Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats

Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Edo, Great Iruoghene [verfasserIn] Ugbune, Ufuoma Onoharigho, Favour Ogheneoruese Ezekiel, Gracious Okeoghene Agbo, Joy Johnson

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Nephrotoxicity Antioxidant Paracetamol Phytochemicals

Anmerkung:	© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Nutrire - [London] : BioMed Central, 2000, 48(2023), 1 vom: 15. Mai
Übergeordnetes Werk:	volume:48 ; year:2023 ; number:1 ; day:15 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s41110-023-00214-x

Katalog-ID:	SPR052076350

Internformat


LEADER	01000caa a22002652 4500
001	SPR052076350
003	DE-627
005	20230726104615.0
007	cr uuu---uuuuu
008	230628s2023 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1186/s41110-023-00214-x \|2 doi
035			\|a (DE-627)SPR052076350
035			\|a (SPR)s41110-023-00214-x-e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	1		\|a Edo, Great Iruoghene \|e verfasserin \|4 aut
245	1	0	\|a Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats
264		1	\|c 2023
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
520			\|a Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity.
650		4	\|a Nephrotoxicity \|7 (dpeaa)DE-He213
650		4	\|a Antioxidant \|7 (dpeaa)DE-He213
650		4	\|a Paracetamol \|7 (dpeaa)DE-He213
650		4	\|a Phytochemicals \|7 (dpeaa)DE-He213
700	1		\|a Ugbune, Ufuoma \|4 aut
700	1		\|a Onoharigho, Favour Ogheneoruese \|4 aut
700	1		\|a Ezekiel, Gracious Okeoghene \|4 aut
700	1		\|a Agbo, Joy Johnson \|4 aut
773	0	8	\|i Enthalten in \|t Nutrire \|d [London] : BioMed Central, 2000 \|g 48(2023), 1 vom: 15. Mai \|w (DE-627)859794636 \|w (DE-600)2856760-2 \|x 2316-7874 \|7 nnns
773	1	8	\|g volume:48 \|g year:2023 \|g number:1 \|g day:15 \|g month:05
856	4	0	\|u https://dx.doi.org/10.1186/s41110-023-00214-x \|z lizenzpflichtig \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_SPRINGER
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 48 \|j 2023 \|e 1 \|b 15 \|c 05

