Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis
Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who under...
Ausführliche Beschreibung
Autor*in: |
Xanthouli, Panagiota [verfasserIn] |
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E-Artikel |
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Englisch |
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2022 |
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Anmerkung: |
© The Author(s) 2022 |
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Übergeordnetes Werk: |
Enthalten in: Arthritis Research & Therapy - London : BioMed Central, 1999, 24(2022), 1 vom: 21. Juli |
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Übergeordnetes Werk: |
volume:24 ; year:2022 ; number:1 ; day:21 ; month:07 |
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DOI / URN: |
10.1186/s13075-022-02863-1 |
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Katalog-ID: |
SPR050873113 |
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245 | 1 | 0 | |a Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis |
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520 | |a Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. | ||
650 | 4 | |a Systemic sclerosis |7 (dpeaa)DE-He213 | |
650 | 4 | |a Right ventricular reserve |7 (dpeaa)DE-He213 | |
650 | 4 | |a Pulmonary hypertension |7 (dpeaa)DE-He213 | |
650 | 4 | |a Screening |7 (dpeaa)DE-He213 | |
650 | 4 | |a Echocardiography |7 (dpeaa)DE-He213 | |
650 | 4 | |a Right heart catheterisation |7 (dpeaa)DE-He213 | |
700 | 1 | |a Miazgowski, Julia |4 aut | |
700 | 1 | |a Benjamin, Nicola |4 aut | |
700 | 1 | |a Gordjani, Ojan |4 aut | |
700 | 1 | |a Egenlauf, Benjamin |4 aut | |
700 | 1 | |a Harutyunova, Satenik |4 aut | |
700 | 1 | |a Seeger, Rebekka |4 aut | |
700 | 1 | |a Marra, Alberto M. |4 aut | |
700 | 1 | |a Blank, Norbert |4 aut | |
700 | 1 | |a Lorenz, Hanns-Martin |4 aut | |
700 | 1 | |a Grünig, Ekkehard |4 aut | |
700 | 1 | |a Eichstaedt, Christina A. |4 aut | |
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10.1186/s13075-022-02863-1 doi (DE-627)SPR050873113 (SPR)s13075-022-02863-1-e DE-627 ger DE-627 rakwb eng Xanthouli, Panagiota verfasserin aut Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. Systemic sclerosis (dpeaa)DE-He213 Right ventricular reserve (dpeaa)DE-He213 Pulmonary hypertension (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Right heart catheterisation (dpeaa)DE-He213 Miazgowski, Julia aut Benjamin, Nicola aut Gordjani, Ojan aut Egenlauf, Benjamin aut Harutyunova, Satenik aut Seeger, Rebekka aut Marra, Alberto M. aut Blank, Norbert aut Lorenz, Hanns-Martin aut Grünig, Ekkehard aut Eichstaedt, Christina A. aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 24(2022), 1 vom: 21. Juli (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:24 year:2022 number:1 day:21 month:07 https://dx.doi.org/10.1186/s13075-022-02863-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2022 1 21 07 |
spelling |
10.1186/s13075-022-02863-1 doi (DE-627)SPR050873113 (SPR)s13075-022-02863-1-e DE-627 ger DE-627 rakwb eng Xanthouli, Panagiota verfasserin aut Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. Systemic sclerosis (dpeaa)DE-He213 Right ventricular reserve (dpeaa)DE-He213 Pulmonary hypertension (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Right heart catheterisation (dpeaa)DE-He213 Miazgowski, Julia aut Benjamin, Nicola aut Gordjani, Ojan aut Egenlauf, Benjamin aut Harutyunova, Satenik aut Seeger, Rebekka aut Marra, Alberto M. aut Blank, Norbert aut Lorenz, Hanns-Martin aut Grünig, Ekkehard aut Eichstaedt, Christina A. aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 24(2022), 1 vom: 21. Juli (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:24 year:2022 number:1 day:21 month:07 https://dx.doi.org/10.1186/s13075-022-02863-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2022 1 21 07 |
allfields_unstemmed |
10.1186/s13075-022-02863-1 doi (DE-627)SPR050873113 (SPR)s13075-022-02863-1-e DE-627 ger DE-627 rakwb eng Xanthouli, Panagiota verfasserin aut Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. Systemic sclerosis (dpeaa)DE-He213 Right ventricular reserve (dpeaa)DE-He213 Pulmonary hypertension (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Right heart catheterisation (dpeaa)DE-He213 Miazgowski, Julia aut Benjamin, Nicola aut Gordjani, Ojan aut Egenlauf, Benjamin aut Harutyunova, Satenik aut Seeger, Rebekka aut Marra, Alberto M. aut Blank, Norbert aut Lorenz, Hanns-Martin aut Grünig, Ekkehard aut Eichstaedt, Christina A. aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 24(2022), 1 vom: 21. Juli (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:24 year:2022 number:1 day:21 month:07 https://dx.doi.org/10.1186/s13075-022-02863-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2022 1 21 07 |
allfieldsGer |
