Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management

Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Asano, Koichiro [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	ABPA Biologics Eosinophils IgE Mucus plugs

Anmerkung:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Current respiratory care reports - New York, NY : Springer, 2012, 12(2023), 3 vom: 25. Juni, Seite 91-96
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:3 ; day:25 ; month:06 ; pages:91-96

Links:	Volltext

DOI / URN:	10.1007/s13665-023-00316-x

Katalog-ID:	SPR052580768

Internformat


LEADER	01000naa a22002652 4500
001	SPR052580768
003	DE-627
005	20230730064711.0
007	cr uuu---uuuuu
008	230730s2023 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1007/s13665-023-00316-x \|2 doi
035			\|a (DE-627)SPR052580768
035			\|a (SPR)s13665-023-00316-x-e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	1		\|a Asano, Koichiro \|e verfasserin \|0 (orcid)0000-0002-9044-3061 \|4 aut
245	1	0	\|a Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management
264		1	\|c 2023
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
520			\|a Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management.
650		4	\|a ABPA \|7 (dpeaa)DE-He213
650		4	\|a Biologics \|7 (dpeaa)DE-He213
650		4	\|a Eosinophils \|7 (dpeaa)DE-He213
650		4	\|a IgE \|7 (dpeaa)DE-He213
650		4	\|a Mucus plugs \|7 (dpeaa)DE-He213
773	0	8	\|i Enthalten in \|t Current respiratory care reports \|d New York, NY : Springer, 2012 \|g 12(2023), 3 vom: 25. Juni, Seite 91-96 \|w (DE-627)718610954 \|w (DE-600)2660484-X \|x 2161-332X \|7 nnns
773	1	8	\|g volume:12 \|g year:2023 \|g number:3 \|g day:25 \|g month:06 \|g pages:91-96
856	4	0	\|u https://dx.doi.org/10.1007/s13665-023-00316-x \|z lizenzpflichtig \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_SPRINGER
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_105
912			\|a GBV_ILN_120
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_224
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
951			\|a AR
952			\|d 12 \|j 2023 \|e 3 \|b 25 \|c 06 \|h 91-96

