Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of slee...
Ausführliche Beschreibung
Autor*in: |
Sammallahti, Sara [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2022 |
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Übergeordnetes Werk: |
Enthalten in: Clinical epigenetics - [S.l.] : BioMed Central, 2010, 14(2022), 1 vom: 05. Juli |
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Übergeordnetes Werk: |
volume:14 ; year:2022 ; number:1 ; day:05 ; month:07 |
Links: |
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DOI / URN: |
10.1186/s13148-022-01298-4 |
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Katalog-ID: |
SPR05083102X |
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245 | 1 | 0 | |a Longitudinal associations of DNA methylation and sleep in children: a meta-analysis |
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520 | |a Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. | ||
650 | 4 | |a Sleep |7 (dpeaa)DE-He213 | |
650 | 4 | |a Methylation |7 (dpeaa)DE-He213 | |
650 | 4 | |a Epigenomics |7 (dpeaa)DE-He213 | |
650 | 4 | |a Actigraphy |7 (dpeaa)DE-He213 | |
650 | 4 | |a Child |7 (dpeaa)DE-He213 | |
650 | 4 | |a Meta-analysis |7 (dpeaa)DE-He213 | |
650 | 4 | |a Longitudinal studies |7 (dpeaa)DE-He213 | |
700 | 1 | |a Koopman-Verhoeff, M. Elisabeth |4 aut | |
700 | 1 | |a Binter, Anne-Claire |4 aut | |
700 | 1 | |a Mulder, Rosa H. |4 aut | |
700 | 1 | |a Cabré-Riera, Alba |4 aut | |
700 | 1 | |a Kvist, Tuomas |4 aut | |
700 | 1 | |a Malmberg, Anni L. K. |4 aut | |
700 | 1 | |a Pesce, Giancarlo |4 aut | |
700 | 1 | |a Plancoulaine, Sabine |4 aut | |
700 | 1 | |a Heiss, Jonathan A. |4 aut | |
700 | 1 | |a Rifas-Shiman, Sheryl L. |4 aut | |
700 | 1 | |a Röder, Stefan W. |4 aut | |
700 | 1 | |a Starling, Anne P. |4 aut | |
700 | 1 | |a Wilson, Rory |4 aut | |
700 | 1 | |a Guerlich, Kathrin |4 aut | |
700 | 1 | |a Haftorn, Kristine L. |4 aut | |
700 | 1 | |a Page, Christian M. |4 aut | |
700 | 1 | |a Luik, Annemarie I. |4 aut | |
700 | 1 | |a Tiemeier, Henning |4 aut | |
700 | 1 | |a Felix, Janine F. |4 aut | |
700 | 1 | |a Raikkonen, Katri |4 aut | |
700 | 1 | |a Lahti, Jari |4 aut | |
700 | 1 | |a Relton, Caroline L. |4 aut | |
700 | 1 | |a Sharp, Gemma C. |4 aut | |
700 | 1 | |a Waldenberger, Melanie |4 aut | |
700 | 1 | |a Grote, Veit |4 aut | |
700 | 1 | |a Heude, Barbara |4 aut | |
700 | 1 | |a Annesi-Maesano, Isabella |4 aut | |
700 | 1 | |a Hivert, Marie-France |4 aut | |
700 | 1 | |a Zenclussen, Ana C. |4 aut | |
700 | 1 | |a Herberth, Gunda |4 aut | |
700 | 1 | |a Dabelea, Dana |4 aut | |
700 | 1 | |a Grazuleviciene, Regina |4 aut | |
700 | 1 | |a Vafeiadi, Marina |4 aut | |
700 | 1 | |a Håberg, Siri E. |4 aut | |
700 | 1 | |a London, Stephanie J. |4 aut | |
700 | 1 | |a Guxens, Mònica |4 aut | |
700 | 1 | |a Richmond, Rebecca C. |4 aut | |
700 | 1 | |a Cecil, Charlotte A. M. |4 aut | |