10.1186/s13075-022-02863-1 doi (DE-627)SPR050873113 (SPR)s13075-022-02863-1-e DE-627 ger DE-627 rakwb eng Xanthouli, Panagiota verfasserin aut Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. Systemic sclerosis (dpeaa)DE-He213 Right ventricular reserve (dpeaa)DE-He213 Pulmonary hypertension (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Right heart catheterisation (dpeaa)DE-He213 Miazgowski, Julia aut Benjamin, Nicola aut Gordjani, Ojan aut Egenlauf, Benjamin aut Harutyunova, Satenik aut Seeger, Rebekka aut Marra, Alberto M. aut Blank, Norbert aut Lorenz, Hanns-Martin aut Grünig, Ekkehard aut Eichstaedt, Christina A. aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 24(2022), 1 vom: 21. Juli (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:24 year:2022 number:1 day:21 month:07 https://dx.doi.org/10.1186/s13075-022-02863-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2022 1 21 07 |
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10.1186/s13075-022-02863-1 doi (DE-627)SPR050873113 (SPR)s13075-022-02863-1-e DE-627 ger DE-627 rakwb eng Xanthouli, Panagiota verfasserin aut Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. Systemic sclerosis (dpeaa)DE-He213 Right ventricular reserve (dpeaa)DE-He213 Pulmonary hypertension (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Right heart catheterisation (dpeaa)DE-He213 Miazgowski, Julia aut Benjamin, Nicola aut Gordjani, Ojan aut Egenlauf, Benjamin aut Harutyunova, Satenik aut Seeger, Rebekka aut Marra, Alberto M. aut Blank, Norbert aut Lorenz, Hanns-Martin aut Grünig, Ekkehard aut Eichstaedt, Christina A. aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 24(2022), 1 vom: 21. Juli (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:24 year:2022 number:1 day:21 month:07 https://dx.doi.org/10.1186/s13075-022-02863-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2022 1 21 07 |
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Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis Systemic sclerosis (dpeaa)DE-He213 Right ventricular reserve (dpeaa)DE-He213 Pulmonary hypertension (dpeaa)DE-He213 Screening (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Right heart catheterisation (dpeaa)DE-He213 |
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Xanthouli, Panagiota Miazgowski, Julia Benjamin, Nicola Gordjani, Ojan Egenlauf, Benjamin Harutyunova, Satenik Seeger, Rebekka Marra, Alberto M. Blank, Norbert Lorenz, Hanns-Martin Grünig, Ekkehard Eichstaedt, Christina A. |
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prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis |
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Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis |
abstract |
Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. © The Author(s) 2022 |
abstractGer |
Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. © The Author(s) 2022 |
abstract_unstemmed |
Background The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulmonary hypertension (PH). Methods In this study, data from SSc patients who underwent routinely performed examinations for PH screening including echocardiography and right heart catheterization at rest and during exercise were analysed. Uni- and multivariable analyses were performed to identify prognostic parameters. Results Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1±13.0 years, 68% limited cutaneous SSc, WHO-FC II–III 74%, 24 manifest PH). During the observation period of 3.2±2.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest <18 mm (p=0.001), RV output reserve as increase of cardiac index (CI) during exercise <2 l/min (p<0.0001), RV pulmonary vascular reserve (Δ mean pulmonary artery pressure/Δ cardiac output) ≥3 mmHg/l/min (p<0.0001), peak CI <5.5 l/min/$ m^{2} $ (p=0.001), pulmonary arterial compliance <2 ml/mmHg (p=0.002), TAPSE/systolic pulmonary arterial pressure (sPAP) ratio ≤0.6 ml/mmHg (p<0.0001) and echocardiographic qualitative RV function at rest (p<0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE/sPAP ratio and diffusion capacity for carbon monoxide ≤65% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up. Conclusions This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. © The Author(s) 2022 |
collection_details |
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container_issue |
1 |
title_short |
Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis |
url |
https://dx.doi.org/10.1186/s13075-022-02863-1 |
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author2 |
Miazgowski, Julia Benjamin, Nicola Gordjani, Ojan Egenlauf, Benjamin Harutyunova, Satenik Seeger, Rebekka Marra, Alberto M. Blank, Norbert Lorenz, Hanns-Martin Grünig, Ekkehard Eichstaedt, Christina A. |
author2Str |
Miazgowski, Julia Benjamin, Nicola Gordjani, Ojan Egenlauf, Benjamin Harutyunova, Satenik Seeger, Rebekka Marra, Alberto M. Blank, Norbert Lorenz, Hanns-Martin Grünig, Ekkehard Eichstaedt, Christina A. |
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doi_str |
10.1186/s13075-022-02863-1 |
up_date |
2024-07-03T18:20:11.970Z |
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