Indexfelder

author_variant	k a ka
matchkey_str	article:2161332X:2023----::legcrnhploaysegloiptoeeid
hierarchy_sort_str	2023
publishDate	2023
allfields	10.1007/s13665-023-00316-x doi (DE-627)SPR052580768 (SPR)s13665-023-00316-x-e DE-627 ger DE-627 rakwb eng Asano, Koichiro verfasserin (orcid)0000-0002-9044-3061 aut Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. ABPA (dpeaa)DE-He213 Biologics (dpeaa)DE-He213 Eosinophils (dpeaa)DE-He213 IgE (dpeaa)DE-He213 Mucus plugs (dpeaa)DE-He213 Enthalten in Current respiratory care reports New York, NY : Springer, 2012 12(2023), 3 vom: 25. Juni, Seite 91-96 (DE-627)718610954 (DE-600)2660484-X 2161-332X nnns volume:12 year:2023 number:3 day:25 month:06 pages:91-96 https://dx.doi.org/10.1007/s13665-023-00316-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 12 2023 3 25 06 91-96
spelling	10.1007/s13665-023-00316-x doi (DE-627)SPR052580768 (SPR)s13665-023-00316-x-e DE-627 ger DE-627 rakwb eng Asano, Koichiro verfasserin (orcid)0000-0002-9044-3061 aut Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. ABPA (dpeaa)DE-He213 Biologics (dpeaa)DE-He213 Eosinophils (dpeaa)DE-He213 IgE (dpeaa)DE-He213 Mucus plugs (dpeaa)DE-He213 Enthalten in Current respiratory care reports New York, NY : Springer, 2012 12(2023), 3 vom: 25. Juni, Seite 91-96 (DE-627)718610954 (DE-600)2660484-X 2161-332X nnns volume:12 year:2023 number:3 day:25 month:06 pages:91-96 https://dx.doi.org/10.1007/s13665-023-00316-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 12 2023 3 25 06 91-96
allfields_unstemmed	10.1007/s13665-023-00316-x doi (DE-627)SPR052580768 (SPR)s13665-023-00316-x-e DE-627 ger DE-627 rakwb eng Asano, Koichiro verfasserin (orcid)0000-0002-9044-3061 aut Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. ABPA (dpeaa)DE-He213 Biologics (dpeaa)DE-He213 Eosinophils (dpeaa)DE-He213 IgE (dpeaa)DE-He213 Mucus plugs (dpeaa)DE-He213 Enthalten in Current respiratory care reports New York, NY : Springer, 2012 12(2023), 3 vom: 25. Juni, Seite 91-96 (DE-627)718610954 (DE-600)2660484-X 2161-332X nnns volume:12 year:2023 number:3 day:25 month:06 pages:91-96 https://dx.doi.org/10.1007/s13665-023-00316-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 12 2023 3 25 06 91-96
allfieldsGer	10.1007/s13665-023-00316-x doi (DE-627)SPR052580768 (SPR)s13665-023-00316-x-e DE-627 ger DE-627 rakwb eng Asano, Koichiro verfasserin (orcid)0000-0002-9044-3061 aut Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. ABPA (dpeaa)DE-He213 Biologics (dpeaa)DE-He213 Eosinophils (dpeaa)DE-He213 IgE (dpeaa)DE-He213 Mucus plugs (dpeaa)DE-He213 Enthalten in Current respiratory care reports New York, NY : Springer, 2012 12(2023), 3 vom: 25. Juni, Seite 91-96 (DE-627)718610954 (DE-600)2660484-X 2161-332X nnns volume:12 year:2023 number:3 day:25 month:06 pages:91-96 https://dx.doi.org/10.1007/s13665-023-00316-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 12 2023 3 25 06 91-96
allfieldsSound	10.1007/s13665-023-00316-x doi (DE-627)SPR052580768 (SPR)s13665-023-00316-x-e DE-627 ger DE-627 rakwb eng Asano, Koichiro verfasserin (orcid)0000-0002-9044-3061 aut Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. ABPA (dpeaa)DE-He213 Biologics (dpeaa)DE-He213 Eosinophils (dpeaa)DE-He213 IgE (dpeaa)DE-He213 Mucus plugs (dpeaa)DE-He213 Enthalten in Current respiratory care reports New York, NY : Springer, 2012 12(2023), 3 vom: 25. Juni, Seite 91-96 (DE-627)718610954 (DE-600)2660484-X 2161-332X nnns volume:12 year:2023 number:3 day:25 month:06 pages:91-96 https://dx.doi.org/10.1007/s13665-023-00316-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 12 2023 3 25 06 91-96
language	English
source	Enthalten in Current respiratory care reports 12(2023), 3 vom: 25. Juni, Seite 91-96 volume:12 year:2023 number:3 day:25 month:06 pages:91-96
sourceStr	Enthalten in Current respiratory care reports 12(2023), 3 vom: 25. Juni, Seite 91-96 volume:12 year:2023 number:3 day:25 month:06 pages:91-96
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ABPA Biologics Eosinophils IgE Mucus plugs
isfreeaccess_bool	false
container_title	Current respiratory care reports
authorswithroles_txt_mv	Asano, Koichiro @@aut@@
publishDateDaySort_date	2023-06-25T00:00:00Z
hierarchy_top_id	718610954
id	SPR052580768
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR052580768</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230730064711.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230730s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13665-023-00316-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR052580768</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13665-023-00316-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Asano, Koichiro</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-9044-3061</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ABPA</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biologics</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Eosinophils</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IgE</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mucus plugs</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Current respiratory care reports</subfield><subfield code="d">New York, NY : Springer, 2012</subfield><subfield code="g">12(2023), 3 vom: 25. Juni, Seite 91-96</subfield><subfield code="w">(DE-627)718610954</subfield><subfield code="w">(DE-600)2660484-X</subfield><subfield code="x">2161-332X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:3</subfield><subfield code="g">day:25</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:91-96</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13665-023-00316-x</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2116</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2119</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2023</subfield><subfield code="e">3</subfield><subfield code="b">25</subfield><subfield code="c">06</subfield><subfield code="h">91-96</subfield></datafield></record></collection>
