Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia

Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immuno...
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Autor*in:	de Frémont, Grégoire Martin [verfasserIn] Salmona, Maud Maillet, François Garzaro, Margaux Bertinchamp, Rémi Simonnet, Arthur Feghoul, Linda Maki, Guitta Roelens, Marie Chotard, Emilie Picard, Capucine Oksenhendler, Eric LeGoff, Jérôme Boutboul, David

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Adenoviral arthritis Agammaglobulinemia Inborn errors of immunity Metagenomic next generation sequencing

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Virology journal - London : BioMed Central, 2004, 19(2022), 1 vom: 31. Okt.
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:1 ; day:31 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s12985-022-01905-z

Katalog-ID:	SPR051096536

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allfields	10.1186/s12985-022-01905-z doi (DE-627)SPR051096536 (SPR)s12985-022-01905-z-e DE-627 ger DE-627 rakwb eng de Frémont, Grégoire Martin verfasserin aut Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. Adenoviral arthritis (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Inborn errors of immunity (dpeaa)DE-He213 Metagenomic next generation sequencing (dpeaa)DE-He213 Salmona, Maud aut Maillet, François aut Garzaro, Margaux aut Bertinchamp, Rémi aut Simonnet, Arthur aut Feghoul, Linda aut Maki, Guitta aut Roelens, Marie aut Chotard, Emilie aut Picard, Capucine aut Oksenhendler, Eric aut LeGoff, Jérôme aut Boutboul, David aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 31. Okt. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:31 month:10 https://dx.doi.org/10.1186/s12985-022-01905-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 31 10
spelling	10.1186/s12985-022-01905-z doi (DE-627)SPR051096536 (SPR)s12985-022-01905-z-e DE-627 ger DE-627 rakwb eng de Frémont, Grégoire Martin verfasserin aut Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. Adenoviral arthritis (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Inborn errors of immunity (dpeaa)DE-He213 Metagenomic next generation sequencing (dpeaa)DE-He213 Salmona, Maud aut Maillet, François aut Garzaro, Margaux aut Bertinchamp, Rémi aut Simonnet, Arthur aut Feghoul, Linda aut Maki, Guitta aut Roelens, Marie aut Chotard, Emilie aut Picard, Capucine aut Oksenhendler, Eric aut LeGoff, Jérôme aut Boutboul, David aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 31. Okt. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:31 month:10 https://dx.doi.org/10.1186/s12985-022-01905-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 31 10
allfields_unstemmed	10.1186/s12985-022-01905-z doi (DE-627)SPR051096536 (SPR)s12985-022-01905-z-e DE-627 ger DE-627 rakwb eng de Frémont, Grégoire Martin verfasserin aut Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. Adenoviral arthritis (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Inborn errors of immunity (dpeaa)DE-He213 Metagenomic next generation sequencing (dpeaa)DE-He213 Salmona, Maud aut Maillet, François aut Garzaro, Margaux aut Bertinchamp, Rémi aut Simonnet, Arthur aut Feghoul, Linda aut Maki, Guitta aut Roelens, Marie aut Chotard, Emilie aut Picard, Capucine aut Oksenhendler, Eric aut LeGoff, Jérôme aut Boutboul, David aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 31. Okt. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:31 month:10 https://dx.doi.org/10.1186/s12985-022-01905-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 31 10
allfieldsGer	10.1186/s12985-022-01905-z doi (DE-627)SPR051096536 (SPR)s12985-022-01905-z-e DE-627 ger DE-627 rakwb eng de Frémont, Grégoire Martin verfasserin aut Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. Adenoviral arthritis (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Inborn errors of immunity (dpeaa)DE-He213 Metagenomic next generation sequencing (dpeaa)DE-He213 Salmona, Maud aut Maillet, François aut Garzaro, Margaux aut Bertinchamp, Rémi aut Simonnet, Arthur aut Feghoul, Linda aut Maki, Guitta aut Roelens, Marie aut Chotard, Emilie aut Picard, Capucine aut Oksenhendler, Eric aut LeGoff, Jérôme aut Boutboul, David aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 31. Okt. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:31 month:10 https://dx.doi.org/10.1186/s12985-022-01905-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 31 10
allfieldsSound	10.1186/s12985-022-01905-z doi (DE-627)SPR051096536 (SPR)s12985-022-01905-z-e DE-627 ger DE-627 rakwb eng de Frémont, Grégoire Martin verfasserin aut Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. Adenoviral arthritis (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Inborn errors of immunity (dpeaa)DE-He213 Metagenomic next generation sequencing (dpeaa)DE-He213 Salmona, Maud aut Maillet, François aut Garzaro, Margaux aut Bertinchamp, Rémi aut Simonnet, Arthur aut Feghoul, Linda aut Maki, Guitta aut Roelens, Marie aut Chotard, Emilie aut Picard, Capucine aut Oksenhendler, Eric aut LeGoff, Jérôme aut Boutboul, David aut Enthalten in Virology journal London : BioMed Central, 2004 19(2022), 1 vom: 31. Okt. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:19 year:2022 number:1 day:31 month:10 https://dx.doi.org/10.1186/s12985-022-01905-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 31 10
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source	Enthalten in Virology journal 19(2022), 1 vom: 31. Okt. volume:19 year:2022 number:1 day:31 month:10
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topic_facet	Adenoviral arthritis Agammaglobulinemia Inborn errors of immunity Metagenomic next generation sequencing
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author	de Frémont, Grégoire Martin
spellingShingle	de Frémont, Grégoire Martin misc Adenoviral arthritis misc Agammaglobulinemia misc Inborn errors of immunity misc Metagenomic next generation sequencing Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia
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topic_title	Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia Adenoviral arthritis (dpeaa)DE-He213 Agammaglobulinemia (dpeaa)DE-He213 Inborn errors of immunity (dpeaa)DE-He213 Metagenomic next generation sequencing (dpeaa)DE-He213
topic	misc Adenoviral arthritis misc Agammaglobulinemia misc Inborn errors of immunity misc Metagenomic next generation sequencing
topic_unstemmed	misc Adenoviral arthritis misc Agammaglobulinemia misc Inborn errors of immunity misc Metagenomic next generation sequencing
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title	Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia
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title_full	Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia
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author_browse	de Frémont, Grégoire Martin Salmona, Maud Maillet, François Garzaro, Margaux Bertinchamp, Rémi Simonnet, Arthur Feghoul, Linda Maki, Guitta Roelens, Marie Chotard, Emilie Picard, Capucine Oksenhendler, Eric LeGoff, Jérôme Boutboul, David
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title_sort	human adenoviral (hadv) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia
title_auth	Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia
abstract	Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. © The Author(s) 2022
abstractGer	Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. © The Author(s) 2022
abstract_unstemmed	Abstract Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients. © The Author(s) 2022
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title_short	Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia
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author2	Salmona, Maud Maillet, François Garzaro, Margaux Bertinchamp, Rémi Simonnet, Arthur Feghoul, Linda Maki, Guitta Roelens, Marie Chotard, Emilie Picard, Capucine Oksenhendler, Eric LeGoff, Jérôme Boutboul, David
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Human adenoviral (HAdV) chronic arthritis expands the infectious spectrum of primary agammaglobulinemia

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