Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals
Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jeon, Seong Ik [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Polymer Society of Korea and Springer 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Macromolecular research - Heidelberg : Springer, 2010, 30(2022), 12 vom: 24. Nov., Seite 909-916 |
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| Übergeordnetes Werk: |
volume:30 ; year:2022 ; number:12 ; day:24 ; month:11 ; pages:909-916 |
| Links: |
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| DOI / URN: |
10.1007/s13233-022-0100-2 |
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| Katalog-ID: |
SPR051162504 |
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| 100 | 1 | |a Jeon, Seong Ik |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals |
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| 520 | |a Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. | ||
| 650 | 4 | |a hypoxia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a cascade reaction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a fluorescence response |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a ultrasound response |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a stimuli-sensitive material |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kim, Hyung Jun |4 aut | |
| 700 | 1 | |a Lee, Ju Hyeong |4 aut | |
| 700 | 1 | |a Ahn, Cheol-Hee |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Macromolecular research |d Heidelberg : Springer, 2010 |g 30(2022), 12 vom: 24. Nov., Seite 909-916 |w (DE-627)618327576 |w (DE-600)2537708-5 |x 2092-7673 |7 nnns |
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10.1007/s13233-022-0100-2 doi (DE-627)SPR051162504 (SPR)s13233-022-0100-2-e DE-627 ger DE-627 rakwb eng Jeon, Seong Ik verfasserin aut Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer 2022 Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. hypoxia (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 fluorescence response (dpeaa)DE-He213 ultrasound response (dpeaa)DE-He213 stimuli-sensitive material (dpeaa)DE-He213 Kim, Hyung Jun aut Lee, Ju Hyeong aut Ahn, Cheol-Hee aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 30(2022), 12 vom: 24. Nov., Seite 909-916 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:30 year:2022 number:12 day:24 month:11 pages:909-916 https://dx.doi.org/10.1007/s13233-022-0100-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 30 2022 12 24 11 909-916 |
| spelling |
10.1007/s13233-022-0100-2 doi (DE-627)SPR051162504 (SPR)s13233-022-0100-2-e DE-627 ger DE-627 rakwb eng Jeon, Seong Ik verfasserin aut Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer 2022 Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. hypoxia (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 fluorescence response (dpeaa)DE-He213 ultrasound response (dpeaa)DE-He213 stimuli-sensitive material (dpeaa)DE-He213 Kim, Hyung Jun aut Lee, Ju Hyeong aut Ahn, Cheol-Hee aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 30(2022), 12 vom: 24. Nov., Seite 909-916 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:30 year:2022 number:12 day:24 month:11 pages:909-916 https://dx.doi.org/10.1007/s13233-022-0100-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 30 2022 12 24 11 909-916 |
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10.1007/s13233-022-0100-2 doi (DE-627)SPR051162504 (SPR)s13233-022-0100-2-e DE-627 ger DE-627 rakwb eng Jeon, Seong Ik verfasserin aut Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer 2022 Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. hypoxia (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 fluorescence response (dpeaa)DE-He213 ultrasound response (dpeaa)DE-He213 stimuli-sensitive material (dpeaa)DE-He213 Kim, Hyung Jun aut Lee, Ju Hyeong aut Ahn, Cheol-Hee aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 30(2022), 12 vom: 24. Nov., Seite 909-916 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:30 year:2022 number:12 day:24 month:11 pages:909-916 https://dx.doi.org/10.1007/s13233-022-0100-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 30 2022 12 24 11 909-916 |
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10.1007/s13233-022-0100-2 doi (DE-627)SPR051162504 (SPR)s13233-022-0100-2-e DE-627 ger DE-627 rakwb eng Jeon, Seong Ik verfasserin aut Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer 2022 Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. hypoxia (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 fluorescence response (dpeaa)DE-He213 ultrasound response (dpeaa)DE-He213 stimuli-sensitive material (dpeaa)DE-He213 Kim, Hyung Jun aut Lee, Ju Hyeong aut Ahn, Cheol-Hee aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 30(2022), 12 vom: 24. Nov., Seite 909-916 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:30 year:2022 number:12 day:24 month:11 pages:909-916 https://dx.doi.org/10.1007/s13233-022-0100-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 30 2022 12 24 11 909-916 |
