There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial

Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Ai...
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Autor*in:	Schmidt, Marc T. [verfasserIn] Studer, Marc Kunz, Andres Studer, Sandro Bonvini, John M. Bueter, Marco Kook, Lucas Haile, Sarah R. Pregernig, Andreas Beck-Schimmer, Beatrice Schläpfer, Martin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Hypoxia apnea tolerance tissue oxygenation cerebral oxygenation

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: BMC anesthesiology - [S.l.] : BioMed Central, 2001, 23(2023), 1 vom: 06. Feb.
Übergeordnetes Werk:	volume:23 ; year:2023 ; number:1 ; day:06 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s12871-023-01982-9

Katalog-ID:	SPR05142407X

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100	1		\|a Schmidt, Marc T. \|e verfasserin \|4 aut
245	1	0	\|a There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial
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520			\|a Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed.
650		4	\|a Hypoxia \|7 (dpeaa)DE-He213
650		4	\|a apnea tolerance \|7 (dpeaa)DE-He213
650		4	\|a tissue oxygenation \|7 (dpeaa)DE-He213
650		4	\|a cerebral oxygenation \|7 (dpeaa)DE-He213
700	1		\|a Studer, Marc \|4 aut
700	1		\|a Kunz, Andres \|4 aut
700	1		\|a Studer, Sandro \|4 aut
700	1		\|a Bonvini, John M. \|4 aut
700	1		\|a Bueter, Marco \|4 aut
700	1		\|a Kook, Lucas \|4 aut
700	1		\|a Haile, Sarah R. \|4 aut
700	1		\|a Pregernig, Andreas \|4 aut
700	1		\|a Beck-Schimmer, Beatrice \|4 aut
700	1		\|a Schläpfer, Martin \|4 aut
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allfields	10.1186/s12871-023-01982-9 doi (DE-627)SPR05142407X (SPR)s12871-023-01982-9-e DE-627 ger DE-627 rakwb eng Schmidt, Marc T. verfasserin aut There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. Hypoxia (dpeaa)DE-He213 apnea tolerance (dpeaa)DE-He213 tissue oxygenation (dpeaa)DE-He213 cerebral oxygenation (dpeaa)DE-He213 Studer, Marc aut Kunz, Andres aut Studer, Sandro aut Bonvini, John M. aut Bueter, Marco aut Kook, Lucas aut Haile, Sarah R. aut Pregernig, Andreas aut Beck-Schimmer, Beatrice aut Schläpfer, Martin aut Enthalten in BMC anesthesiology [S.l.] : BioMed Central, 2001 23(2023), 1 vom: 06. Feb. (DE-627)355422115 (DE-600)2091252-3 1471-2253 nnns volume:23 year:2023 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12871-023-01982-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 06 02
spelling	10.1186/s12871-023-01982-9 doi (DE-627)SPR05142407X (SPR)s12871-023-01982-9-e DE-627 ger DE-627 rakwb eng Schmidt, Marc T. verfasserin aut There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. Hypoxia (dpeaa)DE-He213 apnea tolerance (dpeaa)DE-He213 tissue oxygenation (dpeaa)DE-He213 cerebral oxygenation (dpeaa)DE-He213 Studer, Marc aut Kunz, Andres aut Studer, Sandro aut Bonvini, John M. aut Bueter, Marco aut Kook, Lucas aut Haile, Sarah R. aut Pregernig, Andreas aut Beck-Schimmer, Beatrice aut Schläpfer, Martin aut Enthalten in BMC anesthesiology [S.l.] : BioMed Central, 2001 23(2023), 1 vom: 06. Feb. (DE-627)355422115 (DE-600)2091252-3 1471-2253 nnns volume:23 year:2023 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12871-023-01982-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 06 02
allfields_unstemmed	10.1186/s12871-023-01982-9 doi (DE-627)SPR05142407X (SPR)s12871-023-01982-9-e DE-627 ger DE-627 rakwb eng Schmidt, Marc T. verfasserin aut There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. Hypoxia (dpeaa)DE-He213 apnea tolerance (dpeaa)DE-He213 tissue oxygenation (dpeaa)DE-He213 cerebral oxygenation (dpeaa)DE-He213 Studer, Marc aut Kunz, Andres aut Studer, Sandro aut Bonvini, John M. aut Bueter, Marco aut Kook, Lucas aut Haile, Sarah R. aut Pregernig, Andreas aut Beck-Schimmer, Beatrice aut Schläpfer, Martin aut Enthalten in BMC anesthesiology [S.l.] : BioMed Central, 2001 23(2023), 1 vom: 06. Feb. (DE-627)355422115 (DE-600)2091252-3 1471-2253 nnns volume:23 year:2023 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12871-023-01982-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 06 02
