Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?

Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can...
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Autor*in:	Marcondes, Mariana Barros [verfasserIn] Susuki, Cíntia Mitsue Pereira Hokama, Newton Key Hokama, Paula de Oliveira Montandon Oliver, Felipe Aguera Chaib, Paulo Sergio Qi, Xingshun Romeiro, Fernando Gomes

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Serum protein electrophoresis Diarrhea Immunodeficiency Agammaglobulinemia Common variable immunodeficiency Case report

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: BMC gastroenterology - London : BioMed Central, 2001, 22(2022), 1 vom: 04. Sept.
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:04 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12876-022-02477-6

Katalog-ID:	SPR050966081

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245	1	0	\|a Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?
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520			\|a Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease.
650		4	\|a Serum protein electrophoresis \|7 (dpeaa)DE-He213
650		4	\|a Diarrhea \|7 (dpeaa)DE-He213
650		4	\|a Immunodeficiency \|7 (dpeaa)DE-He213
650		4	\|a Agammaglobulinemia \|7 (dpeaa)DE-He213
650		4	\|a Common variable immunodeficiency \|7 (dpeaa)DE-He213
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700	1		\|a Romeiro, Fernando Gomes \|0 (orcid)0000-0002-9394-6895 \|4 aut
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912			\|a GBV_ILN_63
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912			\|a GBV_ILN_293
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912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
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912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
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912			\|a GBV_ILN_2113
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912			\|a GBV_ILN_4012
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912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
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author_variant	m b m mb mbm c m p s cmp cmps n k h nk nkh p d o m h pdom pdomh f a o fa fao p s c ps psc x q xq f g r fg fgr
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allfields	10.1186/s12876-022-02477-6 doi (DE-627)SPR050966081 (SPR)s12876-022-02477-6-e DE-627 ger DE-627 rakwb eng Marcondes, Mariana Barros verfasserin aut Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. Serum protein electrophoresis (dpeaa)DE-He213 Diarrhea (dpeaa)DE-He213 Immunodeficiency (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Common variable immunodeficiency (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Susuki, Cíntia Mitsue Pereira aut Hokama, Newton Key aut Hokama, Paula de Oliveira Montandon aut Oliver, Felipe Aguera aut Chaib, Paulo Sergio aut Qi, Xingshun aut Romeiro, Fernando Gomes (orcid)0000-0002-9394-6895 aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 22(2022), 1 vom: 04. Sept. (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:22 year:2022 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12876-022-02477-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 04 09
spelling	10.1186/s12876-022-02477-6 doi (DE-627)SPR050966081 (SPR)s12876-022-02477-6-e DE-627 ger DE-627 rakwb eng Marcondes, Mariana Barros verfasserin aut Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. Serum protein electrophoresis (dpeaa)DE-He213 Diarrhea (dpeaa)DE-He213 Immunodeficiency (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Common variable immunodeficiency (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Susuki, Cíntia Mitsue Pereira aut Hokama, Newton Key aut Hokama, Paula de Oliveira Montandon aut Oliver, Felipe Aguera aut Chaib, Paulo Sergio aut Qi, Xingshun aut Romeiro, Fernando Gomes (orcid)0000-0002-9394-6895 aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 22(2022), 1 vom: 04. Sept. (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:22 year:2022 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12876-022-02477-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 04 09
allfields_unstemmed	10.1186/s12876-022-02477-6 doi (DE-627)SPR050966081 (SPR)s12876-022-02477-6-e DE-627 ger DE-627 rakwb eng Marcondes, Mariana Barros verfasserin aut Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. Serum protein electrophoresis (dpeaa)DE-He213 Diarrhea (dpeaa)DE-He213 Immunodeficiency (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Common variable immunodeficiency (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Susuki, Cíntia Mitsue Pereira aut Hokama, Newton Key aut Hokama, Paula de Oliveira Montandon aut Oliver, Felipe Aguera aut Chaib, Paulo Sergio aut Qi, Xingshun aut Romeiro, Fernando Gomes (orcid)0000-0002-9394-6895 aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 22(2022), 1 vom: 04. Sept. (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:22 year:2022 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12876-022-02477-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 04 09
allfieldsGer	10.1186/s12876-022-02477-6 doi (DE-627)SPR050966081 (SPR)s12876-022-02477-6-e DE-627 ger DE-627 rakwb eng Marcondes, Mariana Barros verfasserin aut Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. Serum protein electrophoresis (dpeaa)DE-He213 Diarrhea (dpeaa)DE-He213 Immunodeficiency (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Common variable immunodeficiency (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Susuki, Cíntia Mitsue Pereira aut Hokama, Newton Key aut Hokama, Paula de Oliveira Montandon aut Oliver, Felipe Aguera aut Chaib, Paulo Sergio aut Qi, Xingshun aut Romeiro, Fernando Gomes (orcid)0000-0002-9394-6895 aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 22(2022), 1 vom: 04. Sept. (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:22 year:2022 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12876-022-02477-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 04 09
