Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia

Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shi, Tingting [verfasserIn] Chen, Chen Fan, Huifeng Yu, Minghua Li, Ming Yang, Diyuan Huang, Li Nie, Zhiqiang Lu, Gen

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Extracorporeal membrane oxygenation Children Severe Adenovirus Pneumonia

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: BMC pulmonary medicine - London : BioMed Central, 2001, 23(2023), 1 vom: 30. Jan.
Übergeordnetes Werk:	volume:23 ; year:2023 ; number:1 ; day:30 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12890-022-02284-5

Katalog-ID:	SPR05140253X

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520			\|a Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia.
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allfields	10.1186/s12890-022-02284-5 doi (DE-627)SPR05140253X (SPR)s12890-022-02284-5-e DE-627 ger DE-627 rakwb eng Shi, Tingting verfasserin aut Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. Extracorporeal membrane oxygenation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Severe (dpeaa)DE-He213 Adenovirus (dpeaa)DE-He213 Pneumonia (dpeaa)DE-He213 Chen, Chen aut Fan, Huifeng aut Yu, Minghua aut Li, Ming aut Yang, Diyuan aut Huang, Li aut Nie, Zhiqiang aut Lu, Gen aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 30. Jan. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:30 month:01 https://dx.doi.org/10.1186/s12890-022-02284-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 30 01
spelling	10.1186/s12890-022-02284-5 doi (DE-627)SPR05140253X (SPR)s12890-022-02284-5-e DE-627 ger DE-627 rakwb eng Shi, Tingting verfasserin aut Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. Extracorporeal membrane oxygenation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Severe (dpeaa)DE-He213 Adenovirus (dpeaa)DE-He213 Pneumonia (dpeaa)DE-He213 Chen, Chen aut Fan, Huifeng aut Yu, Minghua aut Li, Ming aut Yang, Diyuan aut Huang, Li aut Nie, Zhiqiang aut Lu, Gen aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 30. Jan. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:30 month:01 https://dx.doi.org/10.1186/s12890-022-02284-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 30 01
allfields_unstemmed	10.1186/s12890-022-02284-5 doi (DE-627)SPR05140253X (SPR)s12890-022-02284-5-e DE-627 ger DE-627 rakwb eng Shi, Tingting verfasserin aut Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. Extracorporeal membrane oxygenation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Severe (dpeaa)DE-He213 Adenovirus (dpeaa)DE-He213 Pneumonia (dpeaa)DE-He213 Chen, Chen aut Fan, Huifeng aut Yu, Minghua aut Li, Ming aut Yang, Diyuan aut Huang, Li aut Nie, Zhiqiang aut Lu, Gen aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 30. Jan. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:30 month:01 https://dx.doi.org/10.1186/s12890-022-02284-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 30 01
allfieldsGer	10.1186/s12890-022-02284-5 doi (DE-627)SPR05140253X (SPR)s12890-022-02284-5-e DE-627 ger DE-627 rakwb eng Shi, Tingting verfasserin aut Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. Extracorporeal membrane oxygenation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Severe (dpeaa)DE-He213 Adenovirus (dpeaa)DE-He213 Pneumonia (dpeaa)DE-He213 Chen, Chen aut Fan, Huifeng aut Yu, Minghua aut Li, Ming aut Yang, Diyuan aut Huang, Li aut Nie, Zhiqiang aut Lu, Gen aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 30. Jan. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:30 month:01 https://dx.doi.org/10.1186/s12890-022-02284-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 30 01
allfieldsSound	10.1186/s12890-022-02284-5 doi (DE-627)SPR05140253X (SPR)s12890-022-02284-5-e DE-627 ger DE-627 rakwb eng Shi, Tingting verfasserin aut Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. Extracorporeal membrane oxygenation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Severe (dpeaa)DE-He213 Adenovirus (dpeaa)DE-He213 Pneumonia (dpeaa)DE-He213 Chen, Chen aut Fan, Huifeng aut Yu, Minghua aut Li, Ming aut Yang, Diyuan aut Huang, Li aut Nie, Zhiqiang aut Lu, Gen aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 30. Jan. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:30 month:01 https://dx.doi.org/10.1186/s12890-022-02284-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 30 01
language	English
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author	Shi, Tingting
spellingShingle	Shi, Tingting misc Extracorporeal membrane oxygenation misc Children misc Severe misc Adenovirus misc Pneumonia Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia
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topic_title	Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia Extracorporeal membrane oxygenation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Severe (dpeaa)DE-He213 Adenovirus (dpeaa)DE-He213 Pneumonia (dpeaa)DE-He213
topic	misc Extracorporeal membrane oxygenation misc Children misc Severe misc Adenovirus misc Pneumonia
topic_unstemmed	misc Extracorporeal membrane oxygenation misc Children misc Severe misc Adenovirus misc Pneumonia
topic_browse	misc Extracorporeal membrane oxygenation misc Children misc Severe misc Adenovirus misc Pneumonia
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title	Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia
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title_full	Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia
author_sort	Shi, Tingting
journal	BMC pulmonary medicine
journalStr	BMC pulmonary medicine
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author_browse	Shi, Tingting Chen, Chen Fan, Huifeng Yu, Minghua Li, Ming Yang, Diyuan Huang, Li Nie, Zhiqiang Lu, Gen
container_volume	23
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author-letter	Shi, Tingting
doi_str_mv	10.1186/s12890-022-02284-5
title_sort	impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia
title_auth	Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia
abstract	Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. © The Author(s) 2023
abstractGer	Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. © The Author(s) 2023
abstract_unstemmed	Background Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children with severe Adv. pneumonia. This study aimed to assess the impact of ECMO in immunocompetent children with severe Adv. pneumonia. Methods This study evaluated the medical records of 168 hospitalized children with severe Adv. pneumonia at the Guangzhou Women and Children’s Medical Center between 2019 and 2020.Nineteen patients in the ECMO group and 149 patients in the non-ECMO group were enrolled. Results Between these two groups, there were no differences in host factors such as sex, age (all P > 0.05). Significant differences were observed in shortness of breath/increased work of breathing; cyanosis; seizures; tachycardia; the partial pressure of oxygen in arterial blood ($ PO_{2} $); the ratio of $ PaO_{2} $ to the fraction concentration of oxygen in inspired air ($ FiO_{2} $; P/F); white blood cell, lymphocyte, monocytes, lactate dehydrogenase (LDH), serum albumin, and procalcitonin levels; and, pulmonary consolidation (all P < 0.05). There were significant differences in the parameters of mechanical ventilation (MV) therapy and complications such as respiratory failure, acute respiratory distress syndrome, septic shock, length of hospitalization, and death (all P < 0.05). The maximum axillary temperatures, respiratory rates, heart rates and LDH levels after receiving ECMO were significantly lower than those before ECMO (all P < 0.05). Additionally, $ SPO_{2} $, $ PO_{2} $, and P/F were significantly higher than those before ECMO (all P < 0.05). In MV therapy, $ FiO_{2} $, PIP, and PEEP were significantly lower than those before ECMO (all P < 0.05). Conclusions In our study, the clinical conditions of the patients in the ECMO group were much more severe than those in the non-ECMO group. Our study showed that ECMO might be beneficial for the patients with severe Adv. pneumonia. © The Author(s) 2023
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container_issue	1
title_short	Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia
url	https://dx.doi.org/10.1186/s12890-022-02284-5
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author2	Chen, Chen Fan, Huifeng Yu, Minghua Li, Ming Yang, Diyuan Huang, Li Nie, Zhiqiang Lu, Gen
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up_date	2024-07-03T21:35:58.138Z
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