Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer

Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are kn...
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Gespeichert in:

Autor*in:	Gao, Lijuan [verfasserIn] Ren, Ruimin Shen, Jing Hou, Jiayi Ning, Junya Feng, Yanlin Wang, Meiyue Wu, Lifei Sun, Yaojun Wang, Huang Wang, Deping Cao, Jimin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	OAS gene family Bladder cancer Expression signature Immune cell infiltration Prognosis

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 22(2022), 1 vom: 26. Sept.
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:26 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12885-022-10102-8

Katalog-ID:	SPR051017997

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520			\|a Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA.
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allfields	10.1186/s12885-022-10102-8 doi (DE-627)SPR051017997 (SPR)s12885-022-10102-8-e DE-627 ger DE-627 rakwb eng Gao, Lijuan verfasserin aut Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. OAS gene family (dpeaa)DE-He213 Bladder cancer (dpeaa)DE-He213 Expression signature (dpeaa)DE-He213 Immune cell infiltration (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ren, Ruimin aut Shen, Jing aut Hou, Jiayi aut Ning, Junya aut Feng, Yanlin aut Wang, Meiyue aut Wu, Lifei aut Sun, Yaojun aut Wang, Huang aut Wang, Deping (orcid)0000-0002-8479-5415 aut Cao, Jimin (orcid)0000-0002-6546-555X aut Enthalten in BMC cancer London : BioMed Central, 2001 22(2022), 1 vom: 26. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:22 year:2022 number:1 day:26 month:09 https://dx.doi.org/10.1186/s12885-022-10102-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 26 09
spelling	10.1186/s12885-022-10102-8 doi (DE-627)SPR051017997 (SPR)s12885-022-10102-8-e DE-627 ger DE-627 rakwb eng Gao, Lijuan verfasserin aut Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. OAS gene family (dpeaa)DE-He213 Bladder cancer (dpeaa)DE-He213 Expression signature (dpeaa)DE-He213 Immune cell infiltration (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ren, Ruimin aut Shen, Jing aut Hou, Jiayi aut Ning, Junya aut Feng, Yanlin aut Wang, Meiyue aut Wu, Lifei aut Sun, Yaojun aut Wang, Huang aut Wang, Deping (orcid)0000-0002-8479-5415 aut Cao, Jimin (orcid)0000-0002-6546-555X aut Enthalten in BMC cancer London : BioMed Central, 2001 22(2022), 1 vom: 26. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:22 year:2022 number:1 day:26 month:09 https://dx.doi.org/10.1186/s12885-022-10102-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 26 09
allfields_unstemmed	10.1186/s12885-022-10102-8 doi (DE-627)SPR051017997 (SPR)s12885-022-10102-8-e DE-627 ger DE-627 rakwb eng Gao, Lijuan verfasserin aut Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. OAS gene family (dpeaa)DE-He213 Bladder cancer (dpeaa)DE-He213 Expression signature (dpeaa)DE-He213 Immune cell infiltration (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ren, Ruimin aut Shen, Jing aut Hou, Jiayi aut Ning, Junya aut Feng, Yanlin aut Wang, Meiyue aut Wu, Lifei aut Sun, Yaojun aut Wang, Huang aut Wang, Deping (orcid)0000-0002-8479-5415 aut Cao, Jimin (orcid)0000-0002-6546-555X aut Enthalten in BMC cancer London : BioMed Central, 2001 22(2022), 1 vom: 26. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:22 year:2022 number:1 day:26 month:09 https://dx.doi.org/10.1186/s12885-022-10102-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 26 09
allfieldsGer	10.1186/s12885-022-10102-8 doi (DE-627)SPR051017997 (SPR)s12885-022-10102-8-e DE-627 ger DE-627 rakwb eng Gao, Lijuan verfasserin aut Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. OAS gene family (dpeaa)DE-He213 Bladder cancer (dpeaa)DE-He213 Expression signature (dpeaa)DE-He213 Immune cell infiltration (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ren, Ruimin aut Shen, Jing aut Hou, Jiayi aut Ning, Junya aut Feng, Yanlin aut Wang, Meiyue aut Wu, Lifei aut Sun, Yaojun aut Wang, Huang aut Wang, Deping (orcid)0000-0002-8479-5415 aut Cao, Jimin (orcid)0000-0002-6546-555X aut Enthalten in BMC cancer London : BioMed Central, 2001 22(2022), 1 vom: 26. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:22 year:2022 number:1 day:26 month:09 https://dx.doi.org/10.1186/s12885-022-10102-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 26 09
