A DNA Nano-train Carrying a Predefined Drug Combination for Cancer Therapy

Abstract Herein, we reported a tumor cell-targeting aptamer-nano-train to deliver paclitaxel(PTX) and combretastatin A4(CA4) at a predefined ratio to cancer cells based on DNA nanotechnology. Such a drug-carrying aptamer-nano-train(aptamer-NT-PTX/CA4) was prepared via self-assembly of two DNA hairpi...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Huang, Qin [verfasserIn]

Liu, Xin

Zhang, Pengge

Wu, Zhan

Zhao, Zilong

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2022

Schlagwörter:

Targeted therapy

Drug combination cancer therapy

Aptamer

DNA nanostructure

Anmerkung:

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2022

Übergeordnetes Werk:

Enthalten in: Chemical Research in Chinese Universities - Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012, 38(2022), 4 vom: 25. Mai, Seite 928-934

Übergeordnetes Werk:

volume:38 ; year:2022 ; number:4 ; day:25 ; month:05 ; pages:928-934

Links:

Volltext

DOI / URN:

10.1007/s40242-022-2116-8

Katalog-ID:

SPR050850067

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