A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report
Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower...
Ausführliche Beschreibung
Autor*in: |
Ito, Daisuke [verfasserIn] |
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E-Artikel |
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Englisch |
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2022 |
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Schlagwörter: |
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits |
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Anmerkung: |
© The Author(s) 2022 |
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Übergeordnetes Werk: |
Enthalten in: BMC nephrology - London : BioMed Central, 2000, 23(2022), 1 vom: 09. Dez. |
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Übergeordnetes Werk: |
volume:23 ; year:2022 ; number:1 ; day:09 ; month:12 |
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DOI / URN: |
10.1186/s12882-022-03029-6 |
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SPR05121878X |
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520 | |a Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. | ||
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700 | 1 | |a Misaki, Taro |4 aut | |
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10.1186/s12882-022-03029-6 doi (DE-627)SPR05121878X (SPR)s12882-022-03029-6-e DE-627 ger DE-627 rakwb eng Ito, Daisuke verfasserin aut A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (dpeaa)DE-He213 Membranoproliferative glomerulonephritis (dpeaa)DE-He213 IgG2 kappa (dpeaa)DE-He213 Shiozaki, Yuriko aut Shimizu, Yoshitaka aut Suzuki, Yumiko aut Takeda, Asami aut Misaki, Taro aut Enthalten in BMC nephrology London : BioMed Central, 2000 23(2022), 1 vom: 09. Dez. (DE-627)326643672 (DE-600)2041348-8 1471-2369 nnns volume:23 year:2022 number:1 day:09 month:12 https://dx.doi.org/10.1186/s12882-022-03029-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 09 12 |
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10.1186/s12882-022-03029-6 doi (DE-627)SPR05121878X (SPR)s12882-022-03029-6-e DE-627 ger DE-627 rakwb eng Ito, Daisuke verfasserin aut A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (dpeaa)DE-He213 Membranoproliferative glomerulonephritis (dpeaa)DE-He213 IgG2 kappa (dpeaa)DE-He213 Shiozaki, Yuriko aut Shimizu, Yoshitaka aut Suzuki, Yumiko aut Takeda, Asami aut Misaki, Taro aut Enthalten in BMC nephrology London : BioMed Central, 2000 23(2022), 1 vom: 09. Dez. (DE-627)326643672 (DE-600)2041348-8 1471-2369 nnns volume:23 year:2022 number:1 day:09 month:12 https://dx.doi.org/10.1186/s12882-022-03029-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 09 12 |
allfields_unstemmed |
10.1186/s12882-022-03029-6 doi (DE-627)SPR05121878X (SPR)s12882-022-03029-6-e DE-627 ger DE-627 rakwb eng Ito, Daisuke verfasserin aut A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (dpeaa)DE-He213 Membranoproliferative glomerulonephritis (dpeaa)DE-He213 IgG2 kappa (dpeaa)DE-He213 Shiozaki, Yuriko aut Shimizu, Yoshitaka aut Suzuki, Yumiko aut Takeda, Asami aut Misaki, Taro aut Enthalten in BMC nephrology London : BioMed Central, 2000 23(2022), 1 vom: 09. Dez. (DE-627)326643672 (DE-600)2041348-8 1471-2369 nnns volume:23 year:2022 number:1 day:09 month:12 https://dx.doi.org/10.1186/s12882-022-03029-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 09 12 |
allfieldsGer |
10.1186/s12882-022-03029-6 doi (DE-627)SPR05121878X (SPR)s12882-022-03029-6-e DE-627 ger DE-627 rakwb eng Ito, Daisuke verfasserin aut A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (dpeaa)DE-He213 Membranoproliferative glomerulonephritis (dpeaa)DE-He213 IgG2 kappa (dpeaa)DE-He213 Shiozaki, Yuriko aut Shimizu, Yoshitaka aut Suzuki, Yumiko aut Takeda, Asami aut Misaki, Taro aut Enthalten in BMC nephrology London : BioMed Central, 2000 23(2022), 1 vom: 09. Dez. (DE-627)326643672 (DE-600)2041348-8 1471-2369 nnns volume:23 year:2022 number:1 day:09 month:12 https://dx.doi.org/10.1186/s12882-022-03029-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 09 12 |
allfieldsSound |
10.1186/s12882-022-03029-6 doi (DE-627)SPR05121878X (SPR)s12882-022-03029-6-e DE-627 ger DE-627 rakwb eng Ito, Daisuke verfasserin aut A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (dpeaa)DE-He213 Membranoproliferative glomerulonephritis (dpeaa)DE-He213 IgG2 kappa (dpeaa)DE-He213 Shiozaki, Yuriko aut Shimizu, Yoshitaka aut Suzuki, Yumiko aut Takeda, Asami aut Misaki, Taro aut Enthalten in BMC nephrology London : BioMed Central, 2000 23(2022), 1 vom: 09. Dez. (DE-627)326643672 (DE-600)2041348-8 1471-2369 nnns volume:23 year:2022 number:1 day:09 month:12 https://dx.doi.org/10.1186/s12882-022-03029-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 09 12 |
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Enthalten in BMC nephrology 23(2022), 1 vom: 09. Dez. volume:23 year:2022 number:1 day:09 month:12 |
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Enthalten in BMC nephrology 23(2022), 1 vom: 09. Dez. volume:23 year:2022 number:1 day:09 month:12 |
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Ito, Daisuke @@aut@@ Shiozaki, Yuriko @@aut@@ Shimizu, Yoshitaka @@aut@@ Suzuki, Yumiko @@aut@@ Takeda, Asami @@aut@@ Misaki, Taro @@aut@@ |
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Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. 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A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (dpeaa)DE-He213 Membranoproliferative glomerulonephritis (dpeaa)DE-He213 IgG2 kappa (dpeaa)DE-He213 |
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rare case of proliferative glomerulonephritis with monoclonal igg2 kappa deposit: a case report |
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A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report |
abstract |
Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. © The Author(s) 2022 |
abstractGer |
Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. © The Author(s) 2022 |
abstract_unstemmed |
Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin. Case presentation We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine. Although his bone marrow biopsy was negative, renal biopsy found features of membranoproliferative glomerulonephritis (MPGN) with deposition of monoclonal IgG2 kappa. Electron microscopy examination revealed non-organized electron-dense deposits in the subepithelial, and subendothelial mesangial regions. Steroid monotherapy was performed after diagnosis of PGNMID but complete remission was not achieved. Conclusion PGNMID with IgG3 kappa deposits is the most common in cases with the histological feature of MPGN. There are few cases of PGNMID with IgG2 kappa deposits exhibiting MPGN. This report describes a very rare case of PGNMID with the histological feature of MPGN. © The Author(s) 2022 |
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7.4002647 |