Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020)
Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence r...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Boon, Hanne A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2022 |
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| Übergeordnetes Werk: |
Enthalten in: BMC family practice - London : BioMed Central, 2000, 23(2022), 1 vom: 20. Juli |
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| Übergeordnetes Werk: |
volume:23 ; year:2022 ; number:1 ; day:20 ; month:07 |
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| DOI / URN: |
10.1186/s12875-022-01784-x |
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SPR050869094 |
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| 100 | 1 | |a Boon, Hanne A. |e verfasserin |4 aut | |
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| 520 | |a Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. | ||
| 650 | 4 | |a Retrospective studies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Incidence |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a General practice |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a General practitioners |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Urinary tract infections |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Urinalysis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-bacterial agents |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Struyf, Thomas |4 aut | |
| 700 | 1 | |a Crèvecoeur, Jonas |4 aut | |
| 700 | 1 | |a Delvaux, Nicolas |4 aut | |
| 700 | 1 | |a Van Pottelbergh, Gijs |4 aut | |
| 700 | 1 | |a Vaes, Bert |4 aut | |
| 700 | 1 | |a Van den Bruel, Ann |4 aut | |
| 700 | 1 | |a Verbakel, Jan Y. |4 aut | |
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10.1186/s12875-022-01784-x doi (DE-627)SPR050869094 (SPR)s12875-022-01784-x-e DE-627 ger DE-627 rakwb eng Boon, Hanne A. verfasserin aut Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. Retrospective studies (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 General practice (dpeaa)DE-He213 General practitioners (dpeaa)DE-He213 Urinary tract infections (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Anti-bacterial agents (dpeaa)DE-He213 Struyf, Thomas aut Crèvecoeur, Jonas aut Delvaux, Nicolas aut Van Pottelbergh, Gijs aut Vaes, Bert aut Van den Bruel, Ann aut Verbakel, Jan Y. aut Enthalten in BMC family practice London : BioMed Central, 2000 23(2022), 1 vom: 20. Juli (DE-627)326644911 (DE-600)2041495-X 1471-2296 nnns volume:23 year:2022 number:1 day:20 month:07 https://dx.doi.org/10.1186/s12875-022-01784-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_2021 AR 23 2022 1 20 07 |
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10.1186/s12875-022-01784-x doi (DE-627)SPR050869094 (SPR)s12875-022-01784-x-e DE-627 ger DE-627 rakwb eng Boon, Hanne A. verfasserin aut Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. Retrospective studies (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 General practice (dpeaa)DE-He213 General practitioners (dpeaa)DE-He213 Urinary tract infections (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Anti-bacterial agents (dpeaa)DE-He213 Struyf, Thomas aut Crèvecoeur, Jonas aut Delvaux, Nicolas aut Van Pottelbergh, Gijs aut Vaes, Bert aut Van den Bruel, Ann aut Verbakel, Jan Y. aut Enthalten in BMC family practice London : BioMed Central, 2000 23(2022), 1 vom: 20. Juli (DE-627)326644911 (DE-600)2041495-X 1471-2296 nnns volume:23 year:2022 number:1 day:20 month:07 https://dx.doi.org/10.1186/s12875-022-01784-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_2021 AR 23 2022 1 20 07 |
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10.1186/s12875-022-01784-x doi (DE-627)SPR050869094 (SPR)s12875-022-01784-x-e DE-627 ger DE-627 rakwb eng Boon, Hanne A. verfasserin aut Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. Retrospective studies (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 General practice (dpeaa)DE-He213 General practitioners (dpeaa)DE-He213 Urinary tract infections (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Anti-bacterial agents (dpeaa)DE-He213 Struyf, Thomas aut Crèvecoeur, Jonas aut Delvaux, Nicolas aut Van Pottelbergh, Gijs aut Vaes, Bert aut Van den Bruel, Ann aut Verbakel, Jan Y. aut Enthalten in BMC family practice London : BioMed Central, 2000 23(2022), 1 vom: 20. Juli (DE-627)326644911 (DE-600)2041495-X 1471-2296 nnns volume:23 year:2022 number:1 day:20 month:07 https://dx.doi.org/10.1186/s12875-022-01784-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_2021 AR 23 2022 1 20 07 |
