Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients

Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chen, Yao [verfasserIn] Zhao, Xue Ke Xu, Rui Hua Song, Xin Yang, Miao Miao Zhou, Fu You Lei, Ling Ling Fan, Zong Min Han, Xue Na Gao, She Gan Wang, Xian Zeng Liu, Zhi Cai Li Li, Ai Gao, Wen Jun Hu, Jing Feng Zhang, Li Guo Wei, Jin Chang Jiao, Fu Lin Zhong, Kan Wang, Wei Peng Li, Liu Yu Ji, Jia Jia Li, Xue Min Wang, Li Dong

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Surgical approach Survival Clinicopathology Gastric cardia adenocarcinoma (GCA)

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: World journal of surgical oncology - London : Biomed Central, 2003, 20(2022), 1 vom: 28. Juni
Übergeordnetes Werk:	volume:20 ; year:2022 ; number:1 ; day:28 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12957-022-02680-5

Katalog-ID:	SPR050818112

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allfields	10.1186/s12957-022-02680-5 doi (DE-627)SPR050818112 (SPR)s12957-022-02680-5-e DE-627 ger DE-627 rakwb eng Chen, Yao verfasserin aut Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. Surgical approach (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Gastric cardia adenocarcinoma (GCA) (dpeaa)DE-He213 Zhao, Xue Ke aut Xu, Rui Hua aut Song, Xin aut Yang, Miao Miao aut Zhou, Fu You aut Lei, Ling Ling aut Fan, Zong Min aut Han, Xue Na aut Gao, She Gan aut Wang, Xian Zeng aut Liu, Zhi Cai aut Li Li, Ai aut Gao, Wen Jun aut Hu, Jing Feng aut Zhang, Li Guo aut Wei, Jin Chang aut Jiao, Fu Lin aut Zhong, Kan aut Wang, Wei Peng aut Li, Liu Yu aut Ji, Jia Jia aut Li, Xue Min aut Wang, Li Dong aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 20(2022), 1 vom: 28. Juni (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:20 year:2022 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12957-022-02680-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 28 06
spelling	10.1186/s12957-022-02680-5 doi (DE-627)SPR050818112 (SPR)s12957-022-02680-5-e DE-627 ger DE-627 rakwb eng Chen, Yao verfasserin aut Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. Surgical approach (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Gastric cardia adenocarcinoma (GCA) (dpeaa)DE-He213 Zhao, Xue Ke aut Xu, Rui Hua aut Song, Xin aut Yang, Miao Miao aut Zhou, Fu You aut Lei, Ling Ling aut Fan, Zong Min aut Han, Xue Na aut Gao, She Gan aut Wang, Xian Zeng aut Liu, Zhi Cai aut Li Li, Ai aut Gao, Wen Jun aut Hu, Jing Feng aut Zhang, Li Guo aut Wei, Jin Chang aut Jiao, Fu Lin aut Zhong, Kan aut Wang, Wei Peng aut Li, Liu Yu aut Ji, Jia Jia aut Li, Xue Min aut Wang, Li Dong aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 20(2022), 1 vom: 28. Juni (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:20 year:2022 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12957-022-02680-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 28 06
allfields_unstemmed	10.1186/s12957-022-02680-5 doi (DE-627)SPR050818112 (SPR)s12957-022-02680-5-e DE-627 ger DE-627 rakwb eng Chen, Yao verfasserin aut Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. Surgical approach (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Gastric cardia adenocarcinoma (GCA) (dpeaa)DE-He213 Zhao, Xue Ke aut Xu, Rui Hua aut Song, Xin aut Yang, Miao Miao aut Zhou, Fu You aut Lei, Ling Ling aut Fan, Zong Min aut Han, Xue Na aut Gao, She Gan aut Wang, Xian Zeng aut Liu, Zhi Cai aut Li Li, Ai aut Gao, Wen Jun aut Hu, Jing Feng aut Zhang, Li Guo aut Wei, Jin Chang aut Jiao, Fu Lin aut Zhong, Kan aut Wang, Wei Peng aut Li, Liu Yu aut Ji, Jia Jia aut Li, Xue Min aut Wang, Li Dong aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 20(2022), 1 vom: 28. Juni (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:20 year:2022 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12957-022-02680-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 28 06
allfieldsGer	10.1186/s12957-022-02680-5 doi (DE-627)SPR050818112 (SPR)s12957-022-02680-5-e DE-627 ger DE-627 rakwb eng Chen, Yao verfasserin aut Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. Surgical approach (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Gastric cardia adenocarcinoma (GCA) (dpeaa)DE-He213 Zhao, Xue Ke aut Xu, Rui Hua aut Song, Xin aut Yang, Miao Miao aut Zhou, Fu You aut Lei, Ling Ling aut Fan, Zong Min aut Han, Xue Na aut Gao, She Gan aut Wang, Xian Zeng aut Liu, Zhi Cai aut Li Li, Ai aut Gao, Wen Jun aut Hu, Jing Feng aut Zhang, Li Guo aut Wei, Jin Chang aut Jiao, Fu Lin aut Zhong, Kan aut Wang, Wei Peng aut Li, Liu Yu aut Ji, Jia Jia aut Li, Xue Min aut Wang, Li Dong aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 20(2022), 1 vom: 28. Juni (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:20 year:2022 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12957-022-02680-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 28 06
allfieldsSound	10.1186/s12957-022-02680-5 doi (DE-627)SPR050818112 (SPR)s12957-022-02680-5-e DE-627 ger DE-627 rakwb eng Chen, Yao verfasserin aut Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. Surgical approach (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Gastric cardia adenocarcinoma (GCA) (dpeaa)DE-He213 Zhao, Xue Ke aut Xu, Rui Hua aut Song, Xin aut Yang, Miao Miao aut Zhou, Fu You aut Lei, Ling Ling aut Fan, Zong Min aut Han, Xue Na aut Gao, She Gan aut Wang, Xian Zeng aut Liu, Zhi Cai aut Li Li, Ai aut Gao, Wen Jun aut Hu, Jing Feng aut Zhang, Li Guo aut Wei, Jin Chang aut Jiao, Fu Lin aut Zhong, Kan aut Wang, Wei Peng aut Li, Liu Yu aut Ji, Jia Jia aut Li, Xue Min aut Wang, Li Dong aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 20(2022), 1 vom: 28. Juni (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:20 year:2022 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12957-022-02680-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 28 06
