Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2

Background SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an important challenge. Here, we studied the envelope protein E of SARS-CoV and SARS-CoV-2, a highly conserved 75–76 amino acid viroporin that is crucial for v...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Breitinger, Ulrike [verfasserIn]

Sedky, Christine Adel

Sticht, Heinrich

Breitinger, Hans-Georg

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2023

Schlagwörter:

SARS-CoV-2

E protein

Viroporins

Cell viability assay

Patch-clamp electrophysiology

Viroporin inhibitors

Ivermectin derivatives

Anmerkung:

© The Author(s) 2023

Übergeordnetes Werk:

Enthalten in: Virology journal - London : BioMed Central, 2004, 20(2023), 1 vom: 08. Juli

Übergeordnetes Werk:

volume:20 ; year:2023 ; number:1 ; day:08 ; month:07

Links:

Volltext

DOI / URN:

10.1186/s12985-023-02095-y

Katalog-ID:

SPR052195414

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