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10.1186/s12875-022-01784-x doi (DE-627)SPR050869094 (SPR)s12875-022-01784-x-e DE-627 ger DE-627 rakwb eng Boon, Hanne A. verfasserin aut Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. Retrospective studies (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 General practice (dpeaa)DE-He213 General practitioners (dpeaa)DE-He213 Urinary tract infections (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Anti-bacterial agents (dpeaa)DE-He213 Struyf, Thomas aut Crèvecoeur, Jonas aut Delvaux, Nicolas aut Van Pottelbergh, Gijs aut Vaes, Bert aut Van den Bruel, Ann aut Verbakel, Jan Y. aut Enthalten in BMC family practice London : BioMed Central, 2000 23(2022), 1 vom: 20. Juli (DE-627)326644911 (DE-600)2041495-X 1471-2296 nnns volume:23 year:2022 number:1 day:20 month:07 https://dx.doi.org/10.1186/s12875-022-01784-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_2021 AR 23 2022 1 20 07 |
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10.1186/s12875-022-01784-x doi (DE-627)SPR050869094 (SPR)s12875-022-01784-x-e DE-627 ger DE-627 rakwb eng Boon, Hanne A. verfasserin aut Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. Retrospective studies (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 General practice (dpeaa)DE-He213 General practitioners (dpeaa)DE-He213 Urinary tract infections (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Anti-bacterial agents (dpeaa)DE-He213 Struyf, Thomas aut Crèvecoeur, Jonas aut Delvaux, Nicolas aut Van Pottelbergh, Gijs aut Vaes, Bert aut Van den Bruel, Ann aut Verbakel, Jan Y. aut Enthalten in BMC family practice London : BioMed Central, 2000 23(2022), 1 vom: 20. Juli (DE-627)326644911 (DE-600)2041495-X 1471-2296 nnns volume:23 year:2022 number:1 day:20 month:07 https://dx.doi.org/10.1186/s12875-022-01784-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_2021 AR 23 2022 1 20 07 |
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Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. 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Boon, Hanne A. misc Retrospective studies misc Incidence misc General practice misc General practitioners misc Urinary tract infections misc Urinalysis misc Anti-bacterial agents Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) |
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Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) Retrospective studies (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 General practice (dpeaa)DE-He213 General practitioners (dpeaa)DE-He213 Urinary tract infections (dpeaa)DE-He213 Urinalysis (dpeaa)DE-He213 Anti-bacterial agents (dpeaa)DE-He213 |
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incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) |
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Incidence rates and trends of childhood urinary tract infections and antibiotic prescribing: registry-based study in general practices (2000 to 2020) |
| abstract |
Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. © The Author(s) 2022 |
| abstractGer |
Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. © The Author(s) 2022 |
| abstract_unstemmed |
Background To improve the management of childhood urinary tract infections, it is essential to understand the incidence rates, testing and treatment strategy. Methods A retrospective study using data from 45 to 104 general practices (2000 to 2020) in Flanders (Belgium). We calculated the incidence rates (per 1000 person-years) of cystitis, pyelonephritis, and lab-based urine tests per age (< 2, 2-4, 5-9 and 10-18 years)) and gender in children and performed an autoregressive time-series analysis and seasonality analysis. In children with UTI, we calculated the number of lab-based urine tests and antibiotic prescriptions per person-year and performed an autoregressive time-series analysis. Results There was a statistically significant increase in the number of UTI episodes from 2000 to 2020 in each age group (p < 0.05), except in boys 2-4 years. Overall, the change in incidence rate was low. In 2020, the incidence rates of cystitis were highest in girls 2-4 years old (40.3 /1000 person-years 95%CI 34.5-46.7) and lowest in boys 10-18 (2.6 /1000 person-years 95%CI 1.8-3.6) The incidence rates of pyelonephritis were highest in girls 2-4 years (5.5, 95%CI 3.5-8.1 /1000 person-years) and children < 2 years of age (boys: 5.4, 95%CI 3.1-8.8 and girls: 4.9, 95%CI 2.7-8.8 /1000 person-years). In children 2-10 years, there was an increase in number of lab-based urine tests per cystitis episode per year and a decrease in total number of electronic antibiotic prescriptions per cystitis episode per year, from 2000 to 2020. In children with cystitis < 10 years in 2020, 51% (95%CI 47-56%) received an electronic antibiotic prescription, of which the majority were broad-spectrum agents. Conclusions Over the last 21 years, there was a slight increase in the number of UTI episodes diagnosed in children in Flemish general practices, although the overall change was low. More targeted antibiotic therapy for cystitis in accordance with clinical guidelines is necessary to reduce the use of broad-spectrum agents in children below 10 years. © The Author(s) 2022 |
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