The function of prohibitins in mitochondria and the clinical potentials

Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in e...
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Autor*in:	Oyang, Linda [verfasserIn] Li, Jian Jiang, Xianjie Lin, Jinguan Xia, Longzheng Yang, Lixia Tan, Shiming Wu, Nayiyuan Han, Yaqian Yang, Yiqing Luo, Xia Li, Jinyun Liao, Qianjin Shi, Yingrui Zhou, Yujuan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Prohibitin Mitochondria Mitophagy Mitochondrial dynamics Mitochondrial biogenesis and quality control Cancer Mitochondria disease

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Cancer cell international - London : BioMed Central, 2001, 22(2022), 1 vom: 08. Nov.
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:08 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12935-022-02765-x

Katalog-ID:	SPR051115263

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Indexfelder

author_variant	l o lo j l jl x j xj j l jl l x lx l y ly s t st n w nw y h yh y y yy x l xl j l jl q l ql y s ys y z yz
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allfields	10.1186/s12935-022-02765-x doi (DE-627)SPR051115263 (SPR)s12935-022-02765-x-e DE-627 ger DE-627 rakwb eng Oyang, Linda verfasserin aut The function of prohibitins in mitochondria and the clinical potentials 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. Prohibitin (dpeaa)DE-He213 Mitochondria (dpeaa)DE-He213 Mitophagy (dpeaa)DE-He213 Mitochondrial dynamics (dpeaa)DE-He213 Mitochondrial biogenesis and quality control (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Mitochondria disease (dpeaa)DE-He213 Li, Jian aut Jiang, Xianjie aut Lin, Jinguan aut Xia, Longzheng aut Yang, Lixia aut Tan, Shiming aut Wu, Nayiyuan aut Han, Yaqian aut Yang, Yiqing aut Luo, Xia aut Li, Jinyun aut Liao, Qianjin aut Shi, Yingrui aut Zhou, Yujuan aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 08. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:08 month:11 https://dx.doi.org/10.1186/s12935-022-02765-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 08 11
spelling	10.1186/s12935-022-02765-x doi (DE-627)SPR051115263 (SPR)s12935-022-02765-x-e DE-627 ger DE-627 rakwb eng Oyang, Linda verfasserin aut The function of prohibitins in mitochondria and the clinical potentials 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. Prohibitin (dpeaa)DE-He213 Mitochondria (dpeaa)DE-He213 Mitophagy (dpeaa)DE-He213 Mitochondrial dynamics (dpeaa)DE-He213 Mitochondrial biogenesis and quality control (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Mitochondria disease (dpeaa)DE-He213 Li, Jian aut Jiang, Xianjie aut Lin, Jinguan aut Xia, Longzheng aut Yang, Lixia aut Tan, Shiming aut Wu, Nayiyuan aut Han, Yaqian aut Yang, Yiqing aut Luo, Xia aut Li, Jinyun aut Liao, Qianjin aut Shi, Yingrui aut Zhou, Yujuan aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 08. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:08 month:11 https://dx.doi.org/10.1186/s12935-022-02765-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 08 11
allfields_unstemmed	10.1186/s12935-022-02765-x doi (DE-627)SPR051115263 (SPR)s12935-022-02765-x-e DE-627 ger DE-627 rakwb eng Oyang, Linda verfasserin aut The function of prohibitins in mitochondria and the clinical potentials 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. Prohibitin (dpeaa)DE-He213 Mitochondria (dpeaa)DE-He213 Mitophagy (dpeaa)DE-He213 Mitochondrial dynamics (dpeaa)DE-He213 Mitochondrial biogenesis and quality control (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Mitochondria disease (dpeaa)DE-He213 Li, Jian aut Jiang, Xianjie aut Lin, Jinguan aut Xia, Longzheng aut Yang, Lixia aut Tan, Shiming aut Wu, Nayiyuan aut Han, Yaqian aut Yang, Yiqing aut Luo, Xia aut Li, Jinyun aut Liao, Qianjin aut Shi, Yingrui aut Zhou, Yujuan aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 08. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:08 month:11 https://dx.doi.org/10.1186/s12935-022-02765-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 08 11
allfieldsGer	10.1186/s12935-022-02765-x doi (DE-627)SPR051115263 (SPR)s12935-022-02765-x-e DE-627 ger DE-627 rakwb eng Oyang, Linda verfasserin aut The function of prohibitins in mitochondria and the clinical potentials 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. Prohibitin (dpeaa)DE-He213 Mitochondria (dpeaa)DE-He213 Mitophagy (dpeaa)DE-He213 Mitochondrial dynamics (dpeaa)DE-He213 Mitochondrial biogenesis and quality control (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Mitochondria disease (dpeaa)DE-He213 Li, Jian aut Jiang, Xianjie aut Lin, Jinguan aut Xia, Longzheng aut Yang, Lixia aut Tan, Shiming aut Wu, Nayiyuan aut Han, Yaqian aut Yang, Yiqing aut Luo, Xia aut Li, Jinyun aut Liao, Qianjin aut Shi, Yingrui aut Zhou, Yujuan aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 08. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:08 month:11 https://dx.doi.org/10.1186/s12935-022-02765-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 08 11
