The effect of a silicone sheet on sciatic nerve healing in rats
Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the ski...
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| Autor*in: |
Derebaşınlıoğlu, Handan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: European journal of plastic surgery - Berlin : Springer, 1986, 46(2023), 4 vom: 27. Apr., Seite 453-463 |
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| Übergeordnetes Werk: |
volume:46 ; year:2023 ; number:4 ; day:27 ; month:04 ; pages:453-463 |
| Links: |
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| DOI / URN: |
10.1007/s00238-023-02071-3 |
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| Katalog-ID: |
SPR052365867 |
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| 245 | 1 | 4 | |a The effect of a silicone sheet on sciatic nerve healing in rats |
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| 520 | |a Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. | ||
| 650 | 4 | |a Peripheral nerve healing |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Silicone sheet |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a primer nerve repair |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a nerve crush injury |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a peripheral nerve |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a neurotmesis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a crush injury |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a electrophysiological measurement |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nerve action potential |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Demirkazık, Ayşe |4 aut | |
| 700 | 1 | |a Çiçek Doğan, İnanç |4 aut | |
| 700 | 1 | |a Eğilmez, H. Reyhan |4 aut | |
| 700 | 1 | |a Çam, Selim |4 aut | |
| 700 | 1 | |a Yeldir, Neşe |4 aut | |
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10.1007/s00238-023-02071-3 doi (DE-627)SPR052365867 (SPR)s00238-023-02071-3-e DE-627 ger DE-627 rakwb eng Derebaşınlıoğlu, Handan verfasserin (orcid)0000-0003-1412-4672 aut The effect of a silicone sheet on sciatic nerve healing in rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. Peripheral nerve healing (dpeaa)DE-He213 Silicone sheet (dpeaa)DE-He213 primer nerve repair (dpeaa)DE-He213 nerve crush injury (dpeaa)DE-He213 peripheral nerve (dpeaa)DE-He213 neurotmesis (dpeaa)DE-He213 crush injury (dpeaa)DE-He213 electrophysiological measurement (dpeaa)DE-He213 Nerve action potential (dpeaa)DE-He213 Demirkazık, Ayşe aut Çiçek Doğan, İnanç aut Eğilmez, H. Reyhan aut Çam, Selim aut Yeldir, Neşe aut Enthalten in European journal of plastic surgery Berlin : Springer, 1986 46(2023), 4 vom: 27. Apr., Seite 453-463 (DE-627)265508436 (DE-600)1464220-7 1435-0130 nnns volume:46 year:2023 number:4 day:27 month:04 pages:453-463 https://dx.doi.org/10.1007/s00238-023-02071-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 2023 4 27 04 453-463 |
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10.1007/s00238-023-02071-3 doi (DE-627)SPR052365867 (SPR)s00238-023-02071-3-e DE-627 ger DE-627 rakwb eng Derebaşınlıoğlu, Handan verfasserin (orcid)0000-0003-1412-4672 aut The effect of a silicone sheet on sciatic nerve healing in rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. Peripheral nerve healing (dpeaa)DE-He213 Silicone sheet (dpeaa)DE-He213 primer nerve repair (dpeaa)DE-He213 nerve crush injury (dpeaa)DE-He213 peripheral nerve (dpeaa)DE-He213 neurotmesis (dpeaa)DE-He213 crush injury (dpeaa)DE-He213 electrophysiological measurement (dpeaa)DE-He213 Nerve action potential (dpeaa)DE-He213 Demirkazık, Ayşe aut Çiçek Doğan, İnanç aut Eğilmez, H. Reyhan aut Çam, Selim aut Yeldir, Neşe aut Enthalten in European journal of plastic surgery Berlin : Springer, 1986 46(2023), 4 vom: 27. Apr., Seite 453-463 (DE-627)265508436 (DE-600)1464220-7 1435-0130 nnns volume:46 year:2023 number:4 day:27 month:04 pages:453-463 https://dx.doi.org/10.1007/s00238-023-02071-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 2023 4 27 04 453-463 |
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10.1007/s00238-023-02071-3 doi (DE-627)SPR052365867 (SPR)s00238-023-02071-3-e DE-627 ger DE-627 rakwb eng Derebaşınlıoğlu, Handan verfasserin (orcid)0000-0003-1412-4672 aut The effect of a silicone sheet on sciatic nerve healing in rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. Peripheral nerve healing (dpeaa)DE-He213 Silicone sheet (dpeaa)DE-He213 primer nerve repair (dpeaa)DE-He213 nerve crush injury (dpeaa)DE-He213 peripheral nerve (dpeaa)DE-He213 neurotmesis (dpeaa)DE-He213 crush injury (dpeaa)DE-He213 electrophysiological measurement (dpeaa)DE-He213 Nerve action potential (dpeaa)DE-He213 Demirkazık, Ayşe aut Çiçek Doğan, İnanç aut Eğilmez, H. Reyhan aut Çam, Selim aut Yeldir, Neşe aut Enthalten in European journal of plastic surgery Berlin : Springer, 1986 46(2023), 4 vom: 27. Apr., Seite 453-463 (DE-627)265508436 (DE-600)1464220-7 1435-0130 nnns volume:46 year:2023 number:4 day:27 month:04 pages:453-463 https://dx.doi.org/10.1007/s00238-023-02071-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 2023 4 27 04 453-463 |
