 Tang, Wenjing aut Yu, Shengyuan aut Liu, Huwei aut Bai, Yu aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 3 vom: 26. Apr., Seite 809-815 (DE-627)SPR03290777X nnns volume:38 year:2022 number:3 day:26 month:04 pages:809-815 https://dx.doi.org/10.1007/s40242-022-2035-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 3 26 04 809-815 |
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10.1007/s40242-022-2035-8 doi (DE-627)SPR050742981 (SPR)s40242-022-2035-8-e DE-627 ger DE-627 rakwb eng Song, Shiyao verfasserin aut Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. Migraine (dpeaa)DE-He213 Bile acid (dpeaa)DE-He213 Metabolomics (dpeaa)DE-He213 Liquid chromatography-tandem mass spectrometry(LC-MS/MS) (dpeaa)DE-He213 Gender-stratified analysis (dpeaa)DE-He213 Tang, Wenjing aut Yu, Shengyuan aut Liu, Huwei aut Bai, Yu aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 3 vom: 26. Apr., Seite 809-815 (DE-627)SPR03290777X nnns volume:38 year:2022 number:3 day:26 month:04 pages:809-815 https://dx.doi.org/10.1007/s40242-022-2035-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 3 26 04 809-815 |
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10.1007/s40242-022-2035-8 doi (DE-627)SPR050742981 (SPR)s40242-022-2035-8-e DE-627 ger DE-627 rakwb eng Song, Shiyao verfasserin aut Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. Migraine (dpeaa)DE-He213 Bile acid (dpeaa)DE-He213 Metabolomics (dpeaa)DE-He213 Liquid chromatography-tandem mass spectrometry(LC-MS/MS) (dpeaa)DE-He213 Gender-stratified analysis (dpeaa)DE-He213 Tang, Wenjing aut Yu, Shengyuan aut Liu, Huwei aut Bai, Yu aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 3 vom: 26. Apr., Seite 809-815 (DE-627)SPR03290777X nnns volume:38 year:2022 number:3 day:26 month:04 pages:809-815 https://dx.doi.org/10.1007/s40242-022-2035-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 3 26 04 809-815 |
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Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients |
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Song, Shiyao |
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Chemical Research in Chinese Universities |
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Chemical Research in Chinese Universities |
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eng |
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2022 |
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Song, Shiyao Tang, Wenjing Yu, Shengyuan Liu, Huwei Bai, Yu |
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38 |
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Elektronische Aufsätze |
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Song, Shiyao |
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10.1007/s40242-022-2035-8 |
| title_sort |
targeted metabolomics based on lc-ms/ms revealing alteration of bile acids in male migraine patients |
| title_auth |
Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients |
| abstract |
Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 |
| abstractGer |
Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 |
| abstract_unstemmed |
Abstract Migraine is an episodic neurological disorder and the second most disabling disease with unclear pathogenesis. Since dietary adjustment and probiotics supplement can improve the symptoms of migraine, the intestinal flora metabolites of bile acids(BAs) attract attentions in this work. 21 BAs, including cholic acid(CA), chenodeoxycholic acid(CDCA), deoxycholic acid (DCA), lithocholic acid(LCA), ursodeoxycholic acid(UDCA), hyocholic acid(HCA), hyodeoxycholic acid(HDCA) and their glycine- and taurine-conjugated species, were compared in serum of migraine patients and healthy controls using liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is the first study about the correlation between BAs and migraine. Two secondary BAs, DCA and LCA as well as their glycine- and taurine-conjugated forms, were demonstrated with significant difference between male patients and male controls, while no obvious difference was found in the two female groups. The result indicated that the variation of BAs might be gender-related when referred to migraine, which would emphasize the importance of gender-stratified analysis for the disease with varying morbidity in male and female. Five differential metabolites may serve as potential serum biomarkers for the male migraine patients, providing a new sight for the understanding and biomarker exploring of the migraine in male. © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022 |
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| title_short |
Targeted Metabolomics Based on LC-MS/MS Revealing Alteration of Bile Acids in Male Migraine Patients |
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https://dx.doi.org/10.1007/s40242-022-2035-8 |
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Tang, Wenjing Yu, Shengyuan Liu, Huwei Bai, Yu |
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