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10.1007/s13233-022-0100-2 doi (DE-627)SPR051162504 (SPR)s13233-022-0100-2-e DE-627 ger DE-627 rakwb eng Jeon, Seong Ik verfasserin aut Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer 2022 Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. hypoxia (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 fluorescence response (dpeaa)DE-He213 ultrasound response (dpeaa)DE-He213 stimuli-sensitive material (dpeaa)DE-He213 Kim, Hyung Jun aut Lee, Ju Hyeong aut Ahn, Cheol-Hee aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 30(2022), 12 vom: 24. Nov., Seite 909-916 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:30 year:2022 number:12 day:24 month:11 pages:909-916 https://dx.doi.org/10.1007/s13233-022-0100-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 30 2022 12 24 11 909-916 |
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Enthalten in Macromolecular research 30(2022), 12 vom: 24. Nov., Seite 909-916 volume:30 year:2022 number:12 day:24 month:11 pages:909-916 |
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Enthalten in Macromolecular research 30(2022), 12 vom: 24. Nov., Seite 909-916 volume:30 year:2022 number:12 day:24 month:11 pages:909-916 |
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Jeon, Seong Ik @@aut@@ Kim, Hyung Jun @@aut@@ Lee, Ju Hyeong @@aut@@ Ahn, Cheol-Hee @@aut@@ |
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2022-11-24T00:00:00Z |
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Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. 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Jeon, Seong Ik |
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Jeon, Seong Ik misc hypoxia misc cascade reaction misc fluorescence response misc ultrasound response misc stimuli-sensitive material Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals |
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Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals hypoxia (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 fluorescence response (dpeaa)DE-He213 ultrasound response (dpeaa)DE-He213 stimuli-sensitive material (dpeaa)DE-He213 |
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Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals |
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development of a hypoxia-sensitive material producing fluorescence and ultrasound signals |
| title_auth |
Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals |
| abstract |
Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. © The Polymer Society of Korea and Springer 2022 |
| abstractGer |
Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. © The Polymer Society of Korea and Springer 2022 |
| abstract_unstemmed |
Abstract Hypoxia, defined as a local insufficiency in the oxygen level, is one of the typical phenomena found in spinal cord injury and solid tumors. Deficiency in the oxygen offers a reductive environment and results in the conversion of nitro groups to amino groups, which can be utilized in the initiation of stimuli-sensitive cascade reactions. A novel hypoxia-sensitive material was synthesized as composed of a hypoxia-activatable trigger unit and two pyrene dyes bound via carbamate linkers, and it produced fluorescence and ultrasound signals. The material was successfully produced through seven synthetic steps and characterized via1H-NMR and UV-vis absorption analysis. The material maintained its chemical structure at the normoxic state, but underwent degradation into free pyrene dyes, activated trigger units, and carbon dioxides by cascade reactions under the reductive hypoxic condition. Accompanied by the material decomposition, remarkably rapid recovery of the quenched fluorescence was observed within 3 min, and its intensity was completely saturated after 15 min. Notably, the fluorescence intensity from the degraded material was 9.2-fold stronger than that from the same concentration of native pyrene dyes because both the activated trigger unit and free pyrene exhibited bright fluorescence emission. Moreover, the carbon dioxide generated during the degradation of the material formed nanobubbles in the media, increasing the ultrasound contrast by 1.2-fold over the background. In summary, the synthesized material was found to produce a potent, hypoxia-sensitive system to visualize the hypoxic condition in terms of fluorescence and ultrasound responses. © The Polymer Society of Korea and Springer 2022 |
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Development of a Hypoxia-Sensitive Material Producing Fluorescence and Ultrasound Signals |
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https://dx.doi.org/10.1007/s13233-022-0100-2 |
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Kim, Hyung Jun Lee, Ju Hyeong Ahn, Cheol-Hee |
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10.1007/s13233-022-0100-2 |
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|
| score |
7.401613 |