Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study

Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelli...
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Autor*in:	Vale, Thiago Cardoso [verfasserIn] Cardoso, Francisco Eduardo Costa da Silva, Danilo Jorge Resende, Elisa de Paula Franca Maia, Débora Palma Cunningham, Mauro César Quintão Guimarães, Henrique Cerqueira Machado, João Carlos Barbosa Teixeira, Antônio Lúcio Caramelli, Paulo Barbosa, Maira Tonidandel

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Parkinsonism Parkinson’s disease Dementia Alzheimer’s disease Functional decline

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: BMC neurology - London : BioMed Central, 2001, 23(2023), 1 vom: 21. Juli
Übergeordnetes Werk:	volume:23 ; year:2023 ; number:1 ; day:21 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s12883-023-03290-8

Katalog-ID:	SPR05233418X

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520			\|a Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample.
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allfields	10.1186/s12883-023-03290-8 doi (DE-627)SPR05233418X (SPR)s12883-023-03290-8-e DE-627 ger DE-627 rakwb eng Vale, Thiago Cardoso verfasserin aut Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. Parkinsonism (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Functional decline (dpeaa)DE-He213 Cardoso, Francisco Eduardo Costa aut da Silva, Danilo Jorge aut Resende, Elisa de Paula Franca aut Maia, Débora Palma aut Cunningham, Mauro César Quintão aut Guimarães, Henrique Cerqueira aut Machado, João Carlos Barbosa aut Teixeira, Antônio Lúcio aut Caramelli, Paulo aut Barbosa, Maira Tonidandel aut Enthalten in BMC neurology London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12883-023-03290-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07
spelling	10.1186/s12883-023-03290-8 doi (DE-627)SPR05233418X (SPR)s12883-023-03290-8-e DE-627 ger DE-627 rakwb eng Vale, Thiago Cardoso verfasserin aut Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. Parkinsonism (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Functional decline (dpeaa)DE-He213 Cardoso, Francisco Eduardo Costa aut da Silva, Danilo Jorge aut Resende, Elisa de Paula Franca aut Maia, Débora Palma aut Cunningham, Mauro César Quintão aut Guimarães, Henrique Cerqueira aut Machado, João Carlos Barbosa aut Teixeira, Antônio Lúcio aut Caramelli, Paulo aut Barbosa, Maira Tonidandel aut Enthalten in BMC neurology London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12883-023-03290-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07
allfields_unstemmed	10.1186/s12883-023-03290-8 doi (DE-627)SPR05233418X (SPR)s12883-023-03290-8-e DE-627 ger DE-627 rakwb eng Vale, Thiago Cardoso verfasserin aut Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. Parkinsonism (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Functional decline (dpeaa)DE-He213 Cardoso, Francisco Eduardo Costa aut da Silva, Danilo Jorge aut Resende, Elisa de Paula Franca aut Maia, Débora Palma aut Cunningham, Mauro César Quintão aut Guimarães, Henrique Cerqueira aut Machado, João Carlos Barbosa aut Teixeira, Antônio Lúcio aut Caramelli, Paulo aut Barbosa, Maira Tonidandel aut Enthalten in BMC neurology London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12883-023-03290-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07
allfieldsGer	10.1186/s12883-023-03290-8 doi (DE-627)SPR05233418X (SPR)s12883-023-03290-8-e DE-627 ger DE-627 rakwb eng Vale, Thiago Cardoso verfasserin aut Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. Parkinsonism (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Functional decline (dpeaa)DE-He213 Cardoso, Francisco Eduardo Costa aut da Silva, Danilo Jorge aut Resende, Elisa de Paula Franca aut Maia, Débora Palma aut Cunningham, Mauro César Quintão aut Guimarães, Henrique Cerqueira aut Machado, João Carlos Barbosa aut Teixeira, Antônio Lúcio aut Caramelli, Paulo aut Barbosa, Maira Tonidandel aut Enthalten in BMC neurology London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12883-023-03290-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07
allfieldsSound	10.1186/s12883-023-03290-8 doi (DE-627)SPR05233418X (SPR)s12883-023-03290-8-e DE-627 ger DE-627 rakwb eng Vale, Thiago Cardoso verfasserin aut Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. Parkinsonism (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Functional decline (dpeaa)DE-He213 Cardoso, Francisco Eduardo Costa aut da Silva, Danilo Jorge aut Resende, Elisa de Paula Franca aut Maia, Débora Palma aut Cunningham, Mauro César Quintão aut Guimarães, Henrique Cerqueira aut Machado, João Carlos Barbosa aut Teixeira, Antônio Lúcio aut Caramelli, Paulo aut Barbosa, Maira Tonidandel aut Enthalten in BMC neurology London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12883-023-03290-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07
language	English
source	Enthalten in BMC neurology 23(2023), 1 vom: 21. Juli volume:23 year:2023 number:1 day:21 month:07
sourceStr	Enthalten in BMC neurology 23(2023), 1 vom: 21. Juli volume:23 year:2023 number:1 day:21 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Parkinsonism Parkinson’s disease Dementia Alzheimer’s disease Functional decline
isfreeaccess_bool	true
container_title	BMC neurology
authorswithroles_txt_mv	Vale, Thiago Cardoso @@aut@@ Cardoso, Francisco Eduardo Costa @@aut@@ da Silva, Danilo Jorge @@aut@@ Resende, Elisa de Paula Franca @@aut@@ Maia, Débora Palma @@aut@@ Cunningham, Mauro César Quintão @@aut@@ Guimarães, Henrique Cerqueira @@aut@@ Machado, João Carlos Barbosa @@aut@@ Teixeira, Antônio Lúcio @@aut@@ Caramelli, Paulo @@aut@@ Barbosa, Maira Tonidandel @@aut@@
publishDateDaySort_date	2023-07-21T00:00:00Z
hierarchy_top_id	326643664
id	SPR05233418X
language_de	englisch
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We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. 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author	Vale, Thiago Cardoso
spellingShingle	Vale, Thiago Cardoso misc Parkinsonism misc Parkinson’s disease misc Dementia misc Alzheimer’s disease misc Functional decline Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study
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topic_title	Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study Parkinsonism (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Dementia (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Functional decline (dpeaa)DE-He213
topic	misc Parkinsonism misc Parkinson’s disease misc Dementia misc Alzheimer’s disease misc Functional decline
topic_unstemmed	misc Parkinsonism misc Parkinson’s disease misc Dementia misc Alzheimer’s disease misc Functional decline
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title	Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study
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title_full	Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study
author_sort	Vale, Thiago Cardoso
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author_browse	Vale, Thiago Cardoso Cardoso, Francisco Eduardo Costa da Silva, Danilo Jorge Resende, Elisa de Paula Franca Maia, Débora Palma Cunningham, Mauro César Quintão Guimarães, Henrique Cerqueira Machado, João Carlos Barbosa Teixeira, Antônio Lúcio Caramelli, Paulo Barbosa, Maira Tonidandel
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title_sort	clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the pietà study
title_auth	Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study
abstract	Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. © The Author(s) 2023
abstractGer	Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. © The Author(s) 2023
abstract_unstemmed	Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. © The Author(s) 2023
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title_short	Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study
url	https://dx.doi.org/10.1186/s12883-023-03290-8
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author2	Cardoso, Francisco Eduardo Costa da Silva, Danilo Jorge Resende, Elisa de Paula Franca Maia, Débora Palma Cunningham, Mauro César Quintão Guimarães, Henrique Cerqueira Machado, João Carlos Barbosa Teixeira, Antônio Lúcio Caramelli, Paulo Barbosa, Maira Tonidandel
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Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study

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