author	Asano, Koichiro
spellingShingle	Asano, Koichiro misc ABPA misc Biologics misc Eosinophils misc IgE misc Mucus plugs Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management
authorStr	Asano, Koichiro
ppnlink_with_tag_str_mv	@@773@@(DE-627)718610954
format	electronic Article
delete_txt_mv	keep
author_role	aut
collection	springer
remote_str	true
illustrated	Not Illustrated
issn	2161-332X
topic_title	Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management ABPA (dpeaa)DE-He213 Biologics (dpeaa)DE-He213 Eosinophils (dpeaa)DE-He213 IgE (dpeaa)DE-He213 Mucus plugs (dpeaa)DE-He213
topic	misc ABPA misc Biologics misc Eosinophils misc IgE misc Mucus plugs
topic_unstemmed	misc ABPA misc Biologics misc Eosinophils misc IgE misc Mucus plugs
topic_browse	misc ABPA misc Biologics misc Eosinophils misc IgE misc Mucus plugs
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Current respiratory care reports
hierarchy_parent_id	718610954
hierarchy_top_title	Current respiratory care reports
isfreeaccess_txt	false
familylinks_str_mv	(DE-627)718610954 (DE-600)2660484-X
title	Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management
ctrlnum	(DE-627)SPR052580768 (SPR)s13665-023-00316-x-e
title_full	Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management
author_sort	Asano, Koichiro
journal	Current respiratory care reports
journalStr	Current respiratory care reports
lang_code	eng
isOA_bool	false
recordtype	marc
publishDateSort	2023
contenttype_str_mv	txt
container_start_page	91
author_browse	Asano, Koichiro
container_volume	12
format_se	Elektronische Aufsätze
author-letter	Asano, Koichiro
doi_str_mv	10.1007/s13665-023-00316-x
normlink	(ORCID)0000-0002-9044-3061
normlink_prefix_str_mv	(orcid)0000-0002-9044-3061
title_sort	allergic bronchopulmonary aspergillosis: pathogenesis, diagnosis, and management
title_auth	Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management
abstract	Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153
container_issue	3
title_short	Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management
url	https://dx.doi.org/10.1007/s13665-023-00316-x
remote_bool	true
ppnlink	718610954
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s13665-023-00316-x
up_date	2024-07-04T03:18:27.178Z
_version_	1803616892683812864
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR052580768</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230730064711.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230730s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13665-023-00316-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR052580768</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13665-023-00316-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Asano, Koichiro</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-9044-3061</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose of Review This review highlights the role of eosinophilic mucus plugs in the bronchi and IgE immune responses in the pathogenesis, diagnosis, and management of allergic bronchopulmonary aspergillosis (ABPA). Recent Findings In addition to type I hypersensitivity to fungi, extracellular trap cell death of eosinophils is closely associated with disease mechanisms. In addition, biologics targeting either the IgE- or eosinophil-mediated pathways may be effective in the treatment of ABPA. Therefore, new diagnostic criteria focusing on both pathways have been validated as being more useful than the existing criteria. Summary Eosinophilic mucus plug formation in the bronchi due to the IL-5/IL-5 receptor/eosinophil pathway and type I hypersensitivity to fungi due to allergic or IgE-mediated pathway are important for disease pathogenesis, diagnosis, and management.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ABPA</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biologics</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Eosinophils</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IgE</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mucus plugs</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Current respiratory care reports</subfield><subfield code="d">New York, NY : Springer, 2012</subfield><subfield code="g">12(2023), 3 vom: 25. Juni, Seite 91-96</subfield><subfield code="w">(DE-627)718610954</subfield><subfield code="w">(DE-600)2660484-X</subfield><subfield code="x">2161-332X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:3</subfield><subfield code="g">day:25</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:91-96</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13665-023-00316-x</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2116</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2119</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2023</subfield><subfield code="e">3</subfield><subfield code="b">25</subfield><subfield code="c">06</subfield><subfield code="h">91-96</subfield></datafield></record></collection>
score	7.4015484

Nicht das Richtige dabei?

Schreiben Sie uns!

Allergic Bronchopulmonary Aspergillosis: Pathogenesis, Diagnosis, and Management

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?