Functional Xeno Nucleic Acids for Biomedical Application
Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tu, Tingting [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Chemical Research in Chinese Universities - Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012, 38(2022), 4 vom: 13. Juli, Seite 912-918 |
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| Übergeordnetes Werk: |
volume:38 ; year:2022 ; number:4 ; day:13 ; month:07 ; pages:912-918 |
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| DOI / URN: |
10.1007/s40242-021-2186-7 |
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| 520 | |a Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. | ||
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10.1007/s40242-021-2186-7 doi (DE-627)SPR05085013X (SPR)s40242-021-2186-7-e DE-627 ger DE-627 rakwb eng Tu, Tingting verfasserin aut Functional Xeno Nucleic Acids for Biomedical Application 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. Functional nucleic acid (dpeaa)DE-He213 Xeno nucleic acid (dpeaa)DE-He213 Chemical modification (dpeaa)DE-He213 Biomedical application (dpeaa)DE-He213 Huan, Shuangya aut Ke, Guoliang aut Zhang, Xiaobing aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 4 vom: 13. Juli, Seite 912-918 (DE-627)SPR03290777X nnns volume:38 year:2022 number:4 day:13 month:07 pages:912-918 https://dx.doi.org/10.1007/s40242-021-2186-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 4 13 07 912-918 |
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10.1007/s40242-021-2186-7 doi (DE-627)SPR05085013X (SPR)s40242-021-2186-7-e DE-627 ger DE-627 rakwb eng Tu, Tingting verfasserin aut Functional Xeno Nucleic Acids for Biomedical Application 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. Functional nucleic acid (dpeaa)DE-He213 Xeno nucleic acid (dpeaa)DE-He213 Chemical modification (dpeaa)DE-He213 Biomedical application (dpeaa)DE-He213 Huan, Shuangya aut Ke, Guoliang aut Zhang, Xiaobing aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 4 vom: 13. Juli, Seite 912-918 (DE-627)SPR03290777X nnns volume:38 year:2022 number:4 day:13 month:07 pages:912-918 https://dx.doi.org/10.1007/s40242-021-2186-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 4 13 07 912-918 |
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10.1007/s40242-021-2186-7 doi (DE-627)SPR05085013X (SPR)s40242-021-2186-7-e DE-627 ger DE-627 rakwb eng Tu, Tingting verfasserin aut Functional Xeno Nucleic Acids for Biomedical Application 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. Functional nucleic acid (dpeaa)DE-He213 Xeno nucleic acid (dpeaa)DE-He213 Chemical modification (dpeaa)DE-He213 Biomedical application (dpeaa)DE-He213 Huan, Shuangya aut Ke, Guoliang aut Zhang, Xiaobing aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 4 vom: 13. Juli, Seite 912-918 (DE-627)SPR03290777X nnns volume:38 year:2022 number:4 day:13 month:07 pages:912-918 https://dx.doi.org/10.1007/s40242-021-2186-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 4 13 07 912-918 |
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10.1007/s40242-021-2186-7 doi (DE-627)SPR05085013X (SPR)s40242-021-2186-7-e DE-627 ger DE-627 rakwb eng Tu, Tingting verfasserin aut Functional Xeno Nucleic Acids for Biomedical Application 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. Functional nucleic acid (dpeaa)DE-He213 Xeno nucleic acid (dpeaa)DE-He213 Chemical modification (dpeaa)DE-He213 Biomedical application (dpeaa)DE-He213 Huan, Shuangya aut Ke, Guoliang aut Zhang, Xiaobing aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 4 vom: 13. Juli, Seite 912-918 (DE-627)SPR03290777X nnns volume:38 year:2022 number:4 day:13 month:07 pages:912-918 https://dx.doi.org/10.1007/s40242-021-2186-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 4 13 07 912-918 |
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10.1007/s40242-021-2186-7 doi (DE-627)SPR05085013X (SPR)s40242-021-2186-7-e DE-627 ger DE-627 rakwb eng Tu, Tingting verfasserin aut Functional Xeno Nucleic Acids for Biomedical Application 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. Functional nucleic acid (dpeaa)DE-He213 Xeno nucleic acid (dpeaa)DE-He213 Chemical modification (dpeaa)DE-He213 Biomedical application (dpeaa)DE-He213 Huan, Shuangya aut Ke, Guoliang aut Zhang, Xiaobing aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 38(2022), 4 vom: 13. Juli, Seite 912-918 (DE-627)SPR03290777X nnns volume:38 year:2022 number:4 day:13 month:07 pages:912-918 https://dx.doi.org/10.1007/s40242-021-2186-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 38 2022 4 13 07 912-918 |
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Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 |
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Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 |
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Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR05085013X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230509103642.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40242-021-2186-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR05085013X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40242-021-2186-7-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Tu, Tingting</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Functional Xeno Nucleic Acids for Biomedical Application</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. 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7.399967 |