Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease

Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean...
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Autor*in:	Ishido, Shun [verfasserIn] Tamaki, Nobuharu Takahashi, Yuka Uchihara, Naoki Suzuki, Keito Tanaka, Yuki Miyamoto, Haruka Yamada, Michiko Matsumoto, Hiroaki Nobusawa, Tsubasa Keitoku, Taisei Takaura, Kenta Tanaka, Shohei Maeyashiki, Chiaki Yasui, Yutaka Tsuchiya, Kaoru Nakanishi, Hiroyuki Kurosaki, Masayuki Izumi, Namiki

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	NAFLD Lean NAFLD Non-lean NAFLD Cardiovascular disease

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: BMC gastroenterology - London : BioMed Central, 2001, 23(2023), 1 vom: 17. Juni
Übergeordnetes Werk:	volume:23 ; year:2023 ; number:1 ; day:17 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12876-023-02848-7

Katalog-ID:	SPR051941783

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520			\|a Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD.
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allfields	10.1186/s12876-023-02848-7 doi (DE-627)SPR051941783 (SPR)s12876-023-02848-7-e DE-627 ger DE-627 rakwb eng Ishido, Shun verfasserin aut Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. NAFLD (dpeaa)DE-He213 Lean NAFLD (dpeaa)DE-He213 Non-lean NAFLD (dpeaa)DE-He213 Cardiovascular disease (dpeaa)DE-He213 Tamaki, Nobuharu aut Takahashi, Yuka aut Uchihara, Naoki aut Suzuki, Keito aut Tanaka, Yuki aut Miyamoto, Haruka aut Yamada, Michiko aut Matsumoto, Hiroaki aut Nobusawa, Tsubasa aut Keitoku, Taisei aut Takaura, Kenta aut Tanaka, Shohei aut Maeyashiki, Chiaki aut Yasui, Yutaka aut Tsuchiya, Kaoru aut Nakanishi, Hiroyuki aut Kurosaki, Masayuki aut Izumi, Namiki aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 23(2023), 1 vom: 17. Juni (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:23 year:2023 number:1 day:17 month:06 https://dx.doi.org/10.1186/s12876-023-02848-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 17 06
spelling	10.1186/s12876-023-02848-7 doi (DE-627)SPR051941783 (SPR)s12876-023-02848-7-e DE-627 ger DE-627 rakwb eng Ishido, Shun verfasserin aut Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. NAFLD (dpeaa)DE-He213 Lean NAFLD (dpeaa)DE-He213 Non-lean NAFLD (dpeaa)DE-He213 Cardiovascular disease (dpeaa)DE-He213 Tamaki, Nobuharu aut Takahashi, Yuka aut Uchihara, Naoki aut Suzuki, Keito aut Tanaka, Yuki aut Miyamoto, Haruka aut Yamada, Michiko aut Matsumoto, Hiroaki aut Nobusawa, Tsubasa aut Keitoku, Taisei aut Takaura, Kenta aut Tanaka, Shohei aut Maeyashiki, Chiaki aut Yasui, Yutaka aut Tsuchiya, Kaoru aut Nakanishi, Hiroyuki aut Kurosaki, Masayuki aut Izumi, Namiki aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 23(2023), 1 vom: 17. Juni (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:23 year:2023 number:1 day:17 month:06 https://dx.doi.org/10.1186/s12876-023-02848-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 17 06
allfields_unstemmed	10.1186/s12876-023-02848-7 doi (DE-627)SPR051941783 (SPR)s12876-023-02848-7-e DE-627 ger DE-627 rakwb eng Ishido, Shun verfasserin aut Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. NAFLD (dpeaa)DE-He213 Lean NAFLD (dpeaa)DE-He213 Non-lean NAFLD (dpeaa)DE-He213 Cardiovascular disease (dpeaa)DE-He213 Tamaki, Nobuharu aut Takahashi, Yuka aut Uchihara, Naoki aut Suzuki, Keito aut Tanaka, Yuki aut Miyamoto, Haruka aut Yamada, Michiko aut Matsumoto, Hiroaki aut Nobusawa, Tsubasa aut Keitoku, Taisei aut Takaura, Kenta aut Tanaka, Shohei aut Maeyashiki, Chiaki aut Yasui, Yutaka aut Tsuchiya, Kaoru aut Nakanishi, Hiroyuki aut Kurosaki, Masayuki aut Izumi, Namiki aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 23(2023), 1 vom: 17. Juni (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:23 year:2023 number:1 day:17 month:06 https://dx.doi.org/10.1186/s12876-023-02848-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 17 06
