Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction

Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative ana...
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Autor*in:	Jalava, Maina P. [verfasserIn] Savontaus, Mikko Ahvenvaara, Tuomas Laakso, Teemu Virtanen, Marko Niemelä, Matti Tauriainen, Tuomas Maaranen, Pasi Husso, Annastiina Kinnunen, Eve Dahlbacka, Sebastian Jaakkola, Jussi Rosato, Stefano D’Errigo, Paola Laine, Mika Mäkikallio, Timo Raivio, Peter Eskola, Markku Valtola, Antti Juvonen, Tatu Biancari, Fausto Airaksinen, Juhani Anttila, Vesa

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Transcatheter aortic valve replacement, TAVR Surgical aortic valve replacement, SAVR Aortic stenosis, AS Left ventricular ejection fraction Left ventricular dysfunction Heart failure

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Journal of cardiothoracic surgery - London : BioMed Central, 2006, 17(2022), 1 vom: 18. Dez.
Übergeordnetes Werk:	volume:17 ; year:2022 ; number:1 ; day:18 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s13019-022-02061-9

Katalog-ID:	SPR051244713

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520			\|a Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915.
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allfields	10.1186/s13019-022-02061-9 doi (DE-627)SPR051244713 (SPR)s13019-022-02061-9-e DE-627 ger DE-627 rakwb eng Jalava, Maina P. verfasserin aut Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. Transcatheter aortic valve replacement, TAVR (dpeaa)DE-He213 Surgical aortic valve replacement, SAVR (dpeaa)DE-He213 Aortic stenosis, AS (dpeaa)DE-He213 Left ventricular ejection fraction (dpeaa)DE-He213 Left ventricular dysfunction (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Savontaus, Mikko aut Ahvenvaara, Tuomas aut Laakso, Teemu aut Virtanen, Marko aut Niemelä, Matti aut Tauriainen, Tuomas aut Maaranen, Pasi aut Husso, Annastiina aut Kinnunen, Eve aut Dahlbacka, Sebastian aut Jaakkola, Jussi aut Rosato, Stefano aut D’Errigo, Paola aut Laine, Mika aut Mäkikallio, Timo aut Raivio, Peter aut Eskola, Markku aut Valtola, Antti aut Juvonen, Tatu aut Biancari, Fausto aut Airaksinen, Juhani aut Anttila, Vesa aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 17(2022), 1 vom: 18. Dez. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:17 year:2022 number:1 day:18 month:12 https://dx.doi.org/10.1186/s13019-022-02061-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 18 12
spelling	10.1186/s13019-022-02061-9 doi (DE-627)SPR051244713 (SPR)s13019-022-02061-9-e DE-627 ger DE-627 rakwb eng Jalava, Maina P. verfasserin aut Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. Transcatheter aortic valve replacement, TAVR (dpeaa)DE-He213 Surgical aortic valve replacement, SAVR (dpeaa)DE-He213 Aortic stenosis, AS (dpeaa)DE-He213 Left ventricular ejection fraction (dpeaa)DE-He213 Left ventricular dysfunction (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Savontaus, Mikko aut Ahvenvaara, Tuomas aut Laakso, Teemu aut Virtanen, Marko aut Niemelä, Matti aut Tauriainen, Tuomas aut Maaranen, Pasi aut Husso, Annastiina aut Kinnunen, Eve aut Dahlbacka, Sebastian aut Jaakkola, Jussi aut Rosato, Stefano aut D’Errigo, Paola aut Laine, Mika aut Mäkikallio, Timo aut Raivio, Peter aut Eskola, Markku aut Valtola, Antti aut Juvonen, Tatu aut Biancari, Fausto aut Airaksinen, Juhani aut Anttila, Vesa aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 17(2022), 1 vom: 18. Dez. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:17 year:2022 number:1 day:18 month:12 https://dx.doi.org/10.1186/s13019-022-02061-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 18 12
