The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats

Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug the...
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Autor*in:	Badary, Dalia M. [verfasserIn] Galal, Heba A. Abdelraheim, Mahmoud H. Sedeek, Mohamed I. Mohamed, Nesma M. Abd Elmageed, Zakaria Y. Farrag, Magda M. Y.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Osteoporosis, rats, olive oil Lepidium sativum Alendronate Osteopontin

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: European journal of medical research - London : BioMed Central, 2000, 27(2022), 1 vom: 28. Nov.
Übergeordnetes Werk:	volume:27 ; year:2022 ; number:1 ; day:28 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s40001-022-00904-8

Katalog-ID:	SPR051167875

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520			\|a Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model.
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spelling	10.1186/s40001-022-00904-8 doi (DE-627)SPR051167875 (SPR)s40001-022-00904-8-e DE-627 ger DE-627 rakwb eng Badary, Dalia M. verfasserin aut The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. Osteoporosis, rats, olive oil (dpeaa)DE-He213 Lepidium sativum (dpeaa)DE-He213 Alendronate (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Galal, Heba A. aut Abdelraheim, Mahmoud H. aut Sedeek, Mohamed I. aut Mohamed, Nesma M. aut Abd Elmageed, Zakaria Y. aut Farrag, Magda M. Y. aut Enthalten in European journal of medical research London : BioMed Central, 2000 27(2022), 1 vom: 28. Nov. (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:27 year:2022 number:1 day:28 month:11 https://dx.doi.org/10.1186/s40001-022-00904-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 1 28 11
allfields_unstemmed	10.1186/s40001-022-00904-8 doi (DE-627)SPR051167875 (SPR)s40001-022-00904-8-e DE-627 ger DE-627 rakwb eng Badary, Dalia M. verfasserin aut The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. Osteoporosis, rats, olive oil (dpeaa)DE-He213 Lepidium sativum (dpeaa)DE-He213 Alendronate (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Galal, Heba A. aut Abdelraheim, Mahmoud H. aut Sedeek, Mohamed I. aut Mohamed, Nesma M. aut Abd Elmageed, Zakaria Y. aut Farrag, Magda M. Y. aut Enthalten in European journal of medical research London : BioMed Central, 2000 27(2022), 1 vom: 28. Nov. (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:27 year:2022 number:1 day:28 month:11 https://dx.doi.org/10.1186/s40001-022-00904-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 1 28 11
allfieldsGer	10.1186/s40001-022-00904-8 doi (DE-627)SPR051167875 (SPR)s40001-022-00904-8-e DE-627 ger DE-627 rakwb eng Badary, Dalia M. verfasserin aut The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. Osteoporosis, rats, olive oil (dpeaa)DE-He213 Lepidium sativum (dpeaa)DE-He213 Alendronate (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Galal, Heba A. aut Abdelraheim, Mahmoud H. aut Sedeek, Mohamed I. aut Mohamed, Nesma M. aut Abd Elmageed, Zakaria Y. aut Farrag, Magda M. Y. aut Enthalten in European journal of medical research London : BioMed Central, 2000 27(2022), 1 vom: 28. Nov. (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:27 year:2022 number:1 day:28 month:11 https://dx.doi.org/10.1186/s40001-022-00904-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 1 28 11
allfieldsSound	10.1186/s40001-022-00904-8 doi (DE-627)SPR051167875 (SPR)s40001-022-00904-8-e DE-627 ger DE-627 rakwb eng Badary, Dalia M. verfasserin aut The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. Osteoporosis, rats, olive oil (dpeaa)DE-He213 Lepidium sativum (dpeaa)DE-He213 Alendronate (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Galal, Heba A. aut Abdelraheim, Mahmoud H. aut Sedeek, Mohamed I. aut Mohamed, Nesma M. aut Abd Elmageed, Zakaria Y. aut Farrag, Magda M. Y. aut Enthalten in European journal of medical research London : BioMed Central, 2000 27(2022), 1 vom: 28. Nov. (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:27 year:2022 number:1 day:28 month:11 https://dx.doi.org/10.1186/s40001-022-00904-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 1 28 11
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author	Badary, Dalia M.
spellingShingle	Badary, Dalia M. misc Osteoporosis, rats, olive oil misc Lepidium sativum misc Alendronate misc Osteopontin The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats
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topic_title	The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats Osteoporosis, rats, olive oil (dpeaa)DE-He213 Lepidium sativum (dpeaa)DE-He213 Alendronate (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213
topic	misc Osteoporosis, rats, olive oil misc Lepidium sativum misc Alendronate misc Osteopontin
topic_unstemmed	misc Osteoporosis, rats, olive oil misc Lepidium sativum misc Alendronate misc Osteopontin
topic_browse	misc Osteoporosis, rats, olive oil misc Lepidium sativum misc Alendronate misc Osteopontin
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title	The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats
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title_full	The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats
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author_browse	Badary, Dalia M. Galal, Heba A. Abdelraheim, Mahmoud H. Sedeek, Mohamed I. Mohamed, Nesma M. Abd Elmageed, Zakaria Y. Farrag, Magda M. Y.
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title_sort	combination of olive oil and lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats
title_auth	The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats
abstract	Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. © The Author(s) 2022
abstractGer	Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. © The Author(s) 2022
abstract_unstemmed	Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of $ Ca^{2+} $, $ P^{3+} $, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum $ Ca^{2+} $, $ P^{3+} $, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. © The Author(s) 2022
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title_short	The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats
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author2	Galal, Heba A. Abdelraheim, Mahmoud H. Sedeek, Mohamed I. Mohamed, Nesma M. Abd Elmageed, Zakaria Y. Farrag, Magda M. Y.
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