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10.1186/s13148-022-01298-4 doi (DE-627)SPR05083102X (SPR)s13148-022-01298-4-e DE-627 ger DE-627 rakwb eng Sammallahti, Sara verfasserin aut Longitudinal associations of DNA methylation and sleep in children: a meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. Sleep (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 Epigenomics (dpeaa)DE-He213 Actigraphy (dpeaa)DE-He213 Child (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Koopman-Verhoeff, M. Elisabeth aut Binter, Anne-Claire aut Mulder, Rosa H. aut Cabré-Riera, Alba aut Kvist, Tuomas aut Malmberg, Anni L. K. aut Pesce, Giancarlo aut Plancoulaine, Sabine aut Heiss, Jonathan A. aut Rifas-Shiman, Sheryl L. aut Röder, Stefan W. aut Starling, Anne P. aut Wilson, Rory aut Guerlich, Kathrin aut Haftorn, Kristine L. aut Page, Christian M. aut Luik, Annemarie I. aut Tiemeier, Henning aut Felix, Janine F. aut Raikkonen, Katri aut Lahti, Jari aut Relton, Caroline L. aut Sharp, Gemma C. aut Waldenberger, Melanie aut Grote, Veit aut Heude, Barbara aut Annesi-Maesano, Isabella aut Hivert, Marie-France aut Zenclussen, Ana C. aut Herberth, Gunda aut Dabelea, Dana aut Grazuleviciene, Regina aut Vafeiadi, Marina aut Håberg, Siri E. aut London, Stephanie J. aut Guxens, Mònica aut Richmond, Rebecca C. aut Cecil, Charlotte A. M. aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 14(2022), 1 vom: 05. Juli (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:14 year:2022 number:1 day:05 month:07 https://dx.doi.org/10.1186/s13148-022-01298-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 05 07 |
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10.1186/s13148-022-01298-4 doi (DE-627)SPR05083102X (SPR)s13148-022-01298-4-e DE-627 ger DE-627 rakwb eng Sammallahti, Sara verfasserin aut Longitudinal associations of DNA methylation and sleep in children: a meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. Sleep (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 Epigenomics (dpeaa)DE-He213 Actigraphy (dpeaa)DE-He213 Child (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Koopman-Verhoeff, M. Elisabeth aut Binter, Anne-Claire aut Mulder, Rosa H. aut Cabré-Riera, Alba aut Kvist, Tuomas aut Malmberg, Anni L. K. aut Pesce, Giancarlo aut Plancoulaine, Sabine aut Heiss, Jonathan A. aut Rifas-Shiman, Sheryl L. aut Röder, Stefan W. aut Starling, Anne P. aut Wilson, Rory aut Guerlich, Kathrin aut Haftorn, Kristine L. aut Page, Christian M. aut Luik, Annemarie I. aut Tiemeier, Henning aut Felix, Janine F. aut Raikkonen, Katri aut Lahti, Jari aut Relton, Caroline L. aut Sharp, Gemma C. aut Waldenberger, Melanie aut Grote, Veit aut Heude, Barbara aut Annesi-Maesano, Isabella aut Hivert, Marie-France aut Zenclussen, Ana C. aut Herberth, Gunda aut Dabelea, Dana aut Grazuleviciene, Regina aut Vafeiadi, Marina aut Håberg, Siri E. aut London, Stephanie J. aut Guxens, Mònica aut Richmond, Rebecca C. aut Cecil, Charlotte A. M. aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 14(2022), 1 vom: 05. Juli (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:14 year:2022 number:1 day:05 month:07 https://dx.doi.org/10.1186/s13148-022-01298-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 05 07 |
allfields_unstemmed |
10.1186/s13148-022-01298-4 doi (DE-627)SPR05083102X (SPR)s13148-022-01298-4-e DE-627 ger DE-627 rakwb eng Sammallahti, Sara verfasserin aut Longitudinal associations of DNA methylation and sleep in children: a meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. Sleep (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 Epigenomics (dpeaa)DE-He213 Actigraphy (dpeaa)DE-He213 Child (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Koopman-Verhoeff, M. Elisabeth aut Binter, Anne-Claire aut Mulder, Rosa H. aut Cabré-Riera, Alba aut Kvist, Tuomas aut Malmberg, Anni L. K. aut Pesce, Giancarlo