Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists
Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lac...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sars, Carl [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2023 |
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| Übergeordnetes Werk: |
Enthalten in: Breast cancer research and treatment - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981, 199(2023), 2 vom: 06. März, Seite 293-304 |
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| Übergeordnetes Werk: |
volume:199 ; year:2023 ; number:2 ; day:06 ; month:03 ; pages:293-304 |
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| DOI / URN: |
10.1007/s10549-023-06896-1 |
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SPR052402053 |
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| 245 | 1 | 0 | |a Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists |
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| 520 | |a Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. | ||
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| 650 | 4 | |a Breast neoplasms |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Margins of excision |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Surgical oncology |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sackey, Helena |4 aut | |
| 700 | 1 | |a Frisell, Jan |4 aut | |
| 700 | 1 | |a Dickman, Paul W. |4 aut | |
| 700 | 1 | |a Karlsson, Fredrik |4 aut | |
| 700 | 1 | |a Kindts, Isabelle |4 aut | |
| 700 | 1 | |a Marta, Gustavo Nader |4 aut | |
| 700 | 1 | |a Freitas-Junior, Ruffo |4 aut | |
| 700 | 1 | |a Tvedskov, Tove Filtenborg |4 aut | |
| 700 | 1 | |a Kassem, Loay |4 aut | |
| 700 | 1 | |a Ali, Ahmed S. |4 aut | |
| 700 | 1 | |a Ihalainen, Hanna |4 aut | |
| 700 | 1 | |a Neron, Mathias |4 aut | |
| 700 | 1 | |a Kontos, Michalis |4 aut | |
| 700 | 1 | |a Kaidar-Person, Orit |4 aut | |
| 700 | 1 | |a Meattini, Icro |4 aut | |
| 700 | 1 | |a Francken, Anne Brecht |4 aut | |
| 700 | 1 | |a van Duijnhoven, Frederieke |4 aut | |
| 700 | 1 | |a Moberg, Ingvild Ona |4 aut | |
| 700 | 1 | |a Marinko, Tanja |4 aut | |
| 700 | 1 | |a Kollar, Attila |4 aut | |
| 700 | 1 | |a Ahmed, Mahbubl |4 aut | |
| 700 | 1 | |a Remoundos, Dennis |4 aut | |
| 700 | 1 | |a Banks, Jenny |4 aut | |
| 700 | 1 | |a Jagsi, Reshma |4 aut | |
| 700 | 1 | |a Dossett, Lesly A. |4 aut | |
| 700 | 1 | |a Lindqvist, Ebba K. |4 aut | |
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10.1007/s10549-023-06896-1 doi (DE-627)SPR052402053 (SPR)s10549-023-06896-1-e DE-627 ger DE-627 rakwb eng Sars, Carl verfasserin (orcid)0000-0003-1691-8871 aut Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. Phyllodes tumor (dpeaa)DE-He213 Breast neoplasms (dpeaa)DE-He213 Margins of excision (dpeaa)DE-He213 Surgical oncology (dpeaa)DE-He213 Sackey, Helena aut Frisell, Jan aut Dickman, Paul W. aut Karlsson, Fredrik aut Kindts, Isabelle aut Marta, Gustavo Nader aut Freitas-Junior, Ruffo aut Tvedskov, Tove Filtenborg aut Kassem, Loay aut Ali, Ahmed S. aut Ihalainen, Hanna aut Neron, Mathias aut Kontos, Michalis aut Kaidar-Person, Orit aut Meattini, Icro aut Francken, Anne Brecht aut van Duijnhoven, Frederieke aut Moberg, Ingvild Ona aut Marinko, Tanja aut Kollar, Attila aut Ahmed, Mahbubl aut Remoundos, Dennis aut Banks, Jenny aut Jagsi, Reshma aut Dossett, Lesly A. aut Lindqvist, Ebba K. aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 199(2023), 2 vom: 06. März, Seite 293-304 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:199 year:2023 number:2 day:06 month:03 pages:293-304 https://dx.doi.org/10.1007/s10549-023-06896-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 199 2023 2 06 03 293-304 |
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10.1007/s10549-023-06896-1 doi (DE-627)SPR052402053 (SPR)s10549-023-06896-1-e DE-627 ger DE-627 rakwb eng Sars, Carl verfasserin (orcid)0000-0003-1691-8871 aut Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. Phyllodes tumor (dpeaa)DE-He213 Breast neoplasms (dpeaa)DE-He213 Margins of excision (dpeaa)DE-He213 Surgical oncology (dpeaa)DE-He213 Sackey, Helena aut Frisell, Jan aut Dickman, Paul W. aut Karlsson, Fredrik aut Kindts, Isabelle aut Marta, Gustavo Nader aut Freitas-Junior, Ruffo aut Tvedskov, Tove Filtenborg aut Kassem, Loay aut Ali, Ahmed S. aut Ihalainen, Hanna aut Neron, Mathias aut Kontos, Michalis aut Kaidar-Person, Orit aut Meattini, Icro aut Francken, Anne Brecht aut van Duijnhoven, Frederieke aut Moberg, Ingvild Ona aut Marinko, Tanja aut Kollar, Attila aut Ahmed, Mahbubl aut Remoundos, Dennis aut Banks, Jenny aut Jagsi, Reshma aut Dossett, Lesly A. aut Lindqvist, Ebba K. aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 199(2023), 2 vom: 06. März, Seite 293-304 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:199 year:2023 number:2 day:06 month:03 pages:293-304 https://dx.doi.org/10.1007/s10549-023-06896-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 199 2023 2 06 03 293-304 |
