Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1

Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, in...
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Autor*in:	Zhou, Jiang [verfasserIn] Wang, Chengbin Liu, Yingliang Cui, Daming Wang, Zhenlin Jiang, Yang Gao, Liang

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Glioblastoma Glioma stem cells Circular RNAs CircPTPRF MiR-1208 YY1

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Cancer cell international - London : BioMed Central, 2001, 22(2022), 1 vom: 17. Nov.
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:17 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12935-022-02753-1

Katalog-ID:	SPR051144387

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allfields	10.1186/s12935-022-02753-1 doi (DE-627)SPR051144387 (SPR)s12935-022-02753-1-e DE-627 ger DE-627 rakwb eng Zhou, Jiang verfasserin aut Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. Glioblastoma (dpeaa)DE-He213 Glioma stem cells (dpeaa)DE-He213 Circular RNAs (dpeaa)DE-He213 CircPTPRF (dpeaa)DE-He213 MiR-1208 (dpeaa)DE-He213 YY1 (dpeaa)DE-He213 Wang, Chengbin aut Liu, Yingliang aut Cui, Daming aut Wang, Zhenlin aut Jiang, Yang aut Gao, Liang aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 17. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:17 month:11 https://dx.doi.org/10.1186/s12935-022-02753-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17 11
spelling	10.1186/s12935-022-02753-1 doi (DE-627)SPR051144387 (SPR)s12935-022-02753-1-e DE-627 ger DE-627 rakwb eng Zhou, Jiang verfasserin aut Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. Glioblastoma (dpeaa)DE-He213 Glioma stem cells (dpeaa)DE-He213 Circular RNAs (dpeaa)DE-He213 CircPTPRF (dpeaa)DE-He213 MiR-1208 (dpeaa)DE-He213 YY1 (dpeaa)DE-He213 Wang, Chengbin aut Liu, Yingliang aut Cui, Daming aut Wang, Zhenlin aut Jiang, Yang aut Gao, Liang aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 17. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:17 month:11 https://dx.doi.org/10.1186/s12935-022-02753-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17 11
allfields_unstemmed	10.1186/s12935-022-02753-1 doi (DE-627)SPR051144387 (SPR)s12935-022-02753-1-e DE-627 ger DE-627 rakwb eng Zhou, Jiang verfasserin aut Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. Glioblastoma (dpeaa)DE-He213 Glioma stem cells (dpeaa)DE-He213 Circular RNAs (dpeaa)DE-He213 CircPTPRF (dpeaa)DE-He213 MiR-1208 (dpeaa)DE-He213 YY1 (dpeaa)DE-He213 Wang, Chengbin aut Liu, Yingliang aut Cui, Daming aut Wang, Zhenlin aut Jiang, Yang aut Gao, Liang aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 17. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:17 month:11 https://dx.doi.org/10.1186/s12935-022-02753-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17 11
allfieldsGer	10.1186/s12935-022-02753-1 doi (DE-627)SPR051144387 (SPR)s12935-022-02753-1-e DE-627 ger DE-627 rakwb eng Zhou, Jiang verfasserin aut Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. Glioblastoma (dpeaa)DE-He213 Glioma stem cells (dpeaa)DE-He213 Circular RNAs (dpeaa)DE-He213 CircPTPRF (dpeaa)DE-He213 MiR-1208 (dpeaa)DE-He213 YY1 (dpeaa)DE-He213 Wang, Chengbin aut Liu, Yingliang aut Cui, Daming aut Wang, Zhenlin aut Jiang, Yang aut Gao, Liang aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 17. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:17 month:11 https://dx.doi.org/10.1186/s12935-022-02753-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17 11
allfieldsSound	10.1186/s12935-022-02753-1 doi (DE-627)SPR051144387 (SPR)s12935-022-02753-1-e DE-627 ger DE-627 rakwb eng Zhou, Jiang verfasserin aut Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. Glioblastoma (dpeaa)DE-He213 Glioma stem cells (dpeaa)DE-He213 Circular RNAs (dpeaa)DE-He213 CircPTPRF (dpeaa)DE-He213 MiR-1208 (dpeaa)DE-He213 YY1 (dpeaa)DE-He213 Wang, Chengbin aut Liu, Yingliang aut Cui, Daming aut Wang, Zhenlin aut Jiang, Yang aut Gao, Liang aut Enthalten in Cancer cell international London : BioMed Central, 2001 22(2022), 1 vom: 17. Nov. (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:22 year:2022 number:1 day:17 month:11 https://dx.doi.org/10.1186/s12935-022-02753-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 17 11
language	English
source	Enthalten in Cancer cell international 22(2022), 1 vom: 17. Nov. volume:22 year:2022 number:1 day:17 month:11
sourceStr	Enthalten in Cancer cell international 22(2022), 1 vom: 17. Nov. volume:22 year:2022 number:1 day:17 month:11
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institution	findex.gbv.de
topic_facet	Glioblastoma Glioma stem cells Circular RNAs CircPTPRF MiR-1208 YY1
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container_title	Cancer cell international
authorswithroles_txt_mv	Zhou, Jiang @@aut@@ Wang, Chengbin @@aut@@ Liu, Yingliang @@aut@@ Cui, Daming @@aut@@ Wang, Zhenlin @@aut@@ Jiang, Yang @@aut@@ Gao, Liang @@aut@@
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author	Zhou, Jiang
spellingShingle	Zhou, Jiang misc Glioblastoma misc Glioma stem cells misc Circular RNAs misc CircPTPRF misc MiR-1208 misc YY1 Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1
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topic_title	Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1 Glioblastoma (dpeaa)DE-He213 Glioma stem cells (dpeaa)DE-He213 Circular RNAs (dpeaa)DE-He213 CircPTPRF (dpeaa)DE-He213 MiR-1208 (dpeaa)DE-He213 YY1 (dpeaa)DE-He213
topic	misc Glioblastoma misc Glioma stem cells misc Circular RNAs misc CircPTPRF misc MiR-1208 misc YY1
topic_unstemmed	misc Glioblastoma misc Glioma stem cells misc Circular RNAs misc CircPTPRF misc MiR-1208 misc YY1
topic_browse	misc Glioblastoma misc Glioma stem cells misc Circular RNAs misc CircPTPRF misc MiR-1208 misc YY1
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title	Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1
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title_full	Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1
author_sort	Zhou, Jiang
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author_browse	Zhou, Jiang Wang, Chengbin Liu, Yingliang Cui, Daming Wang, Zhenlin Jiang, Yang Gao, Liang
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title_sort	circular rna circptprf promotes the progression of gbm via sponging mir-1208 to up-regulate yy1
title_auth	Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1
abstract	Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. © The Author(s) 2022
abstractGer	Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. © The Author(s) 2022
abstract_unstemmed	Abstract Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. CircPTPRF may play an essential role in GBM diagnosis and prognostic prediction and be an important molecular target for GBM therapy. © The Author(s) 2022
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title_short	Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1
url	https://dx.doi.org/10.1186/s12935-022-02753-1
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author2	Wang, Chengbin Liu, Yingliang Cui, Daming Wang, Zhenlin Jiang, Yang Gao, Liang
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up_date	2024-07-03T20:03:26.326Z
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Circular RNAs (circRNAs) play an essential role in various tumors, such as regulating tumor cell proliferation, apoptosis, invasion, metastasis, and other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to the prognosis of GBM and provide the basis for the targeted therapy of GBM. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3’UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. 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Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1

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