allfieldsGer	10.1186/s12876-023-02848-7 doi (DE-627)SPR051941783 (SPR)s12876-023-02848-7-e DE-627 ger DE-627 rakwb eng Ishido, Shun verfasserin aut Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. NAFLD (dpeaa)DE-He213 Lean NAFLD (dpeaa)DE-He213 Non-lean NAFLD (dpeaa)DE-He213 Cardiovascular disease (dpeaa)DE-He213 Tamaki, Nobuharu aut Takahashi, Yuka aut Uchihara, Naoki aut Suzuki, Keito aut Tanaka, Yuki aut Miyamoto, Haruka aut Yamada, Michiko aut Matsumoto, Hiroaki aut Nobusawa, Tsubasa aut Keitoku, Taisei aut Takaura, Kenta aut Tanaka, Shohei aut Maeyashiki, Chiaki aut Yasui, Yutaka aut Tsuchiya, Kaoru aut Nakanishi, Hiroyuki aut Kurosaki, Masayuki aut Izumi, Namiki aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 23(2023), 1 vom: 17. Juni (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:23 year:2023 number:1 day:17 month:06 https://dx.doi.org/10.1186/s12876-023-02848-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 17 06
allfieldsSound	10.1186/s12876-023-02848-7 doi (DE-627)SPR051941783 (SPR)s12876-023-02848-7-e DE-627 ger DE-627 rakwb eng Ishido, Shun verfasserin aut Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. NAFLD (dpeaa)DE-He213 Lean NAFLD (dpeaa)DE-He213 Non-lean NAFLD (dpeaa)DE-He213 Cardiovascular disease (dpeaa)DE-He213 Tamaki, Nobuharu aut Takahashi, Yuka aut Uchihara, Naoki aut Suzuki, Keito aut Tanaka, Yuki aut Miyamoto, Haruka aut Yamada, Michiko aut Matsumoto, Hiroaki aut Nobusawa, Tsubasa aut Keitoku, Taisei aut Takaura, Kenta aut Tanaka, Shohei aut Maeyashiki, Chiaki aut Yasui, Yutaka aut Tsuchiya, Kaoru aut Nakanishi, Hiroyuki aut Kurosaki, Masayuki aut Izumi, Namiki aut Enthalten in BMC gastroenterology London : BioMed Central, 2001 23(2023), 1 vom: 17. Juni (DE-627)326643702 (DE-600)2041351-8 1471-230X nnns volume:23 year:2023 number:1 day:17 month:06 https://dx.doi.org/10.1186/s12876-023-02848-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 17 06
language	English
source	Enthalten in BMC gastroenterology 23(2023), 1 vom: 17. Juni volume:23 year:2023 number:1 day:17 month:06
sourceStr	Enthalten in BMC gastroenterology 23(2023), 1 vom: 17. Juni volume:23 year:2023 number:1 day:17 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	NAFLD Lean NAFLD Non-lean NAFLD Cardiovascular disease
isfreeaccess_bool	true
container_title	BMC gastroenterology
authorswithroles_txt_mv	Ishido, Shun @@aut@@ Tamaki, Nobuharu @@aut@@ Takahashi, Yuka @@aut@@ Uchihara, Naoki @@aut@@ Suzuki, Keito @@aut@@ Tanaka, Yuki @@aut@@ Miyamoto, Haruka @@aut@@ Yamada, Michiko @@aut@@ Matsumoto, Hiroaki @@aut@@ Nobusawa, Tsubasa @@aut@@ Keitoku, Taisei @@aut@@ Takaura, Kenta @@aut@@ Tanaka, Shohei @@aut@@ Maeyashiki, Chiaki @@aut@@ Yasui, Yutaka @@aut@@ Tsuchiya, Kaoru @@aut@@ Nakanishi, Hiroyuki @@aut@@ Kurosaki, Masayuki @@aut@@ Izumi, Namiki @@aut@@
publishDateDaySort_date	2023-06-17T00:00:00Z
hierarchy_top_id	326643702
id	SPR051941783
language_de	englisch
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However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. 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author	Ishido, Shun
