Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis

Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded w...
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Autor*in:	Zhang, Caiyun [verfasserIn] Wang, Peng Zhang, Ya’ nan Lu, Pengpeng Huang, Xiaodan Wang, Yinfeng Ran, Lang Xin, Huan Xu, Xiaotong Gao, Wenjuan Sun, Yu Zhang, Li Zhang, Guilong

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Biodegradable nanoplatform Tumor microenvironment Increased acidity Starvation therapy Enhanced chemodynamic therapy

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Journal of nanobiotechnology - London : Biomed Central, 2003, 21(2023), 1 vom: 22. Feb.
Übergeordnetes Werk:	volume:21 ; year:2023 ; number:1 ; day:22 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s12951-023-01814-5

Katalog-ID:	SPR051485028

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520			\|a Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics.
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700	1		\|a Zhang, Guilong \|4 aut
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allfields	10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02
spelling	10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02
allfields_unstemmed	10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02
allfieldsGer	10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02
allfieldsSound	10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02
language	English
source	Enthalten in Journal of nanobiotechnology 21(2023), 1 vom: 22. Feb. volume:21 year:2023 number:1 day:22 month:02
sourceStr	Enthalten in Journal of nanobiotechnology 21(2023), 1 vom: 22. Feb. volume:21 year:2023 number:1 day:22 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biodegradable nanoplatform Tumor microenvironment Increased acidity Starvation therapy Enhanced chemodynamic therapy
isfreeaccess_bool	true
container_title	Journal of nanobiotechnology
authorswithroles_txt_mv	Zhang, Caiyun @@aut@@ Wang, Peng @@aut@@ Zhang, Ya’ nan @@aut@@ Lu, Pengpeng @@aut@@ Huang, Xiaodan @@aut@@ Wang, Yinfeng @@aut@@ Ran, Lang @@aut@@ Xin, Huan @@aut@@ Xu, Xiaotong @@aut@@ Gao, Wenjuan @@aut@@ Sun, Yu @@aut@@ Zhang, Li @@aut@@ Zhang, Guilong @@aut@@
publishDateDaySort_date	2023-02-22T00:00:00Z
hierarchy_top_id	362770328
id	SPR051485028
language_de	englisch
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author	Zhang, Caiyun
spellingShingle	Zhang, Caiyun misc Biodegradable nanoplatform misc Tumor microenvironment misc Increased acidity misc Starvation therapy misc Enhanced chemodynamic therapy Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis
authorStr	Zhang, Caiyun
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topic_title	Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213
topic	misc Biodegradable nanoplatform misc Tumor microenvironment misc Increased acidity misc Starvation therapy misc Enhanced chemodynamic therapy
topic_unstemmed	misc Biodegradable nanoplatform misc Tumor microenvironment misc Increased acidity misc Starvation therapy misc Enhanced chemodynamic therapy
topic_browse	misc Biodegradable nanoplatform misc Tumor microenvironment misc Increased acidity misc Starvation therapy misc Enhanced chemodynamic therapy
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title	Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis
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title_full	Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis
author_sort	Zhang, Caiyun
journal	Journal of nanobiotechnology
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author_browse	Zhang, Caiyun Wang, Peng Zhang, Ya’ nan Lu, Pengpeng Huang, Xiaodan Wang, Yinfeng Ran, Lang Xin, Huan Xu, Xiaotong Gao, Wenjuan Sun, Yu Zhang, Li Zhang, Guilong
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author-letter	Zhang, Caiyun
doi_str_mv	10.1186/s12951-023-01814-5
title_sort	biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis
title_auth	Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis
abstract	Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. © The Author(s) 2023
abstractGer	Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. © The Author(s) 2023
abstract_unstemmed	Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. © The Author(s) 2023
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title_short	Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis
url	https://dx.doi.org/10.1186/s12951-023-01814-5
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author2	Wang, Peng Zhang, Ya’ nan Lu, Pengpeng Huang, Xiaodan Wang, Yinfeng Ran, Lang Xin, Huan Xu, Xiaotong Gao, Wenjuan Sun, Yu Zhang, Li Zhang, Guilong
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