aut Plancoulaine, Sabine aut Heiss, Jonathan A. aut Rifas-Shiman, Sheryl L. aut Röder, Stefan W. aut Starling, Anne P. aut Wilson, Rory aut Guerlich, Kathrin aut Haftorn, Kristine L. aut Page, Christian M. aut Luik, Annemarie I. aut Tiemeier, Henning aut Felix, Janine F. aut Raikkonen, Katri aut Lahti, Jari aut Relton, Caroline L. aut Sharp, Gemma C. aut Waldenberger, Melanie aut Grote, Veit aut Heude, Barbara aut Annesi-Maesano, Isabella aut Hivert, Marie-France aut Zenclussen, Ana C. aut Herberth, Gunda aut Dabelea, Dana aut Grazuleviciene, Regina aut Vafeiadi, Marina aut Håberg, Siri E. aut London, Stephanie J. aut Guxens, Mònica aut Richmond, Rebecca C. aut Cecil, Charlotte A. M. aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 14(2022), 1 vom: 05. Juli (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:14 year:2022 number:1 day:05 month:07 https://dx.doi.org/10.1186/s13148-022-01298-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 05 07 |
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10.1186/s13148-022-01298-4 doi (DE-627)SPR05083102X (SPR)s13148-022-01298-4-e DE-627 ger DE-627 rakwb eng Sammallahti, Sara verfasserin aut Longitudinal associations of DNA methylation and sleep in children: a meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. Sleep (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 Epigenomics (dpeaa)DE-He213 Actigraphy (dpeaa)DE-He213 Child (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Koopman-Verhoeff, M. Elisabeth aut Binter, Anne-Claire aut Mulder, Rosa H. aut Cabré-Riera, Alba aut Kvist, Tuomas aut Malmberg, Anni L. K. aut Pesce, Giancarlo aut Plancoulaine, Sabine aut Heiss, Jonathan A. aut Rifas-Shiman, Sheryl L. aut Röder, Stefan W. aut Starling, Anne P. aut Wilson, Rory aut Guerlich, Kathrin aut Haftorn, Kristine L. aut Page, Christian M. aut Luik, Annemarie I. aut Tiemeier, Henning aut Felix, Janine F. aut Raikkonen, Katri aut Lahti, Jari aut Relton, Caroline L. aut Sharp, Gemma C. aut Waldenberger, Melanie aut Grote, Veit aut Heude, Barbara aut Annesi-Maesano, Isabella aut Hivert, Marie-France aut Zenclussen, Ana C. aut Herberth, Gunda aut Dabelea, Dana aut Grazuleviciene, Regina aut Vafeiadi, Marina aut Håberg, Siri E. aut London, Stephanie J. aut Guxens, Mònica aut Richmond, Rebecca C. aut Cecil, Charlotte A. M. aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 14(2022), 1 vom: 05. Juli (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:14 year:2022 number:1 day:05 month:07 https://dx.doi.org/10.1186/s13148-022-01298-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 05 07 |
allfieldsSound |
10.1186/s13148-022-01298-4 doi (DE-627)SPR05083102X (SPR)s13148-022-01298-4-e DE-627 ger DE-627 rakwb eng Sammallahti, Sara verfasserin aut Longitudinal associations of DNA methylation and sleep in children: a meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. Sleep (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 Epigenomics (dpeaa)DE-He213 Actigraphy (dpeaa)DE-He213 Child (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Koopman-Verhoeff, M. Elisabeth aut Binter, Anne-Claire aut Mulder, Rosa H. aut Cabré-Riera, Alba aut Kvist, Tuomas aut Malmberg, Anni L. K. aut Pesce, Giancarlo aut Plancoulaine, Sabine aut Heiss, Jonathan A. aut Rifas-Shiman, Sheryl L. aut Röder, Stefan W. aut Starling, Anne P. aut Wilson, Rory aut Guerlich, Kathrin aut