spellingShingle	Ishido, Shun misc NAFLD misc Lean NAFLD misc Non-lean NAFLD misc Cardiovascular disease Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
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topic_title	Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease NAFLD (dpeaa)DE-He213 Lean NAFLD (dpeaa)DE-He213 Non-lean NAFLD (dpeaa)DE-He213 Cardiovascular disease (dpeaa)DE-He213
topic	misc NAFLD misc Lean NAFLD misc Non-lean NAFLD misc Cardiovascular disease
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title	Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
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title_full	Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
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author_browse	Ishido, Shun Tamaki, Nobuharu Takahashi, Yuka Uchihara, Naoki Suzuki, Keito Tanaka, Yuki Miyamoto, Haruka Yamada, Michiko Matsumoto, Hiroaki Nobusawa, Tsubasa Keitoku, Taisei Takaura, Kenta Tanaka, Shohei Maeyashiki, Chiaki Yasui, Yutaka Tsuchiya, Kaoru Nakanishi, Hiroyuki Kurosaki, Masayuki Izumi, Namiki
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doi_str_mv	10.1186/s12876-023-02848-7
title_sort	risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
title_auth	Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
abstract	Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. © The Author(s) 2023
abstractGer	Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. © The Author(s) 2023
abstract_unstemmed	Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aimed to compare the CVD incidence in Japanese patients with lean NAFLD and those with non-lean NAFLD. Methods A total of 581 patients with NAFLD (219 with lean and 362 with non-lean NAFLD) were recruited. All patients underwent annual health checkups for at least 3 years, and CVD incidence was investigated during follow-up. The primary end-point was CVD incidence at 3 years. Results The 3-year new CVD incidence rates in patients with lean and non-lean NAFLD were 2.3% and 3.9%, respectively, and there was no significant difference between two groups (p = 0.3). Multivariable analysis adjusted for age, sex, hypertension, diabetes, and lean NAFLD/non-lean NAFLD revealed that age (every 10 years) as an independent factor associated with CVD incidence with an odds ratio (OR) of 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas lean NAFLD was not associated with CVD incidence (OR: 0.6; 95% CI: 0.2–1.9). Conclusions CVD incidence was comparable between patients with lean NAFLD and those with non-lean NAFLD. Therefore, CVD prevention is needed even in patients with lean NAFLD. © The Author(s) 2023
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title_short	Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
url	https://dx.doi.org/10.1186/s12876-023-02848-7
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author2	Tamaki, Nobuharu Takahashi, Yuka Uchihara, Naoki Suzuki, Keito Tanaka, Yuki Miyamoto, Haruka Yamada, Michiko Matsumoto, Hiroaki Nobusawa, Tsubasa Keitoku, Taisei Takaura, Kenta Tanaka, Shohei Maeyashiki, Chiaki Yasui, Yutaka Tsuchiya, Kaoru Nakanishi, Hiroyuki Kurosaki, Masayuki Izumi, Namiki
author2Str	Tamaki, Nobuharu Takahashi, Yuka Uchihara, Naoki Suzuki, Keito Tanaka, Yuki Miyamoto, Haruka Yamada, Michiko Matsumoto, Hiroaki Nobusawa, Tsubasa Keitoku, Taisei Takaura, Kenta Tanaka, Shohei Maeyashiki, Chiaki Yasui, Yutaka Tsuchiya, Kaoru Nakanishi, Hiroyuki Kurosaki, Masayuki Izumi, Namiki
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