Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study
Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy...
Ausführliche Beschreibung
Autor*in: |
Taniguchi, Jumpei [verfasserIn] |
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E-Artikel |
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Englisch |
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2023 |
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Anmerkung: |
© The Author(s) 2023 |
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Übergeordnetes Werk: |
Enthalten in: BMC pulmonary medicine - London : BioMed Central, 2001, 23(2023), 1 vom: 21. Juli |
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Übergeordnetes Werk: |
volume:23 ; year:2023 ; number:1 ; day:21 ; month:07 |
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DOI / URN: |
10.1186/s12890-023-02559-5 |
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SPR052334376 |
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245 | 1 | 0 | |a Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study |
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520 | |a Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. | ||
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700 | 1 | |a Nagai, Tatsuya |4 aut | |
700 | 1 | |a Otsuki, Ayumu |4 aut | |
700 | 1 | |a Ito, Hiroyuki |4 aut | |
700 | 1 | |a Sugimura, Hiroshi |4 aut | |
700 | 1 | |a Nakashima, Kei |4 aut | |
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10.1186/s12890-023-02559-5 doi (DE-627)SPR052334376 (SPR)s12890-023-02559-5-e DE-627 ger DE-627 rakwb eng Taniguchi, Jumpei verfasserin aut Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. Drainage (dpeaa)DE-He213 Empyema (dpeaa)DE-He213 Retrospective study (dpeaa)DE-He213 Pleural infection (dpeaa)DE-He213 Urokinase (dpeaa)DE-He213 Matsui, Hiroki aut Nagai, Tatsuya aut Otsuki, Ayumu aut Ito, Hiroyuki aut Sugimura, Hiroshi aut Nakashima, Kei aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12890-023-02559-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07 |
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10.1186/s12890-023-02559-5 doi (DE-627)SPR052334376 (SPR)s12890-023-02559-5-e DE-627 ger DE-627 rakwb eng Taniguchi, Jumpei verfasserin aut Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. Drainage (dpeaa)DE-He213 Empyema (dpeaa)DE-He213 Retrospective study (dpeaa)DE-He213 Pleural infection (dpeaa)DE-He213 Urokinase (dpeaa)DE-He213 Matsui, Hiroki aut Nagai, Tatsuya aut Otsuki, Ayumu aut Ito, Hiroyuki aut Sugimura, Hiroshi aut Nakashima, Kei aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12890-023-02559-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07 |
allfields_unstemmed |
10.1186/s12890-023-02559-5 doi (DE-627)SPR052334376 (SPR)s12890-023-02559-5-e DE-627 ger DE-627 rakwb eng Taniguchi, Jumpei verfasserin aut Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. Drainage (dpeaa)DE-He213 Empyema (dpeaa)DE-He213 Retrospective study (dpeaa)DE-He213 Pleural infection (dpeaa)DE-He213 Urokinase (dpeaa)DE-He213 Matsui, Hiroki aut Nagai, Tatsuya aut Otsuki, Ayumu aut Ito, Hiroyuki aut Sugimura, Hiroshi aut Nakashima, Kei aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12890-023-02559-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07 |
allfieldsGer |
10.1186/s12890-023-02559-5 doi (DE-627)SPR052334376 (SPR)s12890-023-02559-5-e DE-627 ger DE-627 rakwb eng Taniguchi, Jumpei verfasserin aut Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. Drainage (dpeaa)DE-He213 Empyema (dpeaa)DE-He213 Retrospective study (dpeaa)DE-He213 Pleural infection (dpeaa)DE-He213 Urokinase (dpeaa)DE-He213 Matsui, Hiroki aut Nagai, Tatsuya aut Otsuki, Ayumu aut Ito, Hiroyuki aut Sugimura, Hiroshi aut Nakashima, Kei aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12890-023-02559-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07 |
allfieldsSound |
10.1186/s12890-023-02559-5 doi (DE-627)SPR052334376 (SPR)s12890-023-02559-5-e DE-627 ger DE-627 rakwb eng Taniguchi, Jumpei verfasserin aut Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. Drainage (dpeaa)DE-He213 Empyema (dpeaa)DE-He213 Retrospective study (dpeaa)DE-He213 Pleural infection (dpeaa)DE-He213 Urokinase (dpeaa)DE-He213 Matsui, Hiroki aut Nagai, Tatsuya aut Otsuki, Ayumu aut Ito, Hiroyuki aut Sugimura, Hiroshi aut Nakashima, Kei aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 23(2023), 1 vom: 21. Juli (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:23 year:2023 number:1 day:21 month:07 https://dx.doi.org/10.1186/s12890-023-02559-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 21 07 |
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Enthalten in BMC pulmonary medicine 23(2023), 1 vom: 21. Juli volume:23 year:2023 number:1 day:21 month:07 |
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After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. 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association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study |
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Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study |
abstract |
Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. © The Author(s) 2023 |
abstractGer |
Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. © The Author(s) 2023 |
abstract_unstemmed |
Background Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration The participants were retrospectively registered. © The Author(s) 2023 |
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Matsui, Hiroki Nagai, Tatsuya Otsuki, Ayumu Ito, Hiroyuki Sugimura, Hiroshi Nakashima, Kei |
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7.3994904 |