language	English
source	Enthalten in World journal of surgical oncology 20(2022), 1 vom: 28. Juni volume:20 year:2022 number:1 day:28 month:06
sourceStr	Enthalten in World journal of surgical oncology 20(2022), 1 vom: 28. Juni volume:20 year:2022 number:1 day:28 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Surgical approach Survival Clinicopathology Gastric cardia adenocarcinoma (GCA)
isfreeaccess_bool	true
container_title	World journal of surgical oncology
authorswithroles_txt_mv	Chen, Yao @@aut@@ Zhao, Xue Ke @@aut@@ Xu, Rui Hua @@aut@@ Song, Xin @@aut@@ Yang, Miao Miao @@aut@@ Zhou, Fu You @@aut@@ Lei, Ling Ling @@aut@@ Fan, Zong Min @@aut@@ Han, Xue Na @@aut@@ Gao, She Gan @@aut@@ Wang, Xian Zeng @@aut@@ Liu, Zhi Cai @@aut@@ Li Li, Ai @@aut@@ Gao, Wen Jun @@aut@@ Hu, Jing Feng @@aut@@ Zhang, Li Guo @@aut@@ Wei, Jin Chang @@aut@@ Jiao, Fu Lin @@aut@@ Zhong, Kan @@aut@@ Wang, Wei Peng @@aut@@ Li, Liu Yu @@aut@@ Ji, Jia Jia @@aut@@ Li, Xue Min @@aut@@ Wang, Li Dong @@aut@@
publishDateDaySort_date	2022-06-28T00:00:00Z
hierarchy_top_id	369082907
id	SPR050818112
language_de	englisch
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Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. 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author	Chen, Yao
spellingShingle	Chen, Yao misc Surgical approach misc Survival misc Clinicopathology misc Gastric cardia adenocarcinoma (GCA) Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients
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topic_title	Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients Surgical approach (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Gastric cardia adenocarcinoma (GCA) (dpeaa)DE-He213
topic	misc Surgical approach misc Survival misc Clinicopathology misc Gastric cardia adenocarcinoma (GCA)
topic_unstemmed	misc Surgical approach misc Survival misc Clinicopathology misc Gastric cardia adenocarcinoma (GCA)
topic_browse	misc Surgical approach misc Survival misc Clinicopathology misc Gastric cardia adenocarcinoma (GCA)
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title	Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients
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title_full	Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients
author_sort	Chen, Yao
journal	World journal of surgical oncology
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author_browse	Chen, Yao Zhao, Xue Ke Xu, Rui Hua Song, Xin Yang, Miao Miao Zhou, Fu You Lei, Ling Ling Fan, Zong Min Han, Xue Na Gao, She Gan Wang, Xian Zeng Liu, Zhi Cai Li Li, Ai Gao, Wen Jun Hu, Jing Feng Zhang, Li Guo Wei, Jin Chang Jiao, Fu Lin Zhong, Kan Wang, Wei Peng Li, Liu Yu Ji, Jia Jia Li, Xue Min Wang, Li Dong
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doi_str_mv	10.1186/s12957-022-02680-5
title_sort	transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients
title_auth	Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients
abstract	Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. © The Author(s) 2022
abstractGer	Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. © The Author(s) 2022
abstract_unstemmed	Background This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA. Methods A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. The main criteria for the enrolled patients included treatment with radical surgery, no radio- or chemotherapy before the operation, and detailed clinicopathological information. Follow-up was mainly performed by telephone or through home interviews. According to the medical records, the surgical approaches included transthoracic, thoracoabdominal, and transabdominal approaches. Kaplan–Meier and Cox proportional hazards regression models were applied to correlate the surgical approach with survival in patients with GCA. Results There were marked differences in age and tumor stage among the patients who underwent the three surgical approaches (P < 0.001). Univariate analysis showed that survival was related to sex, age, tumor stage, and N stage (P < 0.001 for all). Cox regression model analysis revealed that thoracoabdominal approach (P < 0.001) and transabdominal approach (P < 0.001) were significant risk factors for poor survival. GCA patients treated with the transthoracic approach had the best survival (5-year survival rate of 53.7%), and survival varied among the different surgical approaches for different tumor stages. Conclusion Thoracoabdominal approach and transabdominal approach were shown to be poor prognostic factors. Patients with (locally advanced) GCA may benefit from the transthoracic approach. Further prospective randomized clinical trials are necessary. © The Author(s) 2022
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title_short	Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients
url	https://dx.doi.org/10.1186/s12957-022-02680-5
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author2	Zhao, Xue Ke Xu, Rui Hua Song, Xin Yang, Miao Miao Zhou, Fu You Lei, Ling Ling Fan, Zong Min Han, Xue Na Gao, She Gan Wang, Xian Zeng Liu, Zhi Cai Li Li, Ai Gao, Wen Jun Hu, Jing Feng Zhang, Li Guo Wei, Jin Chang Jiao, Fu Lin Zhong, Kan Wang, Wei Peng Li, Liu Yu Ji, Jia Jia Li, Xue Min Wang, Li Dong
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