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10.1007/s00238-023-02071-3 doi (DE-627)SPR052365867 (SPR)s00238-023-02071-3-e DE-627 ger DE-627 rakwb eng Derebaşınlıoğlu, Handan verfasserin (orcid)0000-0003-1412-4672 aut The effect of a silicone sheet on sciatic nerve healing in rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. Peripheral nerve healing (dpeaa)DE-He213 Silicone sheet (dpeaa)DE-He213 primer nerve repair (dpeaa)DE-He213 nerve crush injury (dpeaa)DE-He213 peripheral nerve (dpeaa)DE-He213 neurotmesis (dpeaa)DE-He213 crush injury (dpeaa)DE-He213 electrophysiological measurement (dpeaa)DE-He213 Nerve action potential (dpeaa)DE-He213 Demirkazık, Ayşe aut Çiçek Doğan, İnanç aut Eğilmez, H. Reyhan aut Çam, Selim aut Yeldir, Neşe aut Enthalten in European journal of plastic surgery Berlin : Springer, 1986 46(2023), 4 vom: 27. Apr., Seite 453-463 (DE-627)265508436 (DE-600)1464220-7 1435-0130 nnns volume:46 year:2023 number:4 day:27 month:04 pages:453-463 https://dx.doi.org/10.1007/s00238-023-02071-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 2023 4 27 04 453-463 |
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10.1007/s00238-023-02071-3 doi (DE-627)SPR052365867 (SPR)s00238-023-02071-3-e DE-627 ger DE-627 rakwb eng Derebaşınlıoğlu, Handan verfasserin (orcid)0000-0003-1412-4672 aut The effect of a silicone sheet on sciatic nerve healing in rats 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. Peripheral nerve healing (dpeaa)DE-He213 Silicone sheet (dpeaa)DE-He213 primer nerve repair (dpeaa)DE-He213 nerve crush injury (dpeaa)DE-He213 peripheral nerve (dpeaa)DE-He213 neurotmesis (dpeaa)DE-He213 crush injury (dpeaa)DE-He213 electrophysiological measurement (dpeaa)DE-He213 Nerve action potential (dpeaa)DE-He213 Demirkazık, Ayşe aut Çiçek Doğan, İnanç aut Eğilmez, H. Reyhan aut Çam, Selim aut Yeldir, Neşe aut Enthalten in European journal of plastic surgery Berlin : Springer, 1986 46(2023), 4 vom: 27. Apr., Seite 453-463 (DE-627)265508436 (DE-600)1464220-7 1435-0130 nnns volume:46 year:2023 number:4 day:27 month:04 pages:453-463 https://dx.doi.org/10.1007/s00238-023-02071-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 2023 4 27 04 453-463 |
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Derebaşınlıoğlu, Handan @@aut@@ Demirkazık, Ayşe @@aut@@ Çiçek Doğan, İnanç @@aut@@ Eğilmez, H. Reyhan @@aut@@ Çam, Selim @@aut@@ Yeldir, Neşe @@aut@@ |
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). 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Derebaşınlıoğlu, Handan |
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Derebaşınlıoğlu, Handan misc Peripheral nerve healing misc Silicone sheet misc primer nerve repair misc nerve crush injury misc peripheral nerve misc neurotmesis misc crush injury misc electrophysiological measurement misc Nerve action potential The effect of a silicone sheet on sciatic nerve healing in rats |
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The effect of a silicone sheet on sciatic nerve healing in rats Peripheral nerve healing (dpeaa)DE-He213 Silicone sheet (dpeaa)DE-He213 primer nerve repair (dpeaa)DE-He213 nerve crush injury (dpeaa)DE-He213 peripheral nerve (dpeaa)DE-He213 neurotmesis (dpeaa)DE-He213 crush injury (dpeaa)DE-He213 electrophysiological measurement (dpeaa)DE-He213 Nerve action potential (dpeaa)DE-He213 |
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Elektronische Aufsätze |
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Derebaşınlıoğlu, Handan |
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effect of a silicone sheet on sciatic nerve healing in rats |
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The effect of a silicone sheet on sciatic nerve healing in rats |
| abstract |
Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Background Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries. Methods The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated. Results After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023). Conclusions In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury. Level of evidence Not gradable. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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The effect of a silicone sheet on sciatic nerve healing in rats |
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| score |
7.401063 |