Indexfelder

author_variant	g i e gi gie u u uu f o o fo foo g o e go goe j j a jj jja
matchkey_str	article:23167874:2023----::nixdnatvteorisniidcwldoaeadeoadehortciefetnaaeaoi
hierarchy_sort_str	2023
publishDate	2023
allfields	10.1186/s41110-023-00214-x doi (DE-627)SPR052076350 (SPR)s41110-023-00214-x-e DE-627 ger DE-627 rakwb eng Edo, Great Iruoghene verfasserin aut Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. Nephrotoxicity (dpeaa)DE-He213 Antioxidant (dpeaa)DE-He213 Paracetamol (dpeaa)DE-He213 Phytochemicals (dpeaa)DE-He213 Ugbune, Ufuoma aut Onoharigho, Favour Ogheneoruese aut Ezekiel, Gracious Okeoghene aut Agbo, Joy Johnson aut Enthalten in Nutrire [London] : BioMed Central, 2000 48(2023), 1 vom: 15. Mai (DE-627)859794636 (DE-600)2856760-2 2316-7874 nnns volume:48 year:2023 number:1 day:15 month:05 https://dx.doi.org/10.1186/s41110-023-00214-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2023 1 15 05
spelling	10.1186/s41110-023-00214-x doi (DE-627)SPR052076350 (SPR)s41110-023-00214-x-e DE-627 ger DE-627 rakwb eng Edo, Great Iruoghene verfasserin aut Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. Nephrotoxicity (dpeaa)DE-He213 Antioxidant (dpeaa)DE-He213 Paracetamol (dpeaa)DE-He213 Phytochemicals (dpeaa)DE-He213 Ugbune, Ufuoma aut Onoharigho, Favour Ogheneoruese aut Ezekiel, Gracious Okeoghene aut Agbo, Joy Johnson aut Enthalten in Nutrire [London] : BioMed Central, 2000 48(2023), 1 vom: 15. Mai (DE-627)859794636 (DE-600)2856760-2 2316-7874 nnns volume:48 year:2023 number:1 day:15 month:05 https://dx.doi.org/10.1186/s41110-023-00214-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2023 1 15 05
allfields_unstemmed	10.1186/s41110-023-00214-x doi (DE-627)SPR052076350 (SPR)s41110-023-00214-x-e DE-627 ger DE-627 rakwb eng Edo, Great Iruoghene verfasserin aut Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. Nephrotoxicity (dpeaa)DE-He213 Antioxidant (dpeaa)DE-He213 Paracetamol (dpeaa)DE-He213 Phytochemicals (dpeaa)DE-He213 Ugbune, Ufuoma aut Onoharigho, Favour Ogheneoruese aut Ezekiel, Gracious Okeoghene aut Agbo, Joy Johnson aut Enthalten in Nutrire [London] : BioMed Central, 2000 48(2023), 1 vom: 15. Mai (DE-627)859794636 (DE-600)2856760-2 2316-7874 nnns volume:48 year:2023 number:1 day:15 month:05 https://dx.doi.org/10.1186/s41110-023-00214-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2023 1 15 05
allfieldsGer	10.1186/s41110-023-00214-x doi (DE-627)SPR052076350 (SPR)s41110-023-00214-x-e DE-627 ger DE-627 rakwb eng Edo, Great Iruoghene verfasserin aut Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. Nephrotoxicity (dpeaa)DE-He213 Antioxidant (dpeaa)DE-He213 Paracetamol (dpeaa)DE-He213 Phytochemicals (dpeaa)DE-He213 Ugbune, Ufuoma aut Onoharigho, Favour Ogheneoruese aut Ezekiel, Gracious Okeoghene aut Agbo, Joy Johnson aut Enthalten in Nutrire [London] : BioMed Central, 2000 48(2023), 1 vom: 15. Mai (DE-627)859794636 (DE-600)2856760-2 2316-7874 nnns volume:48 year:2023 number:1 day:15 month:05 https://dx.doi.org/10.1186/s41110-023-00214-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2023 1 15 05
allfieldsSound	10.1186/s41110-023-00214-x doi (DE-627)SPR052076350 (SPR)s41110-023-00214-x-e DE-627 ger DE-627 rakwb eng Edo, Great Iruoghene verfasserin aut Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. Nephrotoxicity (dpeaa)DE-He213 Antioxidant (dpeaa)DE-He213 Paracetamol (dpeaa)DE-He213 Phytochemicals (dpeaa)DE-He213 Ugbune, Ufuoma aut Onoharigho, Favour Ogheneoruese aut Ezekiel, Gracious Okeoghene aut Agbo, Joy Johnson aut Enthalten in Nutrire [London] : BioMed Central, 2000 48(2023), 1 vom: 15. Mai (DE-627)859794636 (DE-600)2856760-2 2316-7874 nnns volume:48 year:2023 number:1 day:15 month:05 https://dx.doi.org/10.1186/s41110-023-00214-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 48 2023 1 15 05
language	English
source	Enthalten in Nutrire 48(2023), 1 vom: 15. Mai volume:48 year:2023 number:1 day:15 month:05
sourceStr	Enthalten in Nutrire 48(2023), 1 vom: 15. Mai volume:48 year:2023 number:1 day:15 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Nephrotoxicity Antioxidant Paracetamol Phytochemicals
isfreeaccess_bool	false
container_title	Nutrire
authorswithroles_txt_mv	Edo, Great Iruoghene @@aut@@ Ugbune, Ufuoma @@aut@@ Onoharigho, Favour Ogheneoruese @@aut@@ Ezekiel, Gracious Okeoghene @@aut@@ Agbo, Joy Johnson @@aut@@
publishDateDaySort_date	2023-05-15T00:00:00Z
hierarchy_top_id	859794636
id	SPR052076350
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR052076350</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230726104615.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230628s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s41110-023-00214-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR052076350</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s41110-023-00214-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Edo, Great Iruoghene</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nephrotoxicity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidant</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Paracetamol</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phytochemicals</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ugbune, Ufuoma</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Onoharigho, Favour Ogheneoruese</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ezekiel, Gracious Okeoghene</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Agbo, Joy Johnson</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Nutrire</subfield><subfield code="d">[London] : BioMed Central, 2000</subfield><subfield code="g">48(2023), 1 vom: 15. Mai</subfield><subfield code="w">(DE-627)859794636</subfield><subfield code="w">(DE-600)2856760-2</subfield><subfield code="x">2316-7874</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:48</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:1</subfield><subfield code="g">day:15</subfield><subfield code="g">month:05</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s41110-023-00214-x</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_101</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_138</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_150</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_636</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2065</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2093</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2107</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2446</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2472</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2522</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4046</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4246</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4328</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">48</subfield><subfield code="j">2023</subfield><subfield code="e">1</subfield><subfield code="b">15</subfield><subfield code="c">05</subfield></datafield></record></collection>
