Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ol’khovich, Marina [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Korean Institute of Chemical Engineers 2023 |
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| Übergeordnetes Werk: |
Enthalten in: The Korean journal of chemical engineering - Seoul : Inst., 1984, 40(2023), 6 vom: 17. Mai, Seite 1474-1485 |
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| Übergeordnetes Werk: |
volume:40 ; year:2023 ; number:6 ; day:17 ; month:05 ; pages:1474-1485 |
| Links: |
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| DOI / URN: |
10.1007/s11814-023-1429-8 |
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| Katalog-ID: |
SPR051897563 |
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| 100 | 1 | |a Ol’khovich, Marina |e verfasserin |4 aut | |
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| 520 | |a Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. | ||
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| 650 | 4 | |a Solubility |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Solvation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Activity Coefficients |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Partition |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Thermodynamics |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sharapova, Angelica |4 aut | |
| 700 | 1 | |a Blokhina, Svetlana |4 aut | |
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10.1007/s11814-023-1429-8 doi (DE-627)SPR051897563 (SPR)s11814-023-1429-8-e DE-627 ger DE-627 rakwb eng Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin (dpeaa)DE-He213 Solubility (dpeaa)DE-He213 Solvation (dpeaa)DE-He213 Activity Coefficients (dpeaa)DE-He213 Partition (dpeaa)DE-He213 Thermodynamics (dpeaa)DE-He213 Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Seoul : Inst., 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)391337246 (DE-600)2152566-3 1975-7220 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://dx.doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)SPR051897563 (SPR)s11814-023-1429-8-e DE-627 ger DE-627 rakwb eng Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin (dpeaa)DE-He213 Solubility (dpeaa)DE-He213 Solvation (dpeaa)DE-He213 Activity Coefficients (dpeaa)DE-He213 Partition (dpeaa)DE-He213 Thermodynamics (dpeaa)DE-He213 Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Seoul : Inst., 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)391337246 (DE-600)2152566-3 1975-7220 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://dx.doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)SPR051897563 (SPR)s11814-023-1429-8-e DE-627 ger DE-627 rakwb eng Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin (dpeaa)DE-He213 Solubility (dpeaa)DE-He213 Solvation (dpeaa)DE-He213 Activity Coefficients (dpeaa)DE-He213 Partition (dpeaa)DE-He213 Thermodynamics (dpeaa)DE-He213 Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Seoul : Inst., 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)391337246 (DE-600)2152566-3 1975-7220 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://dx.doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)SPR051897563 (SPR)s11814-023-1429-8-e DE-627 ger DE-627 rakwb eng Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin (dpeaa)DE-He213 Solubility (dpeaa)DE-He213 Solvation (dpeaa)DE-He213 Activity Coefficients (dpeaa)DE-He213 Partition (dpeaa)DE-He213 Thermodynamics (dpeaa)DE-He213 Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Seoul : Inst., 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)391337246 (DE-600)2152566-3 1975-7220 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://dx.doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)SPR051897563 (SPR)s11814-023-1429-8-e DE-627 ger DE-627 rakwb eng Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin (dpeaa)DE-He213 Solubility (dpeaa)DE-He213 Solvation (dpeaa)DE-He213 Activity Coefficients (dpeaa)DE-He213 Partition (dpeaa)DE-He213 Thermodynamics (dpeaa)DE-He213 Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Seoul : Inst., 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)391337246 (DE-600)2152566-3 1975-7220 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://dx.doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 40 2023 6 17 05 1474-1485 |
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It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. 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| author |
Ol’khovich, Marina |
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Ol’khovich, Marina misc Griseofulvin misc Solubility misc Solvation misc Activity Coefficients misc Partition misc Thermodynamics Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
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Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes Griseofulvin (dpeaa)DE-He213 Solubility (dpeaa)DE-He213 Solvation (dpeaa)DE-He213 Activity Coefficients (dpeaa)DE-He213 Partition (dpeaa)DE-He213 Thermodynamics (dpeaa)DE-He213 |
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Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
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Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
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Ol’khovich, Marina |
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10.1007/s11814-023-1429-8 |
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griseofulvin: thermodynamic insight to solubility, solvation and partition processes |
| title_auth |
Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
| abstract |
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. © The Korean Institute of Chemical Engineers 2023 |
| abstractGer |
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. © The Korean Institute of Chemical Engineers 2023 |
| abstract_unstemmed |
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. © The Korean Institute of Chemical Engineers 2023 |
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Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
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https://dx.doi.org/10.1007/s11814-023-1429-8 |
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Sharapova, Angelica Blokhina, Svetlana |
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10.1007/s11814-023-1429-8 |
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2024-07-04T00:19:50.465Z |
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| score |
7.402648 |