Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors

Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical...
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Autor*in:	Wang, Chen [verfasserIn] Wang, Di Pan, Changqing Zhang, Jiazheng Cheng, Cheng Zhai, You Yu, Mingchen Wang, Zhiliang Li, Guanzhang Zhang, Wei

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Glioblastoma Multiple primary tumors Clinical and pathological characteristics Prognosis

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Chinese neurosurgical journal - London : BioMed Central, 2015, 8(2022), 1 vom: 27. Dez.
Übergeordnetes Werk:	volume:8 ; year:2022 ; number:1 ; day:27 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s41016-022-00312-1

Katalog-ID:	SPR051268906

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520			\|a Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes.
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allfields	10.1186/s41016-022-00312-1 doi (DE-627)SPR051268906 (SPR)s41016-022-00312-1-e DE-627 ger DE-627 rakwb eng Wang, Chen verfasserin aut Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. Glioblastoma (dpeaa)DE-He213 Multiple primary tumors (dpeaa)DE-He213 Clinical and pathological characteristics (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Wang, Di aut Pan, Changqing aut Zhang, Jiazheng aut Cheng, Cheng aut Zhai, You aut Yu, Mingchen aut Wang, Zhiliang aut Li, Guanzhang aut Zhang, Wei aut Enthalten in Chinese neurosurgical journal London : BioMed Central, 2015 8(2022), 1 vom: 27. Dez. (DE-627)837397626 (DE-600)2836334-6 2057-4967 nnns volume:8 year:2022 number:1 day:27 month:12 https://dx.doi.org/10.1186/s41016-022-00312-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 27 12
spelling	10.1186/s41016-022-00312-1 doi (DE-627)SPR051268906 (SPR)s41016-022-00312-1-e DE-627 ger DE-627 rakwb eng Wang, Chen verfasserin aut Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. Glioblastoma (dpeaa)DE-He213 Multiple primary tumors (dpeaa)DE-He213 Clinical and pathological characteristics (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Wang, Di aut Pan, Changqing aut Zhang, Jiazheng aut Cheng, Cheng aut Zhai, You aut Yu, Mingchen aut Wang, Zhiliang aut Li, Guanzhang aut Zhang, Wei aut Enthalten in Chinese neurosurgical journal London : BioMed Central, 2015 8(2022), 1 vom: 27. Dez. (DE-627)837397626 (DE-600)2836334-6 2057-4967 nnns volume:8 year:2022 number:1 day:27 month:12 https://dx.doi.org/10.1186/s41016-022-00312-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 27 12
allfields_unstemmed	10.1186/s41016-022-00312-1 doi (DE-627)SPR051268906 (SPR)s41016-022-00312-1-e DE-627 ger DE-627 rakwb eng Wang, Chen verfasserin aut Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. Glioblastoma (dpeaa)DE-He213 Multiple primary tumors (dpeaa)DE-He213 Clinical and pathological characteristics (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Wang, Di aut Pan, Changqing aut Zhang, Jiazheng aut Cheng, Cheng aut Zhai, You aut Yu, Mingchen aut Wang, Zhiliang aut Li, Guanzhang aut Zhang, Wei aut Enthalten in Chinese neurosurgical journal London : BioMed Central, 2015 8(2022), 1 vom: 27. Dez. (DE-627)837397626 (DE-600)2836334-6 2057-4967 nnns volume:8 year:2022 number:1 day:27 month:12 https://dx.doi.org/10.1186/s41016-022-00312-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 27 12
allfieldsGer	10.1186/s41016-022-00312-1 doi (DE-627)SPR051268906 (SPR)s41016-022-00312-1-e DE-627 ger DE-627 rakwb eng Wang, Chen verfasserin aut Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. Glioblastoma (dpeaa)DE-He213 Multiple primary tumors (dpeaa)DE-He213 Clinical and pathological characteristics (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Wang, Di aut Pan, Changqing aut Zhang, Jiazheng aut Cheng, Cheng aut Zhai, You aut Yu, Mingchen aut Wang, Zhiliang aut Li, Guanzhang aut Zhang, Wei aut Enthalten in Chinese neurosurgical journal London : BioMed Central, 2015 8(2022), 1 vom: 27. Dez. (DE-627)837397626 (DE-600)2836334-6 2057-4967 nnns volume:8 year:2022 number:1 day:27 month:12 https://dx.doi.org/10.1186/s41016-022-00312-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 27 12
allfieldsSound	10.1186/s41016-022-00312-1 doi (DE-627)SPR051268906 (SPR)s41016-022-00312-1-e DE-627 ger DE-627 rakwb eng Wang, Chen verfasserin aut Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. Glioblastoma (dpeaa)DE-He213 Multiple primary tumors (dpeaa)DE-He213 Clinical and pathological characteristics (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Wang, Di aut Pan, Changqing aut Zhang, Jiazheng aut Cheng, Cheng aut Zhai, You aut Yu, Mingchen aut Wang, Zhiliang aut Li, Guanzhang aut Zhang, Wei aut Enthalten in Chinese neurosurgical journal London : BioMed Central, 2015 8(2022), 1 vom: 27. Dez. (DE-627)837397626 (DE-600)2836334-6 2057-4967 nnns volume:8 year:2022 number:1 day:27 month:12 https://dx.doi.org/10.1186/s41016-022-00312-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 1 27 12
language	English
source	Enthalten in Chinese neurosurgical journal 8(2022), 1 vom: 27. Dez. volume:8 year:2022 number:1 day:27 month:12
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authorswithroles_txt_mv	Wang, Chen @@aut@@ Wang, Di @@aut@@ Pan, Changqing @@aut@@ Zhang, Jiazheng @@aut@@ Cheng, Cheng @@aut@@ Zhai, You @@aut@@ Yu, Mingchen @@aut@@ Wang, Zhiliang @@aut@@ Li, Guanzhang @@aut@@ Zhang, Wei @@aut@@
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The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. 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author	Wang, Chen
spellingShingle	Wang, Chen misc Glioblastoma misc Multiple primary tumors misc Clinical and pathological characteristics misc Prognosis Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors
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topic_title	Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors Glioblastoma (dpeaa)DE-He213 Multiple primary tumors (dpeaa)DE-He213 Clinical and pathological characteristics (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213
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title	Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors
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title_full	Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors
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title_sort	clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors
title_auth	Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors
abstract	Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. © The Author(s) 2022
abstractGer	Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. © The Author(s) 2022
abstract_unstemmed	Background Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation. Methods Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival. Results It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors. Conclusions Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes. © The Author(s) 2022
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title_short	Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors
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author2	Wang, Di Pan, Changqing Zhang, Jiazheng Cheng, Cheng Zhai, You Yu, Mingchen Wang, Zhiliang Li, Guanzhang Zhang, Wei
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Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors

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