Haftorn, Kristine L. aut Page, Christian M. aut Luik, Annemarie I. aut Tiemeier, Henning aut Felix, Janine F. aut Raikkonen, Katri aut Lahti, Jari aut Relton, Caroline L. aut Sharp, Gemma C. aut Waldenberger, Melanie aut Grote, Veit aut Heude, Barbara aut Annesi-Maesano, Isabella aut Hivert, Marie-France aut Zenclussen, Ana C. aut Herberth, Gunda aut Dabelea, Dana aut Grazuleviciene, Regina aut Vafeiadi, Marina aut Håberg, Siri E. aut London, Stephanie J. aut Guxens, Mònica aut Richmond, Rebecca C. aut Cecil, Charlotte A. M. aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 14(2022), 1 vom: 05. Juli (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:14 year:2022 number:1 day:05 month:07 https://dx.doi.org/10.1186/s13148-022-01298-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 05 07 |
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Enthalten in Clinical epigenetics 14(2022), 1 vom: 05. Juli volume:14 year:2022 number:1 day:05 month:07 |
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Sleep Methylation Epigenomics Actigraphy Child Meta-analysis Longitudinal studies |
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Sammallahti, Sara @@aut@@ Koopman-Verhoeff, M. Elisabeth @@aut@@ Binter, Anne-Claire @@aut@@ Mulder, Rosa H. @@aut@@ Cabré-Riera, Alba @@aut@@ Kvist, Tuomas @@aut@@ Malmberg, Anni L. K. @@aut@@ Pesce, Giancarlo @@aut@@ Plancoulaine, Sabine @@aut@@ Heiss, Jonathan A. @@aut@@ Rifas-Shiman, Sheryl L. @@aut@@ Röder, Stefan W. @@aut@@ Starling, Anne P. @@aut@@ Wilson, Rory @@aut@@ Guerlich, Kathrin @@aut@@ Haftorn, Kristine L. @@aut@@ Page, Christian M. @@aut@@ Luik, Annemarie I. @@aut@@ Tiemeier, Henning @@aut@@ Felix, Janine F. @@aut@@ Raikkonen, Katri @@aut@@ Lahti, Jari @@aut@@ Relton, Caroline L. @@aut@@ Sharp, Gemma C. @@aut@@ Waldenberger, Melanie @@aut@@ Grote, Veit @@aut@@ Heude, Barbara @@aut@@ Annesi-Maesano, Isabella @@aut@@ Hivert, Marie-France @@aut@@ Zenclussen, Ana C. @@aut@@ Herberth, Gunda @@aut@@ Dabelea, Dana @@aut@@ Grazuleviciene, Regina @@aut@@ Vafeiadi, Marina @@aut@@ Håberg, Siri E. @@aut@@ London, Stephanie J. @@aut@@ Guxens, Mònica @@aut@@ Richmond, Rebecca C. @@aut@@ Cecil, Charlotte A. M. @@aut@@ |
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Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. 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Sammallahti, Sara misc Sleep misc Methylation misc Epigenomics misc Actigraphy misc Child misc Meta-analysis misc Longitudinal studies Longitudinal associations of DNA methylation and sleep in children: a meta-analysis |
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Longitudinal associations of DNA methylation and sleep in children: a meta-analysis Sleep (dpeaa)DE-He213 Methylation (dpeaa)DE-He213 Epigenomics (dpeaa)DE-He213 Actigraphy (dpeaa)DE-He213 Child (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 |
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Longitudinal associations of DNA methylation and sleep in children: a meta-analysis |