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10.1007/s10549-023-06896-1 doi (DE-627)SPR052402053 (SPR)s10549-023-06896-1-e DE-627 ger DE-627 rakwb eng Sars, Carl verfasserin (orcid)0000-0003-1691-8871 aut Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. Phyllodes tumor (dpeaa)DE-He213 Breast neoplasms (dpeaa)DE-He213 Margins of excision (dpeaa)DE-He213 Surgical oncology (dpeaa)DE-He213 Sackey, Helena aut Frisell, Jan aut Dickman, Paul W. aut Karlsson, Fredrik aut Kindts, Isabelle aut Marta, Gustavo Nader aut Freitas-Junior, Ruffo aut Tvedskov, Tove Filtenborg aut Kassem, Loay aut Ali, Ahmed S. aut Ihalainen, Hanna aut Neron, Mathias aut Kontos, Michalis aut Kaidar-Person, Orit aut Meattini, Icro aut Francken, Anne Brecht aut van Duijnhoven, Frederieke aut Moberg, Ingvild Ona aut Marinko, Tanja aut Kollar, Attila aut Ahmed, Mahbubl aut Remoundos, Dennis aut Banks, Jenny aut Jagsi, Reshma aut Dossett, Lesly A. aut Lindqvist, Ebba K. aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 199(2023), 2 vom: 06. März, Seite 293-304 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:199 year:2023 number:2 day:06 month:03 pages:293-304 https://dx.doi.org/10.1007/s10549-023-06896-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 199 2023 2 06 03 293-304 |
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10.1007/s10549-023-06896-1 doi (DE-627)SPR052402053 (SPR)s10549-023-06896-1-e DE-627 ger DE-627 rakwb eng Sars, Carl verfasserin (orcid)0000-0003-1691-8871 aut Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. Phyllodes tumor (dpeaa)DE-He213 Breast neoplasms (dpeaa)DE-He213 Margins of excision (dpeaa)DE-He213 Surgical oncology (dpeaa)DE-He213 Sackey, Helena aut Frisell, Jan aut Dickman, Paul W. aut Karlsson, Fredrik aut Kindts, Isabelle aut Marta, Gustavo Nader aut Freitas-Junior, Ruffo aut Tvedskov, Tove Filtenborg aut Kassem, Loay aut Ali, Ahmed S. aut Ihalainen, Hanna aut Neron, Mathias aut Kontos, Michalis aut Kaidar-Person, Orit aut Meattini, Icro aut Francken, Anne Brecht aut van Duijnhoven, Frederieke aut Moberg, Ingvild Ona aut Marinko, Tanja aut Kollar, Attila aut Ahmed, Mahbubl aut Remoundos, Dennis aut Banks, Jenny aut Jagsi, Reshma aut Dossett, Lesly A. aut Lindqvist, Ebba K. aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 199(2023), 2 vom: 06. März, Seite 293-304 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:199 year:2023 number:2 day:06 month:03 pages:293-304 https://dx.doi.org/10.1007/s10549-023-06896-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 199 2023 2 06 03 293-304 |
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10.1007/s10549-023-06896-1 doi (DE-627)SPR052402053 (SPR)s10549-023-06896-1-e DE-627 ger DE-627 rakwb eng Sars, Carl verfasserin (orcid)0000-0003-1691-8871 aut Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. Phyllodes tumor (dpeaa)DE-He213 Breast neoplasms (dpeaa)DE-He213 Margins of excision (dpeaa)DE-He213 Surgical oncology (dpeaa)DE-He213 Sackey, Helena aut Frisell, Jan aut Dickman, Paul W. aut Karlsson, Fredrik aut Kindts, Isabelle aut Marta, Gustavo Nader aut Freitas-Junior, Ruffo aut Tvedskov, Tove Filtenborg aut Kassem, Loay aut Ali, Ahmed S. aut Ihalainen, Hanna aut Neron, Mathias aut Kontos, Michalis aut Kaidar-Person, Orit aut Meattini, Icro aut Francken, Anne Brecht aut van Duijnhoven, Frederieke aut Moberg, Ingvild Ona aut Marinko, Tanja aut Kollar, Attila aut Ahmed, Mahbubl aut Remoundos, Dennis aut Banks, Jenny aut Jagsi, Reshma aut Dossett, Lesly A. aut Lindqvist, Ebba K. aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 199(2023), 2 vom: 06. März, Seite 293-304 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:199 year:2023 number:2 day:06 month:03 pages:293-304 https://dx.doi.org/10.1007/s10549-023-06896-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 199 2023 2 06 03 293-304 |