allfieldsSound	10.1186/s12876-022-02477-6 doi (DE-627)SPR050966081 (SPR)s12876-022-02477-6-e DE-627 ger DE-627 rakwb eng Marcondes, Mariana Barros verfasserin aut Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. Serum protein electrophoresis (dpeaa)DE-He213 Diarrhea (dpeaa)DE-He213 Immunodeficiency (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Common variable immunodeficiency (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Susuki, Cíntia Mitsue Pereira aut Hokama, Newton Key aut Hokama, Paula de Oliveira Montandon aut Oliver, Felipe Aguera aut Chaib, Paulo Sergio aut Qi, Xingshun aut Romeiro, Fernando Gomes (orcid)0000-0002-9394-6895 aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 22(2022), 1 vom: 04. Sept. (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:22 year:2022 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12876-022-02477-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 04 09
language	English
source	Enthalten in BMC gastroenterology 22(2022), 1 vom: 04. Sept. volume:22 year:2022 number:1 day:04 month:09
sourceStr	Enthalten in BMC gastroenterology 22(2022), 1 vom: 04. Sept. volume:22 year:2022 number:1 day:04 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Serum protein electrophoresis Diarrhea Immunodeficiency Agammaglobulinemia Common variable immunodeficiency Case report
isfreeaccess_bool	true
container_title	BMC gastroenterology
authorswithroles_txt_mv	Marcondes, Mariana Barros @@aut@@ Susuki, Cíntia Mitsue Pereira @@aut@@ Hokama, Newton Key @@aut@@ Hokama, Paula de Oliveira Montandon @@aut@@ Oliver, Felipe Aguera @@aut@@ Chaib, Paulo Sergio @@aut@@ Qi, Xingshun @@aut@@ Romeiro, Fernando Gomes @@aut@@
publishDateDaySort_date	2022-09-04T00:00:00Z
hierarchy_top_id	326643702
id	SPR050966081
language_de	englisch
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Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. 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author	Marcondes, Mariana Barros
spellingShingle	Marcondes, Mariana Barros misc Serum protein electrophoresis misc Diarrhea misc Immunodeficiency misc Agammaglobulinemia misc Common variable immunodeficiency misc Case report Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?
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topic_title	Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup? Serum protein electrophoresis (dpeaa)DE-He213 Diarrhea (dpeaa)DE-He213 Immunodeficiency (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Common variable immunodeficiency (dpeaa)DE-He213 Case report (dpeaa)DE-He213
topic	misc Serum protein electrophoresis misc Diarrhea misc Immunodeficiency misc Agammaglobulinemia misc Common variable immunodeficiency misc Case report
topic_unstemmed	misc Serum protein electrophoresis misc Diarrhea misc Immunodeficiency misc Agammaglobulinemia misc Common variable immunodeficiency misc Case report
topic_browse	misc Serum protein electrophoresis misc Diarrhea misc Immunodeficiency misc Agammaglobulinemia misc Common variable immunodeficiency misc Case report
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title	Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?
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title_full	Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?
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author_browse	Marcondes, Mariana Barros Susuki, Cíntia Mitsue Pereira Hokama, Newton Key Hokama, Paula de Oliveira Montandon Oliver, Felipe Aguera Chaib, Paulo Sergio Qi, Xingshun Romeiro, Fernando Gomes
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title_sort	are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?
title_auth	Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?
abstract	Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. © The Author(s) 2022
abstractGer	Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. © The Author(s) 2022
abstract_unstemmed	Background Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastrointestinal (GI), respiratory, and hematological systems, the disease onset can have heterogeneous and intermittent symptoms, frequently leading to diagnostic delay. GI symptoms are common and can include diarrhea, but the asymptomatic periods lead to overlooking the recurrent pattern. The same can occur with respiratory infections, thus delaying CVID suspicion. The starting point for CVID diagnosis is the decreased gamma globulin levels in serum protein electrophoresis (SPE), also observed through direct immunoglobulin’s dosage. Case presentation The patient is a 38 years-old man who had intermittent diarrhea and recurrent airway infections for 19 years, but the CVID diagnosis was achieved only after SPE was carried out. At that time, he was already malnourished, and developed other complications related to CVID in a short period. Conclusions SPE is readily available and inexpensive, but is not part of the laboratory approach in diarrhea. According to the case presented herein, it can be useful for patients with recurrent infections or other clues of the disease. © The Author(s) 2022
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title_short	Are we forgetting to carry out serum protein electrophoresis as part of diagnosis workup?
url	https://dx.doi.org/10.1186/s12876-022-02477-6
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author2	Susuki, Cíntia Mitsue Pereira Hokama, Newton Key Hokama, Paula de Oliveira Montandon Oliver, Felipe Aguera Chaib, Paulo Sergio Qi, Xingshun Romeiro, Fernando Gomes
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up_date	2024-07-03T18:55:43.143Z
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