allfieldsSound	10.1186/s12935-022-02765-x doi (DE-627)SPR051115263 (SPR)s12935-022-02765-x-e DE-627 ger DE-627 rakwb eng Oyang, Linda verfasserin aut The function of prohibitins in mitochondria and the clinical potentials 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. Prohibitin (dpeaa)DE-He213 Mitochondria (dpeaa)DE-He213 Mitophagy (dpeaa)DE-He213 Mitochondrial dynamics (dpeaa)DE-He213 Mitochondrial biogenesis and quality control (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Mitochondria disease (dpeaa)DE-He213 Li, Jian aut Jiang, Xianjie aut Lin, Jinguan aut Xia, Longzheng aut Yang, Lixia aut Tan, Shiming aut Wu, Nayiyuan aut Han, Yaqian aut Yang, Yiqing aut Luo, Xia aut Li, Jinyun aut Liao, Qianjin aut Shi, Yingrui aut Zhou, Yujuan aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 08. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:08 month:11 https://dx.doi.org/10.1186/s12935-022-02765-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 08 11
language	English
source	Enthalten in Cancer cell international 22(2022), 1 vom: 08. Nov. volume:22 year:2022 number:1 day:08 month:11
sourceStr	Enthalten in Cancer cell international 22(2022), 1 vom: 08. Nov. volume:22 year:2022 number:1 day:08 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Prohibitin Mitochondria Mitophagy Mitochondrial dynamics Mitochondrial biogenesis and quality control Cancer Mitochondria disease
isfreeaccess_bool	true
container_title	Cancer cell international
authorswithroles_txt_mv	Oyang, Linda @@aut@@ Li, Jian @@aut@@ Jiang, Xianjie @@aut@@ Lin, Jinguan @@aut@@ Xia, Longzheng @@aut@@ Yang, Lixia @@aut@@ Tan, Shiming @@aut@@ Wu, Nayiyuan @@aut@@ Han, Yaqian @@aut@@ Yang, Yiqing @@aut@@ Luo, Xia @@aut@@ Li, Jinyun @@aut@@ Liao, Qianjin @@aut@@ Shi, Yingrui @@aut@@ Zhou, Yujuan @@aut@@
publishDateDaySort_date	2022-11-08T00:00:00Z
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author	Oyang, Linda
spellingShingle	Oyang, Linda misc Prohibitin misc Mitochondria misc Mitophagy misc Mitochondrial dynamics misc Mitochondrial biogenesis and quality control misc Cancer misc Mitochondria disease The function of prohibitins in mitochondria and the clinical potentials
authorStr	Oyang, Linda
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topic_title	The function of prohibitins in mitochondria and the clinical potentials Prohibitin (dpeaa)DE-He213 Mitochondria (dpeaa)DE-He213 Mitophagy (dpeaa)DE-He213 Mitochondrial dynamics (dpeaa)DE-He213 Mitochondrial biogenesis and quality control (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Mitochondria disease (dpeaa)DE-He213
topic	misc Prohibitin misc Mitochondria misc Mitophagy misc Mitochondrial dynamics misc Mitochondrial biogenesis and quality control misc Cancer misc Mitochondria disease
topic_unstemmed	misc Prohibitin misc Mitochondria misc Mitophagy misc Mitochondrial dynamics misc Mitochondrial biogenesis and quality control misc Cancer misc Mitochondria disease
topic_browse	misc Prohibitin misc Mitochondria misc Mitophagy misc Mitochondrial dynamics misc Mitochondrial biogenesis and quality control misc Cancer misc Mitochondria disease
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title	The function of prohibitins in mitochondria and the clinical potentials
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title_full	The function of prohibitins in mitochondria and the clinical potentials
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author_browse	Oyang, Linda Li, Jian Jiang, Xianjie Lin, Jinguan Xia, Longzheng Yang, Lixia Tan, Shiming Wu, Nayiyuan Han, Yaqian Yang, Yiqing Luo, Xia Li, Jinyun Liao, Qianjin Shi, Yingrui Zhou, Yujuan
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doi_str_mv	10.1186/s12935-022-02765-x
title_sort	function of prohibitins in mitochondria and the clinical potentials
title_auth	The function of prohibitins in mitochondria and the clinical potentials
abstract	Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. © The Author(s) 2022
abstractGer	Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. © The Author(s) 2022
abstract_unstemmed	Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics. © The Author(s) 2022
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title_short	The function of prohibitins in mitochondria and the clinical potentials
url	https://dx.doi.org/10.1186/s12935-022-02765-x
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author2	Li, Jian Jiang, Xianjie Lin, Jinguan Xia, Longzheng Yang, Lixia Tan, Shiming Wu, Nayiyuan Han, Yaqian Yang, Yiqing Luo, Xia Li, Jinyun Liao, Qianjin Shi, Yingrui Zhou, Yujuan
author2Str	Li, Jian Jiang, Xianjie Lin, Jinguan Xia, Longzheng Yang, Lixia Tan, Shiming Wu, Nayiyuan Han, Yaqian Yang, Yiqing Luo, Xia Li, Jinyun Liao, Qianjin Shi, Yingrui Zhou, Yujuan
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up_date	2024-07-03T19:52:28.595Z
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The function of prohibitins in mitochondria and the clinical potentials

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