Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity

Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to m...
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Autor*in:	Maeda, Yuichi [verfasserIn] Motooka, Daisuke Kawasaki, Takahiro Oki, Hiroya Noda, Yoshimi Adachi, Yuichi Niitsu, Takayuki Okamoto, Shota Tanaka, Kentaro Fukushima, Kiyoharu Amiya, Saori Hara, Reina Oguro-Igashira, Eri Matsuki, Takanori Hirata, Haruhiko Takeda, Yoshito Kida, Hiroshi Kumanogoh, Atsushi Nakamura, Shota Takeda, Kiyoshi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	COVID-19 Mycobiota Microbiota Gut

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 22(2022), 1 vom: 24. Juni
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:24 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12879-022-07358-7

Katalog-ID:	SPR050808028

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520			\|a Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery.
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700	1		\|a Takeda, Kiyoshi \|4 aut
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allfields	10.1186/s12879-022-07358-7 doi (DE-627)SPR050808028 (SPR)s12879-022-07358-7-e DE-627 ger DE-627 rakwb eng Maeda, Yuichi verfasserin aut Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. COVID-19 (dpeaa)DE-He213 Mycobiota (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Gut (dpeaa)DE-He213 Motooka, Daisuke aut Kawasaki, Takahiro aut Oki, Hiroya aut Noda, Yoshimi aut Adachi, Yuichi aut Niitsu, Takayuki aut Okamoto, Shota aut Tanaka, Kentaro aut Fukushima, Kiyoharu aut Amiya, Saori aut Hara, Reina aut Oguro-Igashira, Eri aut Matsuki, Takanori aut Hirata, Haruhiko aut Takeda, Yoshito aut Kida, Hiroshi aut Kumanogoh, Atsushi aut Nakamura, Shota aut Takeda, Kiyoshi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 22(2022), 1 vom: 24. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:22 year:2022 number:1 day:24 month:06 https://dx.doi.org/10.1186/s12879-022-07358-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 24 06
spelling	10.1186/s12879-022-07358-7 doi (DE-627)SPR050808028 (SPR)s12879-022-07358-7-e DE-627 ger DE-627 rakwb eng Maeda, Yuichi verfasserin aut Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. COVID-19 (dpeaa)DE-He213 Mycobiota (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Gut (dpeaa)DE-He213 Motooka, Daisuke aut Kawasaki, Takahiro aut Oki, Hiroya aut Noda, Yoshimi aut Adachi, Yuichi aut Niitsu, Takayuki aut Okamoto, Shota aut Tanaka, Kentaro aut Fukushima, Kiyoharu aut Amiya, Saori aut Hara, Reina aut Oguro-Igashira, Eri aut Matsuki, Takanori aut Hirata, Haruhiko aut Takeda, Yoshito aut Kida, Hiroshi aut Kumanogoh, Atsushi aut Nakamura, Shota aut Takeda, Kiyoshi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 22(2022), 1 vom: 24. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:22 year:2022 number:1 day:24 month:06 https://dx.doi.org/10.1186/s12879-022-07358-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 24 06
allfields_unstemmed	10.1186/s12879-022-07358-7 doi (DE-627)SPR050808028 (SPR)s12879-022-07358-7-e DE-627 ger DE-627 rakwb eng Maeda, Yuichi verfasserin aut Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. COVID-19 (dpeaa)DE-He213 Mycobiota (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Gut (dpeaa)DE-He213 Motooka, Daisuke aut Kawasaki, Takahiro aut Oki, Hiroya aut Noda, Yoshimi aut Adachi, Yuichi aut Niitsu, Takayuki aut Okamoto, Shota aut Tanaka, Kentaro aut Fukushima, Kiyoharu aut Amiya, Saori aut Hara, Reina aut Oguro-Igashira, Eri aut Matsuki, Takanori aut Hirata, Haruhiko aut Takeda, Yoshito aut Kida, Hiroshi aut Kumanogoh, Atsushi aut Nakamura, Shota aut Takeda, Kiyoshi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 22(2022), 1 vom: 24. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:22 year:2022 number:1 day:24 month:06 https://dx.doi.org/10.1186/s12879-022-07358-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 24 06
allfieldsGer	10.1186/s12879-022-07358-7 doi (DE-627)SPR050808028 (SPR)s12879-022-07358-7-e DE-627 ger DE-627 rakwb eng Maeda, Yuichi verfasserin aut Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. COVID-19 (dpeaa)DE-He213 Mycobiota (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Gut (dpeaa)DE-He213 Motooka, Daisuke aut Kawasaki, Takahiro aut Oki, Hiroya aut Noda, Yoshimi aut Adachi, Yuichi aut Niitsu, Takayuki aut Okamoto, Shota aut Tanaka, Kentaro aut Fukushima, Kiyoharu aut Amiya, Saori aut Hara, Reina aut Oguro-Igashira, Eri aut Matsuki, Takanori aut Hirata, Haruhiko aut Takeda, Yoshito aut Kida, Hiroshi aut Kumanogoh, Atsushi aut Nakamura, Shota aut Takeda, Kiyoshi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 22(2022), 1 vom: 24. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:22 year:2022 number:1 day:24 month:06 https://dx.doi.org/10.1186/s12879-022-07358-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 24 06