allfieldsGer	10.1186/s12871-023-01982-9 doi (DE-627)SPR05142407X (SPR)s12871-023-01982-9-e DE-627 ger DE-627 rakwb eng Schmidt, Marc T. verfasserin aut There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. Hypoxia (dpeaa)DE-He213 apnea tolerance (dpeaa)DE-He213 tissue oxygenation (dpeaa)DE-He213 cerebral oxygenation (dpeaa)DE-He213 Studer, Marc aut Kunz, Andres aut Studer, Sandro aut Bonvini, John M. aut Bueter, Marco aut Kook, Lucas aut Haile, Sarah R. aut Pregernig, Andreas aut Beck-Schimmer, Beatrice aut Schläpfer, Martin aut Enthalten in BMC anesthesiology [S.l.] : BioMed Central, 2001 23(2023), 1 vom: 06. Feb. (DE-627)355422115 (DE-600)2091252-3 1471-2253 nnns volume:23 year:2023 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12871-023-01982-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 06 02
allfieldsSound	10.1186/s12871-023-01982-9 doi (DE-627)SPR05142407X (SPR)s12871-023-01982-9-e DE-627 ger DE-627 rakwb eng Schmidt, Marc T. verfasserin aut There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. Hypoxia (dpeaa)DE-He213 apnea tolerance (dpeaa)DE-He213 tissue oxygenation (dpeaa)DE-He213 cerebral oxygenation (dpeaa)DE-He213 Studer, Marc aut Kunz, Andres aut Studer, Sandro aut Bonvini, John M. aut Bueter, Marco aut Kook, Lucas aut Haile, Sarah R. aut Pregernig, Andreas aut Beck-Schimmer, Beatrice aut Schläpfer, Martin aut Enthalten in BMC anesthesiology [S.l.] : BioMed Central, 2001 23(2023), 1 vom: 06. Feb. (DE-627)355422115 (DE-600)2091252-3 1471-2253 nnns volume:23 year:2023 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12871-023-01982-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 06 02
language	English
source	Enthalten in BMC anesthesiology 23(2023), 1 vom: 06. Feb. volume:23 year:2023 number:1 day:06 month:02
sourceStr	Enthalten in BMC anesthesiology 23(2023), 1 vom: 06. Feb. volume:23 year:2023 number:1 day:06 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Hypoxia apnea tolerance tissue oxygenation cerebral oxygenation
isfreeaccess_bool	true
container_title	BMC anesthesiology
authorswithroles_txt_mv	Schmidt, Marc T. @@aut@@ Studer, Marc @@aut@@ Kunz, Andres @@aut@@ Studer, Sandro @@aut@@ Bonvini, John M. @@aut@@ Bueter, Marco @@aut@@ Kook, Lucas @@aut@@ Haile, Sarah R. @@aut@@ Pregernig, Andreas @@aut@@ Beck-Schimmer, Beatrice @@aut@@ Schläpfer, Martin @@aut@@
publishDateDaySort_date	2023-02-06T00:00:00Z
hierarchy_top_id	355422115
id	SPR05142407X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR05142407X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230510062234.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230508s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12871-023-01982-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR05142407X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12871-023-01982-9-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Schmidt, Marc T.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2023</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. 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author	Schmidt, Marc T.
spellingShingle	Schmidt, Marc T. misc Hypoxia misc apnea tolerance misc tissue oxygenation misc cerebral oxygenation There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial
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topic_title	There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial Hypoxia (dpeaa)DE-He213 apnea tolerance (dpeaa)DE-He213 tissue oxygenation (dpeaa)DE-He213 cerebral oxygenation (dpeaa)DE-He213
