Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial

Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect prof...
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Autor*in:	Abdelfattah, Laila Ezzat [verfasserIn] Aboshama, Rehab Abdelhamid Abdelbadie, Amr S. Abulhasan, Mohamed H. Anan, Mohamed A. Abdelaal, Ibraheem I

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Azithromycin Latency period Chorioamnionitis Preterm Pre-labor Rupture of Membranes Neonatal outcomes

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: BMC pregnancy and childbirth - London : BioMed Central, 2001, 22(2022), 1 vom: 23. Nov.
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; day:23 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12884-022-05189-7

Katalog-ID:	SPR051161494

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520			\|a Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380
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allfields	10.1186/s12884-022-05189-7 doi (DE-627)SPR051161494 (SPR)s12884-022-05189-7-e DE-627 ger DE-627 rakwb eng Abdelfattah, Laila Ezzat verfasserin aut Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 Azithromycin (dpeaa)DE-He213 Latency period (dpeaa)DE-He213 Chorioamnionitis (dpeaa)DE-He213 Preterm Pre-labor Rupture of Membranes (dpeaa)DE-He213 Neonatal outcomes (dpeaa)DE-He213 Aboshama, Rehab Abdelhamid aut Abdelbadie, Amr S. aut Abulhasan, Mohamed H. aut Anan, Mohamed A. aut Abdelaal, Ibraheem I aut Enthalten in BMC pregnancy and childbirth London : BioMed Central, 2001 22(2022), 1 vom: 23. Nov. (DE-627)335489087 (DE-600)2059869-5 1471-2393 nnns volume:22 year:2022 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12884-022-05189-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 23 11
spelling	10.1186/s12884-022-05189-7 doi (DE-627)SPR051161494 (SPR)s12884-022-05189-7-e DE-627 ger DE-627 rakwb eng Abdelfattah, Laila Ezzat verfasserin aut Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 Azithromycin (dpeaa)DE-He213 Latency period (dpeaa)DE-He213 Chorioamnionitis (dpeaa)DE-He213 Preterm Pre-labor Rupture of Membranes (dpeaa)DE-He213 Neonatal outcomes (dpeaa)DE-He213 Aboshama, Rehab Abdelhamid aut Abdelbadie, Amr S. aut Abulhasan, Mohamed H. aut Anan, Mohamed A. aut Abdelaal, Ibraheem I aut Enthalten in BMC pregnancy and childbirth London : BioMed Central, 2001 22(2022), 1 vom: 23. Nov. (DE-627)335489087 (DE-600)2059869-5 1471-2393 nnns volume:22 year:2022 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12884-022-05189-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 23 11
allfields_unstemmed	10.1186/s12884-022-05189-7 doi (DE-627)SPR051161494 (SPR)s12884-022-05189-7-e DE-627 ger DE-627 rakwb eng Abdelfattah, Laila Ezzat verfasserin aut Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 Azithromycin (dpeaa)DE-He213 Latency period (dpeaa)DE-He213 Chorioamnionitis (dpeaa)DE-He213 Preterm Pre-labor Rupture of Membranes (dpeaa)DE-He213 Neonatal outcomes (dpeaa)DE-He213 Aboshama, Rehab Abdelhamid aut Abdelbadie, Amr S. aut Abulhasan, Mohamed H. aut Anan, Mohamed A. aut Abdelaal, Ibraheem I aut Enthalten in BMC pregnancy and childbirth London : BioMed Central, 2001 22(2022), 1 vom: 23. Nov. (DE-627)335489087 (DE-600)2059869-5 1471-2393 nnns volume:22 year:2022 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12884-022-05189-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 23 11
allfieldsGer	10.1186/s12884-022-05189-7 doi (DE-627)SPR051161494 (SPR)s12884-022-05189-7-e DE-627 ger DE-627 rakwb eng Abdelfattah, Laila Ezzat verfasserin aut Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 Azithromycin (dpeaa)DE-He213 Latency period (dpeaa)DE-He213 Chorioamnionitis (dpeaa)DE-He213 Preterm Pre-labor Rupture of Membranes (dpeaa)DE-He213 Neonatal outcomes (dpeaa)DE-He213 Aboshama, Rehab Abdelhamid aut Abdelbadie, Amr S. aut Abulhasan, Mohamed H. aut Anan, Mohamed A. aut Abdelaal, Ibraheem I aut Enthalten in BMC pregnancy and childbirth London : BioMed Central, 2001 22(2022), 1 vom: 23. Nov. (DE-627)335489087 (DE-600)2059869-5 1471-2393 nnns volume:22 year:2022 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12884-022-05189-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 23 11
allfieldsSound	10.1186/s12884-022-05189-7 doi (DE-627)SPR051161494 (SPR)s12884-022-05189-7-e DE-627 ger DE-627 rakwb eng Abdelfattah, Laila Ezzat verfasserin aut Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 Azithromycin (dpeaa)DE-He213 Latency period (dpeaa)DE-He213 Chorioamnionitis (dpeaa)DE-He213 Preterm Pre-labor Rupture of Membranes (dpeaa)DE-He213 Neonatal outcomes (dpeaa)DE-He213 Aboshama, Rehab Abdelhamid aut Abdelbadie, Amr S. aut Abulhasan, Mohamed H. aut Anan, Mohamed A. aut Abdelaal, Ibraheem I aut Enthalten in BMC pregnancy and childbirth London : BioMed Central, 2001 22(2022), 1 vom: 23. Nov. (DE-627)335489087 (DE-600)2059869-5 1471-2393 nnns volume:22 year:2022 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12884-022-05189-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 23 11
