Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults

Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertensio...
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Autor*in:	Zhu, Qingqing [verfasserIn] Zhang, Ting Cheang, Iokfai Lu, Xinyi Shi, Mengsha Zhu, Xu Liao, Shengen Gao, Rongrong Li, Xinli Yao, Wenming

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Triglyceride glucose index Skeletal muscle mass index NHANES Hypertension

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: BMC musculoskeletal disorders - London : BioMed Central, 2000, 24(2023), 1 vom: 13. Juli
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:1 ; day:13 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s12891-023-06700-7

Katalog-ID:	SPR052244334

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520			\|a Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass.
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allfields	10.1186/s12891-023-06700-7 doi (DE-627)SPR052244334 (SPR)s12891-023-06700-7-e DE-627 ger DE-627 rakwb eng Zhu, Qingqing verfasserin aut Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. Triglyceride glucose index (dpeaa)DE-He213 Skeletal muscle mass index (dpeaa)DE-He213 NHANES (dpeaa)DE-He213 Hypertension (dpeaa)DE-He213 Zhang, Ting aut Cheang, Iokfai aut Lu, Xinyi aut Shi, Mengsha aut Zhu, Xu aut Liao, Shengen aut Gao, Rongrong aut Li, Xinli aut Yao, Wenming aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 24(2023), 1 vom: 13. Juli (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:24 year:2023 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12891-023-06700-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 13 07
spelling	10.1186/s12891-023-06700-7 doi (DE-627)SPR052244334 (SPR)s12891-023-06700-7-e DE-627 ger DE-627 rakwb eng Zhu, Qingqing verfasserin aut Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. Triglyceride glucose index (dpeaa)DE-He213 Skeletal muscle mass index (dpeaa)DE-He213 NHANES (dpeaa)DE-He213 Hypertension (dpeaa)DE-He213 Zhang, Ting aut Cheang, Iokfai aut Lu, Xinyi aut Shi, Mengsha aut Zhu, Xu aut Liao, Shengen aut Gao, Rongrong aut Li, Xinli aut Yao, Wenming aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 24(2023), 1 vom: 13. Juli (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:24 year:2023 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12891-023-06700-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 13 07
allfields_unstemmed	10.1186/s12891-023-06700-7 doi (DE-627)SPR052244334 (SPR)s12891-023-06700-7-e DE-627 ger DE-627 rakwb eng Zhu, Qingqing verfasserin aut Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. Triglyceride glucose index (dpeaa)DE-He213 Skeletal muscle mass index (dpeaa)DE-He213 NHANES (dpeaa)DE-He213 Hypertension (dpeaa)DE-He213 Zhang, Ting aut Cheang, Iokfai aut Lu, Xinyi aut Shi, Mengsha aut Zhu, Xu aut Liao, Shengen aut Gao, Rongrong aut Li, Xinli aut Yao, Wenming aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 24(2023), 1 vom: 13. Juli (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:24 year:2023 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12891-023-06700-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 13 07
allfieldsGer	10.1186/s12891-023-06700-7 doi (DE-627)SPR052244334 (SPR)s12891-023-06700-7-e DE-627 ger DE-627 rakwb eng Zhu, Qingqing verfasserin aut Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. Triglyceride glucose index (dpeaa)DE-He213 Skeletal muscle mass index (dpeaa)DE-He213 NHANES (dpeaa)DE-He213 Hypertension (dpeaa)DE-He213 Zhang, Ting aut Cheang, Iokfai aut Lu, Xinyi aut Shi, Mengsha aut Zhu, Xu aut Liao, Shengen aut Gao, Rongrong aut Li, Xinli aut Yao, Wenming aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 24(2023), 1 vom: 13. Juli (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:24 year:2023 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12891-023-06700-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 13 07
allfieldsSound	10.1186/s12891-023-06700-7 doi (DE-627)SPR052244334 (SPR)s12891-023-06700-7-e DE-627 ger DE-627 rakwb eng Zhu, Qingqing verfasserin aut Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. Triglyceride glucose index (dpeaa)DE-He213 Skeletal muscle mass index (dpeaa)DE-He213 NHANES (dpeaa)DE-He213 Hypertension (dpeaa)DE-He213 Zhang, Ting aut Cheang, Iokfai aut Lu, Xinyi aut Shi, Mengsha aut Zhu, Xu aut Liao, Shengen aut Gao, Rongrong aut Li, Xinli aut Yao, Wenming aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 24(2023), 1 vom: 13. Juli (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:24 year:2023 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12891-023-06700-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 1 13 07
language	English
source	Enthalten in BMC musculoskeletal disorders 24(2023), 1 vom: 13. Juli volume:24 year:2023 number:1 day:13 month:07
sourceStr	Enthalten in BMC musculoskeletal disorders 24(2023), 1 vom: 13. Juli volume:24 year:2023 number:1 day:13 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Triglyceride glucose index Skeletal muscle mass index NHANES Hypertension
isfreeaccess_bool	true
container_title	BMC musculoskeletal disorders
authorswithroles_txt_mv	Zhu, Qingqing @@aut@@ Zhang, Ting @@aut@@ Cheang, Iokfai @@aut@@ Lu, Xinyi @@aut@@ Shi, Mengsha @@aut@@ Zhu, Xu @@aut@@ Liao, Shengen @@aut@@ Gao, Rongrong @@aut@@ Li, Xinli @@aut@@ Yao, Wenming @@aut@@
publishDateDaySort_date	2023-07-13T00:00:00Z
hierarchy_top_id	326643745
id	SPR052244334
language_de	englisch
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author	Zhu, Qingqing
spellingShingle	Zhu, Qingqing misc Triglyceride glucose index misc Skeletal muscle mass index misc NHANES misc Hypertension Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults
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topic_title	Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults Triglyceride glucose index (dpeaa)DE-He213 Skeletal muscle mass index (dpeaa)DE-He213 NHANES (dpeaa)DE-He213 Hypertension (dpeaa)DE-He213
topic	misc Triglyceride glucose index misc Skeletal muscle mass index misc NHANES misc Hypertension
topic_unstemmed	misc Triglyceride glucose index misc Skeletal muscle mass index misc NHANES misc Hypertension
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title	Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults
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title_full	Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults
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author_browse	Zhu, Qingqing Zhang, Ting Cheang, Iokfai Lu, Xinyi Shi, Mengsha Zhu, Xu Liao, Shengen Gao, Rongrong Li, Xinli Yao, Wenming
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title_sort	negative association between triglyceride glucose index and bmi-adjusted skeletal muscle mass index in hypertensive adults
title_auth	Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults
abstract	Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. © The Author(s) 2023
abstractGer	Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. © The Author(s) 2023
abstract_unstemmed	Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. Methods We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. Results A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). Conclusion This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass. © The Author(s) 2023
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title_short	Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults
url	https://dx.doi.org/10.1186/s12891-023-06700-7
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author2	Zhang, Ting Cheang, Iokfai Lu, Xinyi Shi, Mengsha Zhu, Xu Liao, Shengen Gao, Rongrong Li, Xinli Yao, Wenming
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up_date	2024-07-04T01:58:25.973Z
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Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults

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