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Enthalten in Breast cancer research and treatment 199(2023), 2 vom: 06. März, Seite 293-304 volume:199 year:2023 number:2 day:06 month:03 pages:293-304 |
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Enthalten in Breast cancer research and treatment 199(2023), 2 vom: 06. März, Seite 293-304 volume:199 year:2023 number:2 day:06 month:03 pages:293-304 |
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Phyllodes tumor Breast neoplasms Margins of excision Surgical oncology |
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Sars, Carl @@aut@@ Sackey, Helena @@aut@@ Frisell, Jan @@aut@@ Dickman, Paul W. @@aut@@ Karlsson, Fredrik @@aut@@ Kindts, Isabelle @@aut@@ Marta, Gustavo Nader @@aut@@ Freitas-Junior, Ruffo @@aut@@ Tvedskov, Tove Filtenborg @@aut@@ Kassem, Loay @@aut@@ Ali, Ahmed S. @@aut@@ Ihalainen, Hanna @@aut@@ Neron, Mathias @@aut@@ Kontos, Michalis @@aut@@ Kaidar-Person, Orit @@aut@@ Meattini, Icro @@aut@@ Francken, Anne Brecht @@aut@@ van Duijnhoven, Frederieke @@aut@@ Moberg, Ingvild Ona @@aut@@ Marinko, Tanja @@aut@@ Kollar, Attila @@aut@@ Ahmed, Mahbubl @@aut@@ Remoundos, Dennis @@aut@@ Banks, Jenny @@aut@@ Jagsi, Reshma @@aut@@ Dossett, Lesly A. @@aut@@ Lindqvist, Ebba K. @@aut@@ |
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There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. 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|
| author |
Sars, Carl |
| spellingShingle |
Sars, Carl misc Phyllodes tumor misc Breast neoplasms misc Margins of excision misc Surgical oncology Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists |
| authorStr |
Sars, Carl |
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@@773@@(DE-627)320433722 |
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electronic Article |
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keep |
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aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
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springer |
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true |
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Not Illustrated |
| issn |
1573-7217 |
| topic_title |
Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists Phyllodes tumor (dpeaa)DE-He213 Breast neoplasms (dpeaa)DE-He213 Margins of excision (dpeaa)DE-He213 Surgical oncology (dpeaa)DE-He213 |
| topic |
misc Phyllodes tumor misc Breast neoplasms misc Margins of excision misc Surgical oncology |
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misc Phyllodes tumor misc Breast neoplasms misc Margins of excision misc Surgical oncology |
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Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists |
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Sars, Carl Sackey, Helena Frisell, Jan Dickman, Paul W. Karlsson, Fredrik Kindts, Isabelle Marta, Gustavo Nader Freitas-Junior, Ruffo Tvedskov, Tove Filtenborg Kassem, Loay Ali, Ahmed S. Ihalainen, Hanna Neron, Mathias Kontos, Michalis Kaidar-Person, Orit Meattini, Icro Francken, Anne Brecht van Duijnhoven, Frederieke Moberg, Ingvild Ona Marinko, Tanja Kollar, Attila Ahmed, Mahbubl Remoundos, Dennis Banks, Jenny Jagsi, Reshma Dossett, Lesly A. Lindqvist, Ebba K. |
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current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists |
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Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists |
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Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. © The Author(s) 2023 |
| abstractGer |
Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. © The Author(s) 2023 |
| abstract_unstemmed |
Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors. © The Author(s) 2023 |
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Sackey, Helena Frisell, Jan Dickman, Paul W. Karlsson, Fredrik Kindts, Isabelle Marta, Gustavo Nader Freitas-Junior, Ruffo Tvedskov, Tove Filtenborg Kassem, Loay Ali, Ahmed S. Ihalainen, Hanna Neron, Mathias Kontos, Michalis Kaidar-Person, Orit Meattini, Icro Francken, Anne Brecht van Duijnhoven, Frederieke Moberg, Ingvild Ona Marinko, Tanja Kollar, Attila Ahmed, Mahbubl Remoundos, Dennis Banks, Jenny Jagsi, Reshma Dossett, Lesly A. Lindqvist, Ebba K. |
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| score |
7.400462 |