allfields_unstemmed	10.1186/s13019-022-02061-9 doi (DE-627)SPR051244713 (SPR)s13019-022-02061-9-e DE-627 ger DE-627 rakwb eng Jalava, Maina P. verfasserin aut Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. Transcatheter aortic valve replacement, TAVR (dpeaa)DE-He213 Surgical aortic valve replacement, SAVR (dpeaa)DE-He213 Aortic stenosis, AS (dpeaa)DE-He213 Left ventricular ejection fraction (dpeaa)DE-He213 Left ventricular dysfunction (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Savontaus, Mikko aut Ahvenvaara, Tuomas aut Laakso, Teemu aut Virtanen, Marko aut Niemelä, Matti aut Tauriainen, Tuomas aut Maaranen, Pasi aut Husso, Annastiina aut Kinnunen, Eve aut Dahlbacka, Sebastian aut Jaakkola, Jussi aut Rosato, Stefano aut D’Errigo, Paola aut Laine, Mika aut Mäkikallio, Timo aut Raivio, Peter aut Eskola, Markku aut Valtola, Antti aut Juvonen, Tatu aut Biancari, Fausto aut Airaksinen, Juhani aut Anttila, Vesa aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 17(2022), 1 vom: 18. Dez. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:17 year:2022 number:1 day:18 month:12 https://dx.doi.org/10.1186/s13019-022-02061-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 18 12
allfieldsGer	10.1186/s13019-022-02061-9 doi (DE-627)SPR051244713 (SPR)s13019-022-02061-9-e DE-627 ger DE-627 rakwb eng Jalava, Maina P. verfasserin aut Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. Transcatheter aortic valve replacement, TAVR (dpeaa)DE-He213 Surgical aortic valve replacement, SAVR (dpeaa)DE-He213 Aortic stenosis, AS (dpeaa)DE-He213 Left ventricular ejection fraction (dpeaa)DE-He213 Left ventricular dysfunction (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Savontaus, Mikko aut Ahvenvaara, Tuomas aut Laakso, Teemu aut Virtanen, Marko aut Niemelä, Matti aut Tauriainen, Tuomas aut Maaranen, Pasi aut Husso, Annastiina aut Kinnunen, Eve aut Dahlbacka, Sebastian aut Jaakkola, Jussi aut Rosato, Stefano aut D’Errigo, Paola aut Laine, Mika aut Mäkikallio, Timo aut Raivio, Peter aut Eskola, Markku aut Valtola, Antti aut Juvonen, Tatu aut Biancari, Fausto aut Airaksinen, Juhani aut Anttila, Vesa aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 17(2022), 1 vom: 18. Dez. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:17 year:2022 number:1 day:18 month:12 https://dx.doi.org/10.1186/s13019-022-02061-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 18 12
allfieldsSound	10.1186/s13019-022-02061-9 doi (DE-627)SPR051244713 (SPR)s13019-022-02061-9-e DE-627 ger DE-627 rakwb eng Jalava, Maina P. verfasserin aut Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. Transcatheter aortic valve replacement, TAVR (dpeaa)DE-He213 Surgical aortic valve replacement, SAVR (dpeaa)DE-He213 Aortic stenosis, AS (dpeaa)DE-He213 Left ventricular ejection fraction (dpeaa)DE-He213 Left ventricular dysfunction (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 Savontaus, Mikko aut Ahvenvaara, Tuomas aut Laakso, Teemu aut Virtanen, Marko aut Niemelä, Matti aut Tauriainen, Tuomas aut Maaranen, Pasi aut Husso, Annastiina aut Kinnunen, Eve aut Dahlbacka, Sebastian aut Jaakkola, Jussi aut Rosato, Stefano aut D’Errigo, Paola aut Laine, Mika aut Mäkikallio, Timo aut Raivio, Peter aut Eskola, Markku aut Valtola, Antti aut Juvonen, Tatu aut Biancari, Fausto aut Airaksinen, Juhani aut Anttila, Vesa aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 17(2022), 1 vom: 18. Dez. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:17 year:2022 number:1 day:18 month:12 https://dx.doi.org/10.1186/s13019-022-02061-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 18 12
language	English
source	Enthalten in Journal of cardiothoracic surgery 17(2022), 1 vom: 18. Dez. volume:17 year:2022 number:1 day:18 month:12
sourceStr	Enthalten in Journal of cardiothoracic surgery 17(2022), 1 vom: 18. Dez. volume:17 year:2022 number:1 day:18 month:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Transcatheter aortic valve replacement, TAVR Surgical aortic valve replacement, SAVR Aortic stenosis, AS Left ventricular ejection fraction Left ventricular dysfunction Heart failure
isfreeaccess_bool	true
container_title	Journal of cardiothoracic surgery
