Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis
Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded w...
Ausführliche Beschreibung
Autor*in: |
Zhang, Caiyun [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2023 |
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Übergeordnetes Werk: |
Enthalten in: Journal of nanobiotechnology - London : Biomed Central, 2003, 21(2023), 1 vom: 22. Feb. |
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Übergeordnetes Werk: |
volume:21 ; year:2023 ; number:1 ; day:22 ; month:02 |
Links: |
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DOI / URN: |
10.1186/s12951-023-01814-5 |
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Katalog-ID: |
SPR051485028 |
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520 | |a Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. | ||
650 | 4 | |a Biodegradable nanoplatform |7 (dpeaa)DE-He213 | |
650 | 4 | |a Tumor microenvironment |7 (dpeaa)DE-He213 | |
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700 | 1 | |a Wang, Peng |4 aut | |
700 | 1 | |a Zhang, Ya’ nan |4 aut | |
700 | 1 | |a Lu, Pengpeng |4 aut | |
700 | 1 | |a Huang, Xiaodan |4 aut | |
700 | 1 | |a Wang, Yinfeng |4 aut | |
700 | 1 | |a Ran, Lang |4 aut | |
700 | 1 | |a Xin, Huan |4 aut | |
700 | 1 | |a Xu, Xiaotong |4 aut | |
700 | 1 | |a Gao, Wenjuan |4 aut | |
700 | 1 | |a Sun, Yu |4 aut | |
700 | 1 | |a Zhang, Li |4 aut | |
700 | 1 | |a Zhang, Guilong |4 aut | |
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10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02 |
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10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02 |
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10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02 |
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10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02 |
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10.1186/s12951-023-01814-5 doi (DE-627)SPR051485028 (SPR)s12951-023-01814-5-e DE-627 ger DE-627 rakwb eng Zhang, Caiyun verfasserin aut Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. Biodegradable nanoplatform (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Increased acidity (dpeaa)DE-He213 Starvation therapy (dpeaa)DE-He213 Enhanced chemodynamic therapy (dpeaa)DE-He213 Wang, Peng aut Zhang, Ya’ nan aut Lu, Pengpeng aut Huang, Xiaodan aut Wang, Yinfeng aut Ran, Lang aut Xin, Huan aut Xu, Xiaotong aut Gao, Wenjuan aut Sun, Yu aut Zhang, Li aut Zhang, Guilong aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 21(2023), 1 vom: 22. Feb. (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:21 year:2023 number:1 day:22 month:02 https://dx.doi.org/10.1186/s12951-023-01814-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 22 02 |
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biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis |
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Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis |
abstract |
Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. © The Author(s) 2023 |
abstractGer |
Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. © The Author(s) 2023 |
abstract_unstemmed |
Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous $ H_{2} %$ O_{2} $ generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells induces the disintegration of pLMOFePt-TGO, releasing FePt, GOx, and TAM. The synergistic action of GOx and TAM significantly enhanced the acidity and $ H_{2} %$ O_{2} $ level in the TME by aerobiotic glucose consumption and hypoxic glycolysis pathways, respectively. The combined effect of GSH depletion, acidity enhancement, and $ H_{2} %$ O_{2} $ supplementation dramatically promotes the Fenton-catalytic behavior of FePt alloys, which, in combination with tumor starvation caused by GOx and TAM-mediated chemotherapy, significantly increases the anticancer efficacy of this treatment. In addition, $ T_{2} $-shortening caused by FePt alloys released in TME significantly enhances contrast in the MRI signal of tumor, enabling a more accurate diagnosis. Results of in vitro and in vivo experiments suggest that pLMOFePt-TGO can effectively suppress tumor growth and angiogenesis, thus providing an exciting potential strategy for developing satisfactory tumor theranostics. © The Author(s) 2023 |
collection_details |
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container_issue |
1 |
title_short |
Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis |
url |
https://dx.doi.org/10.1186/s12951-023-01814-5 |
remote_bool |
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author2 |
Wang, Peng Zhang, Ya’ nan Lu, Pengpeng Huang, Xiaodan Wang, Yinfeng Ran, Lang Xin, Huan Xu, Xiaotong Gao, Wenjuan Sun, Yu Zhang, Li Zhang, Guilong |
author2Str |
Wang, Peng Zhang, Ya’ nan Lu, Pengpeng Huang, Xiaodan Wang, Yinfeng Ran, Lang Xin, Huan Xu, Xiaotong Gao, Wenjuan Sun, Yu Zhang, Li Zhang, Guilong |
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doi_str |
10.1186/s12951-023-01814-5 |
up_date |
2024-07-03T22:05:16.826Z |
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