Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored ere...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ma, Xiaolei [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2023 |
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| Übergeordnetes Werk: |
Enthalten in: Andrologie - Paris [u.a.] : Springer, 1991, 33(2023), 1 vom: 18. Mai |
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| Übergeordnetes Werk: |
volume:33 ; year:2023 ; number:1 ; day:18 ; month:05 |
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| DOI / URN: |
10.1186/s12610-023-00187-x |
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SPR052473090 |
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| 520 | |a Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. | ||
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10.1186/s12610-023-00187-x doi (DE-627)SPR052473090 (SPR)s12610-023-00187-x-e DE-627 ger DE-627 rakwb eng Ma, Xiaolei verfasserin aut Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. Skin-derived precursor (dpeaa)DE-He213 Schwann cell (dpeaa)DE-He213 Erectile dysfunction (dpeaa)DE-He213 Bilateral cavernous nerve injury (dpeaa)DE-He213 Cell therapy (dpeaa)DE-He213 Nerve regeneration (dpeaa)DE-He213 Yang, Wende aut Nie, Pan aut Zhang, Zhenbin aut Chen, Zehong aut Wei, Hongbo aut Enthalten in Andrologie Paris [u.a.] : Springer, 1991 33(2023), 1 vom: 18. Mai (DE-627)595710743 (DE-600)2486872-3 1760-5377 nnns volume:33 year:2023 number:1 day:18 month:05 https://dx.doi.org/10.1186/s12610-023-00187-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 GBV_ILN_266 GBV_ILN_281 AR 33 2023 1 18 05 |
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10.1186/s12610-023-00187-x doi (DE-627)SPR052473090 (SPR)s12610-023-00187-x-e DE-627 ger DE-627 rakwb eng Ma, Xiaolei verfasserin aut Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. Skin-derived precursor (dpeaa)DE-He213 Schwann cell (dpeaa)DE-He213 Erectile dysfunction (dpeaa)DE-He213 Bilateral cavernous nerve injury (dpeaa)DE-He213 Cell therapy (dpeaa)DE-He213 Nerve regeneration (dpeaa)DE-He213 Yang, Wende aut Nie, Pan aut Zhang, Zhenbin aut Chen, Zehong aut Wei, Hongbo aut Enthalten in Andrologie Paris [u.a.] : Springer, 1991 33(2023), 1 vom: 18. Mai (DE-627)595710743 (DE-600)2486872-3 1760-5377 nnns volume:33 year:2023 number:1 day:18 month:05 https://dx.doi.org/10.1186/s12610-023-00187-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 GBV_ILN_266 GBV_ILN_281 AR 33 2023 1 18 05 |
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10.1186/s12610-023-00187-x doi (DE-627)SPR052473090 (SPR)s12610-023-00187-x-e DE-627 ger DE-627 rakwb eng Ma, Xiaolei verfasserin aut Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. Skin-derived precursor (dpeaa)DE-He213 Schwann cell (dpeaa)DE-He213 Erectile dysfunction (dpeaa)DE-He213 Bilateral cavernous nerve injury (dpeaa)DE-He213 Cell therapy (dpeaa)DE-He213 Nerve regeneration (dpeaa)DE-He213 Yang, Wende aut Nie, Pan aut Zhang, Zhenbin aut Chen, Zehong aut Wei, Hongbo aut Enthalten in Andrologie Paris [u.a.] : Springer, 1991 33(2023), 1 vom: 18. Mai (DE-627)595710743 (DE-600)2486872-3 1760-5377 nnns volume:33 year:2023 number:1 day:18 month:05 https://dx.doi.org/10.1186/s12610-023-00187-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 GBV_ILN_266 GBV_ILN_281 AR 33 2023 1 18 05 |
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10.1186/s12610-023-00187-x doi (DE-627)SPR052473090 (SPR)s12610-023-00187-x-e DE-627 ger DE-627 rakwb eng Ma, Xiaolei verfasserin aut Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. Skin-derived precursor (dpeaa)DE-He213 Schwann cell (dpeaa)DE-He213 Erectile dysfunction (dpeaa)DE-He213 Bilateral cavernous nerve injury (dpeaa)DE-He213 Cell therapy (dpeaa)DE-He213 Nerve regeneration (dpeaa)DE-He213 Yang, Wende aut Nie, Pan aut Zhang, Zhenbin aut Chen, Zehong aut Wei, Hongbo aut Enthalten in Andrologie Paris [u.a.] : Springer, 1991 33(2023), 1 vom: 18. Mai (DE-627)595710743 (DE-600)2486872-3 1760-5377 nnns volume:33 year:2023 number:1 day:18 month:05 https://dx.doi.org/10.1186/s12610-023-00187-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 GBV_ILN_266 GBV_ILN_281 AR 33 2023 1 18 05 |
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10.1186/s12610-023-00187-x doi (DE-627)SPR052473090 (SPR)s12610-023-00187-x-e DE-627 ger DE-627 rakwb eng Ma, Xiaolei verfasserin aut Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. Skin-derived precursor (dpeaa)DE-He213 Schwann cell (dpeaa)DE-He213 Erectile dysfunction (dpeaa)DE-He213 Bilateral cavernous nerve injury (dpeaa)DE-He213 Cell therapy (dpeaa)DE-He213 Nerve regeneration (dpeaa)DE-He213 Yang, Wende aut Nie, Pan aut Zhang, Zhenbin aut Chen, Zehong aut Wei, Hongbo aut Enthalten in Andrologie Paris [u.a.] : Springer, 1991 33(2023), 1 vom: 18. Mai (DE-627)595710743 (DE-600)2486872-3 1760-5377 nnns volume:33 year:2023 number:1 day:18 month:05 https://dx.doi.org/10.1186/s12610-023-00187-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 GBV_ILN_266 GBV_ILN_281 AR 33 2023 1 18 05 |
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Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model Skin-derived precursor (dpeaa)DE-He213 Schwann cell (dpeaa)DE-He213 Erectile dysfunction (dpeaa)DE-He213 Bilateral cavernous nerve injury (dpeaa)DE-He213 Cell therapy (dpeaa)DE-He213 Nerve regeneration (dpeaa)DE-He213 |
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Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. © The Author(s) 2023 |
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Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. © The Author(s) 2023 |
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Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. © The Author(s) 2023 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR052473090</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230726104333.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230726s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12610-023-00187-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR052473090</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12610-023-00187-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ma, Xiaolei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2023</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Skin-derived precursor</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Schwann cell</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Erectile dysfunction</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bilateral cavernous nerve injury</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell therapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nerve regeneration</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yang, Wende</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nie, Pan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Zhenbin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Zehong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wei, Hongbo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Andrologie</subfield><subfield code="d">Paris [u.a.] : Springer, 1991</subfield><subfield code="g">33(2023), 1 vom: 18. Mai</subfield><subfield code="w">(DE-627)595710743</subfield><subfield code="w">(DE-600)2486872-3</subfield><subfield code="x">1760-5377</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:33</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:1</subfield><subfield code="g">day:18</subfield><subfield code="g">month:05</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s12610-023-00187-x</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_266</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">33</subfield><subfield code="j">2023</subfield><subfield code="e">1</subfield><subfield code="b">18</subfield><subfield code="c">05</subfield></datafield></record></collection>
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