authorswithroles_txt_mv	Jalava, Maina P. @@aut@@ Savontaus, Mikko @@aut@@ Ahvenvaara, Tuomas @@aut@@ Laakso, Teemu @@aut@@ Virtanen, Marko @@aut@@ Niemelä, Matti @@aut@@ Tauriainen, Tuomas @@aut@@ Maaranen, Pasi @@aut@@ Husso, Annastiina @@aut@@ Kinnunen, Eve @@aut@@ Dahlbacka, Sebastian @@aut@@ Jaakkola, Jussi @@aut@@ Rosato, Stefano @@aut@@ D’Errigo, Paola @@aut@@ Laine, Mika @@aut@@ Mäkikallio, Timo @@aut@@ Raivio, Peter @@aut@@ Eskola, Markku @@aut@@ Valtola, Antti @@aut@@ Juvonen, Tatu @@aut@@ Biancari, Fausto @@aut@@ Airaksinen, Juhani @@aut@@ Anttila, Vesa @@aut@@
publishDateDaySort_date	2022-12-18T00:00:00Z
hierarchy_top_id	509401260
id	SPR051244713
language_de	englisch
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The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. 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author	Jalava, Maina P.
spellingShingle	Jalava, Maina P. misc Transcatheter aortic valve replacement, TAVR misc Surgical aortic valve replacement, SAVR misc Aortic stenosis, AS misc Left ventricular ejection fraction misc Left ventricular dysfunction misc Heart failure Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction
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topic_title	Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction Transcatheter aortic valve replacement, TAVR (dpeaa)DE-He213 Surgical aortic valve replacement, SAVR (dpeaa)DE-He213 Aortic stenosis, AS (dpeaa)DE-He213 Left ventricular ejection fraction (dpeaa)DE-He213 Left ventricular dysfunction (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213
topic	misc Transcatheter aortic valve replacement, TAVR misc Surgical aortic valve replacement, SAVR misc Aortic stenosis, AS misc Left ventricular ejection fraction misc Left ventricular dysfunction misc Heart failure
topic_unstemmed	misc Transcatheter aortic valve replacement, TAVR misc Surgical aortic valve replacement, SAVR misc Aortic stenosis, AS misc Left ventricular ejection fraction misc Left ventricular dysfunction misc Heart failure
topic_browse	misc Transcatheter aortic valve replacement, TAVR misc Surgical aortic valve replacement, SAVR misc Aortic stenosis, AS misc Left ventricular ejection fraction misc Left ventricular dysfunction misc Heart failure
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title	Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction
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title_full	Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction
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author_browse	Jalava, Maina P. Savontaus, Mikko Ahvenvaara, Tuomas Laakso, Teemu Virtanen, Marko Niemelä, Matti Tauriainen, Tuomas Maaranen, Pasi Husso, Annastiina Kinnunen, Eve Dahlbacka, Sebastian Jaakkola, Jussi Rosato, Stefano D’Errigo, Paola Laine, Mika Mäkikallio, Timo Raivio, Peter Eskola, Markku Valtola, Antti Juvonen, Tatu Biancari, Fausto Airaksinen, Juhani Anttila, Vesa
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author-letter	Jalava, Maina P.
doi_str_mv	10.1186/s13019-022-02061-9
title_sort	transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction
title_auth	Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction
abstract	Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. © The Author(s) 2022
abstractGer	Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. © The Author(s) 2022
abstract_unstemmed	Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915. © The Author(s) 2022
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title_short	Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction
url	https://dx.doi.org/10.1186/s13019-022-02061-9
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author2	Savontaus, Mikko Ahvenvaara, Tuomas Laakso, Teemu Virtanen, Marko Niemelä, Matti Tauriainen, Tuomas Maaranen, Pasi Husso, Annastiina Kinnunen, Eve Dahlbacka, Sebastian Jaakkola, Jussi Rosato, Stefano D’Errigo, Paola Laine, Mika Mäkikallio, Timo Raivio, Peter Eskola, Markku Valtola, Antti Juvonen, Tatu Biancari, Fausto Airaksinen, Juhani Anttila, Vesa
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Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction

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