allfieldsSound	10.1186/s12879-022-07358-7 doi (DE-627)SPR050808028 (SPR)s12879-022-07358-7-e DE-627 ger DE-627 rakwb eng Maeda, Yuichi verfasserin aut Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. COVID-19 (dpeaa)DE-He213 Mycobiota (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Gut (dpeaa)DE-He213 Motooka, Daisuke aut Kawasaki, Takahiro aut Oki, Hiroya aut Noda, Yoshimi aut Adachi, Yuichi aut Niitsu, Takayuki aut Okamoto, Shota aut Tanaka, Kentaro aut Fukushima, Kiyoharu aut Amiya, Saori aut Hara, Reina aut Oguro-Igashira, Eri aut Matsuki, Takanori aut Hirata, Haruhiko aut Takeda, Yoshito aut Kida, Hiroshi aut Kumanogoh, Atsushi aut Nakamura, Shota aut Takeda, Kiyoshi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 22(2022), 1 vom: 24. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:22 year:2022 number:1 day:24 month:06 https://dx.doi.org/10.1186/s12879-022-07358-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 24 06
language	English
source	Enthalten in BMC infectious diseases 22(2022), 1 vom: 24. Juni volume:22 year:2022 number:1 day:24 month:06
sourceStr	Enthalten in BMC infectious diseases 22(2022), 1 vom: 24. Juni volume:22 year:2022 number:1 day:24 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	COVID-19 Mycobiota Microbiota Gut
isfreeaccess_bool	true
container_title	BMC infectious diseases
authorswithroles_txt_mv	Maeda, Yuichi @@aut@@ Motooka, Daisuke @@aut@@ Kawasaki, Takahiro @@aut@@ Oki, Hiroya @@aut@@ Noda, Yoshimi @@aut@@ Adachi, Yuichi @@aut@@ Niitsu, Takayuki @@aut@@ Okamoto, Shota @@aut@@ Tanaka, Kentaro @@aut@@ Fukushima, Kiyoharu @@aut@@ Amiya, Saori @@aut@@ Hara, Reina @@aut@@ Oguro-Igashira, Eri @@aut@@ Matsuki, Takanori @@aut@@ Hirata, Haruhiko @@aut@@ Takeda, Yoshito @@aut@@ Kida, Hiroshi @@aut@@ Kumanogoh, Atsushi @@aut@@ Nakamura, Shota @@aut@@ Takeda, Kiyoshi @@aut@@
publishDateDaySort_date	2022-06-24T00:00:00Z
hierarchy_top_id	326645381
id	SPR050808028
language_de	englisch
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This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. 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author	Maeda, Yuichi
spellingShingle	Maeda, Yuichi misc COVID-19 misc Mycobiota misc Microbiota misc Gut Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity
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topic_title	Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity COVID-19 (dpeaa)DE-He213 Mycobiota (dpeaa)DE-He213 Microbiota (dpeaa)DE-He213 Gut (dpeaa)DE-He213
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title	Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity
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title_full	Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity
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author_browse	Maeda, Yuichi Motooka, Daisuke Kawasaki, Takahiro Oki, Hiroya Noda, Yoshimi Adachi, Yuichi Niitsu, Takayuki Okamoto, Shota Tanaka, Kentaro Fukushima, Kiyoharu Amiya, Saori Hara, Reina Oguro-Igashira, Eri Matsuki, Takanori Hirata, Haruhiko Takeda, Yoshito Kida, Hiroshi Kumanogoh, Atsushi Nakamura, Shota Takeda, Kiyoshi
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title_sort	longitudinal alterations of the gut mycobiota and microbiota on covid-19 severity
title_auth	Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity
abstract	Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. © The Author(s) 2022
abstractGer	Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. © The Author(s) 2022
abstract_unstemmed	Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery. © The Author(s) 2022
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title_short	Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity
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author2	Motooka, Daisuke Kawasaki, Takahiro Oki, Hiroya Noda, Yoshimi Adachi, Yuichi Niitsu, Takayuki Okamoto, Shota Tanaka, Kentaro Fukushima, Kiyoharu Amiya, Saori Hara, Reina Oguro-Igashira, Eri Matsuki, Takanori Hirata, Haruhiko Takeda, Yoshito Kida, Hiroshi Kumanogoh, Atsushi Nakamura, Shota Takeda, Kiyoshi
author2Str	Motooka, Daisuke Kawasaki, Takahiro Oki, Hiroya Noda, Yoshimi Adachi, Yuichi Niitsu, Takayuki Okamoto, Shota Tanaka, Kentaro Fukushima, Kiyoharu Amiya, Saori Hara, Reina Oguro-Igashira, Eri Matsuki, Takanori Hirata, Haruhiko Takeda, Yoshito Kida, Hiroshi Kumanogoh, Atsushi Nakamura, Shota Takeda, Kiyoshi
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Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity

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