allfieldsSound	10.1186/s12885-022-10102-8 doi (DE-627)SPR051017997 (SPR)s12885-022-10102-8-e DE-627 ger DE-627 rakwb eng Gao, Lijuan verfasserin aut Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. OAS gene family (dpeaa)DE-He213 Bladder cancer (dpeaa)DE-He213 Expression signature (dpeaa)DE-He213 Immune cell infiltration (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Ren, Ruimin aut Shen, Jing aut Hou, Jiayi aut Ning, Junya aut Feng, Yanlin aut Wang, Meiyue aut Wu, Lifei aut Sun, Yaojun aut Wang, Huang aut Wang, Deping (orcid)0000-0002-8479-5415 aut Cao, Jimin (orcid)0000-0002-6546-555X aut Enthalten in BMC cancer London : BioMed Central, 2001 22(2022), 1 vom: 26. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:22 year:2022 number:1 day:26 month:09 https://dx.doi.org/10.1186/s12885-022-10102-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 26 09
language	English
source	Enthalten in BMC cancer 22(2022), 1 vom: 26. Sept. volume:22 year:2022 number:1 day:26 month:09
sourceStr	Enthalten in BMC cancer 22(2022), 1 vom: 26. Sept. volume:22 year:2022 number:1 day:26 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	OAS gene family Bladder cancer Expression signature Immune cell infiltration Prognosis
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	Gao, Lijuan @@aut@@ Ren, Ruimin @@aut@@ Shen, Jing @@aut@@ Hou, Jiayi @@aut@@ Ning, Junya @@aut@@ Feng, Yanlin @@aut@@ Wang, Meiyue @@aut@@ Wu, Lifei @@aut@@ Sun, Yaojun @@aut@@ Wang, Huang @@aut@@ Wang, Deping @@aut@@ Cao, Jimin @@aut@@
publishDateDaySort_date	2022-09-26T00:00:00Z
hierarchy_top_id	326643710
id	SPR051017997
language_de	englisch
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Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. 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author	Gao, Lijuan
spellingShingle	Gao, Lijuan misc OAS gene family misc Bladder cancer misc Expression signature misc Immune cell infiltration misc Prognosis Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer
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topic_title	Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer OAS gene family (dpeaa)DE-He213 Bladder cancer (dpeaa)DE-He213 Expression signature (dpeaa)DE-He213 Immune cell infiltration (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213
topic	misc OAS gene family misc Bladder cancer misc Expression signature misc Immune cell infiltration misc Prognosis
topic_unstemmed	misc OAS gene family misc Bladder cancer misc Expression signature misc Immune cell infiltration misc Prognosis
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title	Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer
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title_full	Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer
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author_browse	Gao, Lijuan Ren, Ruimin Shen, Jing Hou, Jiayi Ning, Junya Feng, Yanlin Wang, Meiyue Wu, Lifei Sun, Yaojun Wang, Huang Wang, Deping Cao, Jimin
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title_sort	values of oas gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer
title_auth	Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer
abstract	Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. © The Author(s) 2022
abstractGer	Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. © The Author(s) 2022
abstract_unstemmed	Background Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expressions of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions The highly expressed OAS genes in BLCA can reflect immune cells infiltration in the tumor microenvironment and predict the better overall survival of BLCA, and thus may be considered as a signature of BLCA. The study provides new insights into the diagnosis, treatment, and prognosis of BLCA. © The Author(s) 2022
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title_short	Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer
url	https://dx.doi.org/10.1186/s12885-022-10102-8
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author2	Ren, Ruimin Shen, Jing Hou, Jiayi Ning, Junya Feng, Yanlin Wang, Meiyue Wu, Lifei Sun, Yaojun Wang, Huang Wang, Deping Cao, Jimin
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up_date	2024-07-03T19:16:13.122Z
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Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer

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