Recent advances and limitations of mTOR inhibitors in the treatment of cancer

Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transf...
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Autor*in:	Ali, Eunus S. [verfasserIn] Mitra, Kangkana Akter, Shamima Ramproshad, Sarker Mondal, Banani Khan, Ishaq N. Islam, Muhammad Torequl Sharifi-Rad, Javad Calina, Daniela Cho, William C.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Cancer Rapamycin mTOR pathway mTORC1 mTORC2 mTOR inhibitors Targeted therapy

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Cancer cell international - London : BioMed Central, 2001, 22(2022), 1 vom: 15. Sept.
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:15 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12935-022-02706-8

Katalog-ID:	SPR050995472

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allfields	10.1186/s12935-022-02706-8 doi (DE-627)SPR050995472 (SPR)s12935-022-02706-8-e DE-627 ger DE-627 rakwb eng Ali, Eunus S. verfasserin aut Recent advances and limitations of mTOR inhibitors in the treatment of cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. Cancer (dpeaa)DE-He213 Rapamycin (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 mTORC2 (dpeaa)DE-He213 mTOR inhibitors (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Mitra, Kangkana aut Akter, Shamima aut Ramproshad, Sarker aut Mondal, Banani aut Khan, Ishaq N. aut Islam, Muhammad Torequl aut Sharifi-Rad, Javad aut Calina, Daniela aut Cho, William C. aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 15. Sept. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:15 month:09 https://dx.doi.org/10.1186/s12935-022-02706-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 15 09
spelling	10.1186/s12935-022-02706-8 doi (DE-627)SPR050995472 (SPR)s12935-022-02706-8-e DE-627 ger DE-627 rakwb eng Ali, Eunus S. verfasserin aut Recent advances and limitations of mTOR inhibitors in the treatment of cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. Cancer (dpeaa)DE-He213 Rapamycin (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 mTORC2 (dpeaa)DE-He213 mTOR inhibitors (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Mitra, Kangkana aut Akter, Shamima aut Ramproshad, Sarker aut Mondal, Banani aut Khan, Ishaq N. aut Islam, Muhammad Torequl aut Sharifi-Rad, Javad aut Calina, Daniela aut Cho, William C. aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 15. Sept. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:15 month:09 https://dx.doi.org/10.1186/s12935-022-02706-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 15 09
allfields_unstemmed	10.1186/s12935-022-02706-8 doi (DE-627)SPR050995472 (SPR)s12935-022-02706-8-e DE-627 ger DE-627 rakwb eng Ali, Eunus S. verfasserin aut Recent advances and limitations of mTOR inhibitors in the treatment of cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. Cancer (dpeaa)DE-He213 Rapamycin (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 mTORC2 (dpeaa)DE-He213 mTOR inhibitors (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Mitra, Kangkana aut Akter, Shamima aut Ramproshad, Sarker aut Mondal, Banani aut Khan, Ishaq N. aut Islam, Muhammad Torequl aut Sharifi-Rad, Javad aut Calina, Daniela aut Cho, William C. aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 15. Sept. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:15 month:09 https://dx.doi.org/10.1186/s12935-022-02706-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 15 09
allfieldsGer	10.1186/s12935-022-02706-8 doi (DE-627)SPR050995472 (SPR)s12935-022-02706-8-e DE-627 ger DE-627 rakwb eng Ali, Eunus S. verfasserin aut Recent advances and limitations of mTOR inhibitors in the treatment of cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. Cancer (dpeaa)DE-He213 Rapamycin (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 mTORC2 (dpeaa)DE-He213 mTOR inhibitors (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Mitra, Kangkana aut Akter, Shamima aut Ramproshad, Sarker aut Mondal, Banani aut Khan, Ishaq N. aut Islam, Muhammad Torequl aut Sharifi-Rad, Javad aut Calina, Daniela aut Cho, William C. aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 15. Sept. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:15 month:09 https://dx.doi.org/10.1186/s12935-022-02706-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 15 09
allfieldsSound	10.1186/s12935-022-02706-8 doi (DE-627)SPR050995472 (SPR)s12935-022-02706-8-e DE-627 ger DE-627 rakwb eng Ali, Eunus S. verfasserin aut Recent advances and limitations of mTOR inhibitors in the treatment of cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. Cancer (dpeaa)DE-He213 Rapamycin (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 mTORC2 (dpeaa)DE-He213 mTOR inhibitors (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Mitra, Kangkana aut Akter, Shamima aut Ramproshad, Sarker aut Mondal, Banani aut Khan, Ishaq N. aut Islam, Muhammad Torequl aut Sharifi-Rad, Javad aut Calina, Daniela aut Cho, William C. aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 15. Sept. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:15 month:09 https://dx.doi.org/10.1186/s12935-022-02706-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 15 09
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source	Enthalten in Cancer cell international 22(2022), 1 vom: 15. Sept. volume:22 year:2022 number:1 day:15 month:09
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authorswithroles_txt_mv	Ali, Eunus S. @@aut@@ Mitra, Kangkana @@aut@@ Akter, Shamima @@aut@@ Ramproshad, Sarker @@aut@@ Mondal, Banani @@aut@@ Khan, Ishaq N. @@aut@@ Islam, Muhammad Torequl @@aut@@ Sharifi-Rad, Javad @@aut@@ Calina, Daniela @@aut@@ Cho, William C. @@aut@@
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author	Ali, Eunus S.
spellingShingle	Ali, Eunus S. misc Cancer misc Rapamycin misc mTOR pathway misc mTORC1 misc mTORC2 misc mTOR inhibitors misc Targeted therapy Recent advances and limitations of mTOR inhibitors in the treatment of cancer
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topic_title	Recent advances and limitations of mTOR inhibitors in the treatment of cancer Cancer (dpeaa)DE-He213 Rapamycin (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 mTORC2 (dpeaa)DE-He213 mTOR inhibitors (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213
topic	misc Cancer misc Rapamycin misc mTOR pathway misc mTORC1 misc mTORC2 misc mTOR inhibitors misc Targeted therapy
topic_unstemmed	misc Cancer misc Rapamycin misc mTOR pathway misc mTORC1 misc mTORC2 misc mTOR inhibitors misc Targeted therapy
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title	Recent advances and limitations of mTOR inhibitors in the treatment of cancer
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title_full	Recent advances and limitations of mTOR inhibitors in the treatment of cancer
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author_browse	Ali, Eunus S. Mitra, Kangkana Akter, Shamima Ramproshad, Sarker Mondal, Banani Khan, Ishaq N. Islam, Muhammad Torequl Sharifi-Rad, Javad Calina, Daniela Cho, William C.
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title_sort	recent advances and limitations of mtor inhibitors in the treatment of cancer
title_auth	Recent advances and limitations of mTOR inhibitors in the treatment of cancer
abstract	Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. © The Author(s) 2022
abstractGer	Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. © The Author(s) 2022
abstract_unstemmed	Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers. © The Author(s) 2022
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title_short	Recent advances and limitations of mTOR inhibitors in the treatment of cancer
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author2	Mitra, Kangkana Akter, Shamima Ramproshad, Sarker Mondal, Banani Khan, Ishaq N. Islam, Muhammad Torequl Sharifi-Rad, Javad Calina, Daniela Cho, William C.
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Recent advances and limitations of mTOR inhibitors in the treatment of cancer

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