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Sammallahti, Sara Koopman-Verhoeff, M. Elisabeth Binter, Anne-Claire Mulder, Rosa H. Cabré-Riera, Alba Kvist, Tuomas Malmberg, Anni L. K. Pesce, Giancarlo Plancoulaine, Sabine Heiss, Jonathan A. Rifas-Shiman, Sheryl L. Röder, Stefan W. Starling, Anne P. Wilson, Rory Guerlich, Kathrin Haftorn, Kristine L. Page, Christian M. Luik, Annemarie I. Tiemeier, Henning Felix, Janine F. Raikkonen, Katri Lahti, Jari Relton, Caroline L. Sharp, Gemma C. Waldenberger, Melanie Grote, Veit Heude, Barbara Annesi-Maesano, Isabella Hivert, Marie-France Zenclussen, Ana C. Herberth, Gunda Dabelea, Dana Grazuleviciene, Regina Vafeiadi, Marina Håberg, Siri E. London, Stephanie J. Guxens, Mònica Richmond, Rebecca C. Cecil, Charlotte A. M. |
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10.1186/s13148-022-01298-4 |
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longitudinal associations of dna methylation and sleep in children: a meta-analysis |
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Longitudinal associations of DNA methylation and sleep in children: a meta-analysis |
abstract |
Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. © The Author(s) 2022 |
abstractGer |
Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. © The Author(s) 2022 |
abstract_unstemmed |
Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. © The Author(s) 2022 |
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Koopman-Verhoeff, M. Elisabeth Binter, Anne-Claire Mulder, Rosa H. Cabré-Riera, Alba Kvist, Tuomas Malmberg, Anni L. K. Pesce, Giancarlo Plancoulaine, Sabine Heiss, Jonathan A. Rifas-Shiman, Sheryl L. Röder, Stefan W. Starling, Anne P. Wilson, Rory Guerlich, Kathrin Haftorn, Kristine L. Page, Christian M. Luik, Annemarie I. Tiemeier, Henning Felix, Janine F. Raikkonen, Katri Lahti, Jari Relton, Caroline L. Sharp, Gemma C. Waldenberger, Melanie Grote, Veit Heude, Barbara Annesi-Maesano, Isabella Hivert, Marie-France Zenclussen, Ana C. Herberth, Gunda Dabelea, Dana Grazuleviciene, Regina Vafeiadi, Marina Håberg, Siri E. London, Stephanie J. Guxens, Mònica Richmond, Rebecca C. Cecil, Charlotte A. M. |
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Koopman-Verhoeff, M. Elisabeth Binter, Anne-Claire Mulder, Rosa H. Cabré-Riera, Alba Kvist, Tuomas Malmberg, Anni L. K. Pesce, Giancarlo Plancoulaine, Sabine Heiss, Jonathan A. Rifas-Shiman, Sheryl L. Röder, Stefan W. Starling, Anne P. Wilson, Rory Guerlich, Kathrin Haftorn, Kristine L. Page, Christian M. Luik, Annemarie I. Tiemeier, Henning Felix, Janine F. Raikkonen, Katri Lahti, Jari Relton, Caroline L. Sharp, Gemma C. Waldenberger, Melanie Grote, Veit Heude, Barbara Annesi-Maesano, Isabella Hivert, Marie-France Zenclussen, Ana C. Herberth, Gunda Dabelea, Dana Grazuleviciene, Regina Vafeiadi, Marina Håberg, Siri E. London, Stephanie J. Guxens, Mònica Richmond, Rebecca C. Cecil, Charlotte A. M. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR05083102X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230507223831.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13148-022-01298-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR05083102X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13148-022-01298-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sammallahti, Sara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Longitudinal associations of DNA methylation and sleep in children: a meta-analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × $ 10^{–8} $). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × $ 10^{–8} $, n = 577) and sleep onset latency (p = 8.8 × $ 10^{–9} $, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. 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