topic	misc Hypoxia misc apnea tolerance misc tissue oxygenation misc cerebral oxygenation
topic_unstemmed	misc Hypoxia misc apnea tolerance misc tissue oxygenation misc cerebral oxygenation
topic_browse	misc Hypoxia misc apnea tolerance misc tissue oxygenation misc cerebral oxygenation
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title	There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial
ctrlnum	(DE-627)SPR05142407X (SPR)s12871-023-01982-9-e
title_full	There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial
author_sort	Schmidt, Marc T.
journal	BMC anesthesiology
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author_browse	Schmidt, Marc T. Studer, Marc Kunz, Andres Studer, Sandro Bonvini, John M. Bueter, Marco Kook, Lucas Haile, Sarah R. Pregernig, Andreas Beck-Schimmer, Beatrice Schläpfer, Martin
container_volume	23
format_se	Elektronische Aufsätze
author-letter	Schmidt, Marc T.
doi_str_mv	10.1186/s12871-023-01982-9
title_sort	there is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial
title_auth	There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial
abstract	Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. © The Author(s) 2023
abstractGer	Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. © The Author(s) 2023
abstract_unstemmed	Purpose Carbon dioxide ($ CO_{2} $) increases cerebral perfusion. The effect of $ CO_{2} $ on apnea tolerance, such as after anesthesia induction, is unknown. This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing $ O_{2} $/Air (95%$ O_{2} $) to $ O_{2} $/$ CO_{2} $ (95%$ O_{2} $/5%$ CO_{2} $). Methods In this single-center, single-blinded, randomized crossover trial, 30 patients 18–65 years, with body mass index > 35 kg/$ m^{2} $, requiring general anesthesia for bariatric surgery, underwent two apneas that were preceded by ventilation with either $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ in random order. After anesthesia induction, intubation, and ventilation with $ O_{2} $/Air or $ O_{2} $/$ CO_{2} $ for 10 min, apnea was performed until the cerebral tissue oxygenation index (TOI) dropped by a relative 20% from baseline (primary endpoint) or oxygen saturation ($ SpO_{2} $) reached 80% (safety abortion criterion). The intervention was then repeated with the second substance. Results The safety criterion was reached in all patients before cerebral TOI decreased by 20%. The time until $ SpO_{2} $ dropped to 80% was similar in the two groups (+ 6 s with $ O_{2} $/$ CO_{2} $, 95%CI -7 to 19 s, p = 0.37). Cerebral TOI and $ PaO_{2} $ were higher after $ O_{2} $/$ CO_{2} $ (+ 1.5%; 95%CI: from 0.3 to 2.6; p = 0.02 and + 0.6 kPa; 95%CI: 0.1 to 1.1; p = 0.02). Conclusion $ O_{2} $/$ CO_{2} $ improves cerebral TOI and $ PaO_{2} $ in anesthetized bariatric patients. Better apnea tolerance could not be confirmed. © The Author(s) 2023
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title_short	There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial
url	https://dx.doi.org/10.1186/s12871-023-01982-9
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author2	Studer, Marc Kunz, Andres Studer, Sandro Bonvini, John M. Bueter, Marco Kook, Lucas Haile, Sarah R. Pregernig, Andreas Beck-Schimmer, Beatrice Schläpfer, Martin
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up_date	2024-07-03T21:43:24.252Z
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There is no evidence that carbon dioxide-enriched oxygen before apnea affects the time to arterial desaturation, but it might improve cerebral oxygenation in anesthetized obese patients: a single-blinded randomized crossover trial

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