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topic_facet	Azithromycin Latency period Chorioamnionitis Preterm Pre-labor Rupture of Membranes Neonatal outcomes
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Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. 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author	Abdelfattah, Laila Ezzat
spellingShingle	Abdelfattah, Laila Ezzat misc Azithromycin misc Latency period misc Chorioamnionitis misc Preterm Pre-labor Rupture of Membranes misc Neonatal outcomes Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial
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topic_title	Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial Azithromycin (dpeaa)DE-He213 Latency period (dpeaa)DE-He213 Chorioamnionitis (dpeaa)DE-He213 Preterm Pre-labor Rupture of Membranes (dpeaa)DE-He213 Neonatal outcomes (dpeaa)DE-He213
topic	misc Azithromycin misc Latency period misc Chorioamnionitis misc Preterm Pre-labor Rupture of Membranes misc Neonatal outcomes
topic_unstemmed	misc Azithromycin misc Latency period misc Chorioamnionitis misc Preterm Pre-labor Rupture of Membranes misc Neonatal outcomes
topic_browse	misc Azithromycin misc Latency period misc Chorioamnionitis misc Preterm Pre-labor Rupture of Membranes misc Neonatal outcomes
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title	Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial
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title_full	Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial
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author_browse	Abdelfattah, Laila Ezzat Aboshama, Rehab Abdelhamid Abdelbadie, Amr S. Abulhasan, Mohamed H. Anan, Mohamed A. Abdelaal, Ibraheem I
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title_sort	different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial
title_auth	Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial
abstract	Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 © The Author(s) 2022
abstractGer	Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 © The Author(s) 2022
abstract_unstemmed	Background Preterm prelabor rupture of membranes is associated with polymicrobial infection; hence broad-spectrum antibiotics are recommended. Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. URL of the registration site: https://www.clinicaltrials.gov/ct2/show/NCT04202380 © The Author(s) 2022
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title_short	Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial
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Nowadays, Azithromycin is used instead of Erythromycin due to erythromycin shortages, its ease of administration, decreased cost, and better side effect profile. This study aimed to evaluate the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. Methods It was a single-blinded randomized clinical trial including pregnant women at 24–$ 36^{+6} $ weeks with viable singleton pregnancies and confirmed preterm prelabor rupture of membranes from January 01, 2020, to June 01, 2021. The participants were randomized into two groups: Group I was made of women who received Azithromycin 1000 mg PO once, and Group II of women who received Azithromycin 500 mg PO once, followed by Azithromycin 250 mg PO daily for four days. The primary study outcome was the length of the latency period from the diagnosis of preterm prelabor rupture of membranes to delivery (days). Results The latency period in group I was significantly higher than that in Group II (5.80 ± 5.44 days vs. 2.88 ± 2.37; respectively, p = 0.0001). The mean gestational age at the time of delivery was significantly higher in Group I (p = 0.0001). However, postpartum endometritis and respiratory distress syndrome (RDS) rates were significantly higher in Group II (p = 0.003 and p = 0.0001, respectively). Conclusion The higher dose of Azithromycin was associated with better maternal and neonatal outcomes. Trial registration Clinical trial identification number: Clinical trial.gov: NCT04202380 (17/ 12/ 2019). Date of registration: 1/1 /2020. Date of initial participant enrollment30 /1/2020. 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Different azithromycin protocols for management of preterm prelabour rupture of membranes: a randomized clinical trial

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