author	Edo, Great Iruoghene
spellingShingle	Edo, Great Iruoghene misc Nephrotoxicity misc Antioxidant misc Paracetamol misc Phytochemicals Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats
authorStr	Edo, Great Iruoghene
ppnlink_with_tag_str_mv	@@773@@(DE-627)859794636
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut
collection	springer
remote_str	true
illustrated	Not Illustrated
issn	2316-7874
topic_title	Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats Nephrotoxicity (dpeaa)DE-He213 Antioxidant (dpeaa)DE-He213 Paracetamol (dpeaa)DE-He213 Phytochemicals (dpeaa)DE-He213
topic	misc Nephrotoxicity misc Antioxidant misc Paracetamol misc Phytochemicals
topic_unstemmed	misc Nephrotoxicity misc Antioxidant misc Paracetamol misc Phytochemicals
topic_browse	misc Nephrotoxicity misc Antioxidant misc Paracetamol misc Phytochemicals
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Nutrire
hierarchy_parent_id	859794636
hierarchy_top_title	Nutrire
isfreeaccess_txt	false
familylinks_str_mv	(DE-627)859794636 (DE-600)2856760-2
title	Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats
ctrlnum	(DE-627)SPR052076350 (SPR)s41110-023-00214-x-e
title_full	Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats
author_sort	Edo, Great Iruoghene
journal	Nutrire
journalStr	Nutrire
lang_code	eng
isOA_bool	false
recordtype	marc
publishDateSort	2023
contenttype_str_mv	txt
author_browse	Edo, Great Iruoghene Ugbune, Ufuoma Onoharigho, Favour Ogheneoruese Ezekiel, Gracious Okeoghene Agbo, Joy Johnson
container_volume	48
format_se	Elektronische Aufsätze
author-letter	Edo, Great Iruoghene
doi_str_mv	10.1186/s41110-023-00214-x
title_sort	antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats
title_auth	Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats
abstract	Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700
container_issue	1
title_short	Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats
url	https://dx.doi.org/10.1186/s41110-023-00214-x
remote_bool	true
author2	Ugbune, Ufuoma Onoharigho, Favour Ogheneoruese Ezekiel, Gracious Okeoghene Agbo, Joy Johnson
author2Str	Ugbune, Ufuoma Onoharigho, Favour Ogheneoruese Ezekiel, Gracious Okeoghene Agbo, Joy Johnson
ppnlink	859794636
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1186/s41110-023-00214-x
up_date	2024-07-04T01:09:14.002Z
_version_	1803608762886389760
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR052076350</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230726104615.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230628s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s41110-023-00214-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR052076350</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s41110-023-00214-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Edo, Great Iruoghene</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference (p < 0.05) between the PCM + extract group and the control group. Meanwhile, the PCM + extract group has a lower urea concentration as compared to the 250 mg PCM group. The PCM + Extract group had a significant increase in GSH levels compared to the PCM 250 only group, thus showing that the extract protected the kidney against the action of reactive oxygen species, lipid peroxidation, produced as a result of PCM’s reactive metabolite NAPQI, which could have led to renal toxicity. Conclusion The recent research shows that R. indica possess antioxidant that can protect the kidney from paracetamol-induced nephrotoxicity.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nephrotoxicity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidant</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Paracetamol</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phytochemicals</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ugbune, Ufuoma</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Onoharigho, Favour Ogheneoruese</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ezekiel, Gracious Okeoghene</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Agbo, Joy Johnson</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Nutrire</subfield><subfield code="d">[London] : BioMed Central, 2000</subfield><subfield code="g">48(2023), 1 vom: 15. Mai</subfield><subfield code="w">(DE-627)859794636</subfield><subfield code="w">(DE-600)2856760-2</subfield><subfield code="x">2316-7874</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:48</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:1</subfield><subfield code="g">day:15</subfield><subfield code="g">month:05</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s41110-023-00214-x</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_101</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_138</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_150</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_636</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2065</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2093</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2107</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2446</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2472</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2522</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4046</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4246</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4328</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">48</subfield><subfield code="j">2023</subfield><subfield code="e">1</subfield><subfield code="b">15</subfield><subfield code="c">05</subfield></datafield></record></collection>
score	7.3985567

Nicht das Richtige dabei?

Schreiben Sie uns!

Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?